OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC10565698	B and C. Evaluation of knockdown efficiency of circUSP10 in HCCLM3 and BEL-7407 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "B", "and", "C.", "Evaluation", "of", "knockdown...
PMC9429973	Extensive DC-FISH study examining additional 1,000 cells showed positive in these ISM-FISH-positive/DC-FISH (200cells)-negative samples, suggesting higher sensitivity of ISM-FISH than that of the standard DC-FISH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11519583	Thus, Ror2 may activate different signaling pathways by associating with different Frizzled receptors in MPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "Ror2", "may", "activate", "different", ...
PMC11770199	Sample comparisons were performed using multiple t test corrected by FDR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sample", "comparisons", "were", "performed", "using", "multiple", "t", "test", "corrected",...
PMC11680391	Yet, it is also essential to consider how skilled the farmer is in defining their own needs and be instrumental in implementing the herd-specific advice from the herd veterinarian.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	In this study, we reported an injectable nanocomposite hydrogel (Cis/Mn/NH@PGP) composed of a TME-responsive polymer framework and multi-structured nanoparticles (Cis/Mn@Lipo-IL11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9325715	Results are presented in milliunits per mL of medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "presented", "in", "milliunits", "per", "mL", "of", "medium", "." ] } ]
PMC11045125	Of note, the Kempkes lab previously showed that a normal human B cell line infected with an EBNA2-deleted (P3HR1) EBV strain can indefinitely proliferate and be switched to a Myc-driven “BL-like” phenotype when EBNA2 expression is turned off and high level Myc expression is induced .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11609529	Cell lysates were collected 72 h post-transduction, and western blotting was performed using an anti-MAML2 antibody (E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lysates", "were", ...
PMC11680049	One of the promising closely related objects, whose biomass contains polyphenols, is the evergreen Sequoia (Sequoia sempervirens (D.Don) Endl.),	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11258145	Several studies have confirmed that curcumin possesses various pharmacological and biological properties, including antioxidant, antibacterial, immunomodulatory and anti-inflammatory antidiabetic, anticancer, hepatoprotective, anti-Alzheimer's, anti-rheumatic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	The RNAs were dissolved in aqueous formulation buffer and subsequently formulated using microfluidic mixing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RNAs", "were", "dissolved", "in", "aqueous", "formulation", ...
PMC11365427	Therefore, our investigation aimed to analyze the metabolic alterations of MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "our", "investigation", "aimed", "to", "analyze", "the", "metab...
PMC7039683	SNP4 is the lead SNP from our meta-analysis of OFC GWAS (Leslie et al., 2017). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SNP4", "is", "the", "lead", ...
PMC7022782	Many free polyribosomes, bundles of cytoskeletal elements, some mitochondria, and lipid droplets are also detectable in the cytoplasm (Figure 7B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11026382	The dashed red line marks x = y. Error bars (in x and y) indicate standard deviation across three experimental measurements, points are centered at the mean.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	Cells were treated with cycloheximide (CHX, 50 μg/ml, HY-12320, MCE, Shanghai, China), RAS-selective lethal 3 (RSL3, 2 µM, S8155, Selleck), erastin (5 µM, HY-15763, MCE), desferrioxamine (DFO, 25 µM, D9533, Sigma, St. Louis, MO, USA), Staurosporine (STS, HY-15141, MCE), or Necroptosis inducer kit with TSZ (TNF-α, SM-164, and Z-VAD-FMK, C1058S, Beyotime).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485648	Based on the growing experimental evidence, SFN acts through various molecular mechanisms that interfere with multiple oncogenic pathways and thereby induce anti-proliferative, anti-inflammatory, and pro-apoptotic responses in diverse tumor cell types (6–9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A. Raska, K. Kalman, B. Egri, I. Roberts, K. Kolev, N. Wohner Department of Hematology and Internal Medicine; HCEMM-SU Thrombosis and Haemostasis Research Group; Department of Biochemistry, Semmelweis University, Budapest, Hungary; Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, United Kingdom Background: Postpartum haemorrhage (PPH) is the leading cause of maternal death world-wide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	A P-value ≤ 0.05 is flagged with one star (*).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "P-value", "≤", "0.05", "is", "flagged", "with", "one", "star", "(", ...
PMC11484188	Absorbance was measured at 450 nm using a microplate reader (TECAN-Spark; Tecan Group, Ltd.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Absorbance", "was", "measured", "at", ...
PMC10944868	The analyses were performed on Agilent 1,260 infinity HPLC system (C-18 column, Hypersil, BDS, 5 μm, 0.4 mm × 25 mm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10595704	Physical, chemical, and biological processes such as erosion, photo-oxidation, and biodegradation cause the plastic to erode, eventually forming debris in the size range from micro-plastics (MP) to nano-plastics (NP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11572213	P-AMPK-α protein expression was increased at low glutamine levels in all three cell lines, although statistically significant only in HL-60 shTET2-3 cells (Figures 6A, C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "I-CellLine", "I-CellLine", ...
PMC11509224	Similarly, only one diterpene was reported from the Hymerhabdia sponges.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "only", "one", "diterpene", "was", "reported", "from", "the", "Hymer...
PMC9429973	Aims: To study the temporal association of COVID-19 vaccination and acquired aplastic anemia Methods: We reviewed the cases of all patients who presented to MD Anderson Cancer Center between January 2021 and December 2021 for pancytopenia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9318744	Next, we conducted single-cell sorting of ACE2plus cells to generate single-cell-derived ACE2plus subclones (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "conducted", "single...
PMC8903741	Even though the sequence of this antibody was disclosed as well as the recombinant antibody was opportunely generated, the yield was not adequate for a large-scale expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	In-house production medium was used for CHO-K1 cells, whereas production medium was same as growth medium for HEK293-derived cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "In-house", ...
PMC8735881	The lentiviral particles were then concentrated by ultracentrifugation and resuspended in RPMI1640 medium with 25mM HEPES and stored in aliquots in a −80°C freezer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	None of the HSCT recipients nor healthy controls has received anti-SARS-Cov2 vaccination before infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "None", "of", "the", "HSCT", "recipients", "nor", "healthy", "con...
PMC11064533	For the proteomic analysis of clumps and planktonic bacteria, the adhesion assay of the wild-type strain 4972 on cell line 5637 was carried out as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11046454	For all primary CAR T cell testing, three independent experiments were performed using human PBMCs collected from at least two donors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "all",...
PMC11730000	Strong and persistent mTOR activation caused by RA treatment increased RA-mediated hepatocyte proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Strong", "and", "persistent", "mTOR", "activation", "caused", "by", "RA", ...
PMC11697189	Therefore, we explored the differential expression of the 47 previously reported immune checkpoint genes in different risk groups (see Supplementary Table S1 online).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	C. Harrison, R. K. Rampal, V. Gupta, S. Verstovsek, M. Talpaz, J.-J. Kiladjian, R. Mesa, A. Kuykendall, A. Vannucchi, F. Palandri, S. Grosicki, T. Devos, E. Jourdan, M. J. Wondergem, H. K. Al-Ali, V. Buxhofer-Ausch, A. Alvarez-Larrán, S. Akhani, R. Muñoz-Carerras, Y. Sheykin, G. Colak, M. Harris, J. Mascarenhas Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Memorial Sloan-Kettering Cancer Center, New York, NY, United States of America; Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada; Leukemia Department, University of Texas MD Anderson Cancer Center, Houston, TX; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, United States of America; Hôpital Saint-Louis, Université de Paris, Paris, France; Mays Cancer Center at UT Health San Antonio MD Anderson Cencer Center, San Antonio, TX; Mofitt Cancer Center, Tampa, FL, United States of America; Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy; Medical University of Silesia in Katowice, Katowice, Poland; University Hospitals Leuven and Laboratory of Molecular Immunology (Rega Institute), KU Leuven, Leuven, Belgium; C.H.U, Nîmes, France; Amsterdam University Medical Centers, Amsterdam, Netherlands; University Hospital Halle, Halle, Germany; KRANKENHAUS DER ELISABETHINEN Linz GmbH, Linz, Austria; Hospital Clínic Barcelona, Barcelona, Spain; MorphoSys AG, Planegg, Germany; Constellation Pharmaceuticals a MorphoSys Company, Boston, MA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America Background: Myelofibrosis (MF) is characterized by bone marrow fibrosis, anemia, splenomegaly and constitutional symptoms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5308810	Cells (2x10) were stained with CXCR4-APC (clone 12G5, BioLegend, San Diego, CA) for 1 h at 4°C under sterile conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696576	Nordihydroguaiaretic acid (NDGA) and Arachidonyl Trifluoromethyl Ketone (ATK) (#62120-10) were obtained from Cayman Chemicals (Ann Arbor, MI, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868	PA-1 cells were treated with 1µM MST-312, 10 µM quercetin and their combination for 24 h. Control group was treated with DMSO as a vehicle.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626	FC, fold change.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "FC", ",", "fold", "change", "." ] } ]
PMC4659567	It can be concluded that, as in the case of 10% DMF-d 7/D2O, 2 and 8 rapidly decompose/solvolyse in the used 10% MeOD-d 4/D2O solution, which is in the case of 8 provably connected with a release of 3I5Braza.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612794	Error bars show the mean ± SD; p-values were calculated by one-way ANOVA (F (2,27) = 672.4; p < 0.0001) followed by Tukey’s test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10968586	Up to now, conclusive studies assessing the influence of nutritionally relevant concentrations of OLE and HT on tumor insurgence and expansion, as well as proof of the absence of OLE- and HT-mediated alterations of chemotherapy metabolism, are still missing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The median follow-up of alive patients was 33 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "follow-up", "of", "alive", "patients", "was", "33", "months", "." ] } ]
PMC9424261	The results show we detected the expression of HERPUD1 at the mRNA and protein levels (Fig. 6E, F), which were consistent with the previous in vitro results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11552389	Our findings demonstrated that FOXN3 is downregulated in melanoma tissues and acts as a potent inhibitor of melanoma cell proliferation and motility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findi...
PMC11658074	WB analysis confirmed the effectiveness of the sorting process (Fig. 6f).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WB", "analysis", "confirmed", "the", "effectiveness", "of", "the", "sorting...
PMC11695546	Besides, the MIC value of crude coconut oil was 62.5 µg/mL and its MBC versus H. pylori was 125 µg/mL. On the other hand, the MIC value of ozonized coconut oil was 15.62 µg/mL, and its MBC was 31.25 µg/mL revealing its bactericidal action of both crude and ozonized coconut oil as shown in (Table 2, Fig. 3).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11201989	Our characterization of PD-L1 in mammalian ciliated fibroblast and epithelial cells has revealed a potentially novel centrosomal localization of PD-L1; however, it is important to validate this localization by either using CRISPR knockout technology or primary cells from PD-L1 knockout mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727306	It has been shown that myelin basic protein, which plays a critical role in the organization of myelin sheaths in the nervous system, is found in the sera of healthy people .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11078693	By using a light microscope, check that adherent cells are not lost.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "using", "a", "light", "microscope", ",", "check", "that", "adhe...
PMC9429973	Aims: MOMENTUM is a pivotal phase 3 study of symptomatic and anemic MF pts previously treated with a JAK inhibitor (JAKi) testing MMB vs DAN.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	The above two sets of PCR products were gel purified and cloned in a pUAST-attB vector digested with EcoRI using NEBuilder HiFi DNA Assembly Master Mix (NEB, E2621L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2777936	These species include the transcription factors POU5F1 and Nanog, bone morphogenetic protein family member GDF-3, developmental pluripotency-associated gene 3 (DPPA3) and fibroblast growth factor 4 (FGF4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727907	Since H2O2 is also a substrate of catalases, GPx activity was obtained by subtracting the result of this assay from the catalase activity values (catalase was assayed spectrophotometrically following the H2O2 decomposition at 240 nm) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8913139	Here, upregulation of ROCK1 was also detected in GBM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "upregulation", "of", "ROCK1", "was", "also", "detected", "in", "GBM", "." ...
PMC11752740	Additionally, several ABC transporters are involved in cellular metabolism and the transport of biological molecules .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "several", "ABC", "transporters", ...
PMC11539788	After the supernatants were discarded, the magnetic beads were boiled in 50 µl of SDS loading buffer, and the samples were finally subjected to immunoblot analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	Therefore, the levels of α-SMA and FN can respond to the degree of fibrosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "levels", "of", "α-SMA", "and", ...
PMC7305184	Permeabilization and survival curves (8 × 100 µs, 1 Hz, 0–600 V) were determined for 1, 5, 10, 15, 20, 25 and 30 generation in three experimental groups: CTRL- never exposed to pulse treatment, CTRL + EP - exposed to PEF treatment only in 1 generation and EP- repeatedly exposed to pulse treatment (for more detailed explanation see Materials and methods section).Figure 2Permeabilization at different electric fields for 15 generation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11724582	The proliferation, migration, and invasion ability of cells treated with 2.4 µM allorertinib for 24 h were altered in colony formation and transwell invasion assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10823017	This was evident from the enhanced effect on the c-Myc level diminution as a result of the combination drug treatment ( Figure 5 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9509578	These nanosystems are able to reverse MDR under the influence of various stimuli depending on the tumor microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "nanosystems", "are", "able", ...
PMC11721295	RAS expression in LC3-547 cells was similar or slightly less than in KPL-86 cells.	[ { "tags": [ "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "RAS", "expression", "in", "LC3...
PMC11658074	p < 0.01. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.01", ".", "(" ] } ]
PMC8345486	Similarly, as found in the structure of 3, the faces of the pentagonal C2B3 were nearly parallel, with a smaller dihedral angle (2.215°).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587866	The generated model had low QMEAN score and potential structural irregularities, both of which required refinement and minimization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "generated", "model", "had"...
PMC11323699	After mouse euthanasia, the kidneys, lungs, spleen, heart, liver, stomach, brain, and bladder were collected and weighed, then the fluorescence count in each sample was determined with instrument sensitivity set to “Normal”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11409031	Detection of the efficiency of PFN1 expression inhibited by small interfering RNA in the HEY cell line. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Detection", "of", "the", "efficienc...
PMC10669128	They consist of the implantation of tumor cells into immunocompromised mice, either under the skin or into the same organ type of origin (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588085	Our study has used OVCAR3 and SKOV3 as ovarian cancer cell models because these two cell lines have been extensively studied and characterized (42, 43), and both of them express relatively high levels of XIST compared to other ovarian cancer cell lines, which allows us to investigate the function of XIST through gene KD.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Methods: This multicentric, phase Ib, prospective, open label, two-part study evaluated safety, tolerability and pharmacokinetics of KRP203 in intermediate to high-risk patients undergoing HSCT for hematological malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087055	Permeabilization was performed in TBST (0.5% Triton-X) for 30 min at RT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Permeabilization", "was", "performed", "in", "TBST", "(", "...
PMC11155445	Arshad et al. synthesized and characterized three novel amantadine-linked acyl thiourea derivatives and screened for their anti-glioma, DNA binding and anti-elastase potentials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Arshad"...
PMC10421378	This was necessary since the samples after trypsinization contained a combination of bacterial and epithelial cells, and as such were not suitable for flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7215832	Cells were maintained in an experimental growth phase for all experiments and were tested negative for mycoplasma periodically every three months with the MycoAlert Mycoplasma Detection Kit (Cat no. LO LT07-705, Westburg, Leusden, The Netherlands).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7342409	Hematoxylin and eosin and immunohistochemical staining were used to detect the pathological characteristics and immunophenotype of the transplanted tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hematoxylin", "and", "eosin", "an...
PMC11078693	Note: In this protocol, we use phalloidin at a final concentration 100 nM by a 1:100 dilution of a 10 μM stock solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5415764	The free drug combination at an optimized ratio dissolved in a Cremophor EL and ethanol (1:1, v/v) mixed solvent was used as a control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472639	Nevertheless, as noted earlier, it appears that any exercise-induced mobilisation of plasma cells is modest in SMM (+3 cells/μL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11499955	As a proof of concept, we performed our study with 4 isotopologues of TMPP which were synthesized in 6 steps from sydnonimine 1, prepared according to previous protocols.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10899471	Due to its rarity and histologic heterogeneity, the understanding of sarcoma biology is also relatively limited, compared with that of common epithelial cancers (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Microbiological analysis of non-sterile compartment in 101 patients revealed 52 cases of E.coli without ESBL, 35 - with E.coli ESBL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Microbiological", "anal...
PMC11367146	The legend with the color key represents the log fold change of DEGs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "legend", "with", "the", "color", "key", "represents", "the", "...
PMC11752740	Additionally, the NF-κB p65 transcription factor was evaluated using ELISA after 24- and 48-hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "NF-κB", "p65", "transcription", ...
PMC9429973	Methods: Here we report a retrospective multicenter analysis of 600 RRMM patients treated with KRd between December 2015 and December 2018 Results: The median age at KRd start was 64 years (range 33-85) and the median number of previous therapies was 2 (range 1-11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7348793	Our survey of the literature suggests that this possibility is not always considered.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "survey", "of", "the", "literature", "suggests", "that", "this", ...
PMC11488203	The presence of stroma cell-derived factor 1 (SDF-1) in MSC-derived EVs/exosomes and its enhanced expression in the vesicles after taxol treatment of MSC was quantified by a specific ELISA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: 301 NDMM pts were enrolled and analyzed; 72% received induction with bortezomib-thalidomide-dexamethasone, 9% a lenalidomide (Len)-based and 3% a daratumumab (Dara)-based regimen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5854676	Cellular responses to the novel NP materials were investigated in HeLa cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Cellular", "responses", "to", "the", "novel", "NP", "materials", "...
PMC11682172	Identified proteins of each type of breast cancer cell lines that were co-cultured with either activated T lymphocytes or T-lymphocyte CM were compared to those of cancer cells cultured without the addition of activated T lymphocytes or T-lymphocyte CM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10852540	Rosmarinic acid (RA) is a polyphenol found in many plants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rosmarinic", "acid", "(", "RA", ")", "is", "a", "polyphenol", "found", "in...
PMC11604830	time 17 min).	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "time", "17", "min", ")", "." ] } ]
PMC6337547	Phenolic acids have multitarget anti-tumour effects; however, their mechanisms are more complicated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phenolic", "acids", "have", "multitarget", "anti-tumour", "effects", "...
PMC3164356	Classical karyotyping of CHO-K1 reveals 21 chromosomes.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Classical", "karyotyping", "of", "CHO-K1", "reveals", "21", "chromosomes", "." ] } ]
PMC11802929	d Bar plots showing the variation of selected TCR physicochemical properties across T cell phenotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Bar", "plots", "showing", "the", "variation", "of", ...
PMC11739504	The proportion of IFT52 distribution by categories are displayed below the graphs; ciliary axoneme, basal body, and not on the cilia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10565698	It promotes cell proliferation, migration, and invasion by regulating the EMT-related molecule Slug .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "promotes", "cell", "proliferation", ",", "migration", ...
PMC10887351	In conclusion, this review highlights all the data that together strengthen the pharmacologic theory of β3-AR as a promising therapeutic target in different treatments, supporting that this is the right path for the treatment of several conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10743717	Results of this study would encourage researchers to solve the question why elevated levels of 17β-HSD10 are present in brains of AD patients and mouse AD models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10565698

B and C. Evaluation of knockdown efficiency of circUSP10 in HCCLM3 and BEL-7407 cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "B", "and", "C.", "Evaluation", "of", "knockdown...

PMC9429973

Extensive DC-FISH study examining additional 1,000 cells showed positive in these ISM-FISH-positive/DC-FISH (200cells)-negative samples, suggesting higher sensitivity of ISM-FISH than that of the standard DC-FISH.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11519583

Thus, Ror2 may activate different signaling pathways by associating with different Frizzled receptors in MPs.

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PMC11770199

Sample comparisons were performed using multiple t test corrected by FDR.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sample", "comparisons", "were", "performed", "using", "multiple", "t", "test", "corrected",...

PMC11680391

Yet, it is also essential to consider how skilled the farmer is in defining their own needs and be instrumental in implementing the herd-specific advice from the herd veterinarian.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11783017

In this study, we reported an injectable nanocomposite hydrogel (Cis/Mn/NH@PGP) composed of a TME-responsive polymer framework and multi-structured nanoparticles (Cis/Mn@Lipo-IL11).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9325715

Results are presented in milliunits per mL of medium.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "presented", "in", "milliunits", "per", "mL", "of", "medium", "." ] } ]

PMC11045125

Of note, the Kempkes lab previously showed that a normal human B cell line infected with an EBNA2-deleted (P3HR1) EBV strain can indefinitely proliferate and be switched to a Myc-driven “BL-like” phenotype when EBNA2 expression is turned off and high level Myc expression is induced .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11609529

Cell lysates were collected 72 h post-transduction, and western blotting was performed using an anti-MAML2 antibody (E).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lysates", "were", ...

PMC11680049

One of the promising closely related objects, whose biomass contains polyphenols, is the evergreen Sequoia (Sequoia sempervirens (D.Don) Endl.),

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11258145

Several studies have confirmed that curcumin possesses various pharmacological and biological properties, including antioxidant, antibacterial, immunomodulatory and anti-inflammatory antidiabetic, anticancer, hepatoprotective, anti-Alzheimer's, anti-rheumatic.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8633974

The RNAs were dissolved in aqueous formulation buffer and subsequently formulated using microfluidic mixing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RNAs", "were", "dissolved", "in", "aqueous", "formulation", ...

PMC11365427

Therefore, our investigation aimed to analyze the metabolic alterations of MM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "our", "investigation", "aimed", "to", "analyze", "the", "metab...

PMC7039683

SNP4 is the lead SNP from our meta-analysis of OFC GWAS (Leslie et al., 2017). (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SNP4", "is", "the", "lead", ...

PMC7022782

Many free polyribosomes, bundles of cytoskeletal elements, some mitochondria, and lipid droplets are also detectable in the cytoplasm (Figure 7B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11026382

The dashed red line marks x = y. Error bars (in x and y) indicate standard deviation across three experimental measurements, points are centered at the mean.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8316344

Cells were treated with cycloheximide (CHX, 50 μg/ml, HY-12320, MCE, Shanghai, China), RAS-selective lethal 3 (RSL3, 2 µM, S8155, Selleck), erastin (5 µM, HY-15763, MCE), desferrioxamine (DFO, 25 µM, D9533, Sigma, St. Louis, MO, USA), Staurosporine (STS, HY-15141, MCE), or Necroptosis inducer kit with TSZ (TNF-α, SM-164, and Z-VAD-FMK, C1058S, Beyotime).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4485648

Based on the growing experimental evidence, SFN acts through various molecular mechanisms that interfere with multiple oncogenic pathways and thereby induce anti-proliferative, anti-inflammatory, and pro-apoptotic responses in diverse tumor cell types (6–9).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

A. Raska, K. Kalman, B. Egri, I. Roberts, K. Kolev, N. Wohner Department of Hematology and Internal Medicine; HCEMM-SU Thrombosis and Haemostasis Research Group; Department of Biochemistry, Semmelweis University, Budapest, Hungary; Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, United Kingdom Background: Postpartum haemorrhage (PPH) is the leading cause of maternal death world-wide.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11188874

A P-value ≤ 0.05 is flagged with one star (*).

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PMC11484188

Absorbance was measured at 450 nm using a microplate reader (TECAN-Spark; Tecan Group, Ltd.).

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PMC10944868

The analyses were performed on Agilent 1,260 infinity HPLC system (C-18 column, Hypersil, BDS, 5 μm, 0.4 mm × 25 mm).

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PMC10595704

Physical, chemical, and biological processes such as erosion, photo-oxidation, and biodegradation cause the plastic to erode, eventually forming debris in the size range from micro-plastics (MP) to nano-plastics (NP).

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PMC11572213

P-AMPK-α protein expression was increased at low glutamine levels in all three cell lines, although statistically significant only in HL-60 shTET2-3 cells (Figures 6A, C).

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PMC11509224

Similarly, only one diterpene was reported from the Hymerhabdia sponges.

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PMC9429973

Aims: To study the temporal association of COVID-19 vaccination and acquired aplastic anemia Methods: We reviewed the cases of all patients who presented to MD Anderson Cancer Center between January 2021 and December 2021 for pancytopenia.

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PMC9318744

Next, we conducted single-cell sorting of ACE2plus cells to generate single-cell-derived ACE2plus subclones (Figure 2A).

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PMC8903741

Even though the sequence of this antibody was disclosed as well as the recombinant antibody was opportunely generated, the yield was not adequate for a large-scale expression.

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PMC10237474

In-house production medium was used for CHO-K1 cells, whereas production medium was same as growth medium for HEK293-derived cell lines.

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PMC8735881

The lentiviral particles were then concentrated by ultracentrifugation and resuspended in RPMI1640 medium with 25mM HEPES and stored in aliquots in a −80°C freezer.

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PMC9429973

None of the HSCT recipients nor healthy controls has received anti-SARS-Cov2 vaccination before infection.

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PMC11064533

For the proteomic analysis of clumps and planktonic bacteria, the adhesion assay of the wild-type strain 4972 on cell line 5637 was carried out as described above.

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PMC11046454

For all primary CAR T cell testing, three independent experiments were performed using human PBMCs collected from at least two donors.

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PMC11730000

Strong and persistent mTOR activation caused by RA treatment increased RA-mediated hepatocyte proliferation.

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PMC11697189

Therefore, we explored the differential expression of the 47 previously reported immune checkpoint genes in different risk groups (see Supplementary Table S1 online).

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PMC9429973

C. Harrison, R. K. Rampal, V. Gupta, S. Verstovsek, M. Talpaz, J.-J. Kiladjian, R. Mesa, A. Kuykendall, A. Vannucchi, F. Palandri, S. Grosicki, T. Devos, E. Jourdan, M. J. Wondergem, H. K. Al-Ali, V. Buxhofer-Ausch, A. Alvarez-Larrán, S. Akhani, R. Muñoz-Carerras, Y. Sheykin, G. Colak, M. Harris, J. Mascarenhas Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Memorial Sloan-Kettering Cancer Center, New York, NY, United States of America; Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada; Leukemia Department, University of Texas MD Anderson Cancer Center, Houston, TX; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, United States of America; Hôpital Saint-Louis, Université de Paris, Paris, France; Mays Cancer Center at UT Health San Antonio MD Anderson Cencer Center, San Antonio, TX; Mofitt Cancer Center, Tampa, FL, United States of America; Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy; Medical University of Silesia in Katowice, Katowice, Poland; University Hospitals Leuven and Laboratory of Molecular Immunology (Rega Institute), KU Leuven, Leuven, Belgium; C.H.U, Nîmes, France; Amsterdam University Medical Centers, Amsterdam, Netherlands; University Hospital Halle, Halle, Germany; KRANKENHAUS DER ELISABETHINEN Linz GmbH, Linz, Austria; Hospital Clínic Barcelona, Barcelona, Spain; MorphoSys AG, Planegg, Germany; Constellation Pharmaceuticals a MorphoSys Company, Boston, MA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America Background: Myelofibrosis (MF) is characterized by bone marrow fibrosis, anemia, splenomegaly and constitutional symptoms.

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PMC5308810

Cells (2x10) were stained with CXCR4-APC (clone 12G5, BioLegend, San Diego, CA) for 1 h at 4°C under sterile conditions.

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PMC11696576

Nordihydroguaiaretic acid (NDGA) and Arachidonyl Trifluoromethyl Ketone (ATK) (#62120-10) were obtained from Cayman Chemicals (Ann Arbor, MI, USA).

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PMC9596868

PA-1 cells were treated with 1µM MST-312, 10 µM quercetin and their combination for 24 h. Control group was treated with DMSO as a vehicle.

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PMC11612626

FC, fold change.

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PMC4659567

It can be concluded that, as in the case of 10% DMF-d 7/D2O, 2 and 8 rapidly decompose/solvolyse in the used 10% MeOD-d 4/D2O solution, which is in the case of 8 provably connected with a release of 3I5Braza.

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PMC11612794

Error bars show the mean ± SD; p-values were calculated by one-way ANOVA (F (2,27) = 672.4; p < 0.0001) followed by Tukey’s test. (

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PMC10968586

Up to now, conclusive studies assessing the influence of nutritionally relevant concentrations of OLE and HT on tumor insurgence and expansion, as well as proof of the absence of OLE- and HT-mediated alterations of chemotherapy metabolism, are still missing.

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PMC9429973

The median follow-up of alive patients was 33 months.

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PMC9424261

The results show we detected the expression of HERPUD1 at the mRNA and protein levels (Fig. 6E, F), which were consistent with the previous in vitro results.

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PMC11552389

Our findings demonstrated that FOXN3 is downregulated in melanoma tissues and acts as a potent inhibitor of melanoma cell proliferation and motility.

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PMC11658074

WB analysis confirmed the effectiveness of the sorting process (Fig. 6f).

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PMC11695546

Besides, the MIC value of crude coconut oil was 62.5 µg/mL and its MBC versus H. pylori was 125 µg/mL. On the other hand, the MIC value of ozonized coconut oil was 15.62 µg/mL, and its MBC was 31.25 µg/mL revealing its bactericidal action of both crude and ozonized coconut oil as shown in (Table 2, Fig. 3).Fig.

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PMC11201989

Our characterization of PD-L1 in mammalian ciliated fibroblast and epithelial cells has revealed a potentially novel centrosomal localization of PD-L1; however, it is important to validate this localization by either using CRISPR knockout technology or primary cells from PD-L1 knockout mice.

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PMC11727306

It has been shown that myelin basic protein, which plays a critical role in the organization of myelin sheaths in the nervous system, is found in the sera of healthy people .

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PMC11078693

By using a light microscope, check that adherent cells are not lost.

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PMC9429973

Aims: MOMENTUM is a pivotal phase 3 study of symptomatic and anemic MF pts previously treated with a JAK inhibitor (JAKi) testing MMB vs DAN.

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PMC11634027

The above two sets of PCR products were gel purified and cloned in a pUAST-attB vector digested with EcoRI using NEBuilder HiFi DNA Assembly Master Mix (NEB, E2621L).

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PMC2777936

These species include the transcription factors POU5F1 and Nanog, bone morphogenetic protein family member GDF-3, developmental pluripotency-associated gene 3 (DPPA3) and fibroblast growth factor 4 (FGF4).

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PMC11727907

Since H2O2 is also a substrate of catalases, GPx activity was obtained by subtracting the result of this assay from the catalase activity values (catalase was assayed spectrophotometrically following the H2O2 decomposition at 240 nm) .

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PMC8913139

Here, upregulation of ROCK1 was also detected in GBM.

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PMC11752740

Additionally, several ABC transporters are involved in cellular metabolism and the transport of biological molecules .

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PMC11539788

After the supernatants were discarded, the magnetic beads were boiled in 50 µl of SDS loading buffer, and the samples were finally subjected to immunoblot analysis.

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PMC9985266

Therefore, the levels of α-SMA and FN can respond to the degree of fibrosis.

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PMC7305184

Permeabilization and survival curves (8 × 100 µs, 1 Hz, 0–600 V) were determined for 1, 5, 10, 15, 20, 25 and 30 generation in three experimental groups: CTRL- never exposed to pulse treatment, CTRL + EP - exposed to PEF treatment only in 1 generation and EP- repeatedly exposed to pulse treatment (for more detailed explanation see Materials and methods section).Figure 2Permeabilization at different electric fields for 15 generation.

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PMC11724582

The proliferation, migration, and invasion ability of cells treated with 2.4 µM allorertinib for 24 h were altered in colony formation and transwell invasion assays.

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PMC10823017

This was evident from the enhanced effect on the c-Myc level diminution as a result of the combination drug treatment ( Figure 5 ).

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PMC9509578

These nanosystems are able to reverse MDR under the influence of various stimuli depending on the tumor microenvironment.

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PMC11721295

RAS expression in LC3-547 cells was similar or slightly less than in KPL-86 cells.

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PMC11658074

p < 0.01. (

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PMC8345486

Similarly, as found in the structure of 3, the faces of the pentagonal C2B3 were nearly parallel, with a smaller dihedral angle (2.215°).

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PMC9587866

The generated model had low QMEAN score and potential structural irregularities, both of which required refinement and minimization.

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PMC11323699

After mouse euthanasia, the kidneys, lungs, spleen, heart, liver, stomach, brain, and bladder were collected and weighed, then the fluorescence count in each sample was determined with instrument sensitivity set to “Normal”.

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PMC11409031

Detection of the efficiency of PFN1 expression inhibited by small interfering RNA in the HEY cell line. (

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PMC10669128

They consist of the implantation of tumor cells into immunocompromised mice, either under the skin or into the same organ type of origin (Figure 1A).

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PMC11588085

Our study has used OVCAR3 and SKOV3 as ovarian cancer cell models because these two cell lines have been extensively studied and characterized (42, 43), and both of them express relatively high levels of XIST compared to other ovarian cancer cell lines, which allows us to investigate the function of XIST through gene KD.

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PMC9429973

Methods: This multicentric, phase Ib, prospective, open label, two-part study evaluated safety, tolerability and pharmacokinetics of KRP203 in intermediate to high-risk patients undergoing HSCT for hematological malignancies.

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PMC11087055

Permeabilization was performed in TBST (0.5% Triton-X) for 30 min at RT.

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PMC11155445

Arshad et al. synthesized and characterized three novel amantadine-linked acyl thiourea derivatives and screened for their anti-glioma, DNA binding and anti-elastase potentials.

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PMC10421378

This was necessary since the samples after trypsinization contained a combination of bacterial and epithelial cells, and as such were not suitable for flow cytometry.

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PMC7215832

Cells were maintained in an experimental growth phase for all experiments and were tested negative for mycoplasma periodically every three months with the MycoAlert Mycoplasma Detection Kit (Cat no. LO LT07-705, Westburg, Leusden, The Netherlands).

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PMC7342409

Hematoxylin and eosin and immunohistochemical staining were used to detect the pathological characteristics and immunophenotype of the transplanted tumor.

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PMC11078693

Note: In this protocol, we use phalloidin at a final concentration 100 nM by a 1:100 dilution of a 10 μM stock solution.

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PMC5415764

The free drug combination at an optimized ratio dissolved in a Cremophor EL and ethanol (1:1, v/v) mixed solvent was used as a control.

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PMC11472639

Nevertheless, as noted earlier, it appears that any exercise-induced mobilisation of plasma cells is modest in SMM (+3 cells/μL).

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PMC11499955

As a proof of concept, we performed our study with 4 isotopologues of TMPP which were synthesized in 6 steps from sydnonimine 1, prepared according to previous protocols.

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PMC10899471

Due to its rarity and histologic heterogeneity, the understanding of sarcoma biology is also relatively limited, compared with that of common epithelial cancers (1).

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PMC9429973

Microbiological analysis of non-sterile compartment in 101 patients revealed 52 cases of E.coli without ESBL, 35 - with E.coli ESBL.

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PMC11367146

The legend with the color key represents the log fold change of DEGs.

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PMC11752740

Additionally, the NF-κB p65 transcription factor was evaluated using ELISA after 24- and 48-hours.

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PMC9429973

Methods: Here we report a retrospective multicenter analysis of 600 RRMM patients treated with KRd between December 2015 and December 2018 Results: The median age at KRd start was 64 years (range 33-85) and the median number of previous therapies was 2 (range 1-11).

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PMC7348793

Our survey of the literature suggests that this possibility is not always considered.

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PMC11488203

The presence of stroma cell-derived factor 1 (SDF-1) in MSC-derived EVs/exosomes and its enhanced expression in the vesicles after taxol treatment of MSC was quantified by a specific ELISA.

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PMC9429973

Results: 301 NDMM pts were enrolled and analyzed; 72% received induction with bortezomib-thalidomide-dexamethasone, 9% a lenalidomide (Len)-based and 3% a daratumumab (Dara)-based regimen.

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PMC5854676

Cellular responses to the novel NP materials were investigated in HeLa cell line.

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PMC11682172

Identified proteins of each type of breast cancer cell lines that were co-cultured with either activated T lymphocytes or T-lymphocyte CM were compared to those of cancer cells cultured without the addition of activated T lymphocytes or T-lymphocyte CM.

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PMC10852540

Rosmarinic acid (RA) is a polyphenol found in many plants.

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PMC11604830

time 17 min).

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PMC6337547

Phenolic acids have multitarget anti-tumour effects; however, their mechanisms are more complicated.

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PMC3164356

Classical karyotyping of CHO-K1 reveals 21 chromosomes.

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PMC11802929

d Bar plots showing the variation of selected TCR physicochemical properties across T cell phenotypes.

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PMC11739504

The proportion of IFT52 distribution by categories are displayed below the graphs; ciliary axoneme, basal body, and not on the cilia.

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PMC10565698

It promotes cell proliferation, migration, and invasion by regulating the EMT-related molecule Slug .

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PMC10887351

In conclusion, this review highlights all the data that together strengthen the pharmacologic theory of β3-AR as a promising therapeutic target in different treatments, supporting that this is the right path for the treatment of several conditions.

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PMC10743717

Results of this study would encourage researchers to solve the question why elevated levels of 17β-HSD10 are present in brains of AD patients and mouse AD models.

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