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OTAR3088
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BioData-CellLine_annotated

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PMC11075223
Due to the strong biological and pharmacological activities, it has become a research hotspot in recent years.
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PMC9429973
The median number of Glofitamab cycles administered was 3 (2-7).
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PMC11789597
The ROS level was then determined using flow cytometry.
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PMC11568601
Compared with the control group, a total of 63 and 328 DEGs were identified (Supplementary Table S1-2), respectively.
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PMC10329074
Three biological replicates were performed and the result was subjected to statistical analysis Overexpression of YBX3 promotes renal cancer proliferation and migration in vitro. (
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PMC8735881
Given a very high mutability with HIV, GPI-anchored inhibitors with a multifunctional activity have potential to overcome virus escape.
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PMC10849234
Finally, using CRISPRi, we generated a promyelocytic cell line that can be differentiated into NLCs with impaired degranulation, showing the genetic tractability of this model.
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PMC11770199
For the colon cancer model, 4 d after cancer cell implantation, the tumor grew to an average volume of approximately 10 mm.
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PMC8481254
We found that STZ could induce an increase in blood glucose in mice, while the blood glucose in mice treated with insulin was significantly decreased, which indicated that the insulin-deficient mouse model was successfully established.
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PMC11730320
Screening is based on the quantitative measurement of T cell receptor excision circles (TREC) levels, a by-product of T cell maturation, and thus a marker of both thymic function and the production of newly formed T cells.
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PMC11731614
DiR-EVs.
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PMC11680391
In the current study, several limitations must be considered when interpreting the results.
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PMC10495912
According to this hypothesis, the current study was designed to investigate the interference of TQ and hydrogen peroxide on the proliferation of HepG2 cells and the SOD/CAT intracellular system.
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PMC9429973
Further, ES is increasingly recognized in pediatric patients with defined inborn errors of immunity (IEIs) including pathogenic variants in CTLA4, STAT3, TNFRSF6, PIK3CD, and KRAS.
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PMC11126803
Then, we sonicated the samples with a predetermined power to yield genomic DNA fragments with lengths of 300 to 1000 bp.
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PMC6133382
The results from this study confirmed that the MGAT1 CHO cell lines could bind this antibody, whereas gp120 produced in the parental CHO-S cell line was unable to bind PG9.
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PMC2247044
A cell line, designated 8701-BC, was established in culture from tissue fragments of primary ductal infiltrating carcinoma of human breast.
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PMC10854447
The most potent antiproliferative 1,2,4-oxadiazole hybrids 7h, 7i, 7j, 7k, and 7l were examined for their ADME/Pharmacokinetics properties using the web tool Swiss ADME by entering a list of the compounds’ SMILES (Simplified Molecule Input Line Entry Specification) provided by ChemDraw software.
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PMC10926885
Immunological association analysis of NDE1. (
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PMC3675084
The DNA pellet was dissolved in 20 µL of TE buffer [10 mM Tris-HCl and 1 mM EDTA, pH 8.0] together with 1 µL of RNAse (10 µg/mL) and 1 µL of Proteinase K (100 µg/mL) and incubated at 37°C for 30 min.
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PMC11791264
F, HEK293T cells were transfected with the indicated combinations of HA-tagged SETD7, empty vector pCMV3-N-HA (HA), and MYC-tagged LC3B WT or K51M mutant.
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PMC5173112
USP21 gene displays amplification of copy number in metastatic urothelial carcinoma .
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PMC10914904
Moreover, in the Burkitt lymphoma cell line, latent membrane protein 1 (LMP1) of EBV can induce the expression of vtRNA 1-1 by activating the transcription factor NF-κB and increasing the expression of antiapoptotic proteins, such as Bcl-xL (apoptotic protein with CARD (ARC) and B-cell lymphoma-extra-large), and promote the inflammatory response mediated by TNF/TNFR superfamily members .
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PMC11216402
Downstream fibroblast genes such as FGF5 and COL1A1 were found to be upregulated in both Mes-like GC and TCGA-STAD, and we identified flanking cis-regulatory enhancer elements with increased activity in Mes-like GC versus Epi-like GC, as well as TCGA-STAD compared with normal stomach.
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PMC11769516
Studies by de Sa et al. indicate the need for further analyses of mycotoxin interactions and adverse effects on the human body due to their wide distribution and mutual occurrence in contaminated food products .
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PMC10582049
Survival analysis demonstrated that high expression of ADH1B is associated with better survival of LUAD patients (stage I and II, p = 0.034) (Fig. 4F).
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PMC11098378
Native crystals diffracted to a minimum Bragg spacing (dmin) of 1.70 Å and exhibited the symmetry of space group C2221 with cell dimensions of a = 86.0 Å, b = 112.3 Å, c = 55.2 Å, and contained one Ceg10 per asymmetric unit.
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PMC11412721
Characterization of the ACKR4 KO 5.2 clone.
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PMC9275501
When the molar ratio of PTX/TET was 4.4:1, the drug resistance of MCF-7/ADR cells to PTX was completely reversed, and it was more effective than PTX-CTAB @ MSN or free PTX in inhibiting the growth of tumor cells.
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PMC11321678
All animal studies strictly adhered to approved protocols by the Ethics Committee of the Shanghai Medical School (202311006Z).
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PMC9429973
No new safety signals with longer follow-up have been observed.
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PMC11734514
Subsequently, ImageJ ver.
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PMC11610461
The relevant genes were downloaded from the molecular signature database (MSigDB, https://www.gsea-msigdb.org/) for GSVA.
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PMC11756937
We reviewed a total of 50 cell lines reprogrammed with the SeV method and 26 cell lines reprogrammed with the episomal method (Table 2).
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PMC6160470
We further investigated whether co-treatment with the most potent crown ethers increased sensitization of resistant A2780/Adr ovarian carcinoma cells to paclitaxel (PTX).
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PMC11638255
Fig. 6).
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PMC9429973
Aspirin is one of the most common thromboprophylaxis agent but also increases bleeding complications.
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PMC9429973
Results: A total of 32 patients were enrolled as of June 30, 2021, with a median age of 63.5 years (range 49–74).
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PMC6450504
Cells were washed gently and incubated for an additional 44 h at the same conditions.
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PMC11641630
Our zymography results showed reduced MMP-9 production in mycobacteria-treated BC cells compared to non-infected cells.
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PMC10222971
Despite the great therapeutic advances made in this area, there is not yet effective treatment that provides acceptable success rates and reduce the adverse effects.
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PMC11763111
Live/dead cell discrimination was performed using FVD (eBioscience, 65-0865-14).
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PMC11459296
We assessed the engraftment dynamics of various human immune cells over time and monitored the development of GvHD in both models.
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PMC11684269
These data suggest that the JAK/STAT pathway may mediate the fate of TRM by modulating cellular metabolism.
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PMC11323699
Here, we chose to assess TAX2 efficacy in a relevant syngeneic model of high-grade serous OC carrying both Tp53 and Brca2 deletions.
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PMC7823217
Depending upon the 3D model, different types of immunohistochemistry or immunofluorescence assays can be performed to understand the expression of various proteins important in the development and maintenance of cancer progression, synthesis of ECM components and membrane proteins .
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PMC11696576
As such, cPLA2α is now generating interest as a chemotherapeutic target, particularly in breast cancer, where PLA2G4A overexpression was initially associated with Her-2 positive basal-like subtype and predicted poor response to endocrine therapy.
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PMC11352666
In A673 cultures, treatment with 300 nM of MRX-2843 or 300 nM of navitoclax mediated 50.9% ± 5.7% and 64.6% ± 2.2% reductions in the cell density compared to the vehicle, while combined treatment reduced the cell density by 78.2% ± 3.5% (Figure 6B, left panel).
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PMC9429973
Summary/Conclusion: In this Phase II study, the novel oral agent tolinapant has shown meaningful clinical activity against PTCL and CTCL with a manageable safety profile.
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PMC11352311
Furthermore, the CCK-8 assay demonstrated that esculin inhibited RCC cell viability.
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PMC8358006
Although narrow and random H3K27me3 peaks loss also results in gene activation, we observed stronger activity on GSDs associated genes than genes harboring narrow or control H3K27me3 peaks.
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PMC4659567
The emitted fluorescence (546 nm excitation wavelength) was recorded on a fluorescence spectrometer AvaSpec HS1024x122TE using a 1 cm quartz cell.
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PMC11718109
Scale bars, 100 μm.
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PMC9780037
Additional biosensors have also been developed for quantification of cyt c in cell lysates [33–39], in nonserum solutions, and/or visualization in living cells [34,40–46]; however, these studies do not include validation for detection of cyt c in human serum.
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PMC11519077
However, there is a lack of studies comparing the effect of different sources of MSCs on the treatment of IBD.
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PMC11391695
I The changes of telomere length in si-NC, si-TERT and si-ACYP2 + si-TERT treatment groups were observed by fluorescence in situ hybridization and qRT-PCR.
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PMC11770130
It also prevented lipolysis, determined by the reduced release of NEFA from adipocytes (Supplementary information, Fig. S2i).
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PMC11397654
Cell imaging studies showed that the ligand accumulated in the mitochondrial region of the cells, as demonstrated by its red fluorescence.
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PMC11240571
Bone and soft tissue tumors may be less associated with cPD-L1.
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PMC6642070
The matching consensus p53RRE bases are shown in uppercase characters.
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PMC10719213
Wilcoxon rank sum test was used to assess the significance of difference between groups in (a) and (c).
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PMC11342785
However, because MTs are the largest filaments of the eukaryotic cytoskeleton, with a diameter of 25 nm and more than 1600 tubulin subunits per micron (11, 12, 13), it is not obvious how to best engineer synthetic MAP proteins such that their nanoscale activities can be effectively integrated across the microscale within cells.
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PMC9429973
No MM-specific therapy is allowed prior to eligibility confirmation.
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PMC11612315
ANOVA analysis of variance, CAP capsaicin, GLP-1 glucagon-like peptide-1, S.E.M. standard error of the mean.
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PMC11711345
However, p-cymene has not been shown to induce antiproliferation in most human cancer cell lines (HCCLs) , even when its concentration is greater than 100 µM [2-4].
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PMC9473868
Therefore, development of a novel therapy for RA which has low cost, is effective, and has less side effects is very important .
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PMC11697703
Other data reported on this paper will be shared by the lead contact upon request.
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PMC7053076
RT-PCR and ELISA assay showed significant overexpression of MDR-related ABC transporters, ABCB1, ABCG2 but especially ABCC1 in the HL-60/5FU, as compared with the parental cell line.
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PMC8557138
Sobrino et al. constructed PDMS-based vascularized micro tumors by co-culturing one of the tumor cells- HCT116, SW620, SW480, MCF-7, MDA-MB-231, and MNT-1 with endothelial colony-forming cells derived endothelial cells and human lung fibroblasts.
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PMC11592008
After 2 h of blocking with 5% milk, the membranes were incubated with primary antibodies for IL-1β (dilution 1:2000, AF-201-NAl; R&D Systems, Minneapolis, MN, USA), cleaved IL-1β (dilution 1:1000, #83186; Cell Signaling Technology, MA, USA), caspase 1 (dilution 1:4000, AG-20B-0048; Adipogen, San Diego, Boston, CA, USA), actin (dilution 1:6000, A2103; Sigma-Aldrich), cleaved GSDMD (dilution 1:1000, #36425; Cell Signaling Technology), NLRP1 (dilution 1:1000, #56719; Cell Signaling Technology), cleaved caspase-3 (dilution 1:1000, #9664; Cell Signaling Technology), and ASC (dilution 1:1000, ALX-210-905; Alexis Bio, Boston, MA, USA).
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PMC11240448
A combination of STAT3i and PKCi triggers cell state transition from oncogenic to normal DPDonc scores, whereas single treatments by individual drugs at twice higher concentrations cannot move the DPDonc scores to the DPDonc range of normal breast tissue-derived cell lines.
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PMC11803918
Tumor weight of the mice with different treatments (n = 6 for each group). (
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PMC11306331
B Representative images displaying nuclear condensates formed from FUS, EWS, and TAF15 constructs consisting of 3 repeats of the IDR.
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PMC11543885
Clustering.i.
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PMC8469018
In recent years, leflunomide has been shown to be cytotoxic in relation to several cancer cell lines: bladder cancer , head and neck cancers , melanoma , leukemia , and thyroid cancer .
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PMC9429973
Regarding the clinical stage, 88% were Durie Salmon III clinical stage, and 46% were ISS III stage.
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PMC7334607
This fusion is the most common genetic aberration found in 90%–95% EWS tumors (Sankar et al., 2014; Szuhai et al., 2006).
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PMC5330095
CBD was shown to have activity against HCV in vitro but not against HBV.
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PMC11762280
The biological effects observed in PANoptosis cannot be completely explained by pyroptosis, apoptosis, or necroptosis alone , and individual blockade of a key molecule of pyroptosis, apoptosis, or necroptosis does not prevent cell death .
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PMC6892818
These findings suggest a role of Nox in CD40 signalling in RCC cells and support the recent observation of Nox-/ROS-dependent mCD40L-mediated apoptosis in UCC cells.
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PMC11400680
SAM uses masked autoencoders (MAE) pre-trained vision transformer (ViT) model as an image encoder and extracts comprehensive features from the input images.
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PMC10698968
To unravel the complex molecular pathogenesis of this sarcoma and to investigate the validity and mode of action of standard and innovative therapies, there is an urgent need to expand the availability of preclinical models.
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PMC10587429
Evaluation of humanization status using peripheral blood, spleen and bone marrow at week 8 post hCD34+ HSC implantation.
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PMC11451940
The reaction system was stirred at room temperature for the next 1 hour, forming a dark-red solution.
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PMC8358176
The geometry of SWCNTs- and MWCNTs-COOH was checked by TEM, and their lengths were about 1–10 µm.
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PMC9429973
Per investigators’ assessment, 20 patients (39.2%) experienced ≥ grade 3 TEAEs possibly related to the drug.
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PMC9111184
The analysis was focused on the first two principal components (PC1 and PC2), as they accounted for more than 90% of the variances.
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PMC11745600
However, the nonfasting plasma glucagon levels were significantly higher (Figure S4D, SDC, http://links.lww.com/TP/D122), which can be attributed to decreased insulin-mediated inhibition of glucagon secretion because of reduced nonfasting plasma insulin levels in these mice (Figure 3O).
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PMC11736898
Potential mechanisms for CYP24A1 overexpression in cancers may involve gene amplification, epigenetic alterations and/or regulation by miRNA .
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PMC9966931
For the first time, we have demonstrated further biological activities in the form of antifungal effects against two different modes of action, and their cytotoxicity results allowed us to propose industry-targeted applications for EO-based hybrid molecules.
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PMC8358006
Eluted chromatin was digested at 65 °C by proteinase K and DNA was purified using columns provided in this kit.
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PMC9895440
SNX9 KO Teff cells showed decreased CD28 surface expression while expression of TCRβ was not affected (Supplementary Fig. 6d).
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PMC11697703
We acknowledge the Stanford Neuroscience Microscopy Service, supported by 10.13039/100000002NIH NS069375, and Tulane Brain Institute microscopy core, supported by Louisiana Board of Regents Enhancement Grant LEQSF(2018-23)-ENH-DE-15.
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PMC9429973
Furthermore, we noted that treatment with ruxolitinib alone decreases the mRNA levels of Bclx-L, but also of the Bcl-xS isoform.
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PMC7305184
In IRE treatment targeted tissue is efficiently destroyed, however, the integrity of nearby tissue structures like vessels and nerves are preserved as well as extracellular matrix.
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PMC11609529
Importantly, YM-positive cancer cells were sensitive to YAP1/TEAD-targeted pharmacologic inhibition.
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PMC11204465
Compounds 16–19 showed better inhibitory activity against KB, MCF-7 and NCl-H187 cell lines with IC50 values ranging from 0.38–78.6 µM .
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PMC11320834
This occurs as a result of direct platelet-derived growth factor receptor (PDGFR) inhibition that suppresses this DNA repair gene expression and partially as a consequence of hypoxia.
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PMC11635087
The images and Z-stacks were processed with ImageJ. To image incorporated chloroplasts in CHO-K1 cells at super-resolution, a FV3000 inverted confocal microscope with FV-OSR (Olympus) was used.
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PMC11686380
Additionally, GAP43 is expressed in medial ganglionic eminence (MGE)-originated SST-positive and caudal ganglionic eminence (CGE)-originated VIP-positive GABAergic interneurons.
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