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PMC11711935
Endothelin 1 (EDN1), produced by fibroblasts, keratinocytes, and endothelial cells, activates the melanogenesis pathway by binding to the endothelin receptor B (EDNRB) on the surface of melanocytes.
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PMC11670407
The number of positive cells per field of view in each group was counted at 400× magnification.
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PMC5839394
Western blotting analyses were performed using a rabbit polyclonal antibodies for Akt 1-2-3 and pAkt 1-2-3, a goat polyclonal antibody for Beclin 1, a mouse monoclonal antibody for Actin β, HSP90, MMP2 and MMP9 by Santa Cruz Biotechnology (Santa Cruz, CA, USA), a rabbit polyclonal antibody for LC3 by Sigma Aldrich and a rabbit polyclonal antibodies for p62, ATG5 and ATG7 by Cell Signaling Technology.
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PMC11011837
This study was carried out on four T-acute lymphoblastic leukemia cell lines: Jurkat, CCRF-CEM, MOLT-16, and MOLT-4, all belonging to the TAL/LMO transcriptional complex , with a well-characterized immunophenotype ; see Table S6 for more details.
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PMC9429973
The approach reduced the required number of experimental mice by a factor 5, in line with the 3R concept.
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PMC11731614
There were 90 significant differentially expressed EV-associated proteins (EAPs; FC ≥ 1.5 and paired t-test, one-way, p ≤ 0.05) between RD and HFD KDEVs that clustered by group.
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PMC11806818
When MCF-7 CTCs are present, they are specifically recognized by EpCAM aptamer.
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PMC10854447
Due to the potential for particular interactions (such as hydrogen bonding), the 1,2,4-oxadiazole achieves bioisosteric equivalence with amide and ester moieties.
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PMC6442998
WST-1 viability assay.
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PMC9429973
The study confirms the overall therapeutic profile of duvelisib and demonstrates that intermittent dosing may decrease the incidence of AEs without compromising efficacy.
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PMC8759873
The empty vector gene was transfected into renal cancer cell lines by the above two methods, respectively, and the effect of the two transfection methods on cell viability was detected by the MTT method .
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PMC11767793
The experimental A490 reading was adjusted for the residual A490AuPEI@NIST absorbance following two rinses with warm PBS.
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PMC9429973
As the immune checkpoint molecules are expressed after T cell activation, the increased percentage of CTLA-4+ and PD-1+ cells in pts BM suggests that there is a T cell immune response in the BM of pts with CCUS/MDS.
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PMC9429973
Only 2patients experienced grade 3 CRS, and 2 patients developed grade 3 neurotoxicity.
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PMC9964635
An FT-IR spectrophotometer (4000–400 cm) by BRUKER was used at the Hi-Tech Lab, GC University, Faisalabad.
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PMC11756937
To address these questions, we conducted a systematic comparison of the most prevalent in-house reprogramming methods—episomal and SeV reprogramming.
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PMC11754784
The computation process of DNP contains three computing layers: 1) input computing layer, 2) shielded internal computing layer, 3) output computing layer (Fig. 1b).
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PMC11502327
Using chitosan materials, HU et al. (194) designed and developed a novel acid-sensitive DOX drug delivery system, CMC-CBA-DOX nanoparticles, which passively released DOX in the acidic environment of tumor cells through the covalent bond between Carboxymethyl chitosan(CMC) and DOX.
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PMC9429973
Median age was 75 yrs, ISS stage I/II/III: 29 (23.8%)/48 (39.3%)/45 (36.9%), ECOG stage 0/1: 64 (52.5%) / 58 (47.5%).
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PMC8414691
CEP55 recruits Alix at the midbody.
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PMC11240448
The python code performing all these operations is available in the supplementary archive “BC_CYTOF_preprocessing.zip”.
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PMC11352311
Finally, we employed Western blotting to assess the expression levels of p-PI3K and p-Akt in RCC cells following esculin treatment.
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PMC9429973
At the time of HMA-F, t-MDS pts presented with more anemia (p=0.005) and thrombocytopenia (p=0.064).
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PMC8041314
This ultimately leads to maintaining, extending, and/or shifting of the resistance profile of multidrug-resistant cancer.
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PMC11676670
Analysis of DNA fragments was performed with an ABI3130 Genetick Analyzer (Applied Biosystems/Thermo Fisher Scientific, Waltham, MA, USA).
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PMC11435360
CD163 macrophages were not altered in any group (Figure 4G).
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PMC11588008
GSH plays critical roles in protecting cells from oxidative damage, the toxicity of xenobiotic electrophiles, and maintaining redox homeostasis .
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PMC11774747
Specifically studies with CAR-VST after TCR engagement have demonstrated: (i) an increased expression of the CAR (85), both in CD4+ and CD8+ populations (84), (ii) an enhanced anti-tumor activity (92, 93), and (iii) a rescue of anti-tumoral dysfunction (89).
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PMC3995603
HH and HS supervised the experimental work.
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PMC10291556
SignalFire ECL Reagent (A + B) was used as a substrate for HRP, and the luminescence was recorded with Amersham Imager 680.
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PMC11544122
A predicted structure of SNX9 and SNX18 reveals several surface-exposed regions that are positively charged, especially the PX-BAR domain (Supplementary Figs. S12 and S13).
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PMC9429973
This contrasts our findings for TLR4 stimulation by LPS, where reduced Fpn mRNA expression depends on classical NFκB signaling, involving the NFкB subunits RELA and p50.
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PMC10898159
A series of small-molecule compounds targeting FTO is developing therapeutic option in acute myeloid leukemia (AML) .
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PMC10253973
The review also briefly examines theoretical approaches to studying the interactions of Ru(II)/Ru(III) complexes with biological receptors, which can facilitate the rational design of ruthenium-based drugs.
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PMC11525028
Agilent MassHunter Work Station Software (B.08.00, Agilent Technologies) was employed for MRM data acquisition and processing.
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PMC11697065
Of these several were shared across all cell lines regardless of the biotherapeutic being expressed (Fig. 6A).
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PMC9429973
High-risk cytogenetics, ISS score III and VCd induction were more common in FDG PET/CT positive patients.
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PMC10936243
Pilot tests reported no issues related to time (e.g. it took 10 min to complete the questionnaire) for respondents.
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PMC10421378
This makes it possible to enumerate the viable probiotic cells; however, it is limited only to the subpopulation of cells with the ability to grow and divide.
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PMC11721295
With the advent of isoform-specific mutant-KRAS inhibitors, understanding how oncogenic KRAS functions in the context of advanced disease is critical to prevent or overcome resistance to targeted treatment.
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PMC9429973
DC/DCleu in PB: Generation of DCleu in AML as well as generation of DC in H was successful with KitM pretreated PB vs. Control. -
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PMC11739670
Affinity of TCR for self‐pMHC is modulated by negative and positive selection in the thymus in the presence of CD8 co‐receptor and results in a pool of circulating T‐lymphocytes with weak affinity for self‐pMHC and it has been shown that CD8 co‐receptor scanning imposes dwell‐time and consequently affinity constraints on the self TCR‐pMHCI interaction .
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PMC11473843
Interestingly, the mesenchymal-like morphology was reversible upon VS-4718 withdrawal, pointing to a drug-tolerant cancer cell state (thereafter named VS4718-T) (Fig. 5A).Figure 5ERK5 feedback activation induces FAK inhibitor tolerant cancer cells by suppressing DNA damage and cancer cell death.(A) Representative bright-field microscopy images of parental vehicle-treated A549 cells (left), VS-4718 tolerant cells (VS4718-T, middle) and VS4718-T upon withdrawal of the drug for 48 h (right).
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PMC11632064
I, J) HLA-DQA2 and CD74 transcript levels in A-375 cells treated with DMSO 0.1%, BIX02565, or LJI308 (both at 0.3, 1, 3, 10 μM) for 72 h. (K) Antigen processing and presentation gene expression in A-375 cells treated with DMSO 0.1% or LJH685 (10 μM) for 72 h and then treated with human recombinant IFN-γ (1 ng/ml) or water for 24 h. (L) Modulation of transcripts associated with phenotype switching from RNA-seq analyses perfomed on A-375 cells treated with LJH685 for 72 h compared to DMSO.
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PMC9429973
Levels of CAR-T cells were very low after the first 1 months postinfusion which detected persistently in 6/10(60%) patients, and the longest lasting time was 355 days post-CAR-T. Although patients’CD7-positive normal T cells were depleted, CD7-negative T cells expanded in all patients.
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PMC9429973
Up to date, a total of 24 loci were found to be associated with MM risk, but very little information is available about their functional role.
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PMC11026382
We refit the model a third time, in order to include all available experimental information in parameterizing the model for this larger set of mutants.
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PMC9429973
The pathology and flow cytometry data of all cases were reviewed.
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PMC11507371
However, measured ROS levels appeared comparable between malignant A431 and non-malignant HaCaT cells (Figure 2A).
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PMC11599565
About 90% of all OCs are of epithelial origin, with serous subtype accounting for around 80% of cases.
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PMC11144200
n = 3. ****
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PMC11354225
Then, medium was discarded and replaced with fresh complete medium to be incubated at 37 °C for 10 min.
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PMC11762280
The high radiation intensity of UVB leads to a series of biological responses in keratinocytes of the epidermis, such as DNA damage , oxidative stress , aberrant production of cytokines and damage-associated molecular patterns (DAMPs) , cell death and so on.
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PMC10092581
Error bars indicate S.D. (C and D) H157 cells were incubated for 24 h with the tested compounds.
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PMC11756937
To assess the potential contributions of reprogramming method and source cell type on reprogramming success (Table 2 and Supporting Information: Table S1), we employed logistic regression using the glm function in R. We first independently assessed each factor variable (logistic regression modelling results for reprogramming method and source material are summarised in Supporting Information: Table S2, S3).
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PMC11589157
Size-selected SMRTbell libraries were prepared using SMRTbell® Express Template Prep Kit 2.0 (PacBio 101-853-100, PacBio, USA) and sequenced for 30 hours using the PacBio Sequel II system (PacBio, USA).
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PMC11185260
We have assessed the antitumor effects of SMRACB1 restoration on various rhabdoid tumor cells.
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PMC9111184
In the band area that can be assigned to β-sheets at ∼1637 and 1683 ​cm, an increase for treated cells with RA and a derease for treated cells with ChA and EZ was detected, whereas treated cells with m-CA didn't show any changes (Fig. 2).
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PMC7570809
The availability of ligands able to discriminate among different integrin subtypes, sharing sequence and structure homology but different biological effects, is a desirable aim in the biomedical field.
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PMC6468656
However, whether Wnt/β-catenin signaling is activated by ghrelin leading AURKA transcriptional activation remains to be explored.
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PMC11695623
The cells of each group after transfection were inoculated in a 6-well plate.
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PMC11332076
Membranes were incubated with antibodies against pERK, pAKT, ERK, AKT, pIR/pIGF1R (3021, Cell Signaling Technology), pIRS-1 (3070, Cell Signaling Technology), IRS-1 (3407, Cell Signaling Technology), myc, actin (612656, BD Biosciences, Franklin Lakes, NJ, USA) in PBS containing 0.05 % Tween 20 (PBS-T) and 2.5 % skimmed milk.
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PMC11762280
D Proteins of N-GSDMD, cleaved PARP, cleaved caspase-3, and p-MLKL in the epidermis of Krt14-Gsdmd mice and Krt14-Gsdmd mice were detected by western blotting assay.
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PMC9429973
2 cycles of NEL (650 mg/m% daily x 5) were initially administered after the 8 cycles (cohort 1) but later moved to after cycle 4 (cohort 2) and then PEG (1500 IU/m2 capped at 3750 IU) was added on day 5 of NEL cycles (cohort 3).
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PMC11300085
An in vitro study confirms the proapoptotic role of chemerin on granulosa cells .
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PMC11759751
Although most patients are cured with standard first-line immunochemotherapy, about one-third of patients do not achieve remission, or relapse or progress after treatment .
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PMC11740508
Similar to previous reports, we find that the combination of Tala and Deci in HRR proficient cells induces some anti-proliferative effects (Figs. 1B, 4A, E, I, 5A).
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PMC7823217
Liu et al. developed a human breast tumor model with physiologically relevant embedded lymphatic vessels by sacrificial bioprinting .
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PMC10174970
Based on the similarity of genetic profiles and bioinformatics analyses, we provide a strategy for choosing the appropriate PAAD cell line.
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PMC11087301
Along with their self-renewal capacity, CSCs can differentiate into various cell types.
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PMC11481779
We load the reference genome (GRCh38) and use pyranges to exclude telomeres and centromeres from the analysis.
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PMC11680578
A one-way analysis of variance (ANOVA) followed by Tukey’s test was utilized to compare the means of multiple groups.
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PMC11419566
The purpose of this review was to summarize the anticancer mechanism of PA by referencing the published documents.
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PMC10669966
The identified genes were referred to the NCATS BioPlanet library with Enrichr to analyze upregulated signaling pathways.
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PMC11637820
The coverslip was carefully removed.
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PMC7185206
Cases of papillary renal cell carcinoma were divided by high versus low protein-to-mRNA ratio (cutoff 2.56E-6) and survival was compared, controlling for age and stage at diagnosis. (
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PMC8750422
This study was reviewed and approved by the Institutional Animal Care and Use Committee (IACUC) of National Cancer Center Research Institute.
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PMC5833712
b Percentage of growth inhibition in ERα-transfected A2780cis cells after 24-h treatment with different doses of KB9520, E2, or PPT, in the range of 0.1 to 10 nM. c Percentage of growth inhibition in ERα-transfected A2780cis cells after 24-h treatment with different doses of KB9520, in the range of 0.1 to 10 nM, in combination with 5 nM E2 or PPT.
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PMC9847912
A similar tendency has been seen in previous studies of HIV-1 integrase inhibitors [65, 67–69] and nucleoside reverse transcriptase inhibitors .
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PMC9429973
Other secondary endpoints included the safety, tolerability, and immunogenicity of the investigational products (IPs).
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PMC9429973
Methods: This was a Phase I/II, single-arm, open-label study of adults with RRMM after ≥3 lines of therapy (LOT, including anti-CD38 monoclonal antibody, proteasome inhibitor, and immunomodulator).
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PMC11420784
E, 5637 cells infected with WT, ΔpldA, or ΔpldA+ for 4 hours were lysed and PI3P levels were measured by competitive ELISA.
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PMC11655498
The host factor TET2, in cooperation with EBNA2, modulates the DNA methylation status of EBV, and the knockout of TET2 promotes the expression of lytic genes (Lu et al., 2017).
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PMC11787651
We utilized an epithelial lung adenocarcinoma cell line, NCI-H1437, as a model to compare the histone PTM levels with or without induced EMT.
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PMC10944868
On the one hand, molecular properties such as partition coefficient (Log Po/w), molecular weight, hydrogen bond donors and acceptors, topological polar surface area (TPSA), violation of Lipinski rule of five were assessed (Table 2).
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PMC9429973
Aims: To analyze multiple chromosomal abnormalities simultaneously with high sensitivity and specificity, we aimed to develop a new diagnostic modality of four-color FISH for multiple translocations in immunophenotyped cells in suspension using imaging flow cytometry (immunophenotyped-suspension-multiplex (ISM)-FISH).
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PMC11401358
The solution was dialyzed with a dialysis bag for 72 h to remove salt ions.
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PMC11754094
e, Variation in large deletion generated by CGBE1 in KO cell lines.
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PMC5941560
Uncovering these past publications required precise knowledge of damaged genes in Jurkat.
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PMC11643491
After stretching, the grid rectangle lengths were measured and dissolved separately according to their stretch ratio: 1.0–1.2, 1.3, or 1.4–1.7 (Figure 1B).
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PMC9429973
In humanized SCD mice, we previously showed that polyunsaturated fatty acid supplementation protects against acute sickle cell-related lung and liver damages during hypoxia/reoxygenation (H/R) induced vaso-occlusive crisis (VOCs) (Kalish B et al. Haematologica 2016).
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PMC7153288
Alternatively, the spore of Streptomyces sp. SS1-1 was sequentially treated with the disinfecting solutions as above and plated on SFM agar to check whether they can grow after the surface sterilization protocol.
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PMC11694346
H NMR (500 MHz, CDCl3, TMS, r.t.):
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PMC9429973
Aims: Here we studied the impact of Mel dose per kilogram of actual body weight (mg/kg) on clinical outcomes of allo-HCT.
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PMC11267830
Additionally, compared to non-T-ALL cell lines, T-ALL cell lines were significantly more sensitive to indisulam (Fig. 1c).Fig.
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PMC11635519
Viral transduction was performed into HEK293T cells, stably expressing the appropriate GPCR with a multiplicity of infection of 0.3.
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PMC10887351
Several studies have reported that stress is connected to tumorigenesis and cancer progression.
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PMC11477621
IC50 values were estimated using the four-parameter method.
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PMC9386809
As a prototypical substrate, the multicomponent Biginelli reaction of p-hydroxybenzaldehyde with ethyl acetoacetate and urea has been carried out in the presence of 5 mol % Cl2Zr–BPC complex 2 in CH2Cl2 at room temperature for 4 h. However, no product formation was observed (Table 1, entry 1).
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PMC9429973
Multiple myeloma was the most prevalent disease 64% followed by Lymphoma 32%.
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