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PMC11381192
Supernatants were harvested after 48 h and used for infecting MM cells.
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PMC8481254
P < 0.0001.
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PMC11547972
The concept of drug targeting with receptor tyrosine kinase inhibitors (TKIs) is also not as efficient as initially thought, due to resistance development .
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PMC9014716
Moreover, miR-224-5p can directly target the 3′-UTR of ABCB1.
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PMC9429973
We hypothesized that Ven-PegC treatment will be safe and effective in the treatment of R/R AML.
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PMC11678368
The presence of trans configurations of the aldehyde group in the 7-azaindole-3-carbaldehyde ligand (7AI3CA) and in the 5-chloro derivative (5ClL) , as well as in metal complexes with these ligands, is confirmed by the Raman spectra of these compounds, where an additional band appears in the C=O stretching region.
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PMC11487720
Extent of cell death was measured by uptake of propidium iodide and by internucleosomal DNA fragmentation using agarose gel electrophoresis.
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PMC10093184
In the current study, MMP-2 mRNA was detected in all cell lines whereas MMP-9 was observed in COS3600B, COS4288, and D-17 cells only.
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PMC11342785
Images were collected at a magnification of 45,000 using 120 kV Talos L120C at UW-Madison Cryo-EM Research Center.
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PMC8992508
In the Hoechst 33342 accumulation assay the 4-methylpyrimidine derivative 58 showed an inhibitory activity similar to the corresponding quinazoline analogue 57 (IC50 = 132 and 134 nM, respectively) demonstrating the high ligand efficacy of this scaffold).
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PMC11552389
Overall, our study underscores the importance of FOXN3 in melanoma biology and highlights its potential as a valuable target for future therapeutic interventions.
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PMC9429973
The overall VTE incidence rate in females and males after MBL/CLL diagnosis was 6.0 (95% CI: 4.0-8.8) and 5.7 (95% CI: 4.1-7.7) higher, respectively, compared to the general population; the risk of VTE was highest in 18–49-year-old MBL/CLL patients (SIR: 16.2, 95% CI: 3.3-47.6) (Figure 1).
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PMC11575040
Subsequently, the pMIR-REPROT-LINC00094 vector was cotransfected with or without miR-1270 mimics into an A2058 cell line by using Lipofectamine 2000 (Invitrogen, Thermo Fisher Scientific).
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PMC11657695
A Heat-map showing color-coded expression of voltage-dependent potassium channels (Kv1)-coding genes in seven Ewing sarcoma cell lines (ES) and six osteosarcoma cell lines (OS).
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PMC10831439
Cytotoxic activity of CD19-CAR-iNKT cells against modified lymphoma cells (n=4).
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PMC11438317
The clarified lysates were preabsorbed on protein G-Sepharose and then incubated with Ab and protein G-Sepharose beads for 1 h. Immune complexes were washed three times in TNE buffer and suspended in SDS sample buffer.
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PMC9429973
Aims: This fact raises the question whether the ANKDR26 c.-140C>G variant is a pathogenic mutation responsible for the THC2 phenotype or, given its frequency, a population polymorphism.
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PMC9429973
We hypothesize that the septal defect is caused by the defective regulation of signalling processes in the neural crest cells, which can also influence thymus development.
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PMC11143482
Mice were randomly divided into three groups: control, 1 × 10 and 3 × 10 cancer cells where n = 3.
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PMC11697065
This pair-wise comparison revealed proteins differentially expressed in high secreting clones for each cell line.
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PMC11528603
Romdoul (Sphaerocoryne affinis) is a flowering plant of the Annonaceae family and has been used customarily in folk medicine.
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PMC9027909
In order to adjust the RNA concentration before complementary DNA (cDNA) synthesis, the concentration of extracted RNAs was determined by a NanoDrop (NanoDrop Technologies, USA) apparatus.
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PMC11575040
U6 was used as a nuclear marker, and GAPDH was used as a cytosolic fraction marker.
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PMC9429973
A. Ortuzar Pasalodos, M. Chicano, F. Díaz-Crespo, P. Muñiz, R. M. Martín-Rojas, I. Gómez-Centurión, J. Menarguez, M. Kwon, J. L. Diez-Martín, I. Buño, C. Martínez-Laperche, M. Bastos-Oreiro Hematology, Gregorio Marañón General University Hospital; Hematology, Gregorio Marañón Health Research Institute (IiSGM); Pathology, Gregorio Marañón General University Hospital, MADRID, Spain Background: MYC rearrangements (MYC-R), genetic hallmark of Burkitt lymphoma (BL), have been identified in 5-15% of DLBCL and 30-60% of high-grade B-cell lymphomas (HGL).
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PMC8524093
In humans and non-human primates, CHIKV primarily targets epithelial tissue in the area of inoculation.
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PMC10507284
First, the tumor microenvironment (TME) score was computed through the ESTIMATE algorithm.
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PMC9429973
Regarding toxicity, 5 out of 22 (23%) patients reported reversible renal (n = 2) and gastrointestinal adverse events (n = 2); one patient developed a non-fatal anaphylactic shock, leading to switch to a different chelator (from DFA to DFX).
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PMC11506670
On a global scale, it ranks third as the most common among the various cancer types, with an estimated 3.2 million cases projected by the year 2040 .
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PMC9856122
There are currently no authorized treatments for several viruses, and immunization is only limited to the hepatitis A virus, mumps, and varicella .
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PMC11583010
Briefly, ThiomAb antibodies in PBS 1× pH 7.4 were reduced with tris (2-carboxy-ethyl)-phosphin-HCl (TCEP), and interchain disulfides were reoxidized by dehydroascorbic acid.
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PMC7570809
In vivo studies have shown that in various types of cancers the expression of some integrins on the surface of neoplastic cells is frequently up-regulated.
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PMC11200978
The freezing block fixture contained a thin coating of ethanol to facilitate uniform thermal contact and heat exchange between sample wells within the block.
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PMC11585254
Mutation of lysine residues within the C-tail of CXCR5 did not impact agonist-stimulated internalization of CXCR5 (Fig. 5C), although we have yet to confirm whether CXCR5 is indeed ubiquitinated.
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PMC11657695
As shown in Fig. 5A, siRNA CT- and siRNA KCNA2- transfected cells display distinct transcriptional profiles, with multiple genes significantly and differentially expressed (Fig. 5A).
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PMC11791203
Level of significance: ***p < 0.001, **p < 0.01.
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PMC11240052
We concluded that miR-211-5p negatively regulated SIRT-1 in ovarian cancer cells.
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PMC11674441
We confirmed a lymphocyte response particularly for HLA class II-restricted neoantigens containing HLA class I epitopes in all cases.
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PMC9429973
N. Burdenko, Moscow; Department of Hospital Therapy, Russian Military Medical Academy of the Ministry of Defense of Russia, St. Petersburg; Cardiology Center, “3 Central Military Clinical Hospital named after A.A. Vishnevsky” of the Ministry of Defense of the Russian Federation, Krasnogorsk; Hematology Center, Main Military Hospital n.a.
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PMC11674834
Alkylanilines, including 3,4-DMA, are classified as category 3B carcinogens .
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PMC10362265
On the other hand, the same complex from the computed models did not show any RG or SASA changes, implying a link between the backbone dynamics of the human heterodimer and conformation of the surface epitope encompassing the residues 68–81.
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PMC9516401
Similarly, our research showed that the treatment of cells with C. verum extract did not display a change in the expression or activity of IDE (Khedr et al., 2020 ▶).
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PMC11792888
Cells were incubated for 10 min at 4°C in the dark, and apoptosis was detected by flow cytometry and analyzed with FlowJo software.
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PMC4816271
Murine antibody 14.18-derived scFv used in previously described GD2 CARs may be a target for immune rejection either due to anti-idiotype (since therapeutic mAbs in current clinical use are derived from the same clone), or from anti-mouse antibodies.
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PMC11055510
Moreover, circRNA_000839 regulates hepatocellular carcinoma (HCC) invasion and migration through the miR-200b–RhoA axis (Wang et al., 2017a).
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PMC8956657
Fig. 3Mutations to key residues at the MERS ORF4b binding interface change the binding mechanism to canonical Lys P2 site.
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PMC11496491
In this study, four differentially expressed genes in postoperative tissue samples of TCTD were selected for qRT-PCR verification, so as to confirm their consistency with transcription sequencing results and further prove the reliability of NGS results.
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PMC10823017
The bar graphs (B, C) indicate the densitometry of the total PKCs and p-PKCs as a percentage of control.
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PMC9429973
S. Sucha, A. Sorf, M. Svoren, D. Vagiannis, F. Ahmed, B. Visek, M. Ceckova Department of Pharmacology and Toxicology, Charles University, Faculty of Pharmacy in Hradec Kralove, Hradec Králové; 4th Department of Internal Medicine - Hematology, University Hospital Hradec Kralove, Hradec Kralove, Czechia Background: In AML, therapeutic outcome of anthracycline-based induction therapy often can be compromised by a resistant phenotype associated with overexpression of ABCB1 transporters.
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PMC9429973
Results: TNF-α (-308) gene variant GA genotype (high expression), IFN-γ (+874) gene variant TT genotype (high expression), IL6 (-174) gene variant GG genotype (high expression), TGF-β1 (T10/C10) gene variant TT genotype, TGF-β1 (C25/G25) gene variant GC genotype, IL10 (-1082) gene variantGG genotype, IL10 (-819) gene variantCC genotype and IL10 (-592) gene variantCC genotype was significantly higher in HL patients compared to healthy controls (respectively; OR= 0.3636, p= 0.0259; OR= 0.3164, p= 0.0349, OR= 0.4189, p = 0.0299, OR= 0.4329, p= 0.0257, OR= 0.4889, p<0.001, OR= 0.4189, p= 0.0299, OR= 0.3951, p= 0.0193, OR= 0.3951, p= 0.0193).
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PMC10926885
Finally, we thoroughly examined the interactions between DCTN1 and NDE1 and PAFAH1B1 with NDE1.
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PMC11721295
These immune changes were distinct from what we observed in the orthotopic lung cancer model, where KP-derived cells (KPL-86) were implanted into the lung and mice treated with MRTX (Supplemental Figure 4D).
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PMC8270637
Animals were maintained in a pathogen-free environment (23 ± 2°C, 55 ± 5% humidity) on a 12-h light/dark cycle throughout the experimental period.
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PMC11489175
Medicinal chemistry efforts in the field will provide also therapeutic opportunities in other diseases because DUBs have been shown to contribute to the pathogenesis of other diseases such as neurodegeneration 141.
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PMC9429973
IM and NCM are collectively referred to CD16 monocytes, which has been studied in many inflammatory diseases.
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PMC11607764
They exhibit aberrant expression in various types of tumors and are closely associated with patient prognosis and clinical features.
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PMC3888431
Taking advantage of the different abilities of the assembler tools used and merging the results of all the different assemblies, a CHO cell transcriptome data set as complete as possible has been created.
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PMC11095939
F–H) The effects and corresponding quantification of Mecp2 OE on quiescence exit and liver regeneration were assessed by WB of Mecp2, pRb, and Cyclin D1 (F), IF staining of Mecp2 (red) and Ki67 (green) in liver sections (G), and liver index at the indicated time points (H). (
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PMC11367146
1 Gene expression levels between normal and Osteoarthritis patients were taken from the Gene Expression Omnibus (GEO) database.
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PMC11695623
We download the clinical information of LUAD patients through TCGA database to analyze the relationship between different clinicopathological features and DCUN1D5 expression.
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PMC11796104
Gender-specific SBNO2 was identified as a potential target for osteoporosis development in male ankylosing spondylitis patients .
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PMC11247842
The first variant is a SNP and the second one is a deletion.
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PMC9429973
Responses were generally early, durable and CRs were maintained off-therapy.
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PMC11648299
Retinoids were defined using the ATC codes D05BB02 (acitretin) and D10BA01 (isotretinoin) in the time period of January 1, 2006 to December 31, 2019.
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PMC9429973
Importantly, inter-device variability has been reported to be high.
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PMC10728200
Our results demonstrated that the CI values in both GIST-T1 and GIST-882 cells were <1, implying that RSL3 exerted synergistic effects with IM in both GIST-T1 and GIST-882 cells, offering an advantage of the combination treatment (Fig. 5B).
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PMC8041314
A biological hit rate of 21.7% is common for single-target computational approaches as reported in the literature that subsequently validated their postulations with biological studies.
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PMC11568601
TUNEL staining was conducted to evaluate nuclear fragmentation.
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PMC11365427
Tumor nodules in NOG mice injected with NCI-H929 cells. (
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PMC11786704
TUNEL staining images indicating apoptosis levels in NIH3T3 cells under various treatments. (
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PMC9895440
f RT-qPCR quantifications of mRNA for NR4A1 and NR4A3 in cells on day 6 of the Tex culture.
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PMC8956657
Purification of complexed proteins were performed by passing cleared lysate over a HisTrap 5 mL column using binding buffer (50 mM phosphate buffer pH 8.0, 300 mM NaCl, 20 mM imidazole), washing with 15 column volumes of binding buffer, and elution using a gradient elution over 5 column volumes to reach 100% elution buffer (50 mM phosphate pH 8.0, 300 mM NaCl, 500 mM imidazole).
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PMC11703992
IL36A and IL21 actively participate in autoimmune disease, activating downstream pro-inflammatory pathways, thus promoting inflammatory responses.
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PMC10560648
The apoptotic effect of Cassiopea andromeda Venom (250 µg/mL) on Jurkat cell versus control group after 72 hours.
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PMC11443022
Calcification is visible in the midline of the scrotum, positioned just below the penis. (
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PMC11185260
Kaplan–Meier survival curves of mice.
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PMC10975211
Like buforin II, it interacts with the gangliosides in cancer cells, enters the cell without rupturing its membrane, and triggers mitochondrial apoptosis by activating caspase-9 through mitochondria-dependent pathways .
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PMC9429973
Data by Herbrecht et al. (Ann Oncol, 2013, 24:2618) comparing R-CHOP as first line treatment for DLBCL with R-CPOP (substituting doxorubicin with pixantrone, 88 mg/m) resulted in similar PFS with reduced grade 3 CHF rates.
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PMC11139449
The objective is to increase the culture lifespan and maximize productivity for industrial applications ( 3 ).
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PMC11765243
The administration of these inhibitors in vivo inhibits immune responses against protein antigens.
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PMC11621565
The data are shown as fold increase to control, each of the controls is considered = 1.0, which explains why in (A) there is only one control bar and in (B) there are three control samples (CTRL Rha LPS, CTRL CsgA PSM, CTRL Rot).
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PMC11766309
Different mutation patterns and signatures reflect specific genetic backgrounds.
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PMC11615101
To strengthen our findings, the infiltration of immune cells into the synovium was also validated by histological analysis using H&E staining (cytosol in pink, and nucleus in blue) (Figure 7A, lower panel).
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PMC10891340
Our data show that DPV can induce upregulation of apoptotic factors (Figure 6), but CCCP treatment results in the suppression of apoptotic factor transcript expression levels.
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PMC9065483
All raw data, including uncropped western blot images and data values, have been deposited at Mendeley Data and are publicly available as of the date of publication (https://doi.org/10.17632/zzpvtnmdw7.1).
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PMC11422497
More recently, miR-494-3p has emerged as a significant member of the miR-494 family.
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PMC10040136
The upper surface of the filter was cleared of cells.
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PMC9220170
The length of the amplified cDNA fragments was in the range of 150–300 bp.
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PMC9847912
Mean IC50 values for these four HIV-1 strains ranged from 1.5 to 2.8 nM (Table 2).
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PMC8316344
TRIB2-FLAG-, βTrCP-FLAG-, TRIB2-single guide (sg) RNA-, PSMB5-sgRNA-, Cas9-, Ub-HA-expressing plasmids were generated from our previous studies .
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PMC9599726
After drug treatment, 10 μL of WST-1 reagent was added and plates were incubated at 37 °C for either 2 h or 3 h for GIST882 and GIST48 cells, respectively.
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PMC11576293
Yield 72%; m. p. 213–215°C; H NMR (300 MHz, CDCl3) δ (ppm) = 8.14 (d, 2H, Ar-H, J = 9 Hz), 7.72 (m, 3H, Ar-H and pyrimidine–C5-H), 7.43 (d.d.,
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PMC11756907
Results of the transcutaneous GO diffusion test presented as chromatograms (A) calibration curve for GO; (B–D) chromatographic results for samples taken after 0.5 hour of diffusion (three repetitions); (E–G) Chromatographic results for samples taken after 1 hour of diffusion (three repetitions).
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PMC11705862
This result could be explained by the fact that astrocytes express the same SNARE proteins isoforms as those present in neurons e.g. SNAP-25 or VAMP-2 .
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PMC9429973
A.-M. Leppä, K. Grimes, H. Jeong, T. Boch, D Karpova, A. Jauch, F. Grünschläger, A. Dolnik, L. Bullinger, A. Krämer, A. D. Sanders, J. O. Korbel, A. Trumpp Division of Stem Cells and Cancer, German Cancer Research Center; Genome Biology Unit, European Molecular Biology Laboratory; Institute of Human Genetics, University of Heidelberg, Heidelberg; Hämatologie, Onkologie und Tumorimmunologie, Charité Universitätsmedizin Berlin, Berlin; Molecular Hematology/Oncology, German Cancer Research Center, Heidelberg, Germany Background: Acute myeloid leukemia (AML) with complex karyotype (CK) is a heterogenous AML subgroup with dismal response to standard treatment.
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PMC9429973
In refractory disease, splenectomy, or administration of TPO agonists can be considered.
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PMC11543853
For these viruses, the dissociation is likely triggered by conformational changes to the receptors or virus capsid proteins induced by acidification or changes in ion concentrations in the lumen of maturing endosomes.
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PMC10874773
No.CompoundsActivitiesSourceReferences1MinwanensinI. minwanenseFukuyama & Huang, 200523-Acetoxy-14-n-butyryloxy-10-deoxyfloridanolideI. floridanumFukuyama & Huang, 2005314-Acetoxy-3-oxofloridanolideI. floridanumFukuyama & Huang, 2005413-Acetoxy-14-butyryloxyfloridanolideI. floridanumHuang, Yang, Takahashi, & Fukuyama, 2000513-Acetoxy-14-(n-butyryloxy) floridanolideI. floridanumSchmidt, Schmidt, Müller, Peters, & Fischer, 19986(1S)-MinwanenoneCytotoxicityI. minwanenseFukuyama & Huang, 20057(1R)-MinwanenoneI. minwanenseFukuyama & Huang, 200583,4-Dehydro-13,14-dihydroxyfloridanolideI. floridanumFukuyama & Huang, 200593,4-DehydrofloridanolideI. merrillianumHuang, Yang, Takahashi, & Fukuyama, 2000103β,14-Dihydroxy-10-deoxyfloridanolideI. floridanumSchmidt, Okuyama, & Fronczek, 19991114-O-BenzoylfloridanolideCytotoxicityI. dunnianumYadav, Mondal, & Ghosh, 2011123β-Acetoxy-14-n-butyryloxy-10-deoxyfloridanolideI. floridanumSchmidt, Schmidt, Müller, Peters, & Fischer, 1998131,6-Dihydroxy-3-deoxyminwanensinI. merrillianumHuang, Yang, Zhao, Takahashi, & Fukuyama, 200414Dunnianolide AI.
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PMC9599726
Each membrane was blocked with Intercept blocking buffer PBS (Li-Cor, Lincoln, NE, USA, Cat# 927-70001).
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PMC10809689
The most mRNA expression of GLS and GDH in HL-60 cells was seen at 72 h after Gal-9 treatment (p = 0.001, p = 0.0001) and in THP-1 cell line was observed at 24 h after Gal-9 addition (p = 0.001, p = 0.0001).
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PMC9429973
Summary/Conclusion: VOD/SOS can develop after auto-HCT and can be severe.
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