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PMC11583010
ETx-22 could also be detected into stromal blood vessels lining tumor cells (Supplementary Fig. S4).
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PMC11566417
Primers were generated using Primer3 with original sequence data from NCBI GenBank (Table 1).
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PMC11502443
T2D incidence increases with age and is strongly associated with the prevalence of obesity (Bhupathiraju and Hu, 2016).
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PMC9429973
Sensitivity analyses were consistent with the base case analyses.
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PMC10093184
Target gene expression values were normalized to the geometric mean of both RGs and expression levels were calculated using the ΔCt method .
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PMC9812014
Light microscopy showed a substantial reduction in the generation of recombinant NDV expressing green fluorescent protein (GFP) in the presence of HHT at 50 nM. When compared to mock-infected samples, cultured HeLa cells showed no difference in morphology or number when treated with 100 nM HHT.
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PMC11745823
Transcription factors exhibit a tendency to bind to specific DNA sequences to govern gene expression.
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PMC11638255
a Experimental design and dosing strategy.
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PMC11366496
This system is critical for regulating life processes encompassing cell cycle, signal transduction, gene expression, and apoptosis. ,
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PMC11394730
Green tea may work well with anticancer medications to prevent cancer by increasing their inhibitory effects on colon cancer cell proliferation, as demonstrated by an earlier study where EGCG amplified the effects of ginseng components in this regard.
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PMC11697189
ICIs are the focus of cancer treatment and have become one of the main treatment modalities for ccRCC.
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PMC9429973
On the 8-th day of hospitalisation rFVIIa was stopped as factor VIII level increased to 6.2% and the inhibitors dropped to 2 and 1.1BU subsequently.
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PMC11078693
Note: Have the T75 flask sit vertically for a least 1 min to allow all cells to accumulate in media at the bottom.
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PMC9611901
The human hepatoma cell line HepG2 was obtained from the American Type Culture Collection (ATCC) (Manassas, VA, USA).
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PMC9454178
We observed that a cluster of genes was particularly sensitive to THZ1 treatment and was mainly enriched in biological processes of transcription regulation mediated by RNAPII.
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PMC9429973
The HOVON-141/VIsion phase-II trial evaluated MRD-guided ibrutinib and venetoclax combination treatment in relapsed or refractory (R/R) CLL patients.
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PMC10728200
Then we further explored whether STUB1 regulates GPX4 stability via the ubiquitination of GPX4.
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PMC11462673
B. LDB1 modulates the expression of downstream target gene MYB in T-ALL cells by cooperating with hematopoietic transcription factors -ERG,ETV6 and IRF1 T-ALL is driven by oncogenic transcription factors and secondary acquired mutations, collectively contributing to the dysregulation of active signaling pathways.
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PMC9429973
Larger spleen size is prognostic of worse survival and higher bleeding risk in PMF but not SMF patients.
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PMC10745221
However, paradoxically cancer cells have the ability to produce large amounts of methionine from homocysteine and can use endogenously synthesized methionine for cellular processes .
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PMC9545714
This study was conducted in accord with the Declaration of Helsinki and was approved by Aisei Hospital Ueno Clinical Research Ethics Committee of Japan (IRB # 12000071).
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PMC9429973
Results: From March 2020 to December 2021, 30 patients were enrolled.
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PMC8382973
This is important because hypertonic products can cause mucosal tissue damage.
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PMC11704834
The melt-curve analysis was following 65-95˚C (0.5˚C increment 5 sec/step).
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PMC3730428
In Ren cells cocultured with TNFα, downregulation of either splice form increased cell death in response to AT-IAP, although the most potent effects were observed when both splice forms were simultaneously downregulated (Figure 3c(i)).
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PMC11762280
RIPA lysis buffer (P0013B, Beyotime Biotechnology, Shanghai, China) containing protease and phosphatase inhibitors (Roche Applied Science, Basel, Switzerland) was used to lyse human primary keratinocytes and the epidermis isolated from mice skin and human skin explants.
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PMC5941560
Furthermore, with the exception of the PTEN and INPP5D defects, these reports had never been consolidated into a single resource, making our documentation of previous reports the first review of damaged genes in the Jurkat cell line.
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PMC11724582
The expression levels of α-SMA and FAP in the NF, CAF-24 h and CAF-48 h groups were detected by Western blotting. (
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PMC11802929
The study cohort is a subset of the INCOV cohort published previously.
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PMC9429973
Treatment of MM cell lines with subasumstat (also TAK-981), a novel small-molecule inhibitor targeting the SUMO E1 activating enzyme, showed synergistic treatment efficacy with CFZ in both PI-sensitive and PI-resistant MM cell lines irrespective of the TP53 state.
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PMC11763533
Furthermore, the higher temperature spectral sensitivity at acidic pH values of this enzyme also reveals a new potential applicability of this luciferase to temperature sensing inside organelles such as mitochondria.
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PMC11799978
Our results suggest that correcting the aberrant physicochemical features of the TME could serve as a potential therapeutic strategy for limiting tumor growth and metastasis via reversing CAFs to their quiescent state.
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PMC10968586
Radical and non-radical ROS (including hydrogen peroxide H2O2, superoxide anion radical O2, and hydroxyl radical OH) may have a pro-tumorigenic effect; they are involved in cancer insurgence determining DNA damage, genomic instability, and interference with signalling and metabolic pathways, enhance cell proliferation through the activation of pro-survival pathways in cancer cells while promoting the reorganization of cellular antioxidant capacities and adaptation to hypoxic conditions, are involved in the development of anti-cancer therapy resistance (through the expansion of cell antioxidant capacities), push the activation of metastasis cellular programs via EMT, and boost immunosuppression and angiogenesis in the cancer microenvironment.
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PMC8806312
The association between CD4 naïve T cells and overall survival of OS. (
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PMC10218459
The number of living cells was determined after 4 h, 24 h, 48 h, 72 h, 96 h, and 120 h. CPP treatment showed antiproliferative effects in both cell lines.
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PMC11680562
Mavrikou et al. reported that 5-Fu can increase the Caspase-3 enzymes up to 48 h of incubation, leading to apoptosis .
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PMC9429973
Differentiation assays of MSCs (non-CHIP=4, CHIP= 2) showed no difference in adipogenic and chondrogenic differentiation after 21 days.
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PMC10170482
Interestingly, it was shown that Huh7 and HepG2 cells cultured on 2D soft (1 kPa stiffness) substrates undergo reversible cellular dormancy.
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PMC10335954
All cells were placed in Dulbecco’s modified Eagle medium with 10% fetal bovine serum.
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PMC6379402
Given that almost 80% of breast cancers are estrogen receptor-positive, this further highlights the importance of estrogen signaling in breast cancer and potential novel roles for the newly identified rewired genes in novel drug target definitions.
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PMC11715478
In Alzheimer’s disease (AD), a major gap remains in the understanding of how the interplay between peripheral and central immune systems drives neuroinflammation and disease progression.
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PMC7757104
These results suggested that OPNc may modulate drug resistance and cell viability in distinct models of drug-resistant ovarian cancer cells.
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PMC5673955
Very low telomerase activity is detected in peripheral blood T lymphocytes 40.
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PMC5415764
The cell cycle results were obtained using flow cytometry (BD Biosciences, California, USA), and the cell distributions were analyzed using ModFit LT software (version 3.0, USA).
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PMC10165258
Libraries were produced in a dedicated microfluidic chip, based on gradient of confinement (2).
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PMC11739504
To generate Kat2b MEF cells, pregnant female mice were sacrificed at the embryonal stage (E13.5–E15.5).
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PMC11300639
g GST-pull down assay was performed by using the recombinant protein of RNF26.
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PMC11678841
The limitation of this study is the use of an immortalized cell line which may not accurately reflect the physiological responses of human epithelial cells.
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PMC7887261
False discovery rate (FDR) adjusted P-value was reported.
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PMC11763111
In this study, we present an allogeneic CD38-targeting universal CAR-T cell therapy with low immunogenicity and high allogeneic persistence.
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PMC11684821
Two of the lines enriched with MM909.24 overexpressing MR1*01 responded well to these targets but exhibited dependency on overexpressed MR1*01 for maximal reactivity, with minimal activation toward WT melanoma cells (Figure 1C).
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PMC11803918
Then, the purified CD14 cells were cultured with 10% human AB serum (ABS) RPMI1640 supplemented with 20 ng/mL Granulocyte-macrophage colony-stimulating factor (GM-CSF) and 50 ng/mL IL-4 for 7 days.
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PMC11730311
In attempts to increase half-life of αCGRP8-37, pharmacokinetic properties of hαCGRP8-37 have been improved by various peptide modifications such as PEGylation and cyclization.
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PMC11593031
The International Neuroblastoma Risk Group Staging System (INRGSS) was developed as a further classification system, which also includes imaging-based risk factors instead of the extent of surgical resection .
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PMC10048572
Genetic instability and subsequent selection of clones led to the fact that advanced human malignancies acquire distinct karyotype and biological features.
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PMC11413393
MS094 is the negative control probe for MS023 (blue).
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PMC11297139
In the case of hepatocellular carcinoma, high expression of ARID1A promotes oncogenic potential by increasing cytochrome P450-mediated oxidative stress.
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PMC11543885
Cells are passaged when they reach confluency of 80%–90%.
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PMC9429973
Finally, treatment with the demethylating agent 5-azacytidine restored Gata2 expression in an AML model with Cebpa and Tet2 mutations and caused a significant survival benefit.
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PMC11515150
Schematic diagram of the treatment process.
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PMC9429973
In summary, findings from this study indicate that patients with LR-MDS who experience ESA treatment failure are likely to have worse outcomes.
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PMC11298021
Five control bone marrow samples from non-leukemia patients were also provided.
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PMC11021472
After incubation, the RNA was concentrated using a Vivacon® 500 Hydrosart filter (Sartorius, Göttingen, Germany).
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PMC9429973
The impact of apheresis in terms of length of hospitalization (4 vs 2 days, P<0.001) and median time from the 4 day of mobilization with G-CSF until first apheresis was lower in group B; 2 vs 1 days, P<0.001).
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PMC11686380
Table 1Six previous cases with GAP43 gene abnormalities.
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PMC11674441
While clinical trials of neoantigen vaccine therapy for breast cancer have recently begun, so far, there has been no research published .
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PMC11549612
Tumor-immune system interactions database analysis linked BOLA1 expression to immune and molecular subtypes.
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PMC6948907
Similar to our report, it has been shown that VPA suppresses tumor cell proliferation in a dose-dependent manner in human hepatocellular cancer cells (HUH7) in vitro (Machado et al., 2011).
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PMC11566417
Scale bar = 25 μm.
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PMC11564322
Interestingly, a truncated alternative splicing variant of PPARγ (γ1tr) was discovered in the K562 cell line, in which it exhibited dominant negative activity .
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PMC7582629
On a different note, Raman imaging can overcome problems resulting from limited stability, bleaching, the use of external biomarkers and long sample preparation associated with traditional morphological analysis like electron microscopy and fluorescence microscopy, opening the way to in vivo analysis.
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PMC11680391
There were a few differences between farmer and veterinarian answers in the constructs, as illustrated in Figure 2.
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PMC11739484
Cells were cultured for 10 days, with the medium changed every 3 days.
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PMC9429973
Since 2018, NICE and the EMA have recommended the use of CPX-351 for adults with newly diagnosed, therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) due to prior myelodysplastic syndrome (MDS)/chronic myelomonocytic leukemia (CMML) or de novo AML with myelodysplasia-related cytogenetic changes.
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PMC11247842
The SNP blocks A+C were associated with the expression of PTGES (BTA11), while block B affected the expression of PEX12 (BTA19).
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PMC7642379
On chromosome 18, there is a conserved pattern of copy number loss of most of the chromosome sequence for all progeny cell lines compared to the parental HEK293 strain, with the exception of a high degree of copy number gain (> 0.8 log2 fold-change) of a region close to the centromere for all cell lines except 293E (Fig. 2a).
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PMC3765139
Functional analysis of the surface markers used in this study revealed that only CD133+ D10 cells constantly demonstrated a significantly higher clonogenic capacity as compared to the CD133- fraction.
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PMC10734950
This is done solely in the absence of the compound so the cells can properly adhere.
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PMC11787651
Histones were extracted from cells and propionylated following previously published protocols (57).
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PMC11267036
However, this work has certain limitations.
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PMC9429973
Mitotic spindle organization was analyzed by immunofluorescence (IF).
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PMC6160470
P-gp ATPase activity was measured using SB-MDR1-PREDEASY ATPase Kit (Solvo Biotechnology, Budapest, Hungary) according to the manufacturer’s instructions and methods described by Sarkadi et al.. Briefly, membrane vesicles containing P-gp transporter, purified from insect cells, were diluted with assay mix and loaded into a 96-well microplate.
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PMC11366496
oeRNF122 might enhance glioblastoma cell proliferation, migration, and invasion, and the impact could be mitigated by knocking down c‐Myc.
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PMC10823017
Of these, the atypical Protein Kinase Cs (aPKCs) have various isoforms (18, 19).
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PMC9429973
Results: As of August 27, 2021, 90 pts had received mosunetuzumab; 67% were aged <65 years and 33% were aged ≥65 years.
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PMC11711663
Based on our model, we developed a nomogram in Fig. 6 that visually represents the CPH model presented in Table 4.
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PMC7348793
Therefore, if for some reason NUMTs are preferentially amplified so that their abundance increased to >20% to the level detectable by Sanger sequencing, we should have also detected heteroplasmy at other loci, which was not the case.
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PMC9046263
One potential role ERVK3-1 may have in oncogenesis is immunomodulation.
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PMC11335267
To test the effects of D-Trp8-γMSH , mice were acclimatized for three days prior to the beginning of the experiments, and then they were injected with saline (i.p.)
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PMC11144200
In this study, we designed a drug delivery system (LPS-RGD-Nb36-DOX) based on LPS-Nb36 that realized the doxorubicin and anti-CTLA-4 Nb co-loaded and RGD modification, and was applied to antitumor therapy.
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PMC11686380
The N-terminal palmitoylation of GAP43 is required for membrane association and interaction with the cortical actin cytoskeleton located just beneath the cell membrane.
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PMC9429973
14/15 cases with Burkitt histology were diagnosed as BL and one case was reclassified into DHL due to concurrent BCL6-R. Excluding BL, 38 cases (6 DLCBL NOS and 32 HGL) were selected for further analysis.
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PMC9429973
Methods: Cell viability assays were performed in ALL cell lines and patient-derived xenograft (PDX) samples analyzing half maximal effective concentrations (EC50).
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PMC10820104
In the current study, a bioassay-guided fractionation allowed for the identification of an active fraction displaying significant cytotoxic activity against the human pancreatic adenocarcinoma cell line PANC-1 from the EtOAc extract of the investigated fungus compared to the standard paclitaxel.
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PMC10522430
Cancer is the second leading cause of death worldwide , with cervical cancer displaying an escalating incidence, particularly prominent in Indonesia.
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PMC11723947
The membrane was treated with a total protein stain (REVERT Total protein Stain kit, LI-COR), and imaged in the 700 nm channel with an Odyssey imaging system.
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PMC11545737
Moreover, the activation of the caspase-3/GSDME pathway may result from the switch from apoptosis to pyroptosis.
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PMC11474209
More studies have yet to be shown in Table 2.
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PMC11576293
We subsequently examined the most efficient derivatives as dual EGFR/VEGFR-2 inhibitors, finding that compounds 22 and 29 functioned as dual inhibitors.
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PMC10154881
Bone marrow‐derived dendritic cells were prepared from the bone marrow cells of B6 mice.
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