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PMC11267830
Moreover, the decrease in RBM39 levels led to an increase in the levels of the apoptosis-inducing proteins cleaved-PARP and cleaved-caspase8 (Fig. 4h).
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PMC11711347
Cells were then removed from the incubator, labeled, and the media was aspirated from each well.
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PMC9429973
Eight pts were Ph- (including 3 Ph-like ALL).
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PMC11638255
Despite their abundance in both mice and humans, neutrophils are underrepresented in single-cell RNA-sequencing datasets owing to relatively low mRNA content resulting in fewer transcripts.
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PMC11537649
Lnc NEAT1 acts as a sponge of miR-152-3p. (
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PMC11049294
Library preparation was performed using IDT xGen2.0 with UDIs and the 2 × 150 bp paired sequencing was done on a NovaSeq 6000 instrument.
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PMC11628904
This resulted in a greater amount of vital tissue 3 days post‐burn.
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PMC11420784
Experiments were repeated 3 times.
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PMC10291556
In contrast, Pt(IV) complex 2 containing no DCF ligand was less efficient in inhibting artificial wound closing. (
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PMC6461034
If the lysate is very viscous, add additional lysis buffer.
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PMC10728535
Epithelial ovarian carcinoma (EOC) has the highest frequency and comprises 90%–98% of ovarian tumors.
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PMC9429973
Aims: Our aim was to investigate the applicability of the integrated use of the whole transcriptome RNA sequencing and conventional cytogenetic methods in the routine diagnostic of the B-other BCP-ALL cases.
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PMC11387401
This study gives a sneak peek into the pathways and HIV-1 replication steps regulated through these interactions, like the potential regulation of the super elongation complex on a post-transcriptional level by Tat.
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PMC11758416
REAGENT or RESOURCESOURCEIDENTIFIERAntibodiesAnnexin V APC; 1:20BioLegend6409207-AAD; 1:20BioLegend420404Annexin V binding bufferBioLegend422201CD3 monoclonal antibody (clone: SK7); 50 μg/mLInvitrogen16-0036-81CD3 monoclonal antibody (clone: OKT3); 50 μg/mLInvitrogen16-0037-81CD32 APC; 1:100BioLegend303208Biological samplesLeukoreduction collarsCrimson Core (BWH)N/AChemicals, peptides, and recombinant proteinsConcanamycin AR&D Systems2656CellTrace CFSEThermo Fisher Scientific65-0850-84Dynabeads human T-activator CD3/CD28Thermo Fisher Scientific11131DRecombinant human IFNβR&D Systems8499-IF-010/CFRecombinant human IL-15R&D SystemsBT-015Fetal bovine serumGeminiBio100-106Gibco Penicillin-Streptomycin (10,000 U/mL)Thermo Fisher Scientific15140122Gibco Gentamicin reagent solutionThermo Fisher Scientific15710064Gibco L-glutamineThermo Fisher Scientific25030081Gibco Trypsin-EDTA 0.5% (10X)Thermo Fisher Scientific15400054Gibco DMEMThermo Fisher Scientific11966025Gibco RPMI 1640 mediumThermo Fisher Scientific11875093Gibco PBS (10X), pH 7.4Thermo Fisher Scientific70011069Critical commercial assaysCD8+ Memory T Cell Isolation Kit, humanMiltenyi Biotec130-094-412CD8+ T Cell Isolation Kit, humanMiltenyi Biotec130-096-495Experimental models: Cell linesL cells expressing CD32Dr.
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PMC8009078
Therefore, in the view of the facts mentioned above, this study was aimed to investigate the TMPRSS2 inhibitory potential of bioactive isolated from the M. alba using in-silico modeling.
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PMC7433824
A Venn diagram shows the common differentially expressed proteins in A172 cells treated with different P4 doses (100 µM P4 versus without P4 and 300 µM P4 versus without P4) (Figure 4).
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PMC9966931
Yield 75.04%; GC-MS (EI, 70 eV): m/z (%): 254 [M] (15), 255 (33), 107 (17), 106 (20), 105 (100), 91 (45), 79 (16), 78 (38), 77 (38), 51 (34).
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PMC11295144
GABAARs and NL2 are co-expressed in many GABAergic inhibitory synapses in the mammalian brain with both proteins being implicated in synaptic initiation and functional maturation (Ali et al., 2020).
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PMC4659567
The reported complexes 1–8 (Fig 1) were, due to known antitumor effect of their structural analogues containing different N-donor ligands, investigated for their in vitro cytotoxic effect against human ovarian cancer cell lines A2780.
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PMC10582049
Altogether, the analysis of the gene expression profile, the activity of signaling pathways, and the Venn diagram of overlapping differentially expressed genes across subtypes may indicate that the three observed subpopulations of CAFs could be transient forms of each other.
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PMC11267830
A One-drop OD-1000 spectrophotometer was used to determine RNA concentration and purity.
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PMC9429973
No ICANS were observed.
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PMC11321678
When we set the cluster number as three, Group 3 and Group 4 samples were merged into one group.
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PMC11240571
These findings suggest that radiated cells including normal cells and tumor cells induce systemic release of exosomal PD-L1, which leads to the risk of exacerbation of distant lesions by systemic immune suppression via exosomal PD-L1.
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PMC11093197
Fluorescent images were captured on KEYENCE BZ‐9000.
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PMC11705862
For the standard PCR, the gels were imaged directly after electrophoresis using a CCD camera (Bio-Rad).
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PMC9635307
This provides direct evidence showing the effect of CEACAM1 on BCR signaling-specific activation in B cells.
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PMC9429973
The median age was 70 years and 67% of the patients were ≥65 years old.
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PMC9583612
The effectiveness of and trust in approaches to address methane emissions, therefore, depend on the availability of accurate methane emission estimates that vary in frequency, duration, and across geographic locations.
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PMC9429973
The baseline characteristics are outlined in Table 1.
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PMC11401350
The supernatant was then concentrated by low speed centrifugation (4 °C, 3000 g, overnight).
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PMC9429973
7 days post-tumor injection, mice were randomized and treated daily 6.25 mg/kg of 5-NL or vehicle for five consecutive days and tumor volume was measured (n = 9-12).
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PMC8010066
The error bars indicate the standard errors of the means in a representative triplicate time. '. *:
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PMC11401358
We also confirm that the β-sheet has a 96 % correlation with the oxidative capability.
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PMC11640419
The presented data indicate that this cell line may serve as a model system for investigating the non-canonical activity of p53 ψ .
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PMC8345486
The resistant cells were comparably sensitive than the other cell lines to the cytotoxic activity of Fe-containing compounds, which had higher impact on the cell viability than carboplatin.
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PMC11486946
b Compounds reducing both EGFR mobility and clustering induce EGFR internalization.
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PMC5963610
Last, but not least, it shall be noticed that the synergism of the combination provides multiple therapeutic advantage into the human setting.
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PMC5941560
Ju and Cummings assumed that the Jurkat cell line had retained its diploid, male genome and possessed only one copy of the X chromosome.
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PMC8009078
The post-processed ensemble of structures are considered from the MD simulation trajectories to calculate the ∆Gbind of each molecule.
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PMC9429973
Variant 2 was detected in 2 carriers, variants 3, 4 - in 3, with an interval of a week.
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PMC8193046
In addition, compound 23 did also reflect all five pharmacophore features as derived from the previously reported similarity search and pharmacophore modelling approach [(i) F1: aromatic; (ii–iii) F2 and F3: aromatic/hydrophobic; (iv) F4: hydrophobic; and (v) F5: acceptor; Fig. 9 C–D] .
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PMC9429973
Avapritinib,a C-KIT tyrosine kinase inhibitor, approved by the FDA in 2021 for patients with AdvSM has an overall response rate of 70% as reported in early phase trials.
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PMC11001582
Exons are shown boxed; untranslated regions of exons are colored yellow with translated regions in purple.
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PMC9844987
In addition, low variable promoters had a weaker response (Figure 3D).
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PMC8540692
The observed methylation level decrease was from 100% to 75% in A-172 cell line, and from 50% to ~25% in T98G cell line.
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PMC11290772
This staining allowed for the visualization of green fluorescence in the organoids, indicating their viability.
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PMC11461833
On the basis of public database analysis, we found that STXBP5 is a potential ageing-related gene.
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PMC9429973
Based on the KarMMa trial criteria, 49/108 pts (45%) would be defined as eligible and 59 (55%) not eligible for CAR-T cell therapy.
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PMC8777939
ATG7 plays a crucial role in autophagosome formation .
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PMC11612626
After 16 hours, media was replaced and puromycin (10 μg/mL, Sigma-Aldrich) added to the transduced E.G7-Ova cells to select and establish a stable cell line expressing the GFP–Luc fusion protein.
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PMC4485648
Therefore, we evaluated the effect of SFN in the chemoresistant variants of A2780 cells under hypoxic conditions using the A2780/CP cell line resistant to cisplatin (expressing the MRP1 gene) and A2780/ADR cell line resistant to adriamycin (expressing the MDR1 gene).
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PMC9429973
M. Stumpf, V. Ecker, P. Giansanti, J. Lu, T. Zenz, I. Ringshausen, B. Küster, J. Ruland, M. Buchner TranslaTUM - Central Institute for Translational Cancer Research, Technische Universität München, München; Bavarian Biomolecular Mass Spectrometry Center (BayBioMS), Technical University of Munich, Freising; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland; Wellcome Trust/MRC Cambridge Stem Cell Institute and Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom; Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany Background: The MAPK-ERK pathway is a key signaling cascade for cellular homeostasis.
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PMC11495567
NCI-H23 (CRL-5800) cells were cultured in complete RPMI 1640, (Genesee Scientific, San Diego, CA) supplemented with 100 U/mL streptomycin,100 μg/mL penicillin and 10% heat-inactivated fetal bovine serum (FBS) (Genesee Scientific, San Diego, CA) at 37°C in 5% CO2/95% humidified air.
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PMC9429973
The anti-leukemia effects of either single drug have been reported by inducing cell apoptosis through suppressing multi-oncogenic pathways in human tumor cells.
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PMC10969097
Harvesting took place in the Konya–Seydişehir and Karaman–Ermenek–Başyayla regions in Tukey between October and November.
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PMC11388384
This “topology-limited” diffusion model predicted parameters that modulate gradient size, including the transition rates between confined and free populations.
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PMC9429973
CALR mutation was revealed in the patient during the initial mutations screening by the presence of heteroduplexes on the electrophoregram and further confirmed and identified by the Sanger’s sequencing as insertion c.1154_1155insGTGTC; p.E386fs*46.
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PMC9429973
Methods: Samples were obtained from 10 MM patients not treated with daratumumab to compare the MFI of CD38-ME vs CD38-nanobody at baseline and after incubation with daratumumab at a concentration of 10 nM for 60 min at room temperature.
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PMC10996034
The results indicated that MMP1, ZYX and UNC5C were not associated with the disease stage of patients with EOC (P>0.05, not statistically significant; Fig. S4D-F).
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PMC11578343
Thus, for the remaining results discussed below, we employed a microfluidic geometry with a 6 mm zone length.
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PMC11746942
We found that FTY720 treatment alleviated clinical-associated pathological features, including acanthosis, parakeratosis, and epidermal thickening (Fig. 1A).
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PMC11401358
Samples of a concentration were 50 mg/mL (for SF) and 5 mg/mL (for peptide).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "of", "a", "concentration", ...
PMC4395774
This finding likely reflects the lack of secretory granules required for efficient perforin trafficking and storage in all cells except TCR-stimulated CD8 T cells (CTL) and NK cells.
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PMC11283030
ACLY inhibition attenuates ccRCC progression possibly through EMT and mTORC1 pathways.
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PMC6487404
The segment was washed several times with normal saline solution and placed immediately into the oxygenated Krebs buffer (composition: NaCl 118 mM, NaHCO3 25 mM, KCl 4.7 mM, CaCl22.5 mM, MgSO4 1.2 mM, KH2PO4 1.2 mM, and d-glucose 11 mM).
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PMC11790971
e Plot of the numbers and ratios of cells in artificial pools and monoclonal wells across all passages.
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PMC11442172
Furthermore, several studies have demonstrated that culturing of cancer cells in physiological media results in metabolic profiles that more closely resemble the metabolic state of tumors (27, 46), and could lead to a better assessment of the effectiveness of antitumor drugs in vivo (26, 47).
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PMC9429973
Several genes (DNMT3A, RUNX1, SRSF2, STAG2) and pathways (Differentiation, Epigenetics, Splicing) were associated with improved outcomes with IVO+AZA, including the RTK pathway, which was previously reported to be associated with primary resistance to IVO monotherapy.
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PMC10958426
Percentage of DEGs located in high CNV variation region and NoCNV/low CNV variation regions.
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PMC9429973
To investigate whether p-STAT3 upregulation is involved in the acquisition of vorinostat resistance, we performed STAT3 knockdown using an siRNA.
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PMC8984067
Figures 4(a)–4(c) are TEM photos of UCNPs, UCNPs-Ce6, and anti-EpCAM-UCNPs-Ce6.
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PMC9429973
In univariate analysis, pts with a ratio <1.31 had a significantly worse OS compared to those with a ratio ≥1.31 (median 45 vs 104 months, p=.0014; HR 2.4 [1.4-4.1]) (Fig.1B).
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PMC10507284
Additionally, the univariate and multivariate analyses were also applied to evaluate the prediction performance.
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PMC11300085
The chemerin-enhanced expressions of RhoA, ROCK1, and the phosphorylation level of MLC were also reversed by the silencing of CMKLR1 (Figures 4(a) and 4(b)).
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PMC7823217
Figure B is reproduced from Ref.
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PMC7185206
Survival between groups without regard to age or stage at diagnosis was also analyzed with similar results (Supplemental Figure 1a, Supplemental Table 1).10.1080/2162402X.2020.1744980-T0001Table 1.Low PD-L1 protein-to-mRNA ratios predict worse survival in multiple malignancies.
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PMC11344246
Knockdowns in MOC cell lines targeting CDK1, CCNA2, CDC20, TRIP13 and PRC1 significantly reduced cell viability compared to the siOTP-NT non-targeting control (Figure 3A, one-sample t-test adjusted for multiple testing P < 0.05).
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PMC11750712
Thirteen patients discontinued before apheresis (5 due to progressive disease; 4 due to screen failure; 2 were outside the allowable screening window for treatment; one due to patient/physician choice; and one due to septic shock/multi-organ failure).
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PMC7823217
This construct also showed the expression of several cancer-associated biomarkers, cancer stem cell markers, and the evidence of epithelial to mesenchymal transition (EMT).
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PMC11525028
Osteosarcoma cells were seeded at a density of 1500 cells per well in 96-well microplates for the Cell Counting Kit-8 (CK04, DOJINDO) assay.
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PMC9429973
A total of 41 patients had a single KIT mutation and 8 patients had 2 or more KIT mutations.
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PMC11323699
Quality control testing was conducted using ultra high-performance liquid chromatography and mass spectrometry.
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PMC11502327
The study found that PLGA-PEG-FA NPs have the ability to continuously release GEN while increasing the uptake of the drug by SKOV-3 cells, with the potential for better specific delivery compared to non-targeted drugs.
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PMC11544771
PRE (Selleckchem, Houston, TX, USA) was prepared to 10 mM stock solution by dissolving it in dimethyl sulfoxide (DMSO) and stored at −20 °C.
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PMC6442998
DNMDP did not affect GIST48 viability at any concentration tested.
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PMC6182045
This homogeneity in net charge facilitates purification by filtration and ion exchange chromatography methods, eliminating the need for expensive custom-made lectin, or immunoaffinity columns.
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PMC9429973
Accurate assessment of CVD risk and prompt detection of subclinical cardiovascular disease in MDS patients will assist clinical decisions on the introduction of intensive monitoring and preventive use of CVD-specific interventions in these individuals.
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PMC11564405
The confocal laser scanning microscope, with its high-resolution optics, is the primary lens utilized in this study, and is capable of penetrating the microscopic realm with unparalleled precision.
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PMC10604092
The cancer cachexia in this model was similar to the latest consensus definition and its pathology closely resembled the findings in humans.
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PMC11519583
Subsequently, the fluorescence intensities of SPiDER-βGal in MPs were monitored by flow cytometric analysis (n = 3).
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PMC9429973
Aims: Investigate and analyze the contamination of nurses’ uniforms after different working hours in hematology general ward, in order to providing some references to improve the quality of hospital infection management.
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PMC7185206
ADAM17 expression correlated inversely with PD-L1 protein-to-mRNA ratios (p < .0001).
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PMC11015054
Based on the sequencing results as well as the results of GO functional enrichment analysis and KEGG pathway enrichment analysis, we found that METTL5 could promote the generation and release of neutrophil extracellular capture network (NETs) and might further accelerate the progression of HCC.
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PMC2196094
The RNA was isolated by the guanidinium thiocyanate method (55).
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PMC7452526
SEM image of AgNPs indicated that the nanoparticles were spherical and mostly dispersed with small size (12 nm).
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PMC11093197
While loss of function (LOF) of retinoblastoma 1 (RB1) tumor suppressor is known to drive initiation of small‐cell lung cancer and retinoblastoma, RB1 mutation is rarely observed in breast cancers at their initiation.
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PMC10605143
In Matrigel, a reduction in the number of disruptive or multi-acinar spheroids in favor of round spheroids was observed after HSF1 silencing (Figure 2g,h).
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PMC9812014
These tulongicin alkaloids were extracted from the Topsentia sp., a sponge of deep waters.
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PMC11204465
Acetic acid or acetate → desmethylsulphanilic acid → averantin → odoriferous flunaricin → heterochromatic trichothecene hemiacetal acetate → heterochromatic trichothecene A → STC.
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