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PMC11673128
In line with this rationale, the administration of anti-CD47 mAb induced an increase in phagocytosis when sensitive and off-target resistant ALK-driven cell lines, previously exposed to TKIs, were co-cultured with macrophages (Figure 3 and Figure 4).
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PMC10605143
MDA-MB-231 and CAL120 breast cancer cells were cultured in high glucose DMEM medium supplemented with 10% FBS (EURx).
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PMC9780037
There has been an extensive development of biosensors for quantification of cyt c in human serum.
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PMC11698348
GFP and Phase imaging was performed using IncuCyte S3 live cell analysis instrument (Sartorius, Germany).
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PMC11357960
cDNA synthesis was carried out by using Hifair III 1st Strand cDNA Synthesis SuperMix for qPCR (YEASEN Biotech Co., Ltd, China).
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PMC11476106
Interesting future lines of study include further analysis of cluster and cell movement in our 3D models with and without added VN, also compared with cell VN secretion, to elucidate whether this pro-migratory capacity also affects ES cells.
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PMC9429973
Moreover, the presence of BM-MSC in the 3D model increased OCI-LY18 resistance to apoptosis both in adherent and in non-adherent cells.
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PMC10482220
Anti-TIA1/R antibody was a gift from Drs.
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PMC11538390
Genomic coordinates are shown according to the human genome build GRCh38/hg38.
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PMC11171319
Although many groups have confirmed the presence of HCMV in glioblastomas, others could not.
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PMC7802142
The antisense nucleotide of miR-100 (anti-miR-100) and negative control (anti-NC) were synthesized and modified with 2′Ome by GenePharma (China).
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PMC9429973
Summary/Conclusion: In conclusion, despite many SNP mismatches between patients and donors, our data demonstrate that the repertoire of minor histocompatibility antigens is confined.
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PMC11240571
On FCM, immunofluorescence for PD-L1 was shifted more in HT1080 cells than in 143B cells (Figure 1C).
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PMC7724160
In brief, the samples were purified using Protein-A and directly injected along with a reference standard into an HPLC connected to a 7.8 × 300 mm Toso Haas Biosep TSK G3000SWXL column.
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PMC8414691
A variety of human genetic diseases is known to be caused by mutations in genes encoding chromatin factors and epigenetic regulators, such as DNA or histone modifying enzymes and members of ATP-dependent chromatin remodeling complexes.
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PMC10988555
DMSO 0.1% (v/v) was used as negative control (solvent control) and DOX 0.4 μM, cisplatin (Cis) 5 μM, and TBHP 22.2 μM as positive controls.
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PMC9429973
Methods: A total of 108 patients, 55 of whom were HL and 53 were NHL, who were treated with the diagnosis of HL and NHL at the Hematology clinic of Gaziantep University Faculty of Medicine, were followed up.
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PMC11486946
The total amount of EGFR was decreased by treatment with the five compounds (Fig. 4c) regardless of EGF stimulation, indicating the destabilization of EGFR.
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PMC11354225
Specifically, EGCG has been observed to decrease iron levels through its chelation activity in HT-29 colorectal cancer cells, inducing endoplasmic reticulum stress and favoring apoptosis .
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PMC11637716
Severe exocrine pancreatic insufficiency was diagnosed at the age of 5 months, with significantly reduced faecal pancreatic elastase values (<15 μg/g, normal >200).
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PMC11495567
The images were captured using the Keyence BZ-X800 fluorescence microscope and analyzed using Keyence BZ-X800 analyzer software.
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PMC7823217
Ongoing and future studies are focusing on the development of integrated microfluidic/bioprinted constructs in a lab-on-a-chip format to minimize the cost and facilitating high throughput testing of a large number of available chemotherapeutic agents enabling selection of the most suitable drug combination for a particular patient and hence personalized medicine approach.
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PMC9429973
88% of CML and 96% of Ph+ALL patients had received ≥2 prior TKIs.
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PMC11742431
The results above revealed that 5637, as a PD‐L1 high‐expressing cell, could be efficiently killed by KVN and K14N, respectively, and as UMUC‐3 cells that were low‐expressed PD‐L1, KVN and K14N were still able to perform a low level of killing function.
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PMC11224020
Strikingly, among the 103 genes following the same expression pattern as Ccr7 were 2 genes encoding the major subunits of ARP2/3 (Actr2 and Actr3), the gene encoding IKKβ (Ikbkb) and several IFN-stimulated genes (Fig. 6d).
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PMC11657695
The FLI1 peak progressively reappears around its binding site after re-expression of EWS::FLI1 following the interruption of doxycycline treatment (Day 7 + 3, Day 7 + 4, Day 7 + 7 and Day 7 + 10, Fig. 4B).
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PMC9429973
Twelve pts had a related donor, 1 pt had an HLA-haploidentical donor and 7 pts had a non-related donor (NRD).
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PMC8978939
Figure S2 and Table S1 in the Supplementary Material show the results for each of these.
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PMC10165258
Some spheroids were subjected to a single drug, because some primary droplets fused with only one secondary droplet or with one droplet containing single drug and a second droplet containing a control solution (DMSO or NaCl).
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PMC9895440
sFasL was not displayed as it only correlated with tumor size (also in source data).
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PMC11126803
As reported, epithelial-mesenchymal transition (EMT) and cancer stem cells are potential mechanisms contributing to VM formation (12), and some EMT-associated transcription factors, including Snail1, Nodal, zinc finger E-box binding homeobox 1 (ZEB1), ZEB2, and Twist1, may also be involved in VM formation (11, 13, 14).
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PMC8316344
G TFRC could be ubiquitinated by βTrCP, as measured by an in vitro ubiquitination assay using anti-TFRC antibodies after incubation with purified proteins as indicated.
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PMC11528603
B: Dose-response curves of inhibitory activity of SA-EA extract on HL60, and NIH 3T3 cell lines.
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PMC10758402
BALB/c nude mice were implanted with 3 × 10 CT26.wt cells or 5 × 10 4T1 cells.
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PMC9429973
Building on these properties, we developed AUTO1/22 in which autologous T cells are co-transduced with 2 different lentiviral vectors encoding our existing CD19 CAR and a novel CD22CAR designed to recognise targets with low antigen density.
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PMC9429973
In our investigation of factors associated with OS, multivariate analyses revealed that there were 7 factors associated with poor OS (panel C).
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PMC11525028
Based on the regulatory mechanism, we examined the mRNA and protein levels of NAT10, ATF4, and ASNS and found a correlation between NAT10 and ATF4 (mRNA level: R = 0.361, p = 0.005, Pearson correlation; protein level: R = 0.504, p < 0.001, Pearson correlation) as well as ASNS (mRNA level: R = 0.261, p = 0.022, Pearson correlation; protein level: R = 0.476, p < 0.001, Pearson correlation) in fresh osteosarcoma tissues (Figures S4F and S4G).
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PMC11612315
This represents a promising strategy in the quest for safer and more effective pain management solutions, signaling a potential shift toward innovative analgesic strategies that prioritize both efficacy and patient safety.
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PMC9429973
Responses were evaluated according to 2009 Marsh criteria Results: We included 25 patients, mainly females (64%) and with a median age of 48 years (17-91) (Table 1).
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PMC11576293
Protein tyrosine kinases are important in transmitting signals that control numerous cellular functions, such as growth, specialization, mobility, and the development of new blood vessels (angiogenesis) (Lemmon and Schlessinger, 2010; Liao, 2007).
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PMC11705547
Cisplatin enters tumor cells via copper transporter 1, and is activated by the cytoplasmic water molecules or other small sulfhydryl-containing molecules .
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PMC10854447
The inhibitory effects of the most potent antiproliferative compounds 7h–l on EGFR, as a potential target for their antiproliferative action, were studied using Erlotinib as a control medication.
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PMC9429973
It is characterized by recurring skin, lung, and deep tissue infections from the first months of life.
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PMC10329237
PFD was approved for treating IPF; however, it has lower toleration by the patients in full dose (10).
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PMC9429973
Toxicology studies have shown a broad therapeutic index and an improved safety profile.
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PMC11742290
4-AAQB negatively regulated stem cell maintenance via the LGR5/WNT/β-catenin signaling pathway.
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PMC11591052
The protein/actin ratio was calculated and is listed in the graphs.
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PMC11643491
The engulfment and uptake of particles by cells require a sufficiently large area of cell–particle adhesion to reduce free energy while minimizing cell morphological changes, which could increase free energy.
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PMC7987994
The formula used was RMA = (Fsample)/(Fcontrol), where Fsample stands for the average fluorescence of resorufin produced by the affected cells (i.e. cells incubated with extracts) and Fcontrol stands for the average fluorescence of resorufin produced by of the unaffected cells (i.e. control cells).
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PMC9429973
Phase 3 trials in ruxolitinib-treated and ruxolitinib-naive patients are underway to further assess the combination of JAK and PI3K inhibitors.
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PMC11765243
PI3K activity mediates many signaling pathways in T lymphocytes, including TCR/CD3 activation.
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PMC3675084
BPR0L075 treatment disrupted microtubule cytoskeleton in both the parental and resistant ovarian cancer cells.
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PMC10024132
In this study, we explored whether it would be beneficial to use γ9δ2 T cells rather than αβ T cells when creating blinatumomab-secreting T cells.
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PMC11768927
Strategies to mitigate neurotoxicity include the generation of rVSV pseudotyped with an attachment protein from a non-neurotropic virus, or the use of attenuated viral strains.
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PMC11742047
Induction of apoptosis in HL-60 cells using cytotoxic drugs and in Jurkat T- cells produces an inhibition of CDP-choline:1,2-diacylglycerol choline phosphotransferase, triggering an accumulation of CDP-choline and an inhibition of phosphatidylcholine biosynthesis.
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PMC6627640
Mean and standard error of mean were used to describe sample variability. (
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PMC11594588
Disruptions in the expression of MT-ND1, MT-ND5, and MT-ND6 genes responsible for the production of NADH phosphate (NADPH)-trans-hydrogenase result in a decrease in the concentration of NAD+ forms.
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PMC11794588
The chemical structure of β-amyrin (3β- hydroxy-olean-12-en-3-ol) is also depicted in Figure and its formula is C30H50O.
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PMC11247842
The summary statistics of MR-MEGA_CM identified CTCF enhancer in lung as a significantly enriched feature for the genome-wide significant variants (Fig. 5a).
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PMC10809689
RP-HPLC was done on a C18 column (150 * 4.6 mm, 5 μm), using Mobile-phase A (1 g K2PO4 + 0.5 g KH2PO4 in 500 mL distilled water), and B (100 mL distilled water, 150 mL acetonitrile, and 300 mL isopropanol) with linear gradient from 10–100% B at a flow rate of 1.2 mL/min in 35 min Changes of glutamate level in control, PMA, and PG24 groups of THP-1 cell line with RP-HPLC chromatograms.
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PMC11566417
Secreted factors from late passage immortalized MDECs exert antimicrobial effects on MRSA, promote fibroblast migration, stimulate neutrophil chemotaxis, and inhibit neutrophil reactive oxygen species (ROS) production in vitro, suggesting that immortalized primary bovine MDECs may serve as a relevant therapy in vivo.
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PMC7582629
Indeed, these imaging tools require cell destruction or selective tagging, thereby negating nonintrusive in vivo and in vitro studies.
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PMC11694625
The development of anticancer agents with better treatment efficiency and fewer clinical side effects has attracted more and more attention of medicinal chemists.
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PMC10380508
Absorbance of the final solution was measured at 570 nm using an Anthos ELISA plate reader, and values were expressed relative to the control samples.
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PMC11718109
I Untagged synaptophysin was visualized by antibody directed against it in a triple co-transfected cell.
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PMC10890055
A higher metabolic activity of the L929 cells was observed in the MEM medium, which is recommended for this cell line.
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PMC11055323
f Schematic illustration shows the 3D chromatin structures of the cells with expression of physiological SS18, condensates deficiency mutant SS18(YA)-SSX and pathological SS18-SSX, respectively.
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PMC11706491
Boxplot represents quartile distribution.
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PMC11300639
First, ectopically overexpressed CDK4 decreased the protein levels of TSC1 in 786-O and A498 cells (Fig. 1a).
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PMC8526701
Mechanism study revealed that BRD9 inhibition promotes PUMA induction via the TUFT1/AKT/GSK-3β/p65 axis.
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PMC9429973
LMWH appears to be associated with better outcomes and fewer new intracranial hemorrhages.
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PMC11706491
pAV plasmids were obtained from the National Biosource Project (NBRP).
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PMC11730000
In vitro and in vivo toxicity assays and clinical trials are required for the use of plant products.
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PMC9429973
None of these AEs were considered study drug related and all resolved without changes to study treatment.
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PMC5035325
In addition, co-expression of both EGFR and NeuGcGM3 ganglioside (30-70 %) was observed in others tumors with small number of patients but of different origin as sarcomas (n = 3) and non-Hodgkin lymphomas (n = 3).
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PMC11785489
Even among T cells that recognize the same antigen, these TCR scores help to explain variation in T cell states.
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PMC11593031
It was initially denominated as C1300 and was first described in 1969 .
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PMC11463018
C20H16FN5O2, [M + H] m/z: 378.13608, found: 378.13602.
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PMC11591052
For the SeaHorse energy profiling experiments with N = 5, the Mann–Whitney (U-test) was applied.
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PMC11747885
Healthy cells produce a higher luminescent signal compared to dead cells, allowing for the quantification of cytotoxic effects.
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PMC9429973
Interestingly, 15 of those 28 enzymes show additional effects on proliferation.
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PMC11596967
The physicochemical properties of peptides were compared (Table 1).
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PMC6934009
However, the levels of LC3I were decreased markedly in these cells on treatment with 25, 30, and 50 µM doses of wogonin.
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PMC11531744
P < 0.05.
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PMC10212663
Considering the evidence suggesting the important role of RANKL in promoting tumor progression in a variety of malignancies and acting as a worse prognostic factor, , , , , it has been suggested that the direct inhibitory effect of denosumab on RANKL may provide a survival benefit for NSCLC patients.
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PMC9429973
Methods: Patient data was taken from the patient herself and hospital records.
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PMC7987994
FBS concentration during extraction and during cytotoxicity testing of degradable metallic biomaterials is frequently discussed.
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PMC10578720
As shown in Figure 2A, besides 10 IU/mL HBV, higher HBV titers (10 and 10 IU/mL) promoted human THP-1 macrophages secretion of anti-inflammatory cytokine (TGF-β1 and IL-10), while decreasing the production of TNFα and IL-1β.
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PMC11078693
Note: A 63× NA1.4 oil lens and 63× NA1.2 water lens provide comparable image quality, with the water lens providing an advantage of refractive index matching, eliminating depth-dependent spherical aberration.
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PMC11656657
Memory profile of T-cells was determined based on CD62L and CD45RA expression.
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PMC11555465
African countries have the greatest average incidence rate of infection of T. gondii (61.4%), followed by Oceania (38.5%), South America (31.2%), Europe (29.6%), the United States and Canada (17.5%) and Asia (16.4%) (13); thus, T. gondii has a high prevalence globally.
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PMC11576293
Compounds 16 (R1 = 4-OMe, R2 = 3-OMe, R3 = Me), 17 (R1 = 4-OMe, R2 = 3-OMe, R3 = Et), 18 (R1 = 4-OMe, R2 = 3-OMe, R3 = n-propyl), 19 (R1 = 4-OMe, R2 = 3-OMe, R3 = iso-propyl), 20 (R1 = 4-OMe, R2 = 3-OMe, R3 = ally), and 21 (R1 = 4-OMe, R2 = 3-OMe, R3 = 4-benzyl), which share the same molecular structure as compound 22 but have different substituent groups attached to the sulphur atom, exhibited GI50 values of 86, 29, 45, 30, 71, and 83 nM, respectively.
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PMC11610461
Further GSVA and correlation analyses in our study demonstrated that the expression levels of PSENEN correlated positively with oxidative phosphorylation.
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PMC5535901
Jurkat cells (ATCC, Manassas, VA, USA) were plated at a density of 4 × 10 cells/mL in a 96 well plate overnight.
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PMC11461874
UBE2G1 and UBE2T were identified by a screening that employed dominant negative mutants of well-characterized E2 enzymes (Fig. 2).
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PMC10887351
The paradoxical nature of β-AR activity in BC cells has recently been studied .
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PMC9429973
Pts aged 60-69 years had better outcomes compared with pts ≥70 years (5-year OS rates: 59% vs 27%, respectively; P=0.04) and as did those without poor cytogenetics (i.e. complex, KMT2A-rearranged, low-hypodiploidy/near-triploidy) compared with poor cytogenetics (5-year OS rates: 54% and 25%, respectively; P=0.02).
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PMC11632064
For crystal violet staining, cells were seeded in 24-well culture plates in 500 μl of media at the following densities: 7,500 cells/ml (A-375) and 45,000 cells/ml (MeWo).
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PMC11701801
Treatment of SMARCA4/SMARCA2-deficient DMS114 xenografts with CP-C27 led to a significant increase in the number of cells positive for the apoptotic markers cleaved caspase-3 and cleaved PARP (Fig. 6I–K).
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PMC11532793
number of false discoveries as a function of the number of transcripts chosen for different DTE and sampling methods. (
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