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OTAR3088
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BioData-CellLine_annotated

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PMC11736898
Although a trend toward decreasing proliferation with increasing vitamin D concentrations was observed, no statistically significant differences were found among different vitamin D concentrations or between normal and keloid keratinocyte groups.
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PMC6835428
Small interfering RNAs (siRNAs) were first described about three decades ago in plants , and then in Caenorhabtidis elegans .
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PMC9621239
However, studies on the effect of HBx genotypic mutation on its phenotype are scarce.
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PMC5035325
Future studies going on carrying out to characterize the expression of NeuGcGM3 in others organs colonized by 4T1-cells different methods.
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PMC11721587
One hundred nanograms of of chromatin DNA was mixed with 20 ng of purified cytoplasmic or nuclear Ci complex (200 ng of Sufu was also added to capture any free Ci due to dissociation) in HAT buffer [20 mM tris-HCl (pH 7.6), 50 mM KCl, 5 mM DTT, 10 mM sodium butyrate, 2 mM MgCl2, and 5% glycerol] at 30°C for 20 min.
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PMC9275501
This indicated that RGD promoted the accumulation of intracellular PTX through active targeting on multidrug-resistant KBCH-R8-5 cells.
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PMC5415764
The activity of caspase-3/7 which is essential for apoptosis in various treated A2780/PTX cells was determined.
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PMC11394227
There are also many studies on the anti-apoptotic effect of BCL-2 family members through CHO cell engineering.
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PMC9844987
These features likely cause, in addition to high expression variability between individuals, a responsiveness to external stimuli, cell-type restricted activity, high transcriptional noise across single cells, and less tolerance for genetic variants.
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PMC10174970
Further details are shown in Figure S1.
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PMC10523483
Measurement of ROS in mouse tissues was performed using dihydroethidium (DHE, Beyotime).
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PMC11525293
Given the time and cost involved in developing new therapies, repurposing existing drugs with known profiles has become a cost-effective strategy .
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PMC11317131
Integration of the donor plasmid was measured by ddPCR using a forward primer and probe designed to bind the genome and reverse primer designed to bind the inserted sequence.
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PMC3888431
To estimate the number of paralogous genes that fall into the same cluster, all transcripts were mapped to the reference genome using gmap with the parameter “-n 1” to get the best gene locus for each gene.
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PMC11471157
Organization of cell spheroids by HaCaT cells and NIH/3T3 cells on Day 3.
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PMC9583612
SeekOps and Bridger detect and quantify emissions at the equipment-level and typically do not distinguish between leaks and vents.
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PMC11391695
Overnight at 4 °C, diluted cell lysates were combined with 2 to 5 µg of antibody and incubated.
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PMC9429973
rHuPH20 depolymerizes hyaluronan in the extracellular matrix to transiently increase local subcutaneous tissue permeability, allowing for fSCIG infusion at rates, volumes, and frequencies comparable to intravenous immunoglobulin with better systemic tolerability.
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PMC6617630
Data represent mean ± SD from three independent experiments.
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PMC9429973
All confidence changes were significant (P<0.01/ P<0.001).
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PMC9917080
The effects of sorafenib on neuroinflammation are shown in in vitro and in vivo models.
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PMC11536589
The pathways of ferroptosis and glutathione metabolism were enriched in the Cluster 5 (Fig. 1E).
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PMC6163708
The GANT61-treated cells revealed massive apoptosis (reflected by the FITC staining, about 60% of apoptotic cells in SK-MEL-3 and 50% in SK-MEL-5 cells, right peaks, left panels, Figure 3A), while negligible apoptosis was observed in control cells.
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PMC10759659
The cells were then fixed with Paraformaldehyde Fix Solution for 30 min and stained with 0.1% crystal violet for 15 min.
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PMC11711663
The dataset was divided into 10 folds, ensuring that each fold maintains the same distribution of race and status as the overall dataset.
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PMC10024132
Twenty-two days post-treatment, bone marrow samples were taken from the femurs of mice receiving combination treatment or left untreated and used for flow cytometry analysis of GFP VAL cells.
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PMC11711347
The Ni(II)ProDtc complex was synthesized and characterized using melting point analysis, conductivity measurements, UV-Vis spectroscopy, and FT-IR spectroscopy.
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PMC8956657
Rather, MERS ORF4b bound IMPα2 and IMPα3 through an Arg residue (position 33, the equivalent of the P0 position) at this site and formed similar interactions to those made by a Lys NZ nitrogen at the P2 site.
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PMC9398137
Concerning MCL1, both, the level of MCL1 protein expression, and its occupational status represent key factors mediating sensitivity to S63845.
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PMC9429973
N. B. E.-D. Farghal, A. Tantawy, F. S. E. Ebied, N. El-Sherif, N. Salah Eldeen, N. Soliman, S. Makkeyah pediatrics, Ain Shams University hospitals, cairo, Egypt Background: Sleep disordered breathing (SDB) is a common underdiagnosed sequela of sickle cell disease (SCD) characterized by daytime sleepiness, behavioral changes, and cognitive deficits.
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PMC11786600
Electrostatic spinning, which involves electrostatic forces to create fibrous membranes from polymer solutions or molten states, has emerged as a promising approach.
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PMC11531735
These findings highlight the ability of ER121 to restrain metastatic growth and dissemination within the brain.
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PMC11468365
These methods depend on different aspects including omics data, structure network interaction, and chemical drug properties.
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PMC11075223
Moreover, the therapeutic efficacy of Cimicifugae Rhizoma was increased when it was compatible with other herbal medicine, such as Atractylodes lancea (Thunb.)
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PMC11604768
Due to their short length relative to endogenous promoter regions, synthetic promoters are advantageous for many applications, including those utilizing vectors with limited cargo sizes.
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PMC9220170
Interestingly, SELENOT-KD significantly affected the expression of the same ER resident selenoproteins (Figure 6c).
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PMC11770746
Moreover, the prodrug that combines cisplatin with paclitaxel, both strong inducers of PN, can efficiently inhibit tumor growth in vivo without causing body weight loss while reducing accumulation in the kidneys and not inducing neuropathic pain.
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PMC11116779
In addition, PS is also used in respiratory care equipment, syringe hubs, and suction canisters, and it is competitive with polypropylene and acrylics in labware and packaging for kits and trays (13).
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PMC11638255
We therefore posit copper chelation skews the immunosuppressive tumor microenvironment and reinvigorates the antitumor immune response via enhanced neutrophil signaling.
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PMC9429973
Complete blood count was evaluated every two weeks.
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PMC4443654
PCC, Pearson correlation coefficient.
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PMC11322866
Cellular senescence is associated with haematopoietic stem cell function and the progression of multiple myeloma (MM) [ 4‒ 6] .
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PMC11790971
From 2018 to 2022, 95 of the 107 (89%) approved biopharmaceutical products made in mammalian systems were produced in CHO cells.
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PMC10040136
The tumor microenvironment (TME) encompasses a complex milieu of stromal cell types, such as MSC, cancer-associated fibroblasts (CAFs), the extracellular matrix (ECM), immune cells, and endothelial cells.
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PMC11599565
After 30 min, slides were rinsed three times in distilled water and incubated in gold chloride solution (0.2%) for 30 s. After threefold rinse with distilled water, sections were incubated with Sodium Thiosulfate Solution (5%) for 2 min and again washed in distilled water, stained with Fast Red solution for 5 min and finally covered using Eukitt® mounting resin.
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PMC10993311
There was an influence of EGWG on maternal biochemical parameters and fetal and neonate growth parameters, and these parameters were correlated with the mean maternal DNAm level.
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PMC10870498
Whether there are other post-translational modifications of KIF23 in ATC needs further studied.
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PMC11290772
In the experiment, SKOV-3 cells were suspended and seeded into E-Plate 16 wells (5469830001, Agilent) with a density of 3 × 10 cells per well.
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PMC6160470
Data analysis was performed using FlowJo software (TreeStar Inc.).
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PMC4485786
Immune reconstitution was evaluated for several individuals 10-12 weeks after transplantation and peripheral blood, spleen, bone marrow, and thymus were analyzed using the following mouse mAbs that were specific for human epitopes and not cross-reactive with murine protein: CD62L(Dreg56)-FITC, CD25(2A3)-APC, CD3(SK7)-PerCP, CD8(SK1)-PerCP, CD8(SK1)-APC-H7, CD4(SK3)-FITC, CD4(SK3)-PerCP, CD14(M5E2)-PE, CD56(My31)-PE, HLA-DR(L243)-PerCP, NKp30(P30-15)-PE, NKp44(P44-8)-APC, NKp46(9E2)-PE and their corresponding IgG isotypes (BD PharMingen, Germany); CD45(MEM-28)-Pacific Blue, CD19(HIB19)-PerCP, CD3(MEM-57)-Alexa Fluor 700, and CD4(MEM-241)-Alexa Fluor 700 (Exbio, Czechoslovakia); CD45(HI30)-PE with respective isotype IgG (Biolegend, Germany).
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PMC11803918
After intravenous injection of free Ce6, liposomes, and hybrid exosomes, the biodistribution of Ce6 was monitored by an in vivo imaging system (IVIS) at 650 nm excitation at different time points.
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PMC10482220
Next, we tested the capacity of G3BP to form multimers and determined the effect of phosphorylation on multimerization.
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PMC11670407
d-i Western blot results and semiquantitative analysis of band density.
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PMC10938377
In particular, the overall cancer cell cytotoxicity and extent of adduct formation at AU1/AU1′ is highest for Au–LANA, but the latter is less than that observed for AuDPPBX or auranofin that is allosterically elicited via RAPTA binding in the acidic patch.
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PMC11143482
Moreover, it is important to consider the burden carried by the mice throughout the tumour growth.
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PMC3995603
The Eczema Area and Severity Index (EASI) scoring system was employed to evaluate the severity of dermatitis.
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PMC11679326
It is likely that D-mannose-specific BPL2 lectin will recognize the trimannosyl core and will be suitable for identifying M3-M1 paucimannose structures and, specifically, the Man3GlcNAc2Fuc epitope that has been found in glioblastoma cells.
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PMC5034105
Pig and/or hamster models have been previously reported for DENV and WNV infection.
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PMC4277423
This two-component system enables efficient genome editing in eukaryotic cells - and even in model organisms , –. Although the two-component sgRNA/Cas9 system has many advantages, such as ease of design and construction, low cost, possibility for highly multicomplexed modifications and efficient site-specific targeting, whether this system could become a viable alternative to ZFN and TALEN in genotypic disruption of CCR5 depends on its efficiency and target sequence specificity.
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PMC11779605
In conclusion, our study identified a clinically significant transcriptomic difference between tumor and ascites cells and provided proof-of-principal that studying differentially expressed genes between tumor and ascites cells can identify candidate cancer drug targets and predictive biomarkers.
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PMC11802855
Small interfering RNA (siRNA) targeting CXCL7 (Genomeditech, China), with the sequence provided in Supplementary Table 1, was used for transfection.
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PMC9429973
The regular review of microbial pattern and susceptibility evaluation is imminent for prevention of microbial resistance and assessment of institutional practices.
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PMC9429973
The randomised BMT CTN 1703 study comparing Tacrolimus and Methotrexate (MTX) to PTCy/Tacrolimus and MMF is ongoing but does not include myeloablative conditioning (MAC) regimens.
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PMC11078693
Otherwise, cap the tube, then shake and rotate it to position the cover glass correctly.d.
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PMC11590005
The topic needs to gain more visibility, and global discussions about prejudice should be encouraged.
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PMC11672881
These data suggest that combining TQ and CU increases ROS production and caspase-9 activity more significantly than caspase-8 activity compared to individual treatments (Figure 5C).
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PMC4277423
HIV-1 envelope pDOL is derived from an X4 tropic clade B virus .
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PMC11805741
These findings highlighted a consistent trend of decreased BCL2 expression with increasing treatment concentrations (Figs. 6 and 4S, Table 2S).
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PMC8526701
The required IHC kit was obtained from Boster (Wuhan, China).
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PMC11742290
However, a limitation of this study is that they only measured LGR5 expression in a small number of lymph node tissues.
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PMC11549612
Cyclosporine, known primarily as an immunosuppressive medication, reveals additional anti-tumor potential through its inhibition of calcineurin signaling, thereby disrupting key pathways involved in tumorigenesis.
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PMC11615828
RIVET is a highly specific system, as trapping target vesicles on MTs does not affect the motility of other unrelated or non‐overlapping vesicles (Figure 2a–c, left; Figure S14 and Videos S15–S17, Supporting Information).
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PMC5916734
The ORF sequence of the FIX gene in plasmid p1.1-F9 was linked to the selection marker, murine dihydrofolate reductase (DHFR), by the attenuated internal ribosome binding site of the encephalomyocarditis virus (EMCV IRES), thus ensuring expression of single bicistronic mRNA.
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PMC11337594
We demonstrated p53-BAX/FAS-CASP3-GSDME as the main mechanism of TER-induced A375 cell death.
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PMC7090062
P < 0.05 vs. non-specific control; P < 0.05 vs. miR-30a inhibitor.
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PMC8913139
In this study, miR-448 was found to be downregulated and exert inhibitory effect in GBM.
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PMC11477621
The crude product was purified by silica gel chromatography to give the brown solid (16 mg, 35%).
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PMC11607764
PPI network; (B) Correlation between expression of PTBP1 and the top 5 PTBP1-correlated genes; (C) The corresponding heatmap data in different cancer types; (D) An intersection analysis of the PTBP1-binding and correlated genes. (
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PMC11742290
By maintaining balanced WNT/β-catenin signaling, LGR5 helps preserve normal tissue architecture and curtails aberrant cellular proliferation that can lead to cancer progression.
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PMC9429973
The standard of care for R/R HL was salvage chemotherapy followed by autologous stem cell transplantation (ASCT) in the national bone marrow transplant center in Tunis.
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PMC11477621
The crude product was purified by silica gel chromatography to give the colorless oil 4a (546 mg, 45%).
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PMC11683240
Values are given as mean ± SEM (n = 8 values from four independent experiments).
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PMC11240448
Given our primary objective of distinguishing between normal and cancer cell states, the constrained number of analytes measured in the CYTOF dataset and used by cSTAR was sufficient to provide ample insights into cell transitions between oncogenic and normal states.
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PMC11470381
This can be achieved by employing bi-directional high-speed scanning at a moderate resolution of 512 × 512 pixels and enhancing magnification for faster scanning of smaller areas.
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PMC11617590
Patients with mutant KRas cancers have poor prognosis, increased tumor aggressiveness and metastasis, and are less likely to respond to chemotherapy and targeted therapies .
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PMC9583612
Without data on the frequency and duration of intermittent emission events, it would be impossible to directly compare methane emissions seen by one or a few top-down snapshot measurements to an annualized inventory.
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PMC11470999
Novel drug development faces increasing challenges such as increasing development costs, high failure rates, and long development cycles.
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PMC11033180
For Sholl analyses, pictures of β3-tubulin-labeled axons were acquired with an Axio observer Zeiss microscope using Zen software and a x10 objective.
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PMC11629192
After OFA treatment, CSF anti-NMDAR antibody became negative in three patients and decreased in two patients.
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PMC11589157
Genomic DNA was isolated using a Blood & Cell Culture DNA Kit (Qiagen 13323, Qiagen, Germany) following the manufacturer’s protocol.
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PMC11551844
MSTFA as a silylating agent is the most volatile trimethylsilyl (TMS) donor available.
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PMC9341513
Some unmappable regions are visible as gaps in the data (white stripes); for ease of comparison, the same regions are masked in the simulation map.
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PMC11224020
Future studies aimed at determining whether and how the here described shape-sensing pathway functionally interacts with these efferocytosis-dependent pathways should shed light on how the balance between tolerance and immunity is critically tuned by distinct tissue environmental properties.
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PMC11021472
Functions beyond acting as a sponge or as a transcriptional regulator have been described for other circRNAs with strong miRNA binding domains.
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PMC11585565
Pathogenic variants from JS patients are indicated in bold text, with those included in this functional study highlighted in bold red text (created with BioRender.com). (
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PMC11786767
Our results show that this ratio is less than 0.4 during prometaphase and metaphase but increases to ∼0.5 and ∼0.6 for anaphase and telophase, respectively (Fig. 3C).
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PMC9429973
69% of index cases had at least 1 relative with STS.
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PMC11455164
Methods: To evaluate the migratory behavior of MSCs in the presence or absence of thyroid hormone treatment in response to tumor-derived signals, a 3D migration assay was performed.
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PMC11335267
Thus, the observed increase in MC3R in the arcuate nucleus could reflect a compensatory mechanism to reduced levels of αMSH.
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PMC9429973
Among the latter, patients with inherited/congenital erythrocytosis can be found, especially if they have a positive family history.
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