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PMC11335267
Muscle strength as assessed by the grip test (n = 7 mice per genotype).
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PMC11225860
FUCCI U2932 cells treated with 1µM alisertib demonstrated endomitotic replication in one third of the entire treatment population, undergoing multiple replication cycles without division (Fig. 4b and Sup Fig. 4b).
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PMC11269933
Previous studies have demonstrated that the metabolic regulation of PEP is a central hub for both aerobic and anaerobic metabolism.
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PMC11670954
However, no study has focused on involvement of the RhoA/ROCK2/MLCK pathway in the protective effects of BA in Caco2 cells.
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PMC6803987
The results exhibited that esculetin could significantly reduce HBsAg and HBeAg levels compared to 3TC.
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PMC11679033
After the combined exposure, the range of scored cells was M2 > M1 > M4 > M3.
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PMC11577421
CHO-K1 cells possess approximately equal levels of HS and CS, whereas pgsA-745 cells lack both HS and CS (with <5% GAG expression compared to CHO-K1).
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PMC11499955
The group of Guo has notably successfully used fluorescent antibodies constructed with an azide-based linker that can be cleaved upon addition of a phosphine to remove the fluorescent label.
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PMC8526701
Staining of active caspase 3 confirmed PUMA-dependent apoptosis in GSK602-induced tumors (Fig. 4E).
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PMC9429973
Most were mild, none was serious, and all resolved without any sequelae.
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PMC3915447
The solution was dialyzed (Mw cutoff of 6 kDa) and then lyophilized.
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PMC9429973
The most frequent (≥20%) treatment-related AEs (TRAEs) of all grades across all doses included cytokine release syndrome (CRS, 60.6%), pyrexia (39.4%), increased alanine aminotransferase (ALT, 30.3%), increased aspartate aminotransferase (AST) and anemia (24.2% each), and the most common grade ≥3 TRAEs (≥10%) included increased AST, lymphopenia (18.2% each), increased ALT (15.2%), CRS and neutropenia (12.1% each).
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PMC7039683
By our definition GFP-positive NFRs have >2 fold more ATAC-seq reads in GFP-positive cells than in GFP-negative cells; perhaps surprisingly, the subset of GFP-positive NFRs with >4 fold more was less strongly associated with genes expressed in periderm than were GFP-positive NFRs overall (Figure 1E).
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PMC10213199
The human immune cell lines in this investigation showed that the drug could also increase the production of protein enzymes, which may directly promote cell proliferation and inhibit cell apoptosis.
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PMC10114490
All values correspond to average plus standard deviation We have generated a fibroblast-derived cell line, with an extended life span beyond 110 doublings, without malignant traits and capable of being efficiently and simplistically reprogrammable into hepatocyte-like cells (HLC) under standard culture conditions.
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PMC11549062
Cell apoptosis leads to inflammation and necrotic core formation, which results in plaque instability .
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PMC9429973
Preclinical data suggest that addition of hydroxyurea potentiates cytarabine efficacy by increasing ara-CTP levels through targeted inhibition of SAMHD1.
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PMC10551595
Glucocorticoids, including Dexa, are chemotherapeutic agents that may selectively induce apoptosis and cell cycle arrest in lymphoid cells.
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PMC11607638
Recently, it has been found that SKR is widely expressed in the CNS, predominantly in neuronal cells of Drosophila melanogaster.
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PMC9164404
After 36 h of injection, mice were sacrificed and the main organs including heart, liver, lung, kidney, spleen and tumors were isolated and used for ex vivo imaging.
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PMC11188874
CD8/annexin-V/propidium iodide cells were then quantitated by flow cytometry.
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PMC9429973
One patient required further dose reduction at cycle 2.
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PMC11468365
During the training of the MultiComb, the learning rate ‘lr’ of the training process is set to 0.1e−4, and the Adam optimizer is applied to optimize the model’s weights.
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PMC11637716
It is unclear to what extent the patient's suspected structural lung disease, which is presumably responsible for the ultimately fatal course of the disease, was related to the EFL1 functional impairment.
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PMC8633974
PCR tests showed intact viral genome (3025 bp) in untreated controls, whereas full-length HIV-1 proviral DNA was not detected in the treated groups.
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PMC8557138
The co-culturing of mesenchymal progenitor cells and neural organoids generated complex vascularized neural organoids.
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PMC11591038
To maintain the balance of redox status, cells possess the capability to counteract excessive ROS through endogenous enzymatic antioxidant systems (such as catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase) and non-enzymatic antioxidants (such as glutathione, thioredoxin, ubiquinone, and uric acid) .
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PMC11748618
Methylation quantitative trait loci of HIV spVL associated SNPs in African populations.
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PMC9429973
The individual prediction of the risk of alloimmunization remains an unresolved problem.
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PMC11782780
Additionally, the results of the RIP experiment showed significant enrichment of EBF3 in the miR-301b-3p-mimic group (Fig. 4G).
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PMC10940855
EFNB2 reverse signaling represents an important new mechanistic target in multiple myeloma.
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PMC11388384
This result was consistent with the model that SCUBE1 increases the effective diffusion rate of SHH during gradient formation.
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PMC7053076
U-332 was highly cytotoxic for HL-60 cells and showed similar cytotoxicity in the 5-FU resistant subclone (HL-60/5FU), in which this analog almost completely abolished expression of the ATP-binding cassette (ABC) transporter, multidrug resistance associate protein 1 (ABCC1).
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PMC11267830
By utilizing rMATS for analysis, distinct patterns of exon and intron mis-splicing events were observed.
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PMC11650848
The cDNA synthesis reaction was carried out under the following conditions: 25 °C for 10 min, 42.5 °C for 50 min and 70 °C for 10 min.
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PMC11737091
Cell apoptosis and the cell cycle were analysed via flow cytometry (BD).
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PMC9429973
Josip Benčević, Slavonski Brod; School of Medicine, University of Osijek Josip Juraj Strossmayer, Osijek; Internal medicine department, General Hospital Sibenik- Knin county, Šibenik; Department of Orthopaedic Surgery, General Hospital dr.
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PMC11342785
These TPPP-IDR chimeras were tagged with GFP at their N terminus.
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PMC11435360
It is synthesized through the reverse transsulfuration pathway by three independent enzymes, namely cystathionine -synthase (CBS), cystathionine -lyase (CSE), and 3-mercaptopyruvate sulftransferase (3-MST) .
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PMC11747467
The log-rank test was performed to estimate the relationship between individual variables and prognosis.
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PMC9429973
27 patients were primary refractory (22.1%).
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PMC11718109
For Fig. 1B, semi-automatic segmentation using Cellpose in Napari was used to segment the nucleus (DAPI staining), followed by manual identification of βIII-tubulin and/or TH signals.
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PMC11754291
Representative images of melanocytes cultured in CM, CMK, and CMiK before lysis for WB analysis on day 12 reveal condition-dependent differences in morphology, pigmentation, and apparent proliferation (Figure 9).
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PMC2614416
During malignant transformation and tumor progression, intracellular concentration of FDH is dramatically down-regulated by gene reprogramming , leading to a build-up of intracellular 10-formyl-THF pool.
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PMC10376064
Although ABCC1 often co-transports substrates with GSH, this may be hindered in the case of Aβ protein due to the deprivation of ABCC1 transport capacity by DMS-SG.
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PMC11301242
Results revealed that 69.96 % of the peaks were located in the promoter regions (Fig. 2A).
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PMC9429973
The presence of NPM1 and IDH1/2 mutations were associated with high CR/CRi rates in both the frontline (85.7% and 84.6% respectively) and R/R groups (100% and 81.8%), with below average response rates seen in TP53 mutated AML (62% in frontline, 40% in R/R).
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PMC10656496
However, SAOS2 is now unaffected by treatment with panobinostat, leaving a robust spheroid after multiple treatment regimens.
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PMC11720107
According to the literature, a decrease in LDH release can occur in vitro with highly toxic compounds that cause rapid cell death, resulting in proteolytic degradation of LDH in the culture medium .
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PMC9454178
OSR1 expression was inhibited by CDK7 knockdown in GIST-T1 and GIST-882 cells.
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PMC7802142
Furthermore, the expressions of C-myc and Cyclin D1, both of which were crucial downstream signaling effectors of β-catenin, were measured.
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PMC8777939
Moreover, AGR2 and CD31-positive staining was also decreased by etravirine treatment and the combination treatment.
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PMC10936243
That’s all” [D062]. “
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PMC10578720
In vivo administration of the TCA cycle agonist dichloroacetate inhibited macrophage M2-like polarization and effectively reduced the number of serum HBV DNA copies.
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PMC10723784
In line with other studies, the results suggested the unlikely involvement of CB2 receptors in mediating cytotoxicity induced by both cannabinoids in ovarian carcinoma cells.
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PMC10243817
These results suggest a possible role of MEX3B in controlling mRNA stability or translation as an RBP.
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PMC9429973
In that study, bezuclastinib led to a reduction in KIT exon 17 mutational burden, temporally correlated with a reduction in tumor burden, and an acceptable safety profile.
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PMC11656380
In addition, Tat-Ram13 did not affect the viability of three adherent cell lines (breast cancer cell MCF-7, lung carcinoma PC-9, and glioblastoma U251MG) at all (Figure 3C).
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PMC11703992
After identifying the input eQTL instrument variables, “TwosampleMR” package (version 0.5.7) was employed to perform the MR analysis on GCA data finn-b-M13_GIANTCELL and finn-b-GIANT_CELL_TEMP_ARTERITIS from ieu database.
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PMC11088135
Fig. 5Expression levels of YAP1 in glioma cell lines.
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PMC11679033
As the alkaline comet assay detects the extent of total primary DNA damage in individual cells, but does not offer information on cytogenetic effects and lymphocyte proliferation, we complemented the research with the Cytokinesis-Block Micronucleus Cytome (CBMN Cyt) Assay.
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PMC9895440
In addition to NFAT activation, CD28 activation is known to promote glycolysis and proliferation, which are, however, also linked to terminal differentiation.
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PMC11653533
Meanwhile, Ateles chamek monkeys utilize 50 % of their meals (Rosnah et al., 2015).
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PMC11637284
and (C) as in (A) but the TAC60-P185E and TAC60-p197helix mutants were analyzed.
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PMC9429973
In addition to this index patient, 3 additional children of 2 independent families were identified with TFRC mutations and hypochromic microcytic anemia.
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PMC9429973
66% of bone marrow biopsies reached a diagnosis, 34% of biopsies were non-diagnostic or non-contributory.
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PMC7724160
Using HILIC and RP methods combined, 109 metabolites were quantified using Component Elucidator, a software package developed at Bristol-Myers Squibb .
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PMC9777812
Cell proliferation was assessed using a CCK-8 Cell Counting kit (Beyotime, Shanghai, China) in a 96-well plate (2 × 10 cells per well).
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PMC11306019
These findings suggest that our in vitro long-term treatment model can, to some extent, reflect the therapeutic effect of BTZ at its average blood concentration.
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PMC7917457
Human melanoma cell line A375 was cultured in DMEM high glucose, supplemented with 10%, 1% L-glutamine, and 1% penicillin and streptomycin, and human melanoma cell line SK-MEL-2 was cultured in Eagle’s minimal essential medium (EMEM), supplemented with 10% FBS, 1% L-glutamine, and 1% penicillin/streptomycin.
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PMC8956657
A list of hydrogen-bonded interactions is presented in Supplementary Table 8.
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PMC8633974
Control gRNAs display complete 20 base pair (bp) recognition of 11-30% of curated HIV-1 strains (Table S3).
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PMC7433824
Next, we ran pathfindR with default parameters except that searching for Reactome pathways that contained at least three significant genes.
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PMC10197932
The study of the biological effects of low-energy ultrasound and its applications is a rapidly expanding research area.
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PMC2777936
Lithium chloride (20 mM 24 hours) was used as a control to show activation of β-catenin, sodium chloride controlled for salt concentration.
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PMC9388315
When the confluency of cells reached 85%, experiments were performed.
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PMC10142392
However, it is important to balance the hydrophilic and hydrophobic content of the polymer to ensure that the carrier remains stable in aqueous media.
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PMC11359735
Proteomes for which replicates are not listed are n = 1.
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PMC11721064
Subsequently, differential expression analysis was performed to identify genes significantly expressed across experimental conditions.
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PMC11727306
The MGL-binding galactose-bearing ligands that are highly expressed on stimulated T-cells offer more sites to affect the binding of abrin in the same way that abrin binds to milk galactose.
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PMC6268318
The aqueous and EtOH extracts of C. quadrangulare were screened for their inhibitory activity against HIV-1 integrase (IN), an enzyme essential for viral replication.
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PMC11705862
Zoomed-in images of microglias in the yellow squares are shown to the right in (C and D).
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PMC11615218
However, the clinical outcomes of these treatments are inconsistent and mixed.
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PMC11772449
The 96-well plates were placed in an incubator at 37° C for 1 h until the color became orange.
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PMC11281366
Overall, these results highlight a novel mechanism by which HIV-1 limits ADCML by upregulating CD59 expression via miRNA-26a downmodulation.
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PMC9100622
Many efforts are presently being undertaken to more thoroughly investigate the mechanisms of development of EwS in order to identify fragilities and dependencies for new targeted therapeutic interventions.
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PMC11803149
Bulk RNA-seq analysis of these cells identified 32 differentially expressed genes (DEGs) between Epas1-Crispr and control-Crispr samples with a log2 fold change >|0.5| and adjusted p-value < 0.05 ( Figure 7F ).
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PMC11568601
Human ERN1 (GenBank Accession: NM_001433.5) was cloned and inserted into the pEX-3 (pGCMV/MCS/EGFP/NEO) vector to construct the IRE1-OE plasmid pEX‐3-ERN1.
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PMC4360730
We include the synonyms of the annotated term in the free text search.
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PMC11618052
0.54 (hexane : ethyl acetate, 1 : 2, v/v).
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PMC11349530
However, in cancer cells, cytokine production is unconditional and context-independent, as cells of different cancer types are capable of spontaneous cytokine production (29–31).
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PMC8357004
Aberrant DNA methylation is catalyzed by DNMTs.
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PMC11126803
We then performed the chromatin immunoprecipitation (ChIP) assay and results revealed that ERβ could selectively bind to the ERE#2 located at the −1592 to −1578 bp from the transcriptional start site of ZEB1.
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PMC11785489
However, this deep learning approach provided no substantial benefit in discovery or external validation data (Figure S5; Table S6).
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PMC9065483
Viral titer was determined 40 hpi by high-throughput titration (mean ± SD; ns = no significance by two-way ANOVA). (
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PMC11607764
It was found that PTBP1 is an important immune regulator involved in the regulation of splicing of multiple immune-related ligands and receptors, which affects the activity and function of immune cells in the tumor microenvironment.
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PMC9503685
In a similar study, T24 (ATCC HTB4™), a human bladder epithelial cell line, was used and it was determined that the combination of LL-37 and ceragenins was more effective in reducing not only extracellular but also intracellular bacteria populations than their use alone .
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PMC10671321
When the expression of COLQ1a mutant RNA levels was normalized to the wt, we observed a 63% increase in RNA levels in COS cells (Figure 2A) and a 75% decrease in muscle cells (Figure 2B).
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PMC11472569
Unlike other ABC transporters, ABCG2 functions as a homodimer, comprising two identical subunits.
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PMC11461874
This RRE-mediated Bmal1 transcription rhythm stabilizes the core E-box loop.
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