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PMC11406030
Furthermore, cell killing was synergistic with cisplatin and docetaxel treatment (Figure 2B).
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PMC11705630
Then cells were washed and added fresh medium for the next 24 h. Images were captured at 0 h and 24 h, respectively.
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PMC9919300
The analysis was referred to the gene expression of HepG2 exposed to the steatosis medium.
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PMC11705862
Group 1 A (n = 6) included (n = 3) non-demented controls (NC) and (n = 3) clinically diagnosed and neuropathologically verified AD cases, Group 1B included (n = 7) clinically diagnosed and neuropathologically verified AD cases, and Group 2 (n = 6) consisted of (n = 3) non‐demented controls without T2D (NC) and (n = 3) clinically diagnosed non-demented T2D cases (NC-T2D).
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PMC11767725
Simultaneously, adiponectin, an anti-inflammatory adipokine, is reduced in obesity and T2DM, removing a regulatory brake on Th2 activity.
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PMC11476837
The expression of NRF2-regulated genes is induced by the binding of NRF2 to the antioxidant response element (ARE) in the regulatory regions.
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PMC11320834
BRCA1/2 are tumor suppressor genes, so there are no hotspot mutations.
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PMC11629461
The typical calcium traces (each trace corresponds to one individual cell) shown in (C–K) are from one typical experiment, out of N identical repeats (N = 5–7) (L) Bar graphs showing means with 95% CI indicated are quantitative analysis of calcium peak areas above baseline (per 10 min) from multiple experiments (N numbers shown in brackets), each dot represent data from one cell.
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PMC9424261
C, D Bel-7402 and Bel-7404 cells with either wild-type or HERPUD1-sg1 were seeded at an indicated density in six-well plates and cultured for 24 h, then treated with: 10 μM erastin or 5 μM RSL3; 10 μM CA; pretreatment with 10 μM CA for 1 h followed by 10 μM erastin or 5 μM RSL3, in complete medium for 24 h. Cell death was quantified by flow cytometry.
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PMC11703992
The DEGs in CD4+ Memory T cells were mainly activated, while most surface proteins, as well as transcriptomic factors NME2 and NR1D1, were activated during the middle period of cell differentiation.
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PMC11261875
Surgical resection is the primary treatment option for GISTs that can be removed.
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PMC11634027
Our studies provide a molecular explanation for part of the impact of the D motif deletion on Ds by the discovery that this motif is necessary and sufficient for mediating physical association with Lft.
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PMC11727638
Briefly, phosphate-buffered saline (PBS, pH 7.4, 1 µL) containing 50 U/mL horseradish peroxidase (HRP; 140 units/mg; Fujifilm Wako Chemical), 3.0 % w/v gelatin from porcine skin (type A, approximately 300 g bloom; Sigma-Aldrich), and 1.2 × 10 cells/mL TK or KML-1 cells was spotted in annular water-repellent patterns (outer/inner diameter: 1.4/1.0 mm) printed on a glass plate.
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PMC10470467
Our study has significant clinical application value, and the constructed signature can be used as a reliable tool for predicting the prognosis of ES patients as well as helpful for the formulation of immunotherapy and chemotherapy strategies.
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PMC2193049
The samples were incubated with rotary shaking at 4°C for 30 min, followed by the addition of 20 μl protein G–Sepharose and another 30-min incubation at 4°C.
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PMC9812014
These alkaloids michellamines D and F showed significant repressive activity against multiple strains of HIV.
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PMC11587606
Reverse transcription and quantitative real-time qPCR were performed by First-strand cDNA synthesis SuperMix kit and Top Green qPCR SuperMix kit (TransGen Biotech, Beijing, China), respectively.
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PMC11615101
The cells were then treated with different doses (0, 6.25, 12.5, 25, 50, and 100ng/ml) of recombinant α-Taxilin (Aprest antigen, USA) to determine the effective dose of α-Taxilin on the NF-kB p65 (Santa Cruz Biotechnology, USA) level.
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PMC9635307
We herein analyzed mature B cells to determine the functions of CEACAM1.
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PMC9684669
Representative western blot images for the CESTA. (
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PMC10253973
Some complexes of Ru(II) ions interact with telomeric DNA, but others affect DNA replication and transcription.
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PMC10213179
The starting aptamer libraries and all selection rounds from both the cell-internalization SELEX and protein SELEX were prepared for next-generation sequencing (NGS) on the Illumina platform.
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PMC9646302
However, in our study, we found that LAPTM5 was upregulated in ccRCC tumor tissues compared with that in the adjacent healthy tissues using Western blot and RT-PCR, which is consistent with previous bioinformatics analyses of kidney renal clear cell carcinoma (Figure 1(a)).
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PMC11612315
This modulation occurs by regulating the spinal dorsal horn microglial pathway through GLP-1R activation, leading to alterations in spinal excitatory synaptic transmission under neuropathic pain conditions.
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PMC10728200
B Body weight was measured every 3 days until day 18.
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PMC10452486
Based on Figure 4, we visualize approximately 144 monoclonal antibodies specific for each one of these dimers.
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PMC11401358
SF can efficiently scavenge •OH, H2O2 and O2−•. (C) The β-sheet structure increased after heating and turned into a random coil structure after being oxidized. (
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PMC11502327
Therefore, some active spatial structures are also regarded as the core content of the compound activity relationship (33–35).
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PMC9844987
We observed an enrichment of highly variable promoters within narrow promoters having an interquartile range (IQR) of their CAGE-inferred TSSs within a width of 1–5 bp (p<2.2 × 10, OR = 2.04, Fisher’s exact test).
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PMC9436459
In addition, like sorocenols C and D (47 and 48), sorocenol E (69) with zero optical ration was also a racemic mixture .
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PMC11673902
The deficiency is the lack of relevant evidence that the degree of cell swelling is related to the ability of cells to deform because the degree of cell swelling may also be related to cell size and membrane stability .
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PMC10940855
As we have previously described for animal studies (34), a power test was used to determine the sample size needed to observe a two-fold difference in means between groups with 0.8 power using a two-sided Student t test.
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PMC7802142
Cell proliferation rates were measured by using a Cell Counting Kit-8 (CCK-8) (Dojindo, Japan).
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PMC11805741
The substantial impact of pigment concentration on the expression of BAX and BCL-2 was investigated at two different concentrations 600 µg & 1200 µg.
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PMC10522430
The cells were then dispensed into a 96-well plate, allotting 5 × 10 cells to each well, followed by overnight incubation.
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PMC9429973
Unexpectedly, we observed a major role of the iron status in myeloid expansion in MDS.
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PMC9429973
Aims: To understand whether the oral pyruvate kinase activator, mitapivat, is not less efficacious than splenectomy in treatment of anemia in 4.2 mice.
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PMC11572213
The amount of glutamine in the FBS is 50 mM. Glutamine was added to its conventional glutamine counterpart at a final concentration of 2 mM. Cells with/without glutamine were cultivated for 3 days.
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PMC9429973
The median follow-up was 24.2 months (follow-up rate of 95.8%).
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PMC10778532
The downregulation of E-cadherin leads to alterations in cell adhesions and confers them with an invasive mesenchymal phenotype.
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PMC11640419
Oleanolic acid and other triterpenes with similar chemical structures possess a diverse range of pharmacological properties .
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PMC8557138
Excessive angiogenesis, a characteristic feature of disorders such as diabetic retinopathy, rheumatoid arthritis, and solid tumors is also caused by dysregulation of the angiogenic signaling pathways.
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PMC11697065
To examine signatures associated with ETE and DTE outcomes, pools were grouped according to expression levels of the biotherapeutic, with cell pools displaying significantly lower qPs than mAb1 being defined as DTE and all others as ETE (Fig. 1D).
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PMC10898159
Homoharringtonine (HHT) is a first-in-class inhibitor of protein biosynthesis and is FDA-approved for the treatment of chronic myeloid leukemia (CML) that is resistance to at least two lines of treatment with TKIs.
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PMC8584319
Indeed, treatment with AZD8055 substantially reduced the γ-isoform of 4E-BP1 by inhibiting the phosphorylation of 4E-BP1 at Ser65 (Figure 3b).
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PMC11499381
Quantification of puncta formation over time.
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PMC10291556
These comparisons suggest that contributions of the DCF moiety to the overall activity of Pt(IV) derivatives of Pt(II) complex 1 other than a mere increase of cellular uptake should also be considered.
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PMC11633763
To further validate our hypothesis, shβ‐catenin‐mediated knockdown of β‐catenin was performed in U2OS cells overexpressing USP22.
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PMC11656380
This inhibition suppresses cell proliferation and induce apoptosis by blocking the expression of NOTCH1 target genes, such as c-MYC or HES1.
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PMC11473843
Notably, in NSCLC patients MEK5-ERK5 signalling is often upregulated and correlates with poor patient survival (Sanchez-Fdez et al, 2021), thus these patients are expected to exhibit inherent FAK inhibitor resistance, providing additional rationale for the use of MEK5 or ERK5 inhibitors in the clinic.
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PMC11804588
They then applied scFOODIE to mouse hippocampus, successfully profiling TF footprints in 11,200 cells from eight major brain cell types.
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PMC11266100
To evaluate transfection efficacy, we employed two distinct plasmids encoding different proteins: green fluorescent protein (pEGFP-N1) and luciferase (Luciferase-pcDNA3).
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PMC11737091
These results suggest that DBF4 may primarily affect the occurrence and development of ccRCC by regulating cell division and is closely associated with immune regulation in the body.
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PMC8357004
A: 5-Aza-CdR (5 μm) treated cells at 24h, B: 5-Aza-CdR (5 μm) treated cells at 48h, C: Control group, D: Apoptotic graph The apoptotic effect of TSA (2.5 μm) on Caco-2 cell versus control groups (24 and 48 h) evaluated by flow cytometric analysis.
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PMC7090062
In accordance with the effects on tumor volume, immunohistochemical staining showed that the lowest percentage of Ki67-positive proliferating cells in the miR-30a upregulated and IM treated group; the apoptosis rate detected by TUNEL assay was also highest in this group (Fig. 8d, e).
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PMC9429973
Grafts are allowed from various sources (bone marrow, peripheral blood stem cells, cord blood cells).
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PMC11185260
However, mice that received scL-SMARCB1 therapy survived for a significantly longer period (up to 99 days), with a median survival time of 74 days.
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PMC9927933
See complete unedited blots in the supplemental material.
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PMC11763126
C PCR analysis of TRPM3 mRNA levels after manipulating YTHDF2 expression.
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PMC11615101
The α-Taxilin, also known as a syntaxin-binding protein, binds STX3 and STX4 and activates toll-like receptors (TLR-2 and TLR-4).
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PMC11791264
SETD7 methylates LC3B at lysine 51 (K51).
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PMC11588085
In both normoxia and hypoxia conditions, we observed an increase of the mesoderm index in sgXIST samples compared to sgCtl samples, suggesting that XIST KD enhances the mesodermal progenitor-like population in ovarian cancer cells.
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PMC9503669
Nef is well known to enhance HIV-1 infectivity and replication, and to promote immune escape of HIV-infected cells by preventing cell surface MHC-I display of HIV-1 antigens.
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PMC11721295
To quantify percentage tumor area on H&E-stained histological lung sections, we imported slide scans into ImageJ, converted scans to 8-bit images, adjusted the image threshold to encompass the total lung area, and measured total lung area.
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PMC11773391
A375 and Sk‐MEL28 are BRAF V600E mutant human malignant melanoma cells obtained from the Guangzhou National Center Cell Bank (NECB).
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PMC11300639
We demonstrated that palbociclib treatment decreased the IC50 of everolimus, and this effect was attenuated after knockdown of TSC1 in 786-O and A498 cells (Supplementary Fig. 6c).
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PMC8922418
HIV-1 provirus could either be cleaved by gene-editing tools or activated by CRISPRa for the “shock and kill” strategy. (
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PMC11525293
DNA fragments obtained by the ChIP assay were analyzed by qPCR using specific primers spanning the responsive elements (RE) found in the first intron of the ACE2 gene.
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PMC9429973
Opioids were taken for VOC-related pain relief by 95% of pts (n=83/87) at baseline and by 69% (n=60/87) in the 12 months after crizanlizumab treatment; the most common was morphine (48% [n=40/83] and 40% [n=24/60], respectively).
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PMC11655536
F, G Western Blot detect the expression of LAMP1 of RPMI-8226 (F) and U266 (G) treated HA at 10 μM for 48 h and statistical analysis of LAMP1 expression, normalized by tubulin.
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PMC11088135
Thus, lncRNA NUTM2A-AS1 may regulate the proliferation and apoptosis of glioma cells through the miR-376a-3p/YAP1 axis.
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PMC9429973
Eligible pts were stratified into 2 groups: 1) Pts with pre-existing HTN before starting BTKi (pre-HTN) and 2) Pts who developed incident HTN after starting BTKis (de novo HTN).
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PMC9429973
Patients with PV tend to develop thrombotic complications across the vasculature tree.
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PMC9429973
Concerning the cardiac parameter NT-ProBNP there was no significant change of the median NT-ProBNP from start of induction (685 pg/ml, range 103-1598) to end of treatment (655 pg/ml, range 96-2199) in 15 patients which received at least 4 cycles R-CPOP and achieved a CR.
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PMC9739791
In the previous work, the role of the triplet excited state of riboflavin derivatives in the photocatalytic reduction of Pt(IV) prodrugs reduction was established.
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PMC11746948
The detailed mass spectrometry data is shown in Supplementary Data 2.
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PMC9429973
In pts with wild-type (65 ZANU; 72 IBR) or mutant CXCR4 (33 ZANU; 20 IBR) from cohort 1, VGPR+CR rates with ZANU vs IBR were 45% vs 28% (p = 0.04) and 21% vs 5% (p = 0.15), respectively.
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PMC9454178
C The enriched GO functional terms of the transcripts that were reduced over twofold in GIST-T1 cells following treatment with 50 nmol/L THZ1 for 6 h. D Immunoblot analyses of RNAPII, RNAPII CTD phosphorylation (S2, S5, and S7), and CDK7 in GIST-T1 and GIST-882 cells treated either with THZ1 or DMSO at the indicated concentrations for 24 h CDK7 inhibition leads to the suppression of RNA transcription in GIST cells.
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PMC11389534
Typically, the activation of RIG‐1 and cGAS triggers downstream IFN‐mediated antiviral responses, typically through mitochondrial antiviral signalling protein (MAVS) and stimulator of interferon genes (STING) separately. ,
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PMC11788920
We also report extensive in vitro biophysical studies which are in quantitative agreement with these cellular studies and provide important mechanistic details about how the transcription is modulated via the interactions of RNA polymerase, CRISPR–dCas9, and the GQ.Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins are found in bacteria and archaea, functioning as an RNA-driven adaptive immune system against invading bacteriophages .
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PMC8592717
PAL was also found to be a potent aldose reductase (AR) inhibitor and might be useful for preventing and/or treating diabetic complications .
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PMC9429973
The primary endpoint was two-year-PFS.
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PMC6182045
Colony selection of MGAT1 transfected cells. (
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PMC11615743
In future studies, L‐DNA probes can be conjugated to antibodies that recognize cell surface markers to expand the application prospects of L‐DNA logic devices.
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PMC6160470
Moreover, most of the MDR reversing compounds are amphiphilic and influence biophysical properties of lipid bilayers by altering membrane fluidity and increasing its permeability (e.g. promethazine, progesterone, quinine and verapamil).
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PMC4443654
This is intriguing as YY1 has recently been shown to co-localize with the architectural protein CTCF and suggests that these proteins cooperate in the establishment of domain boundaries.
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PMC8009078
Transmembrane protease serine-2 (TMPRSS2) is a cell-surface protein expressed by epithelial cells of specific tissues including those in the aerodigestive tract.
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PMC11321678
Finally, we removed multiplets by bap2 (≈5%, Figure S1B, Supporting Information).
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PMC11754094
P = 0.0021 for the LIG IV KO HeLa cell line, P = 0.0004 for the POLQ KO HeLa cell line and P = 0.0213 for the RAD52 KO HeLa cell line compared to the wild-type HeLa cell line.
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PMC9429973
J. Berner, W. Novak, R. Jimenez-Heredia, L. Kager, K. Boztug St.Anna Childrens Cancer Research Institute Vienna; St. Anna Children’s Hospital, Department of Pediatrics, Medical University Vienna; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Background: “Evans syndrome (ES)” denotes a heterogeneous disease entity, defined by two or more autoimmune cytopenias, due to mostly unknown pathogenic mechanisms.
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PMC11766174
Cells were spun at 800 rpm for 10 min at room temperature (RT) in a CytoSpin 4 Cytocentrifuge.
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PMC5941560
This analysis is not exhaustive.
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PMC9429973
Preliminary results from the first-in-human study of IGM-2323 show a 60% overall response rate at a titration dose level of 100 mg, and an excellent safety and tolerability profile up to 1000 mg with low cytokine release syndrome (CRS), no immune effector cell-associated neurotoxicity syndrome (ICANS) and limited neutropenia.
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PMC11686380
The right 3rd and 4th fingers were varus and valgus, respectively.
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PMC7334607
Values above log2(3) or below log2(-3) are represented by log2(3) and log2(-3), respectively.
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PMC11723210
is back-propagated to the object plane 1 to obtain the updated exit wave .
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PMC11779605
23225, Pierce Biotechnology, Waltham, MA, USA).
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PMC10870498
Silencing of KIF23 suppressed the viability and migration of 8505C and BCPAP cells.
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PMC11746948
The human glioblastoma cell line U251-MG was provided by Professor Tengfei Guo of the Institute of Biomedical Engineering at Shenzhen Bay Laboratory (Shenzhen, China).
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PMC9429973
Methods: The study included 47 patients diagnosed with different stages of PMBCL who received treatment from 2013 to 2021.
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