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BioData-CellLine_annotated

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PMC6650823
The recent work by Courtens et al. contributes to expand the chemical space around fosmidomycin and brings hope for future candidate drugs to tackle malaria/TB co-infections.
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PMC11129910
Furthermore, cells express low CD24, high CD44, and low claudin levels, indicating stem-like properties upon transformation.
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PMC7762347
However, the effects of their mixtures have been not yet widely investigated.
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PMC9587866
Toxic Dose, Adverse Effects and Specific Organ Damage Prediction The GUSAR (Lagunin et al., 2011), Adver-Pred (Ivanov et al., 2018), and ROSC-Pred databases (Lagunin et al., 2018) were used to investigate the acute toxicity, compounds side effects and damaging effects of successful ligands.
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PMC11144200
LPS-RGD-Nb36-DOX’s size, dispersion, and form were examined using a transmission electron microscope (TEM, JEM-F200, JEOL, JAPAN).
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PMC8973725
This result indicated that ZNF677 mediates thyroid cancer cell invasion and EMT through the AKT signaling pathway.
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PMC11026382
With this information in mind we defined a mathematical model comprised of two parts: the relationship between intracellular THF abundance and growth rate, and the relationship between enzymatic activity and intracellular THF.
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PMC11095939
Representative liver morphology and liver index of Mecp2 mice without (AAV-EV) or with (AAV-Mecp2) AAV-mediated Mecp2 overexpression at 7 d post-PHx.
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PMC11126803
G, knocking down the ERβ can significantly reduce the luciferase activity in 786-O cells transfected with the WT reporter gene, but there is no statistical difference in the cells with the mutated reporter gene.
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PMC11402217
Representative gene FPKM values (D) and qPCR validation (E).
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PMC11806818
The concentration of GP73 was linearly correlated with the absorbance in the range of 10.0 − 110.0 ng/mL with a detection limit of 4.7 ng/mL. This colorimetric biosensor was successfully applied to detect GP73 in spiked human serum samples, demonstrating the great potential of a high-sensitivity GP73 colorimetric biosensor for clinical detection.
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PMC10196713
Since it has been reported that an upregulated mitochondrial membrane potential is involved in ferroptosis (32), whether suppression of the mitochondrial membrane potential using rotenone, an inhibitor of the mitochondrial respiratory chain complex I, could inhibit cisplatin-induced lipid peroxidation in OVK18 cells was next investigated.
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PMC10938377
Each product was purified via flash column chromatography conducted in the normal phase using CH2Cl2/CH3OH as eluent and isolated as viscous oils.
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PMC11746948
f Intensity scoring of 4-HNE staining in colorectal lesions induced by AOM/DSS in Vil1-Cre; APT2, Vil1-Cre; APT2, and Vil1-Cre; APT2 mice.
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PMC11756907
In addition, the inhibition of phosphotyrosine phosphatase PTP1B was shown to be one of the mechanisms of action of the GO-2-ME (Figure 6).
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PMC10719213
Some CASPASE3 cleavage was observed at 100 nM in Jurkat cells (Fig. 2a), although this concentration did not show clear inhibitory effect in the previous proliferation assay (Fig. 1b).
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PMC10362265
The disulfide contact between C74 of IL18 and the C131 of the host IL18BP is likely to be the latter, more dynamic type.
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PMC11285179
Presently, there is a consensus that optimizing the effectiveness of additional anti-tumor treatments through anti-angiogenic therapy is imperative.
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PMC11519583
b Expression of Ror2 in MPs isolated (sorted) from the skeletal muscles of either control or Ror2 cKO mice was monitored using quantitative RT-PCR analysis (n = 3).
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PMC11321678
Subgroup specific TF binding motifs enrich in promoter of subgroup specific NTR genes.
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PMC11747467
A multicenter phase II study revealed that 51.2% of advanced urothelial carcinoma patients received a partial response, none of them received a complete response, and the rest represented stable disease (39.5%) and disease progression (7%) (11).
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PMC11371747
Example of positive modulation in SW1398 cells and (B) lack of modulation of 5FU activity in LS174T cells with a comparison of three leucovorin stereoisomer formulations.
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PMC8143558
drummondii (Hook. &
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PMC10093184
In the next step, we assessed the presence of extracellular matrix in the spheroids.
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PMC11612794
Cells were treated with IAA for 12 h, fixed, and stained with an anti-FLAG antibody.
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PMC11286266
To prepare samples for deep sequencing, genomic DNA from enriched and sorted populations as well as unsorted cells (to represent the entire library) was extracted from ~3.6 × 10 and~1–3 × 10 cells, respectively, by incubation in proteinase K solution [100 mM Tris–HCl pH 8.5, 5 mM EDTA, 200 mM NaCl, 0.25% (wt/vol) SDS, 0.2 mg/ml Proteinase K] overnight at 50°C.
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PMC11420784
Scale bar, 5 μm.
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PMC10055960
The positive-ion high resolution mass spectrometry (HR-ESI-MS) for complexes 8–10 reveals the base peaks corresponding at m/z = 1768.4221, m/z = 2072.4199, and m/z = 1294.4554, thereby corresponding to the [M + Na], ([M + 4(CH2Cl2) + 2K]) and ([M + 3Na]) ions for complexes 8, 9, and 10, respectively.
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PMC11551844
Taking into consideration that D is at the nano level, eqn (3) can be simplified as follows:4Nparticle = 30.89·D (iv) The AuNPs internalized (Ninternalized) is calculated as follows:5 The data supporting this article have been included as part of the ESI.† There are no conflicts to declare.
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PMC11594806
In tumors, however, ADO’s effects can impair the antitumor activity of these immune cells .
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PMC10605143
This transition between epithelial and mesenchymal states is known as the epithelial-to-mesenchymal transition (EMT) and plays an essential role in morphogenesis during embryogenesis, wound healing, cancer progression and metastasis formation .
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PMC11347429
The results suggested that while many differentially expressed genes (DEGs) and related molecular pathways in influenza-infected individuals were distinct from healthy controls, much less distinguished those who required ICU admission from non-ICU patients and very few were different for age, sex, or ethnic background.
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PMC11770746
The eye-closing ratio test was carried out prior to conducting the induced pain experiments.
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PMC11788920
PQS are more prevalent in promoters of oncogenes and regulatory genes, such as transcription factors, compared to housekeeping genes and have been demonstrated to be involved in transcription regulation [14–18].
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PMC11367146
Fig. 11 Effect of VTE on inflammatory mediators (A) IL-6, (B) IL-8, (C) TNF-α, (D) PGE2 in IL-1β induced SW982 cells by using ELISA assay.
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PMC11786600
Analysis of residual wound area in diabetic rats (n = 3). (
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PMC11400680
Unlike vanilla FCN models, U-Net can provide more contextual information due to the use of feature fusion through skip connections (6,14).
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PMC11725127
These findings highlight the potential of the USP2/KRAS axis as a therapeutic target in MM, suggesting that strategically inducing KRAS degradation via USP2 inhibition could be a promising approach for treating cancers with KRAS mutations.
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PMC7171147
N = 2.
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PMC11767793
This confirmed the inherent Au-PEI@NIST toxicity, which was not disguised by the presence of free PEI in the solution.
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PMC11700247
∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.
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PMC10135767
However, the mechanism by which Kindlin-3 assists integrin α4β7 to activate cytosolic calcium bursting remains unclear.
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PMC10114490
Before addressing the phenotypic analysis, we tested Dox dose–response, incubation time, cell density and media renewal rate in our experimental setting regarding hepatic induction (Additional file 1: Fig. S3).
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PMC11718809
Given the incomplete annotation of yak circRNA, this study offers valuable resources for enhancing the yak circRNA database and provides new insights into the regulatory mechanisms underlying lactation and mammary gland development in yaks.
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PMC11723947
Using a bone marrow allograft model, in which adoptively-transferred naive CD4 T cells coordinate graft rejection that Treg can inhibit, we first demonstrate that the three HP1 variants have no significant impact on the Th cell-mediated allogeneic response that leads to graft rejection.
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PMC11489175
The available evidence supports that the contribution of RPN11/PSMD14 to ovarian cancer aggressiveness may derive from the cooperation among different mechanism, because it has been reported to decrease the enzymatic activity of pyruvate kinase M2 (PKM2).
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PMC10705095
Conversely, when HBQ1 was knocked down, higher ROS levels and increased cell growth were observed in cells treated with NAC, an antioxidant, compared to the control group (Figure 3c,d).
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PMC8524093
Likewise, high levels of Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-5 (IL-5), Interleukin-7 (IL-7), Interleukin-10 (IL-10), Interleukin-15 (IL-15), tumor necrosis factor α (TNF-α), C-X-C Motif Chemokine Ligand 9 (CXCL9), C-X-C Motif Chemokine Ligand 10 (CXCL10), Hepatocyte Growth Factor (HGF), Basic Fibroblast Growth Factor (FGF-basic), and Vascular Endothelial Growth Factor (VEGF) are observed in both infected patients and mice models (Ng et al., 2009; Aarreberg et al., 2018).
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PMC10976516
Due to viral clearance, normal cells are unaffected.
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PMC9429973
Methods: This next generation cytogenomic technique consists of isolating ultra-high molecular weight DNA, genome wide labelling and imaging of the molecules using the Bionano Saphyr system.
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PMC11637820
The plasma device consists of a glass tube with an inner diameter of 4 mm and a thickness of 1 mm which is enclosed in an aluminium casing.
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PMC10810426
Tests used to determine significance are indicated in the figure legends.
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PMC11754436
Each experiment was conducted in triplicate.
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PMC11036064
.
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PMC9429973
While 7.8% of patients fulfilled the CCI criteria for kidney disease, 39.5% had a CKD stage ≥3A.
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PMC11371747
Cells were harvested by trypsinization (trypsin/EDTA), suspended in 5 mL medium and centrifuged for 5 min at 1,500 rpm at 4°C.
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PMC11674891
Rabbit anti-phospho-AKT (#9271), anti-AKT (#9272), and mouse anti-β-actin (#3700) were purchased from Cell Signaling Technology (Boston, MA, USA).
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PMC8524093
Similarly, Sudeep et al. (2019) evaluated the sensitivity and susceptibility of Vero-E6, BHK-21, RD, A-549, and C6/36 cell lineages to three different CHIKV genotypes.
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PMC10507284
Therefore, early diagnosis, exploration of valuable prognostic indicators, and precise treatment are of great significance in improving the clinical prognosis of patients with STS.
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PMC11536589
Additionally, the expression level of MGST1 were significantly higher in the AMG510-resistant MIA PaCa2 cells compared to MIA PaCa2 cells (Fig. S2J).
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PMC9964654
The polymer (50 mg), Me-PEG-b-PCL, and [Au(cdc)2] (2–8 mg) were dissolved in CHCl3 (4 mL) under constant stirring for 4 h at atmospheric pressure and room temperature (RT).
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PMC11098378
Controls included: an LDH positive control provided with the kit, LD652 “media-only” negative control, and an “untransfected” cell control, and a”lysed moth cells” positive control that indicates where untransfected LD652 cells were lysed per manufacturer’s instructions 1 h before collecting supernatant media.
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PMC11489351
Each band was enclosed using a rectangular selection of the same size.
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PMC9341513
The lower read depth of the data necessitates a lower map resolution (20-kbp bins compared to 10-kbp bins for GM12878 data).
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PMC11543885
The graphical abstract/figures were created using BioRender.com.
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PMC8753818
After 4 h of incubation, media was replaced by 100 µL of DMSO and mixing thoroughly by using an orbit plate shaker.
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PMC11674891
The cells were then transfected with targeting sequences and non-targeting controls using Lipofectamine 2000 in Opti-MEM.
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PMC9429973
M. Herling, E. Deconinck, M. Anant, D. Manteigas, M. Riggi, E. Angelucci Department of Hematology, Cell Therapy and Hemostaseology, University Hospital Leipzig, Leipzig, Germany; Regional University Hospital of Besançon, Besançon, France; Stemline Therapeutics Switzerland GmbH, Zug, Switzerland; Cmed, West Sussex, United Kingdom; Hematology and Cellular Therapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive hematologic malignancy, with poor prognosis (median age 67 yr).
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PMC9429973
Median follow up period was 24 months.
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PMC9672323
Dexamethasone is a potent synthetic glucocorticoid used in glioblastoma treatment regimens to relieve patients' neurological symptoms as well as chemotherapy-induced nausea and vomiting.
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PMC11750696
Deletion of GRP78 from CTL also displayed lowered granzyme B secretion and compromised cytotoxic potential.
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PMC8041314
Although dual inhibition was not in the scope of the present study, it must be acknowledged that these numbers mean that suitable molecular patterns were extracted for multitarget ABCB1, ABCC1, and ABCG2 inhibition.
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PMC11240052
Therefore, we further explored the underlying functions of hsa_circ_0008285 in ovarian cancer cells and speculated that overexpression of hsa_circ_0008285 could serve as a sponge of miR-211-5p to elevate SIRT-1 expression and cause high proliferation and invasion of ovarian cancer cells.
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PMC11743316
Therefore, this review covers the production of ROS in tumor cells, their detoxification, their biological consequences, and the main signaling cascades they use.
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PMC9844987
TFs follow the same order as in panel A. Figure 2—figure supplement 4.Association between TF binding sites and promoter expression level.
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PMC11701801
Thus, based on genetic abnormality data alone, SMARCA4/SMARCA2-deficient cell lines cannot be often detected.
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PMC11572213
The loss of TET2 function due to mutations is associated with DNA hypermethylation and therefore transcriptional reprograming that promotes leukemogenesis.
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PMC11361748
Conventional CyTOF was performed by the UMICH CyTOF Core.
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PMC10577955
Due to the severe side effects of chemotherapy and radiotherapy in cancer treatment, where non-selectivity is one of their major drawbacks, additionally, multi-drug resistance is a massive challenge in treatment.
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PMC9429973
Human β-defensin 2 (hBD-2) is an endogenous epithelial cell-derived host-defense peptide, which is induced by inflammatory stimuli and possesses both antimicrobial and immunomodulatory functions.
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PMC11576293
Inhibition studies on tumor angiogenesis regulators and wound closure %.
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PMC11545868
These bioactive compounds have potential health-promoting effects through mechanisms of antioxidant, anti-inflammatory, anti-allergic, anticancer, and cardioprotective properties, scavenging free radicals, modulating enzyme activity, inhibiting inflammatory pathways, and modulating cell signaling pathways.
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PMC11607321
In our study, we systematically evaluated and benchmarked MOSA, demonstrating its generative capacity across independent drug response and proteomic datasets and accurately recovering cancer tissue-of-origin clustering.
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PMC11686380
The detected variant was evaluated for its potential pathogenic effect using SIFT, Polyphen-2, Mutation Taster, and CADD Phred score.
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PMC9429973
The primary outcome was the proportion of patients with 0 VOCs during a 1-year follow-up.
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PMC10898159
Physiologically, in addition to interstitial cells of Cajal (ICC), KIT receptor is expressed in germ cells, bone marrow stem cells, melanocytes, and mast cells.
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PMC7192625
AND-ChAs detects preferential contacts involving regions presenting both feature 1 and feature 2.
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PMC11740207
Present in the vascular systems, these cells can differentiate into neuronal cells in vitro.
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PMC6889484
Although the efficiency of gene delivery was not addressed, expression of A3G-D128K alone was shown to provide the strongest protection (100- to 200-fold) from HIV-1 replication compared to human/rhesus TRIM5α and RevM10.
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PMC11180402
Wild-type SOX2 promoter-driven luciferase reporter cotransfected with pRL-TK into 5637 cells. (
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PMC11453018
Following the completion of the ATP viability assays, data were imported into SynergyFinder Plus for synergy score analysis.
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PMC11026382
Error bars (in x and y) indicate standard deviation across three experimental measurements, points are centered at the mean.
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PMC8010066
In the current study, pyocyanin production increased in PA-2 and PA-3.
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PMC9429973
54 patients were diagnosed with COVID19 when Omicron strain was the dominant strain circulating.
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PMC10728200
Generally, GIST patients with high expression of GPX4 may benefit more from IM treatment.
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PMC11591052
Taken together, these data clearly demonstrate 20E-induced glucose uptake, glycolysis, respiration, and ATP production, which are all fully consistent with the RNA-seq data, real-time PCR, and Western blot results, indicating the up-regulation of energy metabolism.
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PMC11741906
7 Kaplan–Meier (KM) overall survival analysis for ovarian cancer patients based on the expression of hsa-miR-133b, hsa-miR-512, hsa-miR-200b, and hsa-miR-451a.
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PMC8143558
Therefore, only the antimicrobial activity that is attributed to purified saponins and saponin-enriched extracts was reported in this review, as evidence of antimicrobial activity of saponins, particularly triterpenoid saponins which exist in abundance in soapy plants.
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PMC9219615
However, the molecular mechanism by which this unique compound induces cell death was not explored.
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PMC9817179
Simulations based on the model suggest that protein localization in fixed cells depends on an intricate balance of protein–protein interaction dynamics, the overall rate of fixation, and notably, the difference between fixation rates of different proteins.
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