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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Patients were stratified by treatment with FEDR post-RUX (FEDR and non-FEDR group); the non-FEDR group was further stratified by time of RUX discontinuation (before [subgroup A] and after [subgroup B] US approval of FEDR) to enable a contemporaneous comparison with the FEDR group.
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PMC11476666
In light of these findings, along with the potent response observed for DHS at 30 μM in this study compared to RSV, further preclinical investigations to evaluate the potential translational benefits of DHS, either as a standalone treatment or as an adjuvant in future anticancer therapy trials.
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PMC9856122
The current review comprises in silico studies (particularly SARS-CoV-2) followed by in vitro and in vivo investigations of different categories of isoquinoline alkaloids and their related moieties against viral strains.
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PMC11225860
A depicts normal cell cycle progression of FUCCI cells, along with corresponding images of a DMSO control cell.
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PMC11612508
The release of the loaded medicine can be considerably improved by the magnetic response of drug carriers with different magnetic frequencies and intensities.
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PMC10993311
The literature has also shown the influence of altered pre-pregnancy BMI on the lipid profile of pregnant women (Gulecoglu Onem et al., 2021).
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PMC11395280
Each experiment was performed in duplicate, and the results were normalized to the number of cells that migrated with the ligand alone.
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PMC11361748
After a 2-h incubation at 37°C, the insert together with neutrophils remaining in the upper chamber were discarded.
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PMC9429973
Summary/Conclusion: Our current data suggest that STAT5B on its own is not able to transform NK cells, in contrast to other cell types.
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PMC11635519
Significantly, all the peptides quickly stabilized in a new equilibrium position close to the initial structure, according to the RMSD profiles calculated for the peptide’s heavy atoms (Figure 5B).
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PMC7987994
Significance codes according to p value: 0 ‘***’0.001 ‘**’0.01 ‘*’0.05 (two-sample t-test).
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PMC8540611
The cell lines were seeded at 1 × 10 cells/mL in 100 µL suitable culture medium on 96-well plates (1 × 10 cells/well).
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PMC11033180
Interestingly, we found that Sema5A exerts a bidirectional control of synapsin 1 phosphorylation depending on neuronal depolarization.
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PMC10454535
Resveratrol (RES), a phenolic compound found in grapes, has a variety of applications due to its antioxidative, anti-inflammatory, anti-cancer, and immunomodulatory properties .
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PMC9856122
Another study performed on cell lines indicated that BBR suppresses viral replication of influenza A virus by interfering the MEK/ERK pathway.
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PMC6222726
Their small flowers are yellowish, white, or green and their fruits glabrous and are up to 1.0 cm long.
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PMC11095939
Data are presented as means ± SEM; n = 3.
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PMC11467964
Frequencies of CNV gain, loss, and non‐CNV among BMRGs.
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PMC11718109
In one population, the ~40 nm vesicles were found as in iNeurons (Fig. 2D, see also Fig. 2B, C), and the post-synaptic membrane had the thick undercoating typical of post-synaptic densities of asymmetric synapses.
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PMC9681981
Based on the primary genomic evaluation of the studied strain by PCR, the presence of α- and ε-toxin genes and the absence of β-toxin gene were confirmed (Fig. 1).
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PMC9429973
Methods: This is a phase 2, open-label, single center clinical trial planning to include 40 newly diagnosed patients with Mayo 2004 stage 3a and 3b AL amyloidosis at Peking Union Medical College Hospital (Beijing, China).
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PMC11626627
EMT is a process in which epithelial-like cells undergo a transition to a mesenchymal-like phenotype.
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PMC11453690
S. Hanif: None.
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PMC10547921
In terms of endocytosis, traditional ADCs are targeted antigen-mediated endocytosis, which directly kills cancer cells.
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PMC11799620
Briefly, the erythrocytes pellet was ground in 1 ml TBS pH 7.4 using an Ultra-turax homogenizer.
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PMC11544122
Cell surface levels relative to FLAG-CXCR4 in parental (1 ± 0.1 for CXCR4) and DKO (1 ± 0.1 for CXCR4) cells were 0.9 ± 0.1 and 1.0 ± 0.2 for FLAG-β2AR and 0.9 ± 0.3 and 1.0 ± 0.2 for FLAG-AT1AR, respectively.
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PMC6799808
The recombinant adenoviruses, including Ad-AMPKα-dn encoding c-myc-tagged dominant-negative AMPKα and Ad-GFP encoding GFP (green fluorescence protein), have been described previously.
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PMC11345828
The reaction was sealed and heated to 100 °C for 2–24 h. The reaction was cooled to room temperature and diluted with 1:1 EtOAc/H2O.
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PMC10568263
The obtained MoO3 nanosheets (blue line) were confirmed with the diffraction peaks of 2θ at 12.72°, 23.32°, 25.68°, 27.28°, 29.61°, 33.72°, 35.52°, 38.92°, 45.8°, 46.28°, 49.24°, 52.81°, 55.21°, 58.83°,64.44°, and 69.52° assigned to the (020), (110), (040), (021), (130), (111), (041), (150), (200), (210), (002), (112), (161), (081), (190), and (202) planes, respectively.
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PMC11291490
Additionally, it underscores the pivotal role of duCD40L as a potent adjuvant in the context of vaccines designed to combat zoonotic infections in avian species.
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PMC11243198
Therefore, identifying drugs that target the Hh/GLI pathway has been a major focus in cancer drug development.
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PMC11224020
Data were analyzed by one-way Mann–Whitney U-test; *P = 0.0221.
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PMC11684269
The translocation, however, can be impeded by diet-derived vitamin B5, which is catabolized into coenzyme A (CoA), thereby binding PKM2 and inhibiting Th17 differentiation (31).
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PMC10421378
DSC is sensitive to protein denaturation and can be used to determine the thermal resistance of cells.
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PMC11765988
Both sarcoidosis and lymphoma can lead to increased FDG uptake in mediastinal lymph nodes; thus, FDG-PET/CT cannot eliminate the need for histological verification .
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PMC10940855
Slides were stained with primary antibodies to BCMA (1:250; R&D Biosystems, MAB107621, and BioLegend, 357518), EPHB4 (1:250, R&D Biosystems, MAB446), EFNB2 (1:100, Invitrogen, MA5–35098), and secondary antibodies against rat (1:1,000, Invitrogen, A11006) and rabbit (1:1,000, Invitrogen, A21428) and DAPI (Thermo Fisher Scientific, D1306).
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PMC9429973
Prior studies have described the correlation between patient characteristics and clinical outcomes from CD19 CAR T cell therapy (Finney, J Clin Invest 2019; Fraietta, Nat Med 2018).
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PMC11680578
Synergism of two or more drugs can overcome toxicity and other side effects on tissues which are associated with high doses of each individual compound by either countering biological compensation or sparing doses on each compound.
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PMC9429973
These data support the inclusion of asymptomatic PH screening in the work up of MF patients.
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PMC9429973
We detected a total of 228 (24.5%) relapses, 115 (22.0%) in GCV and 113 (27.7%) in C (p=0.048).
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PMC11400680
Generally, prompts can be defined as hints to the segmentation model about what specific object or region to segment within the input images.
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PMC11718109
Towards this aim, VMAT2-GFP was transfected into DA neurons at day 50 on gridded glass dishes and visualized for VMAT2 fluorescence at day 53.
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PMC9429973
Results: In N=730 patients, we identified nine proteins with high affinity neoantigens in total (LRT p-value<0.05): MT-CYB, IGHJ5, MAGEC1, IGKV1_5, MT_ND1, IGLV3_1, KRAS, AC245369.1, and NRAS.
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PMC11638255
This is particularly important when considering the liver as the systemic reservoir of copper.
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PMC9031474
On the other side, the selective reduction of the C7–C8 double bond only diminishes the cytotoxicity without a complete loss .
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PMC9429973
We applied an established mathematical model (Hahnel et al., Cancer Res, 2020) and obtain individual fits for all patients using a genetic algorithm.
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PMC11676674
Indeed, previous studies have documented the automated evaluation of micronuclei through image analysis .
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PMC11361748
We conclude from this that the head domain of K17 is crucial for the TPA-induced modulation in the RACK1-K17 interaction, which may subsequently impact the interaction between RACK1 and active PKCα. (
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PMC11696576
b Synthesis of inhibitors.
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PMC7612475
C, Quantification of ongoing forks, new origins, and stalled forks scored in CldU-labeled forks in untreated or HU-treated (2 mmol/L, 2 hours) SF3B1 and SF3B1 cells.
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PMC10040136
Notably, PI3K-AKT represents one of the downstream signals of GIST KIT/PDGFRA, which is implicated in apoptosis and cell cycle regulation.
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PMC11240448
Contrary to the possibility to derive a consensus core network for luminal BC cells, the inferred core network circuitries of 28 basal BC cell lines show dramatic differences.
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PMC9684669
Rhodamine 123 was purchased from MedChemExpress (catalog number: HY-D0186) Antibodies used in experiments are listed in Table S1 .
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PMC11615828
Scale bar, 50 µm.
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PMC10093184
We know yet nothing about the stemness potential of isolated COS cells, so we cannot attribute the lack of colonies to the absence of cancer stem cells in COS3600 and COS4074 cells.
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PMC11806818
Nanozymes can act as recognition receptors or signaling tags.
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PMC9844987
p-values were calculated using Fisher’s exact test. (
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PMC11763111
5LLT1 overexpression renders resistance to allogenic NK cell-mediated lysis.
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PMC11463018
Binding model of 19 (yellow) in the catalytic pocket of human HDAC6 (PDB code: 5EDU). (
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PMC11402217
XD23 also disrupted the Bcl-2 family protein balance by elevating the ratio of pro-apoptotic protein BAX to anti-apoptotic protein Bcl-2 in OS cells, thereby favoring apoptosis (Figures 2D–2F).
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PMC8345486
The toxicity of 2′-deoxyadenosine modification at the N position with ferra bis(dicarbollide) (compound 15) was similar to that of the unmodified parent compound 2 for almost all A2780 sublines; however, for A2780cis cells, compound 15 was twice as toxic as compound 2 (p < 0.01, Figure 2A).
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PMC11723947
I, k, m, n Data show mean ± SD of biological replicates from 4 independent experiments.
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PMC10291556
Since equitoxic concentrations were used, this suggests that inhibition of COX-2 expression contributes approximately equally to the resulting activity of both complexes. (
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PMC3931643
Furthermore, we did not find evidence for 4EBP1 phosphorylation that is resistant to asTORi, a phenomenon observed in KRAS-mutant colon cancer cells .
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PMC11615743
D,F) Statistical analysis of the target CEM cell identification specificities (D) and sensitivities (F) using a dual‐aptamer‐based logic device with D‐DNA and L‐DNA probes in PBS and 10% FBS.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240
Detection in the pellet fraction might be due to unspecific binding of PT to the tube.
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PMC9429973
Preclinical studies demonstrated that tumor resistance and survival via IRAK4 activation could be delayed or reversed.
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PMC10033453
Plates were gently washed and dried overnight before taking phase images with EVOS FL Auto microscope at 10× magnification.
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PMC11107915
There are no conflicts of interest.
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PMC11401350
Six days post-transduction T cells were surface stained for CD8 followed by intracellular staining for IFNγ, perforin and granzyme B and analyzed by FACS.
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PMC11543935
These models offer advantages such as a closer approximation to the tumor microenvironment and the ability to study cellular responses in a 3D context.
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PMC8973085
The methylthio nicotinamide derivatives 12a and 12b were obtained by filtering the solid generated after cooling, drying, and crystallizing it from the specified solvent.
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PMC10419319
Glucose consumption and lactate production were calculated by subtracting from the concentrations of glucose and lactate in the control medium.
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PMC9220170
In addition, under these conditions, SELENOM-KD did not significantly affect the expression of other ER resident selenoproteins (Figure 9c) and thioredoxin reductases, while the expression of glutathione peroxidase 3 decreased by 1.5–2 folds (Figure 9d).
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PMC10932641
Therefore, altering the expression levels of lncRNA may provide new therapeutic targets for reversing resistance to targeted drugs.
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PMC11708541
As a result of their strong binding affinity and notable interactions with the tyrosinase enzyme to target the melanogenesis pathway, the analysis suggests that they could be effective future candidates to regulate hyperpigmentation (Fig. 8).
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PMC11087055
Here, through experimental manipulations, we addressed relationships between the polonaise movements and morphogenesis of the primitive streak, the earliest midline structure in amniotes.
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PMC11698348
Importantly, both Cdk16 and Ccne1, which are significantly up-and downregulated after modulating Elf5 expression are critical regulators of cell cycle progression, and their deregulation can lead to disease or cancer formation .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Supported by AIRC IG 2019 grant (23001).
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PMC9429973
For the cellular complementation assay, Jurkat cells lacking CTPS1 and CTPS2 were transduced with lentivirus carrying different CTPS1 and CTPS2 constructs cloned into a pLVX-EF1α-IRES-mCherry backbone; transduced cells were cultured with or without test compound and cell viability was assessed 72 hours later by CellTiter-Blue.
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PMC8068766
The outputs of this study emphasize the role of DEGs regardless of Se status and as a result of HBV-integration effect as potential targets in HBV-dependent HCC treatments.
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PMC11705547
For example, cisplatin-resistant urothelial carcinoma patients were treated with the combination of PD-L1 inhibitor durvalumab and CTLA-4 inhibitor tremelimumab, and 37.5% of the patients achieved complete pathological remission, while 58% achieved stage reduction to pT1 or lower .
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PMC11787355
We thereby examined antigen expression with RNAscope and found that TMG transcripts were greatly diminished in the recurrent tumors (Fig. 4l, m).
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PMC9454852
All the inhibitors utilized significantly block the BOLD-100 calcium rise, but comparing the inhibitory effects, PLC-IP3R inhibitors showed a higher inhibitory effect than the TLC inhibitor, suggesting the predominant role of the PLC-IP3R pathway (Figure 6E).
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PMC10212663
Values of p < 0.05 were considered statistically significant.
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PMC11206502
One of the main mechanisms of autophagy control is the interaction between the autophagy protein beclin 1 and anti-apoptotic members of the Bcl-2 family (BCL-2, BCL-XL, and MCL-1).
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PMC11495567
The following day, the inserts were removed, creating a “wound” between two adherent confluent monolayers of cells.
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PMC5833712
KB9520 treatment also increased the level of cleaved PARP1 in combination with cisplatin (Fig. 4b, c).Fig.
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PMC9027909
MicroRNAs (miRNAs) are 17–25 nucleotides, non-coding RNA fragment, which was firstly discovered in Caenorhabditis elegans.
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PMC10114490
B Accumulation of glycogen determined by periodic acid-Schiff staining.
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PMC10729469
Slides were masked and coded, and Aβ occupied area was calculated using Cavalieri estimator probe (grid spacing 15 μm), while the number of Iba1-reactive microglia cells were counted using the Optical Fractionator probe of Stereo Investigator system (MBF Bioscience, Williston, VT) as described earlier .
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PMC11730320
Genetic aberrations in key molecules involved in T cell development lead to profound T cell immunodeficiency.
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PMC11731614
Notably, we detected a GFP signal in DRG cross-sections from both RD and HFD EV-reporter mice (Fig. 6A; Supplemental Fig. 4B) with no false signal found in WT DRG controls (Fig. 6B).
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PMC8873393
C Top 10 gene ontology enrichments of genes in clusters 2–5 and 7 with Bonferroni-corrected P values.
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PMC9429973
There was also a trend of fewer serious adverse events with lower rates of hospital admissions due to infection (weekly 33.3% bi-weekly 47.8%).
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PMC9454178
Kaplan–Meier survival analysis demonstrated that high CDK7 expression was strongly correlated with reduced recurrence-free survival (RFS) (P = 0.044, HR = 1.924, CI = 1.005–3.684, Fig. 1D).Table 1Relationship between CDK7 expression and clinicopathological characteristics of GIST patientsFactorCDK7 expressionP valueLow (112)High (69)Age < 6058420.233 ≥ 605427Sex Male51360.385 Female6133Tumor site Stomach74410.374 Intestine, colorectal3427 Others41Tumor size (cm) 0–5.063350.725 5.1–10.03926 > 10108Mitotic index (per 50 HPFs)* 0–576310.002 > 53537Modified NIH criteria* Very low/low48180.011 Intermediate229 High4141*Two cases of mitotic index and modified NIH criteria were not accessible Relationship between CDK7 expression and clinicopathological characteristics of GIST patients *Two cases of mitotic index and modified NIH criteria were not accessible In summary, CDK7 was highly expressed in high-risk GISTs and may participate in GIST progression.
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PMC8740518
The process is catalyzed by branched-chain aminotransferase 1 (BCAT1) and mitochondrial branched-chain aminotransferase 2 (BCAT2).
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PMC11194678
Specimens’ statistics are presented as mean ± SD; ns, not significant. (
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PMC4395774
PRFmut has a missense mutation (PRF-T435M) that causes a postsynaptic defect in lipid binding allowing protein secretion but not binding of target cells.
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PMC11610461
Cell proliferation assays were performed by the CCK-8 method.
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