Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC9429973
Lastly, mononuclear cells in viability from AML or healthy donors were cultured in vitro for dose-response curves to Yoda-1 and GsMTx4 and in methylcellulose to analyse the phenotype and proliferation under those treatments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594806
They also discovered that an AKT inhibitor could potentially reverse CD73-induced GEM resistance.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "also", "discovered", "that", "an", "AKT", "inhibitor", "could", ...
PMC5173112
Representative images of sphere formation assay in 786-O and A-704 cells treated with 100 ng/ml IL-8. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "sph...
PMC9429973
Various studies worldwide have shown correlation between Cmin (trough levels) and incidence of pleural effusion.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Various", "studies", "worldwide", "have", "shown"...
PMC11681005
FOXA1 is known to be a master pioneering factor that is differentially expressed in muscle‐invasive bladder cancer (MIBC) downstream of BMP signalling and determines tumour phenotype.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540611
The cells that fluoresce in the 7AAD channel are cells in an early stage of necrosis (phosphatidylserine has not yet been released to the outer membrane, but there are pores in the lipid bilayer where 7AAD freely passes).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10551595
Cytotoxic effect of Dexa on patients' primary cells when combined with GinA. Patients primary cells were treated with 10 μM GinA and 100 μM Dexa alone or combination of 100 μM Dexa and 10 μM GinA for 48 h. Results were reported as mean ± SEM of nine independent experiments performed in triplicates.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10178190
uPAR is shed from the cell surface, and its soluble form , soluble urokinase plasminogen activator receptor (SuPAR), has been detected in several human body fluids.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394730
It is present in a wide range of fruits and vegetables, including peanuts, grapes, and sprouts.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "present", "in", ...
PMC11247842
To better represent the genomic features across the genome, we collected coordinates for 5ʹ UTR regions, 3ʹ UTR regions, general transcripts, CpG islands, and 13 putative regulatory elements across eight tissues .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271800
They have important implications for tumor progression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "have", "important", "implications", "for", "tumor", "progression", "." ] } ]
PMC11727145
Images were imported using the “File > Open” command, and the region of interest was defined using the ellipse selection tool.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11248911
The cells were seeded in 24-well culture plates at a density of 2 × 10 cells per well in 500 μL volume and allowed to grow for 18 h before treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678
Right: Fluorescence intensities of STAU1 and PABPC1 or RPL7a were quantified along a line drawn in the magnified boxes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ":", "Fluorescence",...
PMC9429973
N. Short, H. Kantarjian, M. Konopleva, N. Jain, F. Ravandi, X. Huang, W. Macaron, W. Wierda, G. Borthakur, T. Kadia, K. Sasaki, G. Issa, G. Montalban-Bravo, Y. Alvarado, G. Garcia-Manero, C. Dinardo, J. Thankachan, R. Delumpa, E. Mayor, W. Deen, A. Milton, J. Rivera, L. Waller, C. Loiselle, R. Garris, E. Jabbour Department of Leukemia; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, United States of America Background: Ponatinib and blinatumomab are both highly effective therapies for Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
The evolution of TP53-mutated clones was assessed by longitudinal NGS analysis of sequential PB samples collected from 38 patients (16 relapsed, and 22 on treatment) corresponding to 127 TP53 mutations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11180402
A point mutation was introduced into the miR-129 binding site within the 3'-UTR of SOX2 mRNA in the luciferase reporter, employing the following specific primers: sense: 5'-ACT GTT AAA AGC TTT AAT GGC CAT GCA GGT-3'; antisense: 5'-ACC TGC ATG GCC ATT AAA GCT TTT AAC AGT-3'.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5417661
Blood samples were collected from three animals (tail vein or orbital sinus) per group in ethylenediaminetetraacetic acid-coated collection tubes (Sarstedt AB, Helsingborg, Sweden) and plasma was separated by centrifugation at 2,000× g for 5 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8427838
Plasmids were expressed in E.coli and GST-fusion proteins were purified from E.coli via glutathione Sepharose Fast-flow resin per manufacturer’s recommendations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plasmids", "were", ...
PMC6379402
All cell lines were maintained under standard conditions, 37 °C, 5% CO2 and appropriate media.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "lines", "were", ...
PMC11088135
The next day, the membranes were washed with TBS containing 1% Tween, followed by incubation with the corresponding secondary antibodies for 2 h at room temperature.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824
Animal well-being and behavior, including grooming and ambulation were monitored at least twice per week.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Animal", "well-being", "and", "behavior", ",", "includ...
PMC9429973
Most common AEs for gilteritinib were anemia (76.1%), thrombocytopenia (46.9%), pyrexia (41.6%), and increased blood lactate dehydrogenase (41.6%); for SC, most common AEs were anemia (64.4%), decreased white blood cell count (41.3%), and thrombocytopenia (38.5%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11155445
Whilst compounds (153a and 153b) exhibited prominent activity against α-glucosidase with IC50 values of 68.3 ± 0.11 and 90.3 ± 1.08 μM, respectively (Fig. 80).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Anemia, hypercalcemia (serum calcium > 2.6 mmol/L) and/or renal impairment (serum creatinine > 133µmol/L) was present in 66%, 66% and 33% of patients respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190238
In the context of dynamic and preformed loops, what are the implications that might arise from such chromatin conformation models during the transition from epithelial to mesenchymal state?
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Laboratory tumor lysis syndrome (TLS) was observed in 1 pt with a known history of chronic kidney disease treated with 160 mg x 10 day; pt was asymptomatic and TLS resolved within 4 days.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525293
C A431 cells were treated or not with LPS 0.5 μg/mL for 2 h. Cell extracts were prepared and analyzed by WB using anti-ACE2 and anti-p63 Abs.
[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014
Emetine's ability to inhibit HCMV was dependent on RPS14 binding to MDM2, which disrupted virus-induced MDM2-p53 and MDM2-IE2 interactions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emetine", "'s", "...
PMC11063646
92113.9213.030.006927.49127.49137.75<0.00013.081E + 0713.081E + 07247.22<0.0001B2.5712.572.410.15940.292010.29201.460.28052.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "92113.9213.030.006927.49127.49137.75<0.00013.081E", "+", "0713.081E", "+", "07247.22<0.0001B2.5712.572.410.15940.292010.29201.460.28052", "." ] } ]
PMC11736898
Therefore, CYP24A1 inhibitors may serve as adjunctive therapies to suppress keloid-associated gene expression changes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "CYP24A1", "inhibitors", "may", "serve", "...
PMC9428827
3LL-D122 and 4T1 survival curves from spontaneous metastasis development.
[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3LL-D122", "and", "4T1", "survival", "curves", "from", "spontaneous", "metastasis", "developmen...
PMC11502327
The mechanism of action of natural drug ingredients against OC in recent years is summarized in Table 1 .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanism", "of", "action", "of...
PMC11765678
Furthermore, we found that longer incubations with ER at lower concentrations resulted in significantly higher sensitization to ADR, aligning with our previous findings .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11424574
Analysis of data in TCGA using the TNMplot software showed that the MTA2 protein level was significantly higher in osteosarcoma tissue than in normal tissue (Figure 1C, P < 0.001).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11805741
From the data, we observe that the concentration at which the cell viability is closest to 50% is 1200 µg.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "the"...
PMC10523483
We further evaluate the total H1 and other canonical histone levels (H2B, H3, H4) in clinical lung cancer samples.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC11271800
In contrast to imatinib alone, the combination of PD-1/PD-L1 inhibitor and imatinib can not only promote the production of CD8 T cells and IFN-γ, but also promote the depletion of Treg cells to inhibit tumor cells and inhibiting the polarization of M2-TAMs (Figure 4).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684297
Our previous study demonstrated that coating ZnO nanoparticles with natural polymer chitosan could protect the zebrafish embryos from bare ZnO-induced toxicity .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "previous", ...
PMC11621565
The medium was replaced every 2–3 days, and the cells were subcultured when reaching 90% confluence.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "medium", "was", "replaced", "ev...
PMC9429973
Pts characteristics are summarized in Table 1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "characteristics", "are", "summarized", "in", "Table", "1", "." ] } ]
PMC11381192
GSEA analyses confirmed the enrichment of these significant pathways in the high CSI group, such as DNA replication and chromosome segregation; while pathways activated in the low CSI group included defence response to bacterium, humoral immune response, and migration of granulocyte, mononuclear cell and myeloid leukocyte (Figure 2M,N).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489
These factors correspond to hydrophobicity, size, charge, secondary structure, and heat capacity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "factors", "correspond", "to", "hydrophobicity", ...
PMC9031474
Therefore, it must be determined if the loss of MMP results from the detergent effects of the sesquiterpenoids on the MM or occurs as a downstream event of another apoptotic pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10965315
Trypsin–EDTA, fetal bovine serum (FBS), and RPMI1640 medium were purchased from Gibco (Grand Island, NY, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10577955
The MTT assay is used to verify the observation of growth inhibition of lung cancer cells .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MTT", "assay", "is", "used", "to", "verif...
PMC5173112
To test this hypothesis, we firstly confirmed the upregulation of USP21 in various RCC cell lines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "test", "this", "hypothesis", ",", "we...
PMC11697703
In apical dendrites, the density of mushroom spines was also increased, although this result did not reach statistical significance.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "apical", "d...
PMC7823217
Using a hydroxyethyl cellulose/alginate/gelatin hydrogel and MCF-7-based spheroid bioprinted construct, the anti-breast cancer activity of phosphoramidates (13 amino acid-containing flavone) was examined and the results indicated that alanine structure induced a stronger drug resistance than phenylalanine in the MCF-7 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
In Phase 2, the primary endpoint is the CR rate at the end of the reinduction block.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "Phase", "2", ",", "the", "...
PMC9429973
The ISTH DIC 2018 score was calculated at AML presentation as follows: platelet count (≥100 x 10/L = 0; 50-99,999 x 10/L = 1; <50 x 10/L = 2), fibrinogen level (≥100 mg/dL = 0; <100 mg/dL = 1), PT prolongation above upper limit of normal (ULN) (<3 seconds = 0, 3-6 seconds = 1, >6 seconds = 2), and D-dimer (<3 µg/ml = 0, 3-7 µg/ml = 2, >7 µg/ml = 3).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711871
This effect was blunted by the HSD.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "effect", "was", "blunted", "by", "the", "HSD", "." ] } ]
PMC11714165
The concentration of peptides was 25 µM. D) Quantification of the number of TRAP‐positive multinucleated osteoclasts (≥ 3 nuclei) based on the images in C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626
Fluorescence intensity was measured at the respective excitation and emission spectrum for each fluorogenic peptide using a SpectraMax i3 plate reader interfaced with SoftMax Pro Software Validation Package (Molecular Devices).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11429241
Further optimization of our models therefore implies the reconstruction of a specialized microenvironment by incorporating more complex structures such as vascular networks, immune system elements, and different types of cells (e.g., endothelial cells, fibroblasts, etc.).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10652261
HRMS spectra were recorded on an LCMS-IT-TOF system (Shimadzu, Kyoto, Japan).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HRMS", "spectra", "were", "recorded", "on", "an", "LCMS-IT-...
PMC10998613
Interestingly, whereas the size of the CXCR4 homomultimers is cell line–dependent, β2AR homomultimer size is not.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "wherea...
PMC7154001
The information extracted included: name of anticancer drug or compound/herb, type of studies (in vitro, in vivo, and clinical studies), gender and species of animals used, route and dose of administration of the investigated drugs/compounds, biochemical tools used (liver, prostate, intestine, or kidney microsomes, subcellular fractions, hepatocytes, recombinant enzymes, and whole blood), type of biological samples (plasma, urine, bile, feces, and tumor), and study conclusion.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682172
Data representative of three independent experiments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "representative", "of", "three", "independent", "experiments", "." ] } ]
PMC9429973
Among them NRAS (n=11 of 62, 17.74%), KRAS (n= 8, 12,90%) and PTEN11 (4, 6,45%) were prevalent.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11572213
Statistical analysis and graphing were performed using GraphPad V9 (GraphPad Software, San Diego, CA, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "a...
PMC10998613
This characterization of CXCR4-β2AR multimers in live cancer cells highlights the importance of cellular context as well as the interplay between receptor structure, agonism/antagonism, and oligomerization state on downstream signaling and behavior.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8735881
By genetically linking 10E8 with a fusion inhibitor peptide, we subsequently designed a group of eight bifunctional constructs as cell membrane-based inhibitors, designated CMI01∼CMI08, which rendered cells completely resistant to HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534377
Investigating the molecular mechanisms underlying the effects of 5-Aza (and radiotherapy) could provide valuable insights into NSCLC response and also set the base for further drug repurposing strategies in additional cancer types.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106
Human nociception/orphanin FQ receptor was purchased from Addgene (Watertown, Massachusetts, USA, plasmid #66463), human kappa opioid receptor (catalog number #OPRK100000) and human delta-opioid receptor (catalog number #OPRD100000) were purchased from the Missouri S&T cDNA Resource Center (cDNA.org, Bloomsburg, Pennsylvania, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742431
This innovative approach could pave the way for more targeted and effective cancer treatments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "innovative", "approach", "could", "pave", "the", "way", ...
PMC11583010
A library of 5,828 different expression vectors, each encoding a full-length human plasma membrane protein or a cell surface–tethered human secreted protein, and a library of 398 different human heterodimers were co-arrayed to check for the binding specificity of humanized mAbs 15A7.5 and 5A12.2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11741577
PDGF-AA aids in repair by promoting new blood vessel growth .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PDGF-AA", "aids", "in", "repair", "by", "promoting", "new", "blood", "vessel", "growth", "...
PMC11594641
Here, 1× Laemmli sample buffer was added to the lysates or sEVs before boiling them for 5 min at 95 °C.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11194678
The expression levels were validated by WB.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "levels", "were", "validated", "by", "WB", "." ] } ]
PMC9688728
This key metabolite in glutamine metabolism can play both healing (as a free radical scavenger) and pathogenic (through tumor progression and increased metastasis) roles.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679033
Concentrations they tested were higher compared to ours.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Concentrations", "they", "tested", "were", "higher", "compared", "to", "ours", "." ] } ]
PMC9119314
All animal procedures were carried out under a project license issued by the UK Home Office, and UK National Cancer Research Institute Guidelines for the Welfare of Animals were followed throughout.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Bone pain was more frequent with luspatercept vs placebo (21.6% vs 8.3%), comparable with the primary data cut (19.7%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301242
By integrating RNA-seq and WGS data, we compared the activation markers of histone (H3K4me3/H3K27ac) between circular and non-circular samples, and explored whether the differences would lead to changes in the RNA expression of cancer-related ecDNA genes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718109
COS7 cells were plated on 35 mm gridded, glass-bottom MatTek dish (P35G-1.5-14-CGRD) and transfected as described above.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COS7", ...
PMC9429973
Age >65 (HR 2.2, p<0.001), prior cardiac disease (HR 1.4, p=0.02) and non-intensive chemotherapy (HR 1.8, p=0.004) were associated with increased CI of non-fatal cardiac event.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5963610
Most data available, in this respect, corresponds to experiments performed with the most abundant NAc variant of GM3, and little information exists on the modulation by NGcGM3 of EGFR and uPAR/α5β1 integrin pathways.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Treatment regimens, costs, and hospitalizations were examined overall, and by line of therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "regimens", ",", "costs", ",", "and", ...
PMC11755624
Some lncRNAs are implicated in interesting signaling loops.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "lncRNAs", "are", "implicated", "in", "interesting", "signaling", "loops", "." ] } ]
PMC11297139
Using tumor samples from two independent patients with Ewing’s sarcoma, we performed immunohistochemistry and imaged the localization of ARID1A.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "tumor", ...
PMC11592008
Moreover, in the lysates of irradiated PKs, we detected reduced unprocessed IL-1β and the cleavage of GSDMD upon UVB irradiation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", "...
PMC9429973
Median time from tisagenlecleucel infusion to data cutoff was 16 mo (range, 6-30 mo).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "time", "from", "tisagen...
PMC11789597
IgG1 control antibody (BE0297) was purchased from BioXcell (Lebanon, NH, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IgG1", "control", "antibody", "(", "BE0297", ...
PMC9954564
According to GMDR v.0.9 , the same second-order combination (rs9380142/rs2114511) previously identified by MDR v.3.0.2 was selected as the best model for this disease (signal p-test = 0.0107), allowing for accurately classifying 64% of the individuals in all 10 validation intervals.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
The use of FFP for Warfarin reversal has correctly indicated (> 95%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "FFP", "for", "Warfarin", "reversal", ...
PMC9429973
Patients were mainly affected by multiple myeloma (40%) and lymphoma.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "were", "mainly", "affected", "by", "multiple", "myeloma", "(", ...
PMC11746948
Immunoreactivity was detected using chemiluminescent substrate (Clarity Western ECL Substrate; Bio-Rad).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunoreactivity", "was", "detected", "using", "chemiluminescent", "substrat...
PMC8740518
A total of 377 peaks were obtained, and 187 metabolites were annotated for further multivariate analysis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "377", "peaks", "were", ...
PMC10818573
The Pearson coefficient of the standard curve was above 0.99, and the CT value of the sample was used to calculate the virus concentration.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973
Although cardiovascular diseases (CVD) mortality have been decreasing in the developed countries along the last decade, it is still rising in the developing countries(Popkin, Adair, & Ng, 2012).Egypt has the largest population in middle east and north Africa with significant high CAD mortality rate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7685376
A–F) The mRNA levels of cell cycle related genes in SK-Hep1 cell lines treated with Huaier (0 and 15 mg/mL) for 24 h with or without a knockdown of indicate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767793
Traditional toxicology is based on animal model safety screening, where hazard data are still lacking for 85% of major chemicals that have been in production for decades .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Previous studies have shown increasing expression of oxidative stress markers and antioxidant enzymes in lymph nodes progressing to aggressive lymphomas.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have"...
PMC11733919
Briefly, 5 μL of the sample was mixed with 195 μL of Bradford reagent and incubated at room temperature for 10 min before quantification at λ = 595 nm (BioTek Synergy H1 UV/vis microplate spectrophotometer, Agilent Technologies, Santa Clara, CA, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10745221
Overall, no significant changes in PRMT activity were observed in the revertant cells, suggesting that the involvement of PRMTs in cancer may be through a mechanism distinct from the Hoffman effect.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705630
The number of cells migrated was counted under the microscope.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "cells", "migrated", "was", "counted", "under", "the", "microscope", ...
PMC11726848
The registered levels of oxidative stress 40 min in cells after LDR and HDR irradiations (Figure 6) indicate that mechanisms for the initial development of radiation damage to cells induced by different dose rates are similar.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329237
P<0.05 and **P<0.01 significant difference vs the control group C: control (medium alone); BLM: bleomycin; LOS: losartan; PFD: pirfenidone Effect of BLM, PFD, LOS, and combination of pirfenidone with losartan (PFD+LOS) on A549 cells migration by scratch assay.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11277157
Figure 2B shows the results using dimensional reduction by principal component analysis (PCA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "2B", "shows", "the", "results", "using", "dimensi...