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BioData-CellLine_annotated

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PMC9014716
The intensity of the regulation between miRNA and mRNA seems to be mild.
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PMC9429973
The 5-year OS rates for pts age 60-69 without poor-risk cytogenetics (n=37), age 60-69 with poor-risk cytogenetics (n=13), age ≥70 without poor-risk cytogenetics (n=24), and age ≥70 with poor-risk cytogenetics (n=6) were 69%, 39%, 36% and 0% respectively (Figure 1C).
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PMC10933092
Antisense: AAT​TCA​AAA​AAG​GCA​CTC​AGT​TGA​CCT​TAT​TCT​CTT​GAA​ATA​AGG​TCA​ACT​GAG​TGC​CG.
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PMC11310713
Representative immunohistochemistry images of the expression of p53 and PTEN as cancer markers and the expression of KI67 as a proliferation marker.
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PMC11459296
This study establishes a fast, efficient, and reliable in vivo platform for various applications in cancer immunotherapy, particularly for exploring the complex interactions between cancer cells, immune cells, and the tumor microenvironment in vivo, prior to clinical development.
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PMC9429973
SPINK2 associated with IR cytogenetics (P=0.014), normal karyotype (P=0.019) and NPM1 mutation (P<0.001), while SPINK2 with t(8;21) and CEBPA double-mutation (both P<0.001).
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PMC9351137
Spastin is a key player in microtubule severing, ensuring the final cut at the midbody , whereas α-tubulin is a major component of spindle and midbody microtubules.
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PMC10253553
This was associated with a significant reduction in 786-0 cell viability compared with 786-0 cells transfected with non-targeting control siRNA (Figure 5D).
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PMC11127909
B–D WB was used to detect BAX expression in the mitochondrial and cytosolic fractions of 143B-V, 143B-EFHD1, 143BR-shV and 143BR-shEFHD1 cells, N = 3.
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PMC11707577
Because of their excellent electron transport properties, optical properties, soft material nature, stability, solution processability, and water dispersibility, TNPs have recently demonstrated their enormous potential as therapeutic , , , , , , , (photodynamic, PDT; sonodynamic, SDT and photothermal, PTT) and imaging , , , , , (fluorescent and photoacoustic imaging) agents in nanomedicine.
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PMC11448304
Subsequently, we adopted transcriptome, quantitative proteome and lysine 2-hydroxyisobutyrylome to construct a differential profile on the transcriptional to post-tanslational levels on A549 and RA549 cell lines, respectively.
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PMC11621493
The human PLA2G4D gene was first identified and cloned in a study investigating differently expressed genes in psoriatic skin (30).
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PMC5311252
Protein extracts were digested using trypsin (Thermo Fisher Scientific, 90058) using a filter-aided sample preparation protocol.
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PMC6461034
In this context, with heterogeneity and plasticity of kinase signaling in a specific tumor at a specific time, it is essential to have an overview of hyperactive kinases and prioritize ones that (help) drive malignancy to maximize therapeutic success and minimize expensive failures and unnecessary burden for the patient.
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PMC11727145
One of these growth factors, EGF, plays a crucial role in promoting cutaneous healing through its high capacity for stimulating cellular proliferation, as demonstrated in our previous experiments.
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PMC11755624
The increased expression of nuclear paraspeckle assembly transcript 1 (NEAT1) in the skin cells of psoriasis patients affects the activity of transcription factors during epithelial differentiation .
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PMC11499381
In the absence of RAMP co-expression, CLR is trapped intracellularly and unable to respond to peptide stimulation.
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PMC11686380
Coronal sections were prepared and stained for GFP at P7.
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PMC4270159
Mix Super Signal West Pico Chemiluminescent Substrate solutions in equal proportions and add it to the blot.c.
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PMC9429973
Each cohort will initially enroll 6 pts for 1 cycle (28 days) to assess dose-limiting toxicities and determine the recommended phase 2 dose (RP2D).
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PMC9429973
As incorporation of AZA into DNA is S-phase-restricted, extended Oral-AZA dosing regimens (> 7d/28d Tx cycle) increase drug incorporation into cycling tumor cells to prolong epigenetic activity throughout the Tx cycle [Laille 2015].
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PMC8806312
In summary, we developed a 4-gene-based risk model for OS prognosis prediction via a thorough analysis of IRGs.
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PMC8992508
Therefore, they can be considered dual P-gp/BCRP inhibitors.
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PMC11395280
Following receptor internalization, the cells were plunged into 10-fold ice-cold cRPMI/2% bovine serum albumin and allowed to rest on ice for 10 min.
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PMC11190062
First-line treatment often includes a combination of drugs of different classes, including proteasome inhibitors (PIs), immunomodulating drugs, monoclonal antibodies targeting CD38, and corticosteroids (1).
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PMC9429973
Treatment-emergent AEs were graded per Common Terminology Criteria for AEs v5.0.
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PMC11683240
Therefore, CHO cells were seeded in 10 cm culture dishes and grown for two to three days.
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PMC9429973
Image: Summary/Conclusion: With the continuing improvement in OS, a higher proportion of MM patients are likely to develop SPM.
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PMC9739791
Photoabsorbers with different maximum absorption wavelengths were used to obtain Pt(IV) prodrugs with controllable photoactivation.
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PMC11541241
Even so, we have much yet to learn.
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PMC11738017
All cases of disease progression as a consequence of antigen escape occurred after an initial response that lasted at least 6 months (median PFS, 10 months; Figure 1D).
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PMC4005030
Safety of the whole plant was concluded in the review.
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PMC11723947
i Percentage of Foxp3 cells among WT or HP1γ KO TCR Vβ6 Tconv, as determined in the spleen 21 days after engraftment.
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PMC5415764
The intracellular concentration of PTX was decreased in the presence of P-gp which led to a reduction of anticancer efficacy in cancer cells.
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PMC11547972
However, superior effects, compared to the monodrug treatment, were only reflected in a G0/G1 increase and loss of G2/M in A498 cells.
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PMC8740518
Based on all differential metabolites, 19 metabolic pathways were enriched.
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PMC11013014
Compounds 2 and 3 are more stable in the human glutathione S-transferase P1-1 pocket than EA because the binding affinity value of the reference compound is greater than the binding affinity values of the synthesised compounds 2 and 3.
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PMC9429973
Total activation frequency of at least one herpesvirus was 80%.
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PMC9429973
In addition, as shown in figure, age at onset ≥ 49 years (HR=2.54, 95%CI 1.51-4.27, p<0.001) and SRC (HR=3.27, 95%CI 1.37-7.79, p=0.008) were proved to be the independent predictors to determine the 20-year incidence of anemia in SSc, while positive anti-centromere proteins (HR=0.42, 95%CI 0.24-0.76, p=0.003) seemed to be a protective factor.
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PMC9429973
Around 16% of hem/oncs improved and 64% reinforced (confirmed) their knowledge regarding the most recent data with epigenetic agents in patients with B-cell lymphomas, with 81% knowing this information post-education (P=0.251).
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PMC10530622
For instance, in vitro models of renal epithelial cells, including the MDCK cell line and human proximal tubular epithelial cells (RPTEC), were used to demonstrate that oxalate exposure (0.35 mM) promotes inflammation by increasing cyclooxygenase 2 (COX-2) and facilitating NF-κB activation via the degradation of IκB-α, respectively .
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PMC11367146
Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genome (KEGG) analysis were carried out on intersecting targets to understand the biological functions of the target genes in OA.
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PMC9429973
It is perhaps not surprising as these two disease groups also had the highest mean patient ages.
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PMC11412721
Right, comparison of the ACKR4 proteins encoded by WT alleles from BL Raji control cells (center), or by the 4.14a (top) and 4.14b mutated alleles (bottom).
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PMC8270637
All animal studies were approved by the Institutional Animal Care and Use Committee of Anhui Medical University.
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PMC7602170
Two rapamycin analogs used in clinic are everolimus (RAD001) and temsirolimus.
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PMC11257988
G12D continuously activates downstream pathways, mainly through the RAF/MEK/ERK signaling pathway, leading to abnormal cell proliferation.
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PMC11381192
The discriminative performance of the nomogram model was evaluated using receiver operating characteristic (ROC) curves.
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PMC9927933
Importantly, UBE2C is expressed at relatively low levels in many normal tissues, but at high levels in human carcinomas derived from the lung, uterus, bladder, and stomach (12), and high UBE2C expression is associated with worse overall survival of lung cancer patients (17–20).
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PMC11476837
Although the NRF2–KEAP1 signaling pathway plays a cytoprotective role in normal cells and tissues, its aberrant activation has been demonstrated in many types of tumors such as lung, breast, head and neck, ovarian, and endometrial cancers .
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PMC10391797
Percentages of CD123 and CLL-1 expression on PBMCs/BMMCs of patients with AML (n=40) and healthy donors (n=5) detected by flow cytometry.
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PMC6600253
Other studies demonstrated that the inhibition of HSP90 could lead hTERT to be ubiquitinated and degraded by the proteasomal pathway, and reduce DNA extension by telomerase .
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PMC9429973
Likewise, no differences were shown in Ly subsets of R before and one month after the third dose (Fig.1H).
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PMC9429973
Associations were investigated by Chi-square or Fisher exact test.
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PMC9429973
The survey was conducted in France, Germany, Italy, Spain, the United Kingdom (UK) and Canada between Jan-May 2021.
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PMC11286266
All statistical analysis was performed by a two-sided unpaired Welch’s t-test and significance is indicated by asterisks (****p < 0.0001; ns: non-significant). (
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PMC10654497
We used consensus clustering to classify patients with lung cancer into two subgroups (cluster1 and cluster2).
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PMC7823217
Bioprinted cancer models containing patient-derived cancer and stromal cells is promising for personalized cancer therapy screening 3D bioprinted constructs form physiologically relevant cell–cell and cell–matrix interactions.
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PMC11298021
The data revealed that more than 75% of Jurkat cells were successfully transfected with FAM-labeled Scramble (Fig. 4B).
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PMC6160470
Data analysis was performed using FlowJo software (TreeStar Inc.).
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PMC9516447
Fig. S2B, C).
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PMC9512971
This study was conducted to investigate whether camostat mesilate is an effective treatment for SARS-CoV-2 infection (COVID-19).
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PMC11342785
To explore this systematically, we built a blue-light triggered TPPP clustering system in 3T3 cells to reconstitute TPPP activity from the bottom-up (Fig. 3A).
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PMC7185206
Wild-type 786–0 renal cancer cells were grown in conditions known to induce sPD-L1 production (density 10 cells/ml with interferon-γ or density 10 cells/ml with vehicle control) in the absence or presence of ADAM10/ADAM17 inhibitor TAPI-0 over 48 h. Supernatants were collected and assayed for sPD-L1 by ELISA.
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PMC9429973
RFS was significant when adjusting for NPM1 mutation status or FLT3 mutation status using multivariable cox regression model with RFS being better with CPX-351 compared to FLAG-Ida (HR:0.58, 95% CI0.36-0.95, p=0.03).
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PMC8875242
However, both approaches had limitations, indicating that inhibitory potency should be tested with at least these two ABCB1 probes.
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PMC9429973
The differences between sperm concentration, % progressive motility and % total motility were all non-statistically significant (p = 0.457, 0.535, and 0.574, respectively).
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PMC11798926
Regardless of treatment, all cells were then rinsed three times with ice cold PBS (+1 mM CaCl2, 0.5 mM MgCl2) and fixed with prechilled 3% glyoxal solution (Richter et al., 2018) for 30 min at RT, followed by one rinse with PBS, quenching with ammonium chloride (50 mM) for 15 min, permeabilization with 0.1% Triton X-100 and blocking with BSA for 60 min (all diluted in PBS).
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PMC11748363
In general, for all groups, derivatives with non‐chlorinated pyridine (R = H) were the least cytotoxic against the HepG2 cell line.
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PMC9454178
CDK inhibitors are of great interest as novel therapeutic agents against cancer, and several CDK inhibitors have been applied in the clinic.
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PMC11790971
Second, the classification performance may benefit from larger datasets and further refinement of ML models.
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PMC11644761
It suggests that an abnormal re-entry of neurons into the cell division cycle may precede the pathological changes leading to neurodegeneration .
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PMC11224020
d, Pathway analysis of differentially expressed genes in confined versus LPS-treated DCs; arrow width corresponds to the enrichment score from the significantly enriched (P < 0.05) genes.
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PMC9429973
Summary/Conclusion: In our series, the DIC rates are correlated with that of the literature, as well as early death rate.
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PMC11496491
In the context of angiogenesis, CXC chemokines are a unique family of cytokines known for their expression in different ways in the regulation of angiogenesis.
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PMC11461874
Proteins (24 µg) in the solution were reduced with final 10 mM DTT at 60 °C for 30 min, and then alkylated by incubation with final 22 mM iodoacetamide [IAA] at 37 °C for 30 min in the dark.
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PMC10898159
Other new drugs targeting KIT mutations in gastrointestinal stromal tumors: Avapritinib, Larotrectinib, Entrectinib, Bezuclastinib, Carbozantinib, Sorafenib.
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PMC10914904
In the serum of patients with hematological malignancies, vtRNA 1-1 and 2-1 are predominantly expressed .
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PMC9429973
Statistical analyses were performed using SPSS.
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PMC9429973
Methods: Splenectomized 4.2 mice (2.5 months of age) were either treated with vehicle or mitapivat at dosages of 100 mg/kg/day over 4 months.
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PMC11640555
Furthermore, knowing that CK2 controls NFs by the direct activation of cascade transduction signaling and BDNF or NGF released by glioma cells promoting tumor growth depending on the presence of microglia , we found a link that exists between neurotrophins-induced signals and regulation of CK2.
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PMC9429973
Mean age was 59±12.7 and 51±15.6 respectively; 68.2% male, 31.8% female.
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PMC11767725
Neural inputs that regulate microvascular tone and glandular activity are also disrupted, creating patchy areas of skin with distinct microbial communities.
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PMC11222184
SOD1 is an important antioxidant with oncogenic effects in many cancers and is overexpressed in various cancers. .
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PMC9429973
However, TKI resistance occurs frequently while the underlying mechanisms remain incompletely understood.
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PMC11277157
We transfected HEK293 cells by siRNA as a negative control (using esiRNA-RLUC, see Section 3) and the siRNA methodology for PARK7 (see Section 3).
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PMC11754432
In addition to ALA, treatment of skin equivalents with ω-3 PUFAs is associated with reduced inflammation.
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PMC9429973
Image: Summary/Conclusion: Both the IPSS-R cytogenetic risk group and the complexity of the 5q- karyotype showed prognostic impact in patients with del(5q).
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PMC10820104
In contrast to the standard-of-care treatment paclitaxel, for which IC50 values in the low nanomolar range are reported , compounds 1 and 4 display only moderate cytotoxic efficacy levels, with IC50 values of 25.8 and 23.4 µM, respectively.
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PMC9352806
L1 worms were supplemented with BMS (100 μg/mL) for 48 h in daf-16 and hlh-30 deficient mutants, and hlh-30 interfered worms.
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PMC11116779
The samples were thermostated for 2 min at 25°C before measurements, which were performed in a 2.5-mL disposable cuvette and then analyzed in triplicate using a 175° detection angle.
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PMC11789597
Most drugs promote the expression of CAV1, but one to two dozen drugs inhibit it (Figure S9A, Supporting Information).
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PMC11388384
Immunoblotting was performed using standard procedures.
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PMC8633974
The research received support from National Institutes of Health grants T32 NS105594, 5R01MH121402, 1R01Al158160, R01 DA054535, PO1 DA028555, R01 NS126089, R01 NS36126, PO1 MH64570, P30 MH062261, and 2R01 NS034239.Research in contextEvidence before this studyClustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (Cas9) approaches were used to eliminate latent integrated proviral DNA from human cells in infected humanized mice.
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PMC11623887
We previously showed B19V decreases the BFU-E and CFU-E progenitors that produced by hematopoietic stem cells that were cocultured with infected mesenchymal stem cells with the virus.
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PMC10440586
gray lines connect the samples before and after the treatment of the same patient. (
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PMC7351993
Here we demonstrate Raman image-activated cell sorting by directly probing chemically specific intracellular molecular vibrations via ultrafast multicolor stimulated Raman scattering (SRS) microscopy for cellular phenotyping.
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PMC11705862
Cells were grown in BDNF-containing neurobasal medium for a minimum of 4 days, and the medium was refreshed daily.
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PMC5308810
When compared to CXCR4, CXCR4 also produced larger and more colonies in a soft agar assay.
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PMC9429973
Four of the patients had no difference in the mean telomere length between diagnosis and remission and these are the only with disease relapse.
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