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OTAR3088
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PMC11590005
Defence mechanisms that cause the oppressed to become oppressors might be a reasonable explanation, and different study de-signs could further investigate this possibility .
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PMC11583690
The cells were seeded on 96-well plates at a density of 5 × 10 cells/mL in Dulbecco's Modified Eagle's Medium (Gibco) supplemented with 10 % fetal bovine serum (Gibco), penicillin (100 IU/mL), and streptomycin (100 μg/mL), and then cultured at 37 °C (5 % CO2) for 24 h. Next, the cells were treated with the test samples at different concentrations, as well as the control.
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PMC9895440
Accordingly, Ecker et al. observed lower but significant recruitment of SNX9 to the immune synapse with low-dose anti-CD3 stimulation alone, however, this was more pronounced with anti-CD3+ anti-CD28 stimulation.
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PMC11574029
The results indicated that only NOTCH3 is upregulated in BLCA (Fig. 1C, D) and is closely associated with poor prognosis in BLCA patients (Fig. 1E, F).
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PMC11687167
Li J et al. reported that shRNA-PCSK9 significantly reduced the phosphorylation of p38 and JNK, thereby promoting endothelial cell apoptosis through the JNK/p38 MAPK pathway .
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PMC10748106
A higher electronic distribution in the carbonyl at C11 until the 3′ and 6′ hydroxyls of the sugar is observed in Geniposide, while in Genipin a different pattern is presented.
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PMC11359735
The gel was fixed, cut in half, and one half was incubated in 0.2 M KOH in methanol and the other in methanol alone.
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PMC10747160
At the current time, our best hypothesis is that even when Griffithsin fully saturates binding to all available epitopes of the SARS-CoV-2 spike protein, Griffithsin does not bind at locations that totally sterically hinder or impair hACE2 recognition of the spike receptor-binding motif.
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PMC11139449
It allows for the insertion of larger gene sequences by introducing a donor DNA template flanked by a CRISPR-Cas9 target site.
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PMC11696576
A complete description of the laboratory and data analysis methods are available in the Supplementary Information file (Supplemental Methods: Cancer Cell Line Screening).
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PMC11194678
The density of each band was normalized by β-actin.
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PMC11765988
The co-occurrence of these diseases may be explained by genetic predispositions, immune dysregulation, and environmental factors that enhance malignancy risk.
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PMC11286266
A representative dataset from more than three experiments is shown. (
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PMC10968586
In vitro, treatment of human papillary thyroid carcinoma cell line TPC-1 and poorly differentiated thyroid gland carcinoma cell line BCPAP with 50–100 μM OLE for 48 h produced a significant reduction in cell viability attributable to S phase and G2/M phase cell cycle block, respectively.
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PMC10197932
It's interesting to note that lymphocytes remain alive after US treatments without any anti- apoptotic cytokines such as IL-2 and IL-7.
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PMC11628309
Cinnamic aldehyde demonstrated a protective effect in a cytotoxicity model induced by MPP+.
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PMC8922418
Therefore, DETECTR can break the ssDNA reporter with fluorescence and quenching groups linked at either end.
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PMC10606998
Nanoparticle cores consisting of iron oxide have a much higher density (about five times) compared to the surrounding cells and can serve as an efficient source of secondary electrons under the action of photon radiation.
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PMC7229095
Top clones screened from each media were tested in batch culture mode using shake flasks or in fed-batch culture mode using Ambr 15 microscale bioreactors (Sartorius, Royston, UK).
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PMC11588085
XIST expression in OVCAR3-KRAB with sgXIST7 and sgXIST9 compared to sgCtl after 24 h in hypoxia chamber. (
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PMC11687167
Cai J et al. reported that PCSK9 promoted Th cell differentiation in AS, suggesting that PCSK9 promotes Th1 and Th17 cell differentiation through the activation of the NF-κB pathway .
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PMC11240448
Forward MRA formalism allows us to predict the global BC cell responses to drug perturbations of core network pathways .
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PMC9429973
In the JAKARTA <mSS and ≥mSS cohorts, median BL spleen volume was 1771 (316–3396) mL and 3329 (983–6430) mL, respectively, and median TSS was 13.0 (0.0–54.9) and 17.2 (0.4–57.0).
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PMC10877303
The length of the MERS-CoV genome is over 30,000 nucleotides (nt).
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PMC11291697
GAPDH was used as housekeeping gene, whereas the cDNA deriving from the #GM05380 control cell line as reference sample.
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PMC11075223
In TCM theory, Cimicifugae Rhizoma was combined with other TCMs to give full play to their efficacy.
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PMC8916024
Currently, little is known about the structure and function of the gut flora of C. chinensis.
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PMC11680562
The synergistic impact of ROS production, activation of apoptotic proteins, and impairment of mitochondrial function culminate in the efficient induction of apoptosis in cancer cells .Fig.
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PMC9000591
In addition, noncancerous cells are indispensably used to confirm the cytotoxic selectivity of potential candidates, since they should suppress tumors without harmful effects on normal cells .
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PMC6268318
These compounds showed good activity against Micrococcus luteus, Shigella sonei, Vibrio cholerae, Enterococcus faecalis and Pseudomonas aeruginosa.
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PMC11334037
IGF2 overexpression increased the expression of IGF1R, p-IGF1R, PI3K, AKT, and p-AKT in GIST-T1 cells.
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PMC6835428
A fourth aspect relates to the possibility of generating siRNA delivery complexes able to target OC cells (Section 4.1) and/or OC-specific gene products (Section 4.2) to minimize side effects and improve effectiveness.
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PMC11013014
Only compounds that meet the criteria without any deviation were selected for the purpose of a docking simulation.
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PMC11552389
Cells were mounted using a mounting medium containing DAPI (P36935, Invitrogen) and imaged using a Leica TCS SP5 confocal microscope (Leica Microsystems, Wetzlar, Germany).
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PMC11247842
The GWAS summary statistics in this study comprised CM and SCS association tests with imputed whole genome sequence variants following harmonized analysis procedures (see Additional file 1: Table S1) from seven partners.
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PMC11695623
Can play a role in enabling cullin family protein activity, involvement in cellular responses to DNA damage stimuli, positive regulation of protein neddylation, and regulation of cell growth.
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PMC7642379
Top ten significant GO cellular components of the 329 common DE genes in pairwise comparisons between progeny cells and HEK293.
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PMC10523483
Detection of H1C mRNA levels in 45 pairs of tumors (T) and para-tumor (P) tissues from NSCLC patients. (
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PMC11727145
Lengths of tissue of 1.5 × 10–15 cm were prepared for the de-epidermalization procedure.
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PMC10452486
Cell surface HLA-I molecules are capable of binding to other proteins to exert a signal-transducing function .
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PMC11531744
Risk curves showing the distribution of survival status.
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PMC11200978
Importantly, the in vitro data presented herein correlate well with studies on the successful application of cryoablation clinically to treat NSCLC, which, when coupled with the literature on cryoablation system performance, indirectly suggests an MLT in the −20 °C to −35 °C range .
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PMC10490530
Specific cell localization at the orthotopic site, i.e., lungs, was observed with A549-Luz and A549-hLuz cells.
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PMC10631132
A limited number of cells expressing Cathepsin K can be seen in both groups (arrow heads in D, H).
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PMC10938377
Four Au(i)–peptide conjugates were generated by connecting the nucleosome-binding region of either the Kaposi's sarcoma-associated herpesvirus LANA protein or foamy virus GAG protein to a AuDPPBX group via a long PEG linker (Fig. 1).
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PMC7961460
PCR reaction mix contained 2.5 µL of cDNA, 12.5 µL of Universal PCR Master Mix (Applied Biosystems), 1.25 µL of Assay-on-Demand primer and probe and 8.75 µL of nuclease-free water.
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PMC11684297
The live-dead assay was conducted according to Deepika et al., using a combination of the dual fluorescent dye, acridine orange, and ethidium bromide .
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PMC9429973
16 had underlying aggressive lymphomas (B cell (N=5), T cell (N=5), NK/T cell (N=5), unknown subtype (N=1)).
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PMC5839394
Both AgNPs-EPS were already characterized and used for antimicrobial activities .
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PMC11721277
A large number of ligands with different structures have been proposed for the chelation of Tc , which can be used individually or as part of conjugates with various biologically active molecules .
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PMC11680982
ET endocrine therapy, CDK4/6i CDK4/6 inhibitor, Ner neratinib.
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PMC11676674
Leaves were immediately frozen in dry ice to preserve their integrity and subsequently homogenized using an A11 Basic Analytical mill (IKA-Werke, Staufen, Germany); the homogeneous powders were then stored at −80 °C for subsequent use.
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PMC11344246
RNA sequencing data were aligned to the human genome GRCh37 (hg19) using TopHat2 (26).
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PMC9479186
The senescence-related gene set was used to look for NDUFC1 to regulate those aging-related genes.
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PMC11011837
On the other hand, in Molt-4, the TG lipid class is uniquely distributed, representing 5.8% of total lipids and showing a higher percentage of this lipid class compared to Jurkat (1.4%), Molt-16 (1.7%), and CCRF-CEM (2.0%).
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PMC9429973
Progression-free survival (PFS) and OS were plotted with Kaplan-Meier; a p<0.05 was considered as statistically significant.
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PMC11604015
However, none of these CAR-T cells could completely prevent immune deficiency and disease relapse after T-targeted CAR-T cell therapy.
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PMC9105697
For structural variant analysis, the sequence reads were uploaded in Integrated Genomics Viewer (IGV), aligned to Homo sapiens (human) genome assembly GRCh38 (hg38).
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PMC5963610
Finally, the sections were counterstained with Mayer’s hematoxylin.
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PMC11544122
TALON® Metal Affinity Resin (cat.
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PMC11730305
The anticancer properties of EA have been reported.
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PMC9429973
MRD negativity at TP1 was not associated with a significant improvement in either OS (P = 0.426) or EFS (P = 0.335) when compared to patients with MRD positivity.
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PMC11740508
We found that treatment with our standard drug dose combination (5 nM Tala, 14 nM Deci) reduced colony formation for all M231 variants and the independent BRCA1 mutant cell line SUM149PT, but with more limited effects on MDA-231 cells (Fig. 4A–D representative images; E–H, # icon is over standard Tala (5 nM) doses with and without 14 nM Deci).
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PMC11674441
We performed TCR repertoire analysis before and after Neo-P DC vaccine treatment for three patients (BC1, BC3, and BC4) (Figure 4).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Two flow cytometry panels (a two tube 8-color panel and a single tube 10-color panel) were used; samples were analyzed using Kaluza Analysis Software (Beckman Coulter) on FACSCanto II (BD Biosciences) and Navios EX (Beckman Coulter) cytometers, respectively.
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PMC11674441
The leukapheresis product was diluted with RPMI-1640 medium (Kojin-Bio Inc., Saitama, Japan) and subjected to density gradient isolation using Ficoll-Paque.
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PMC11525293
Actin was used as the loading control, and one representative experiment is shown.
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PMC8728081
ROS of zebrafish larvae was carried out by the whole-mount method using DCFDA fluorescent probe .
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PMC11216402
PCA was performed using prcomp() and drawn with ggplot2 in R (R Core Team 2023).
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PMC9429973
Aims: To identify predictors of outcome in COVID-19 breakthrough infection in patients carrying hematological neoplasms.
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PMC11632064
In addition, they indicate that the pronounced heterogenous response observed under RSK and PLK1 inhibition is shaped by the expression of mitochondrial proteins associated with a resistance signature.
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PMC10335954
Enrichment analysis done by ingenuity pathway analysis (IPA) software identified possibly involved pathways (Fig. 3C, D).
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PMC10907726
The osteosarcoma cells were inoculated at 10,000 cells into 6-well plate.
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PMC11763764
High expression levels of FGFR4 and FGF19, which is one of the ligands with the highest affinity and specificity to FGFR4, together can provide an even better prognostic marker for advanced stage high-grade serous ovarian carcinoma .
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PMC7709199
Crystals from HEK293S MGAT1 cells have a similar packing to those obtained from GlycoDelete, based on the similarity in space group and unit-cell parameters.
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PMC9429973
Analyses included data obtained from the Gene Expression Omnibus (GEO, GSE79695 and GSE124390) generated from 450K (n= 12) and 850K array data (n=10), respectively.
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PMC11534377
Future research should prioritize advanced preclinical and clinical trials to validate these in vitro and in vivo findings and optimize the dosage and treatment scheduling of 5-Aza to maximize therapeutic benefits while minimizing adverse effects.
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PMC9429973
Finally, we assessed potential off-target effects using thromboelastography (TEG).
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PMC11001582
This suggests that pro-inflammatory astrocytes are characterized by increased ECM gene expression and that this correlates with more severe disease.
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PMC9429973
Relative PK deficiency has been observed in HS red cells (Andreas O et al. BJH 187: 386, 2019).
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PMC9429973
Surface expression of relevant molecules for NK activity showed that NKp30, NKp44 (natural cytotoxicity receptors), CD69 (early activation marker), CD25 (IL2R alpha chain), FasL (mediates FasL-mediated cytotoxicity), NKp80 (C-type lectin-like surface-activating receptor) and TRAIL (TNF-Related Apoptosis Inducing Ligand) were more expressed by transduced NKAE (Fig.2B).
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PMC11679326
N-glycosylation begins in the endoplasmic reticulum with the synthesis of oligomannose structures that are attached to asparagine residues on target proteins via the core chitobiose linker.
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PMC11656380
Flow cytometric analysis revealed that CCRF-CEM and Jurkat cells exhibited significantly higher uptake of 70 kDa-Dex compared to TALL-1 cells (Figure 4C).
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PMC11518702
ROCK further phosphorylates LIMK, which phosphorylates cofilin to inhibit cofilin’s effects on actin disassembly (52, 53).
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PMC11394386
Therefore, the focus on using RNA interference molecules or small molecules designed through molecular docking that targets HOTAIR to modulate the PI3K/AKT/ HIF1a axis could be a further option to avoid chemoprevention.
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PMC11209164
All the drugs were resuspended in 100% DMSO to 100 mM and further diluted at indicated dilutions before use in all in vitro experiments.
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PMC11361748
Data was normalized by subtracting the percentage of migrated cells to control medium .
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PMC11758416
All reagents are commercially available or can be provided by technical and/or lead contact.
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PMC11774747
Simultaneously, there has been a progressive increase in research publications on CAR-VST, reflecting a growing interest in this promising therapy.
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PMC11637276
Membranes were blocked in 5% milk for 1 h at room temperature.
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PMC11721295
R version 4.2.1, RStudio version 2023.06.0+421, and R package Seurat version 4.0.2 were used for scRNA-seq data analysis (33–35).
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PMC11295144
HEK293 cell body was visualized with GFP (green), NL2 was labeled with mCherry (red), and the presynaptic terminals were visualized with an anti-VGAT-specific antibody (blue).
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PMC11634027
They are conserved in vertebrates, where they also function in multiple organs and have been linked to congenital diseases (Alders et al., 2014; Cappello et al., 2013; Durst et al., 2015; Mao et al., 2011; Saburi et al., 2008; Zakaria et al., 2014).
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PMC9424261
Liver cancer remains a major global health challenge with rising incidence worldwide and high mortality, according to estimates by the World Health Organization (WHO) .
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PMC8759873
Most kidney cancer patients overexpress VEGF, EGF, PDGF, TGF2a, and other growth factors due to VHL gene mutation and abnormal growth of tumor tissues resulting in HIF-related transcriptional activation.
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PMC11665555
Gemcitabine (0.1 μM) was used to measure acute treatment effects.
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PMC11799978
Subsequently, we assessed the migration ability of CAFs in the presence of 4T1 CM and vice versa (Figures 3E and Supporting Information, S3).
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PMC8777939
This drug may be a promising therapeutic agent for the treatment of ovarian cancer.
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PMC10582049
We performed TCGA dataset analysis to validate our findings.
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PMC11632064
Related to Fig 3. (
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