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OTAR3088
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BioData-CellLine_annotated

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PMC7433824
The MALDI matrix was prepared according to Ucal and Ozpinar (2018).
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PMC11588085
XIST expression in ovarian cancer cell lines and effects of XIST KD. (
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PMC6901583
This infiltration was substantially suppressed with the use of antibodies against CCL2 to reduce the growth of tumors caused by BRD4 in vivo.
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PMC9429973
We enrolled 31 healthy adult subjects at a single site in Singapore who received CAN106 (mg/kg) or placebo at one of the following 6 doses (mg/kg) and ratios: (0.25, n=1:0; 0.75, n=1:0; 2, n=3:2; 4, n=6:2; 8, n=6:2 or 12, n=6:2).
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PMC11541409
TFRC may be considered as a potential therapeutic target for GIST.
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PMC10820104
Genome sequencing of the fungus revealed secondary metabolite regions presumably involved in the synthesis of the reported prenylated metabolites.
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PMC11781181
In contrast to apoptosis, ferroptosis is a ROS-dependent form of cell death associated with lipid peroxidation.
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PMC10955424
Fig. 1B shows an example of the chemoresistance promoted in A2780cisR cells by 20 % and 30 % of malignant ascites As001.Fig.
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PMC9429973
Notably, in detail characterization of the drug’s mechanism on the genetic and metabolic level reveal the activity of the iron-metabolism gene HMOX-1 as essential for ferroptosis induction.
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PMC9429973
The primary endpoint was Hb response, defined as ≥1.5 g/dL increase in Hb from baseline sustained at ≥2 scheduled assessments at weeks 16, 20, and 24 in the fixed-dose period.
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PMC11665584
Healthy oral keratinocytes constitutively expressed some of these markers, including Krt6a and Krt16, in the buccal mucosa, supporting prior observations of them existing in a primed and activated state compared with epidermal keratinocytes (Figure 7B) (4).
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PMC11240448
The DPD trajectory is obtained from the following equation:(8) dSdt=fS+σt=−dUdS+∑jrSjSst.stxjst.stxjt This gradient force field and the field of external forces shape the evolving Waddington’s landscape (), as follows:(9)W=U−∑jrSjSst.stxjst.stxjt·St The slope parameters ( and ), stable steady state positions ( and ), and the coefficients are estimated from phosphoproteomic time-course data during model parameterization.
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PMC10291556
Hela cells were treated with the investigated compounds at their concentrations corresponding to 1× or 3× IC50,72h and incubated for 24 h. Then, both cell populations were stained with either green (ThP-1/PMA cells) or red (HeLa cells) tracker dyes and co-incubated for 2.5 h at the ratio of 1:3 (effector/target).
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PMC8481254
WB assay results showed that the expression of CDK19/CDK8 was elevated with increasing concentrations of glucose (Fig. 4D).
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PMC10823017
However, single BYL therapy did not cause a significant reduction in the c-Myc level, while we observed a decrease in the c-Myc level in 786-0 and Caki-1 cells (61% and 41%, respectively) (P<0.01) as a result of ICA-1 monotherapy ( Figures 5A, F ).
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PMC11206251
Primary antibodies for TLR4, MyD88, p-NF-κBp65, IL-1β, TNF-α, INOS, P53, MDM2, cyclinD1, CDK4, Bcl-2, Bax, caspase-9, and cytochrome-C were purchased from Proteintech (Wuhan, China).
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PMC11676674
No differences in the percentage of micronuclei frequency were detected upon treatment with C. monspeliensis extract at different concentrations compared to NC cells, thus indicating the absence of genotoxic potential in C. monspeliensis extract at the tested concentrations.
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PMC8382973
Peptides were synthesized on rink amide 4-methylbenzhydrylamine (MBHA) resin using standard solid phase 9-fluororenyl methoxycarbonyl (FMOC) chemistry at SciLight Peptide Biological Technology Co., Ltd. (SciLight Peptide; Beijing, China) and analyzed by high-performance liquid chromatography (HPLC) and matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) to determine that the purity of the peptide was >95%.
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PMC10440586
RP represents the first surgical sample taken from patients with short-term (under 5 years) recurrence, whereas NP represents patients without recurrence in 5 years. (
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PMC9429973
POLARIX (NCT03274492), a Phase III randomized, double-blind, placebo-controlled study comparing Pola-R-CHP with R-CHOP, demonstrated improved progression-free survival (PFS) with Pola-R-CHP (Tilly et al. NEJM 2022).
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PMC11770199
At the end of experiment, the tumors were isolated and imaged.
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PMC7022782
The strong and sharp peak observed in Figure 3C was due to the effect of unloaded NPs scattering the excitation light.
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PMC11731161
Immunoprecipitation coupled with mass spectrometry (IP-MS), bioinformatics analysis and ubiquitination assays, were employed to identify the molecular targets responsible for SEL-induced degradation of XPO1.
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PMC11711663
Various studies have confirmed the altered expression of specific microRNAs (miRNAs) in HNSCC, including miRNA-184, miR-31, and miR-27b, which are linked to cancerous transformation and the advancement of the disease.
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PMC9318744
SARS-CoV-2 uses the ACE2 receptor for viral entry and TMPRSS2 to prime the SARS-CoV-2 spike protein, both of which are negligibly expressed in A549 cells.
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PMC11310713
The observed distinctions between GTB-injected and pharmaceutical HRT-treated groups highlight potential physiological differences between the 2 HRT approaches.
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PMC7823217
For this purpose, a non-globular protein, fibrin, important for blood clotting , and a gelatinous ECM protein secreted by the mouse sarcoma cells, Matrigel , are widely used.
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PMC4443654
Structurally variable regions show a greater than expected proportion of contacts with other active A compartments, in the cell type in which they are active relative to those same regions in the other two cell types.
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PMC11746942
This observation is consistent with previous reports of elevated S1P levels in psoriasis patients , suggesting a shift toward increased S1P signaling in this disease.
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PMC11011837
The one-way ANOVA test revealed 170 significant lipid species (Table S5); it also includes the Tukey’s test.
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PMC11740399
The FASN plays an essential role in cellular lipid metabolism by providing fatty acids necessary for several vital processes, such as cell membrane synthesis, energy storage, and synthesis of signaling molecules.
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PMC11739504
Kat2b-depleted cells with serum starvation for 6 h, n = 789; 12 h, n = 579; 24 h, n = 649.
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PMC9351137
A Immunoprecipitation of protein extracts from cytoplasmic fraction of telophase synchronized HeLa cells (S2 fraction).
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PMC9874064
The above results clearly showed that NP-Pt-USP1i could significantly inhibit the BEL-7404DPP growth in vitro.
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PMC10976516
Further to this, a synergy of ICI and chemotherapy has already shown its improved efficacy in clinical applications.
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PMC11675244
Furthermore, APC turn-off has been linked to elevated expression of stem cells markers like CD44, Lgr5, Bmi1, and Musashi1, which support the role of Wnt signaling in maintaining CSC characteristics .
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PMC9596868
Isobologram analysis of quercetin and MST-312 co-treatment in A2780cisR cells was performed.
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PMC11650848
To assess if genotype at the rs365052 variant is linked to DNA methylation within the region we analysed 6 CpG sites around the SNP (Fig. 3A).
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PMC10813895
Observations in ELF5 heterozygous mice during gestation revealed an accumulation of CD61+ luminal progenitors that are double positive for K14/K8, suggesting that ELF5 is pivotal in directing the fate of CD61+ luminal progenitors towards mature alveolar cells.
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PMC9429973
Fatigue with its negative impact on QoL is of tremendous concern for patients with cITP.
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PMC8996378
Compound 78 was isolated from Pseudolarix amabilis (Pinaceae) (Table 9).
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PMC11731614
Furthermore, a gene ontology enrichment analysis on the EAPs revealed ‘Wound Healing’ as differentially expressed in HFD KDEVs (3G middle; adjusted p-value ≤ 0.05), consistent with the known impairment in diabetic patients (Greenhalgh, 2003) and as shown in our 2D primary HFD keratinocyte scratch assays (Supplemental Fig. 1A-B).
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PMC10253553
NDRG1 showed the greatest fold increase (3.3-fold) in phosphorylation (on Thr346) in ccRCC relative to normal renal tissue (Table 1).
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PMC11499381
There was one independent experiment where αCGRP was able to stimulate detectable cAMP production at these constructs, with a pEC50 of 6.37 at CTR-C-V1–154, and 6.74 at N-V1–154-CTR, and an Emax of 75.43% and 54.83% of WT at CTR-C-V1–154 or N-V1–154-CTR, respectively.
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PMC11657695
Western blots of Kv1.2 in A673/TR/shEF cell line after doxycycline treatment (1 µg/mL) (N = 3, right panel).
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PMC11718817
The unpaired, two-tailed t-test was used to compare groups of two independent samples.
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PMC9429973
SRSF2 was the only MIPSS70 mutated gene (8%) associated with inferior OS (HR 2.5, p=0.04), while EZH2 and IDH1/2 mutations were only present in 2.5% of patients each.
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PMC11543885
The outcomes of APEX2 proximity labeling can be assessed by multiple experiments, including immunofluorescence (spatial specificity), immunoblotting and silver staining (labeling robustness).
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PMC10777969
The cells were cultured in 96-well tissue culture plates for 24 h before the experiment, allowing them to adhere to the surface.
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PMC7612475
However, it has been shown that the SF3B1 mutation alters the 3′-splice site recognition function of SF3B1, which often leads to cryptic 3′-splice site usage, resulting in loss and/or altered function of target genes and their encoded proteins.
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PMC10728200
Significance denoted by: ns not significant, *P < 0.05, **P < 0.01, and ***P < 0.001.
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PMC10507284
Statistical tests: Student's t‐test. (
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PMC10243817
In addition, further studies are needed to fully exclude the possibility of binding to poly-A tail of targeted mRNAs by MEX3B.
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PMC11750165
Whole-mount in situ hybridization staining shows expression of GAD1 in the maternal mutant embryos of PEX1 (A, B) and in the maternal-zygotic mutant embryos of PEX1 (C, D) at 25-hpf (A, C) and 27-hpf (B, D).
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PMC9351137
D Mock, left panel; long intercellular bridges (LIB) right panel; no DAPI-stained trapped chromatin was observed.
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PMC11765879
Gene expression study by western blot analysis revealed that the extract triggered apoptotic pathways via key apoptotic gene regulators, such as Bax and Bcl-2.
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PMC11496491
When patients underwent TCTD surgery combined with debridement and vacuum closed drainage (VSD), tissue specimens were collected from the wound edges and preserved according to standard procedures for tissue storage.
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PMC11594074
Compounds 2 and 4 showed the best DNMT1 inhibitory activity, but only compound 4 was able to inhibit the growth of several cancer cell lines.
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PMC11653168
The band intensity was measured using ImageJ software (version 1.50i; National Institutes of Health).
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PMC11783017
ns: no significance, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, compared with Control group.
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PMC11224020
Yellow stars indicate nuclear envelope rupture.
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PMC7570809
Afterwards, to evaluate the cell invasion inhibition, HepG2 cells were incubated with 50 µM peptide for 18 h and seeded on trans-well chambers coated with ECL Cell Attachment, an efficient model system that better mimics in vivo cell invasion.
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PMC11468365
Therefore, this paper introduces an MTDL model to enhance the prediction of synergy and sensitivity values for drug combinations.
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PMC9429973
We here report the long-term clinical follow-up.
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PMC11264242
In a western blot experiment, the anti-FLAG antibody only detected a 75 kDa band representing the SS18-SSX2 fusion protein in extracts from CRISPR-modified SSX2-FLAG SYO-1 cells (Supplementary Figure S1B, lanes 1-2).
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PMC11290772
Notably, CAR-T cell therapies have achieved remarkable success in leukemia treatment, resulting in the complete remission of the disease in a young girl .
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PMC9429973
Overall survival ranges from <6 months to 3-4 years.
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PMC11478724
indicates Significance at the P < 0.01 level.
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PMC7039683
Output sequences were trimmed using Trimmomatic (v0.38) (Bolger et al., 2014) (parameter: ILLUMINACLIP:TrueSeq3PE-PE.fa:2:30:10:8:TRUE LEADING:3 TRAILING:3 SLIDINGWINDOW:4:15 MINLEN:30).
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PMC11389534
The field has recently experienced a rapid growth of research revealing that UFMylation directly or indirectly regulates multiple immune processes.
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PMC9429973
Response was assessed after 2 cycles of therapy using CT scanning, and after 4 and 6 cycles of therapy using PET-CT.
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PMC11412752
For the assessment of bacterial replication, 4 × 10 HepG2 cells were initially seeded into 12 well plates and then infected with SL1344 at an MOI of 10 the next day.
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PMC9080589
Papillary thyroid carcinoma (PTC) is the most common histological type, accounting for 85–90% of all cases.
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PMC9429973
Percentages of patients with vascular disorders were 44% in PACE and 32% in OPTIC.
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PMC11394730
Since G6PDH knockdown dramatically decreases cell growth, targeting G6PDH with targeted inhibition may be a helpful therapy option for glycolytic malignancies .
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PMC5673060
An association network of proteins from the ‘transcription’ cluster analysed through the STRING application.
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PMC11530949
At least three independent experiments were conducted for each test, and the assays were repeated using RiaGene6000 Qiagen (34).
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PMC9429973
Image: Summary/Conclusion: Single doses of nipocalimab, administered at doses between 10 mg/kg and 60 mg/kg by IV infusion, were generally safe and well-tolerated in healthy Japanese adults, consistent with the prior phase 1 study in a general population, which included Asian and non-Asian participants.
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PMC11381192
M, N) GSEA analysis for top enriched up‐ and down‐regulated biological functions in the training set.
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PMC11593713
Infected cells were incubated up to 4 days until the CPE could be seen.
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PMC8973085
calcd for C25H22FN3O3S: C, 64.78; H, 4.78; N, 9.07.
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PMC5330095
We report here for the first time in vitro studies to demonstrate the antiviral activity of CBD against HCV.
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PMC10411253
Meanwhile, suspicion of PMDS in infertile males with abnormal testicular position, with or without surgical histories, deserves particular attention from assisted reproductive clinicians.
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PMC9429973
EZH2i leads to increased expression of SREBF1 and SREBF2 as well as ABCG1 and ABCG2.
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PMC5963610
EGFR and NGcGM3 ganglioside are molecules co-expressed on spontaneous lung metastases induced by 3LL-D122 or 4T1-clones .
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PMC10788478
To explore the molecular mechanisms underlying LGR6‐induced malignant phenotypes, mRNA sequencing analysis was performed to compare the expression profiles of siRNA‐mediated LGR6‐silenced cells with those of control siRNA‐treated cells using the CTNNB1‐mutated NSCLC cell lines HCC15 and A427.
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PMC11698348
Elf5 expression is elevated between telogen and anagen stages with a significant reduction in expression in catagen skin.
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PMC11525028
We reported the upregulation of NAT10 in osteosarcoma; however, the underlying mechanisms of NAT10 overexpression remain to be fully elucidated.
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PMC9429973
M. Davidson, F. Wong, M. Atri, H. Sibai, D. Maze, V. Cheung, T. Nye, J. Callum, E. Atenafu, V. Gupta Princess Margaret Hospital; University of Toronto, Toronto; Queen’s Unviversity, Kingston, Canada Background: Portal hypertension (PH) is a well-recognized complication of BCR-ABL negative myeloproliferative neoplasms (MPNs) and is associated with significant morbidity and mortality.
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PMC11742670
In addition, LIME is used to further elucidate the findings, providing interpretable explanations for the selection of the top-ranked compounds.
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PMC11763126
B Mass spectrometry analysis identifying representative proteins bound to CBDP1.
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PMC10998613
These results may aid in the development of pharmaceutical approaches to treat CXCR4-positive cancers, especially using combination therapies or bivalent compounds.
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PMC9429973
We have previously shown that adding Rusfertide, a hepcidin mimetic, to existing PV treatment, significantly, and effectively reverses iron deficiency and essentially eliminates TP requirement for >1 year in PV patients [Hoffman ASH 2021].
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PMC10243817
We found that LPS and poly (I:C) increased the MEX3B expression in epithelial cells, indicating that bacterial and viral infection may decrease the expression of TGF-βR3 through MEX3B in CRS.
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PMC11574271
J Cell migration was assessed using a wound-healing assay.
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PMC9429973
Peking University, People’s Hospital, Peking University Institute of Hematology, 11 Xizhimen South Street, Beijing, China Background: Hypomethylating agents (HMAs) are the preferred treatment for untreated patients (pts) with higher-risk MDS, but the survival of pts after HMAs treatment is poor.
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PMC11144382
NFIX has been reported to bind to the promoter region of the glial fibrillary acidic protein (GFAP) gene to activate gene transcription in astrocytes, while binding of NFIX to the Bobby Sox (BBX) enhancer element suppresses transcription in neural progenitor cells.
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PMC11633763
Further analyses were performed to identify the precise molecular pathway through which USP22 regulates HK2 expression.
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PMC6742971
In parallel, the Melan-A negative melanoma target cell line Na8 was used as a positive and negative control, in absence or presence of the native Melan-A peptide (EAAGIGILTV; “EAA”), respectively.
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PMC5811757
The mixture was denatured and reannealed in a thermocycler (95°C, 10 min; 95-85°C at -2°C/sec; 85-25°C at -0.1°C/sec; hold at 4°C) (18).
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