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PMC9429973
Aims: To explore the clonality relatedness, clinical and molecular characteristics of patients with RS.
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PMC4443654
Importantly, each Hi-C dataset was re-analyzed to provide comparable identically processed data, which was complementary to the identically processed, locus-level ENCODE data.
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PMC10213199
The HL60 cell line showed the same characteristics as the JYL low conc.
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PMC11321678
For immunofluorescence staining, a blocking solution containing normal sheep serum (5%) was applied to the sections.
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PMC9872547
Various experiments have been performed to solve this problem, many of which have performed nano-carriers (26).
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PMC11138140
These results show that during the 24 h imaging duration, the untreated cardiomyocytes did not exhibit any meaningful increase in optical volume (0.98-fold), while the volume of the norepinephrine-treated cardiomyocytes increased by approximately 1.39-fold.
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PMC10376064
As DMF has been demonstrated before to easily form glutathione conjugates under near-physiological conditions , we also analyzed its glutathione conjugate (dimethyl succinate-SG, DMS-SG, 9; Figure 7A).
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PMC10440586
The TAMs fraction in Supplementary Figure 3 was estimated by three algorithms (xCell , EPIC , and quanTIseq ) and scored by three gene sets , , .
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PMC7334607
In addition to the nine drugs displayed in this figure, two additional drugs (Pazopanib and Vincristine) and a drug activation reagent (sodium thiosulfate) were included in the drug sensitivity assays.
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PMC9429973
All patients provided informed consent.
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PMC5261804
Unsupervised hierarchical clustering revealed strong clusters of some subsets of PPIs (S1 Fig).
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PMC11453018
Particularly notable changes were observed in the Hippo, Wnt, and Hedgehog pathways, indicating the widespread effects of P300/CBP inhibition on regulatory networks crucial for tumorigenesis and cell differentiation (Fig. 3I).
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PMC11240052
Cell transfection The synthetic circ-0008285 sequence was subcloned into the pcDNA3.1 vector (Invitrogen).
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PMC11701801
Data are presented as the mean ± SEM; n = 3 independent experiments.
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PMC9429973
Up to 3% of transplant recipients develop a stroke; however, despite the relationship between thrombocytopenia and bleeding at any level, ischemic strokes have also been described in patients with thrombocytopenia.
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PMC11461874
The cell lysates were immunoblotted using antibodies against DBP.
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PMC9429973
Aims: Here we investigated whether the combination of externally administered immunoglobulins (Ig) via CP therapy and specific inhibition of viral replication might be sufficient to effectively treat B-cell depleted patients with COVID-19.
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PMC11244823
Serum No. 29 was no longer used because of its low reaction against the smaller gD1 antigens.
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PMC10421378
The results clearly show that the damage sustained by bacterial cells influences their ability to adhere to Caco-2 cells.
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PMC11222184
However, unexpectedly, HSP90 inhibition caused an increase in the expression of DNA damage repair genes ERCC3 and LIG4.
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PMC9429973
Image: Summary/Conclusion: Regardless the difficulties linked to the COVD-19 pandemic, the TCP2 is recruiting very well and allow us in better understanding the outcome of patients with PTCL classified according to the 2016 WHO in the real world.
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PMC7582629
It was shown that, even for the lowest mixture, i.e., 1/100, the prediction based on the HTS-RS measurements provides highly accurate results, and the sampling of nearly 1000 cells could be achieved in 38 min.
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PMC8956657
ORF4b PDE activity inhibits the innate antiviral 2′-5′ oligoadenylate (2–5 A) synthetase (OAS)-RNase L pathway by degrading 2–5 A produced by OAS, thus preventing activation of the antiviral enzyme RNase L via the 2–5A second messenger molecule.
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PMC11591794
It has been reported that they exhibit anticancer properties by controlling important mechanisms of cancer, such as cell proliferation, angiogenesis, and metastasis and by activating the apoptosis mechanism .
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PMC11789597
Specifically, MM cells adhere to the extracellular matrix or BMSCs in the bone marrow through adhesion molecules, such as integrin family members, CD138, CD44, , vascular cell adhesion molecule‐1, lymphocyte function‐associated antigen‐1, and intercellular adhesion molecule‐1, leading to the enhancement of their survival and CAM‐DR.
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PMC9429973
Navitoclax is a first-in-class, oral, small molecule that binds with high affinity to BCL-XL and BCL-2, key pro-survival proteins in the apoptotic pathway, and has a synergistic effect when used in combination with JAK inhibitors to enhance malignant cell death in MF.
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PMC10669128
Krump-Konvalinkova and Bittinger were able to establish the human endothelial AS-M cell line from a cutaneous angiosarcoma.
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PMC10237474
Our studies demonstrate the versatility of the PB transposon system for stable pool generation.
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PMC8996378
The property of interaction of compound 6 with ABCB1 was studied by ATPase assay (Reis et al., 2016).
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PMC3931643
These findings prompted us to test the effects of asTORi on more common human blood cancers such as DLBCL.
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PMC9592219
Collectively, these results illustrated that TOP2A enhance the motility of HCC cells through EMT.
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PMC10440586
mesenchymal. ****,
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PMC11779605
Whole protein lysates were mixed with Simple Western Sample Buffer (0.1×) (Bio-Techne R&D Systems #PS-ST01EZ, Minneapolis, MN, USA) to a final concentration of 1.5 µg/µl and then denatured through heating at 96°C for 5 min.
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PMC8777939
A recent report revealed that proteasome inhibitor MG132/bortezomib suppressed AGR2 expression in an ER stress-independent manner and proteasome inhibitor-induced AGR2 degradation via activation of autophagy in lung cancer .
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PMC10748106
The 5-deoxypulchelloside has two extras’ hydroxyls at C6 and C7, lacks the double bond in C7–C8, and has a methyl instead of the hydroxymethyl at C8.
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PMC11764090
cv.
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PMC9479186
The results support the results of the bioinformatics analysis.
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PMC11621493
The protein content in each fraction was determined with Pierce BCA reagent (23225, Thermo Fisher Scientific) using BSA standard dilutions for each buffer condition.
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PMC11585254
Agonist-stimulated internalization of CXCR5 and phospho-site cluster variants. (
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PMC11271800
They also promote tumor cell survival and proliferation, angiogenesis, and inhibit innate and adaptive immune responses through a variety of mechanisms to promote tumor progression and metastasis (Figure 1).
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PMC11138140
Then, 10 imaging positions were selected per treatment using the HOLOMONITOR App Suite software.
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PMC10976516
Just as viral gene deletion has been applied to increase the selective infection of tumor cells by OVs, the insertion of therapeutic genes through genetic engineering has been utilized to increase OVs' anti-tumoral responses.
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PMC11502962
Two patients (G01 and G02) were recruited for single-cell transcriptome analysis.
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PMC11502327
Another interesting study showed that a polymer-loaded system of curcumin can double the uptake of cisplatin-resistant A2780CP cells and sixfold increase the uptake of metastatic MDA-MB-231 cells.
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PMC11591794
When compared with other groups, no significance could be found in P53 gene expression in only the GA-applied group.
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PMC11409031
These findings contribute to our comprehension of the immune microenvironment in OV, underscoring the vital functions of T cells and macrophages in tumor immune evasion as well as anti-tumor immune reactions .
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PMC11122631
Subfraction C6B3 (25.4 mg) was purified by reverse-phase HPLC (C18 column) with 75% methanol to yield compound 5 (6.1 mg).
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PMC11402217
Promising clinical and preclinical results have been observed with several DKK1 inhibitors, such as DKN-01, BHQ-880, JS015, and IIIC3, in treating advanced solid tumors.
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PMC8735881
Data are expressed as the means ±standard deviations (SD).
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PMC10823017
PKC-ι; forward: TTGCAATGAGGTTCGAGACA; reverse: CTGAGATGATACTGTACACGGG.
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PMC11423992
Schematic representation of TFAB002s, which consist of three chains that specifically target CD20 and CD3ε in a monovalent binding mode.
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PMC11411131
The amino terminal-fused FLAG tag allowed detection of both the full-length and truncated forms, while the carboxyl terminal-fused HA tag allowed detection of only the full-length form.
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PMC11628309
Staurosporine, for instance, significantly elevates the levels of TH and VMAT2.
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PMC10729469
Notably, our TCRAβ lentiviral constructs while successfully transducing CEMSS, 3T3 and human PBMC’s with the TCRAβ, were less effective at transducing mouse Tregs.
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PMC8701144
Next, the effect of E1B-55k siRNA treatment on β-catenin-mediated transcriptional activation was tested using a HEK293 cell line incorporating the well-established SuperTopFlash (STF) reporter system .
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PMC11721587
Our study reveals a unified mechanism for Hh signal transduction from Drosophila to mammals despite their differential requirement for primary cilia.
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PMC11741577
We showed that HaCaT cell migration was promoted more effectively by HMC-1 CM stimulated with the TLR 2/6 agonist FSL-1 than by other TLR-stimulated HMC-1 CM for 24 h. (A) A comprehensive table shows Toll-like receptors (TLRs) and their agonists.
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PMC11470381
B. Resulting binary masks and outline of analyzed cell ROI at each time frame.
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PMC4485786
Quantitative values are given as mean fluorescence intensity.
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PMC11742670
Cell LineDRY LABWET LABA-5495.09 6.97 A-37524.27 25.78 A-43160.58 > 100 Vidarabine IC50 comparison between the DL model prediction and pharmacological studies.
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PMC11655536
We established subcutaneous MM mouse model by injecting s.c.
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PMC8873393
Here in this study, we identified “recovered” genes and “not recovered” genes within the time window we accessed using the DNA repair sufficient cells, and observed that shorter genes are preferred to be recovered first (Fig. 4).
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PMC10919056
qRT-PCR results of GJA5 and GJB1 expression at the RNA level. (
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PMC10170482
Here, we report that the soft 3D collagen scaffolds cause metabolic rewiring of liver tumor cells resulting in the upregulation of glycolysis.
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PMC9429973
So if in the group of cyclophosphamide CD34+ cells in 1 mkL of blood of patients with MRD (-) status and MRD (+) status were 97 and 90, respectively; p=0.540, then when prescribing vinirelbine 276 and 109, respectively; p=0.116 and 117 and 47, respectively, with the introduction of G-SCF; p=0.173.
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PMC11519583
b Representative images of MPs, taken at 3 days after transfection with the indicated siRNAs, were obtained following staining with an anti-lamin B1 antibody (red) and DAPI (blue).
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PMC8992508
In the last two decades, after the discovery of BCRP, many new molecules acting as BCRP-dependent MDR modulators were reported, but also in this field sound SARs are lacking.
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PMC9429973
Median time to ≤1% BCR::ABL1 response was 5.6 months in PACE and 6 months in OPTIC.
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PMC9429973
Thrombophilia and prothrombotic alleles polymorphism in women with various obstetric history (%) The data of our study showed that there were no differences in the distribution of polymorphism of genes associated with thrombophilia and prothrombotic conditions between the group with recurrent pregnancy loss and the comparison group (p>0.05).
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PMC10956161
The cell lines used in this study were all from our laboratory.
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PMC11730320
E Maintenance of CCR7+ central memory (Tcm) and CCR7- transitional memory (Ttm) subpopulations.
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PMC7185206
Additional flow diagrams in Supplemental Figure 8.
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PMC11449273
To characterize the molecular players that may contribute to the observed differential anti-tumorigenic effects of plakoglobin on p53-R175H and -R273H, we investigated the effect of plakoglobin on the expression of two well-studied growth-regulating and proapoptotic p53-WT target genes–PUMA (p53 upregulated modulator of apoptosis) and BAX (Bcl2-associated X protein) [38–47] that is known to be dysregulated in mutant p53 cells.
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PMC5035325
Primary tumor volume in 4T1-model (f).
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PMC10154881
At 9 dpi, the CD8 T‐cell response to rMV‐SLAMblind treatment differed between the E.G‐7/N4 model and the B16/N4 model (Figure 3F,G).
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PMC10123657
Quality control charts and statistics for mass spectrometry data are shown in Supplementary Figure S1.
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PMC11703992
The GCA RNA-seq dataset GSE174694 was used to conduct validation on DDIT4.
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PMC11763111
Mice were sacrificed based on predefined humane endpoints, including stooped posture, significant weight loss, or mobility difficulties.
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PMC9429973
Finally, the patterns of TNF-alpha and TGF-beta production were differently distributed considering the number of therapy lines: the first both in all AIHA and in CAD patients (p=0.004 and p=0.01, respectively), the second only in CAD patients (p=0.03).
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PMC11615218
Their data identified threefold higher frequencies of TCM (CCR7CD27SELL) subsets in patients who achieved CR than in those with partial response or progressive disease .
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PMC9429973
This negative effect was mitigated by adding EPAG to the post-ATG sera (223 ± 100; p=0.036).
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PMC10759659
In addition, quantitative reverse transcription-PCR (qRT‒PCR) was performed using TB Green® Premix Ex Taq™ II (RR820A; Takara) on a quantitative PCR machine (qTOWER3G, Analytik Jena, Jena, Germany).
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PMC11680562
These natural compounds played a crucial role in reducing copper nitrate to CuO NPs and stabilizing the NPs during formation (Fig. 1) .
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PMC10454535
The membrane was washed with PBST again.
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PMC11317131
Primers are listed in Supplementary Table S6.
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PMC11805741
The PCR product was sequenced and analyzed using BioEdit and BLAST n tools, respectively, with a phylogenetic tree constructed using MEGA X software, for further information, please refer to supplementary, Section 1.
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PMC6114978
Additional studies to identify this ubiquitin ligase is needed.
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PMC7022782
Figure 7A,B show untreated Caco-2 cells (control).
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PMC11674146
For the intervention assays, the small interfering RNAs (siRNAs) against CLP36 (si-CLP36#1, target sequence: 5′-TGGGGAAAATACTAGCAATATGA-3′; si-CLP36#2, target sequence: 5′-GTCATCCATACAAGATGAATTTA-3′) and the corresponding negative control with scramble target sequences (5′-ATTAGTGCAGATACATCTTACAA-3′) were all synthesized by GenePharma (Shanghai, China) and transfected into BJAB and RA 1 cells using Invitrogen™ Lipofectamine 2000 transfection reagent (11668027; ThermoFisher Scientific, Waltham, MA, USA) for 48 h, as recommended by the protocols of the producer.
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PMC8973085
The molecular docking studies have been performed using MOE (2014.0901) (Molecular Operating Environment software).
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PMC9504875
RLRs are broadly expressed in most cell types, and can recognize infection of a variety of RNA viruses .
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PMC11791264
C, alignment of the consensus amino acid residues adjacent to lysine targeted by SETD7, and the identification of a putative SETD7 methylation site in LC3B.
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PMC11774112
Furthermore, the micelle system shows substantial potential for application in the combined treatment of human cancers.
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PMC11638255
Interestingly, statistically significant changes were restricted to the tumor microenvironment except for KC and IFN-γ, suggesting that copper chelation can induce a “finely tuned” local shift in immune response.
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PMC10669966
cDNA was synthesized from RNA with SuperScript™ IV VILO™ Master Mix (Cat.
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PMC11687663
Liver cancer is one of the most prevalent malignant diseases in humans and the second leading cause of cancer-related mortality globally.
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PMC10523483
293T cells were cultured in a DMEM/HG medium.
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PMC11033180
We collected data employing a HEKA amplifier (EPC10 USB double) along with the PATCHMASTER software (HEKA Instrument Inc., New York, USA).
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PMC11472569
These properties make EVs a promising tool for cancer immunotherapy and diagnostics.
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PMC10291556
ATP concentrations were obtained from the standard curve and normalized to cell counts and control.
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