PMCID string | Sentences string | ner list |
|---|---|---|
PMC11799620 | The full factorial design (2) was used to determine the impact of time of extraction, temperature, and liquid-solid ratio on the phenolic extraction yield. | [
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PMC11770746 | Four-week-old female BALB/cAnNTac mice weighing 16–18 g were purchased from InVivos (Singapore). | [
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PMC10890055 | We have shown that hFOB 1.19 cell line was less sensitive to Zn than L929, recommended by the ISO-10993 standard . | [
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PMC8777939 | Images and measurements of fluorescence signals were acquired and analyzed using NEOimage FOBI software. | [
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PMC11488203 | Each experiment represents the mean ± s.d. | [
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PMC9046263 | Figure 1Among all investigated HERVs, certain HERV superfamilies demonstrated high degrees of dysregulation in the A172, M059J, and H4 cell lines in (A). ( | [
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PMC9429973 | Aims: We sought to identify stress response mechanisms associated with adverse prognosis and PI resistance. | [
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PMC11802855 | However, the exact mechanisms by which CXCLs influence tumors remain unclear. | [
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PMC11774251 | RNA seq revealed that Tan-I downregulated several immune and inflammation-related genes, including TREM2, IL-17C, CXCL2, CXCL5, CXCL8, CCL3, S100A7, and IL-1β, thereby further elucidating its potent anti-inflammatory effects. | [
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PMC10380508 | These genes are regulated in a temporal and spatial manner, and expression patterns of PAX2 and PAX8 are typically downregulated in the kidneys during fetal development as they undergo terminal differentiation . | [
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PMC10502403 | OCR and ECAR were measured with a Seahorse XF HS Mini Analyzer using a Seahorse XF Cell Mito Stress Test Kit (Agilent Technologies Inc., Santa Clara, CA, USA). | [
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PMC9429973 | On contrary, SNUPN, responsible for transport of spliceosomal snRNPs, and UQCRC1, involved in cytochrome c regulation and oxidative phosphorylation, were found to be essential for SF3B1-mutated cells. | [
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PMC10734950 | The fluorescent cationic probe (5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide JC-1) is able accumulate inside the mitochondria. | [
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PMC11155445 | Jin et al. developed an ion-imprinted membrane (IIM) and utilized it as an adsorbent for the removal of Ag ions from an aqueous medium. | [
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PMC11487720 | The zinc finger domain of TRAF2 blocked the function of WWOX/p53 in inducing BCD at low temperatures. | [
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PMC11267036 | DHM can inhibit cell proliferation, motivate apoptosis, and regulate redox balance in liver cancer cells . | [
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PMC11013014 | High-resolution mass spectra (HRMS) were obtained on a Maxis Bruker 4G (Bruker, Billerica, MA, USA). | [
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PMC9684669 | Calculated CI values are presented below the plots. ( | [
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PMC9429973 | Results: Unsupervised multi-dimensional scaling analysis of GEP clearly separated T-LGLL from CTR samples. | [
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PMC5600151 | They used this system to deliver different types of siRNA, and effectively knocked down GAPDH, PEPCK (a rate-limiting enzyme for gluconeogenesis), and organic cation transporter 1 (OCT1), reducing the glucose production of rat hepatoma H4IIEC3 cells . | [
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PMC11365427 | In conclusion, we have identified phenylalanine metabolism as a characteristic feature of MM metabolic remodeling. | [
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PMC7612475 | However, treatment with either etoposide or olaparib significantly reduced the volume of the SF3B1-mutant tumors, but had little effect on the volume of SF3B1 tumors (Fig. 4B). | [
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PMC10900886 | At 24 hpi, we detected EV-D68/A- (mean 3% ± SEM 0.9) and EV-D68/B2- (3% ± 0.7) but not for EV-D68/A2-infected cells, based on intracellular expression of EV-D68 capsid protein VP1. | [
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PMC9429973 | MDS pathogenesis is complex and depends on the interaction between HSPC and microenvironment. | [
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PMC11683240 | However, the lack of specific treatment options against pertussis presents a critical challenge in managing and mitigating its impact. | [
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PMC10502403 | Frequency of human CD8NE1-tetramer cells in human CD45 cells. | [
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PMC11711066 | Mechanistically, although there are no reports of the E2‐like actions of AS‐IV, E2‐like effects have been reported in Radix Astragali. | [
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PMC9429973 | An essential component of these regimens is pegaspargase, here incorporated into a national treatment program for patients 18-65 years. | [
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PMC9429973 | I. Serrano-Gonzalo, L. López de Frutos, I. Arévalo-Vargas, M. Á. Fernández-Galán, M. Morales-Conejo, M. V. Calle-Gordo, I. Vitoria-Miñana, P. Correcher-Medina, A. Madinaveitia-Ochoa, J. Á. Hernández-Rivas, J. García-Frade, D. Ibarretxe-Gerediaga, F. Delgado-Mateos, M. D. M. Tormo-Díaz, M. Á. Ruíz-Guinaldo, E. Mora-Cast... | [
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PMC11549062 | Subsequently, cells were washed three times with PBST for 10 min each. | [
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PMC9429973 | Hemoglobin was under 9 g/dL in 75%. | [
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PMC11544771 | Apart from its broad-spectrum antifungal and antibacterial activity, CPX also shows anticancer activity against a spectrum of human tumors, which is related to its inhibition of cell proliferation, induction of apoptosis, suppression of cell migration and invasion, and inhibition of angiogenesis and lymphangiogenesis . | [
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PMC11487720 | No bubble formation was observed. | [
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PMC8316344 | We found that TRIB2 was expressed at a higher level in Bel-7404 cells than that in SK-Hep1 cells (Fig. 2A), suggesting that lower expression of TRIB2 in SK-Hep1 cells might be critical for higher sensitivity to the induction of ferroptosis. | [
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PMC11656657 | Two-way ANOVA was applied for the analysis. * | [
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PMC11190062 | Their main mode of action is to inhibit proteasomal protein degradation, which leads to the accumulation of misfolded proteins, activation of the unfolded protein response (UPR), and subsequent apoptosis. | [
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PMC10391797 | A combination of VPA pre-treatment and CAR-T against AML exhibits synergic effects. | [
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PMC11680391 | The first author verified the answers but did not address potential missing values at the visit. | [
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PMC9429973 | We estimate a sample of 100 patients. | [
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PMC11767817 | Several studies showed that curcumin is a compound capable of inhibiting the progression of bladder cancer cells by triggering apoptosis, inhibiting the PI3K/Akt pathway, blocking the Yes-associated protein (YAP) and/or WW domain–containing transcription regulator 1 (TAZ) pathway, affecting the cell cycle, and suppress... | [
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PMC11590870 | At 300 µg/mL, a soybean peptide reduced Caco-2 cell proliferation by around 70% . | [
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PMC11473843 | The combination index (CI) showing the synergistic effect of combination of the 2 drugs is indicated; n = 3. ( | [
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PMC9812014 | In immunofluorescence staining, emetine also inhibited the MR766 ZIKV strain along with the ZIKV PRVABC59 strain by targeting the synthesis of the E-protein in the SNB-19 cell line with an IC50 concentration of 29.8 nM and confidence intervals of 24.4 to 35.0 nM. Moreover, a ZIKA virus titer assay performed in Vero cel... | [
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PMC9918897 | The mice receiving unfortified ethanol had significantly higher liver weights compared to the other groups (medium combined size effect of the absence of XN fortification and the ethanolic liquid ηp = 0.096; p > 0.05). | [
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PMC11574029 | Data are presented as the mean ± SEM of three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. | [
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PMC11759543 | Table 1The effects and CI values of doxorubicin and vorinostat combination in 5637 cells. | [
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PMC11495567 | NCI-H23 cells were suspended in complete medium, seeded at a density of 2.5 x10 cells/mL in 96U Nunclon Sphera plates (Thermo Scientific, Waltham, MA), and incubated at 37°C/5% CO2 for 72 h to form spheroids. | [
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PMC11477621 | RPMI-8226 cells were seeded in six-well plates and treated with compounds for 24 h. Cells were lysed with 1× SDS loading buffer (50 mM Tris pH 6.8, 100 mM DTT, 2% SDS, 0.1% bromophenol blue, 10% glycerol), and then centrifuged at 12,000 rpm for 5 min at 4 °C. | [
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PMC11095939 | n.s., | [
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PMC6461034 | Lyse cells at room temperature by adding 6 ml lysis buffer to the pellet, pipetting up and down a few times, and vortexing 30 s at maximum speed. | [
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PMC10729469 | A Representative flow cytometric gating strategy for quantification of total Treg frequencies (CD4+ CD25+ FoxP3+). | [
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PMC10253553 | The 786-0 cell line was chosen because it is defective in VHL expression and thus is a good cell line model of ccRCC, given that VHL is inactivated in approximately 80% of ccRCC cases . | [
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PMC8345486 | The measurement was performed at ambient temperature. | [
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PMC10940855 | Multiple myeloma cells were treated with si-EPHB1 or si-Control. | [
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PMC11708541 | This is a therapeutic agent for treatment of Parkinson disease (Fig. 12). | [
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PMC11471176 | Optical density was compared to control optical density for each measurement, allowing the calculation of the average % survival for the three triplicates. | [
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PMC10547921 | The ideal PDC peptide should have strong target binding affinity, high stability, low immunogenicity, high internalization rate, and a relatively long plasma half-life. | [
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PMC11680578 | The media was then removed, and formazan crystals that had formed were dissolved in 100 µl of DMSO. | [
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PMC10988808 | Recent research has implicated several CCDC proteins in cancer development and progression, suggesting that members of this family may serve as valuable therapeutic targets [8–10]. | [
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PMC10631132 | These engineered iRANK cells have been shown to be effective in applications involving the controlled resorption of heterotopic ossifications , necrotic bone and even more potential applications can be envisioned. | [
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PMC11708541 | 4-AP is linked to MS patients for improved motor function, improved vision, and reduced fatigue. | [
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PMC11703992 | After dimensional reduction, the cell differentiation tracks were visualized . | [
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PMC9429973 | Summary/Conclusion: Oral thalidomide, cyclophosphamide and dexamethasone are effective and safe regimen for recurrent/refractory LCH patients, particularly for patients with risk organ involvement. | [
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PMC11352746 | From this, significantly more information can be extracted compared to the historic fashion of disclosing datasets, which are often processed and presented in tablature form. | [
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PMC10890307 | Additionally, this study includes, as controls, the breast cancer cell line MCF-7 because it consumes lactate without glucose and the MRC-5 fibroblasts as proliferative non-transformed cells. | [
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PMC11657695 | In (C, D, E and G), bars indicate means ± SD of the different values.*: | [
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PMC9780037 | In newly diagnosed non-small lung cell cancer patients, serum cyt c levels were about three-fold lower than in healthy individuals . | [
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PMC11684821 | CD69 upregulation by MC.7.G5 (P = 0.0003), MC.27.759S (P = 0.0008), K8T-1 (P = 0.001), and K8T-2 (P = 0.002) TCRs was at its maximum in the absence of endogenous TRBC1 (collective P value of 0.00049), with only K8T-1 showing some reactivity in WT Jurkat cells toward the C1R cells overexpressing MR1*01 in the absence of... | [
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PMC11320084 | The adhesion ability of tumor cells undergoing EMT is significantly weakened, with N‐cadherin and vimentin upregulation, and E‐cadherin downregulation being a key factor in the occurrence of EMT. | [
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PMC10671321 | Nuclei were visualized with DAPI (Invitrogen, Waltham, MA, USA) diluted 1:5000 in PBS. | [
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PMC9429973 | S. Zhou, M. xiong, G. wang, W. ling, J. zhu BeiJing Ludaopei Hospital, BeiJing; Hebei yanda Ludaopei Hospital, hebei, China Background: Antithymocyte Globulin (ATG) are often used as a component of the preparative regimen in allogeneic HSCT to reduce the incidence and severity of GVHD. | [
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PMC10747160 | Given the results from the Raji cell and 3t3 cell trans-infectivity assays, we were left to conclude that, at the very least, no variant of Griffithsin (WT-Grft, Q-Grft, and GLG-3A) exhibited any appreciable ability to act as an inhibitor of DC-SIGN-mediated capture of SARS-CoV-2 pseudotyped lentivirions. | [
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PMC11240571 | AG-CN2-0416). | [
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PMC9960565 | = 1023.27, m/z found = 1023.27 [M+2Na] C46H96N18Na2O20Pt4. | [
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PMC11092382 | The therapeutic application of sophocarpine in these two conditions involves modulation of the NF-κB pathway and ultimately aims to reduce inflammatory mediators such as IL-6 and IL-1β (Yang et al., 2021a). | [
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PMC10759659 | For clone formation, 2000 cells were seeded into a six-well plate and cultured for 2 weeks or more. | [
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PMC11634027 | Ds staining in clones of homozygous ds cells was slightly weaker than that of neighboring heterozygous cells (Fig. S5A), which could explain the mild phenotype induced by this allele. | [
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PMC11224020 | Ikbkb-knockout mice were from the laboratory of T. Lawrence (Centre d’Immunologie de Marseille-Luminy, Marseille, France), as described in Baratin et al.. WASp mice on a C57BL/6 (CD45.2) genetic background were from the laboratory of F.B. Experiments were performed using homozygous WASp mice as knockout animals. | [
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PMC11796104 | Fig. 1Characterization of circRNAs identified in male osteoporosis. | [
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PMC9429973 | The second most common listed diagnosis was for asthma (J45909). | [
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PMC10976516 | Since the FDA recently approved a modified HSV strain, talimogene laherpaprevec (T-vec), for the treatment of melanoma, oncolytic virotherapy has become more accepted. | [
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PMC11718817 | This is linked to a network of filamentous actin with the leading edge being particularly sensitive to the engagement of T cell antigen and chemokine receptors . | [
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PMC9220170 | At the same time, ER stress induced by MSA or SeNPs induced a more pronounced pro-apoptotic effect in SELENOT knockdown cells through suppression of the expression of selenium-containing antioxidant proteins. | [
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PMC9878278 | Profiling of ZIKV-specific response in the SC at the transcriptomics and proteomics level revealed that peak virus replication was associated with induction of TLRs and RLRs, and the type I IFN signaling pathway (Strange et al., 2018a, 2021). | [
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PMC11607638 | Knockingdown sulfakinin and sulfakinin receptor gene expression in the female A. aegypti results in increased blood meal intake, but microinjection in the thorax of the sulfakinin peptide 1 and 2 both inhibits dose dependently blood meal intake (and delays the time course of blood intake), which is reversible with rece... | [
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PMC10978090 | Abbreviations: Anti-PF4/H, anti-PF4-heparin; HIPA, heparin-induced platelet activation; IgG, immunoglobulin G; ND, not determined; OD, optical density; PF4, platelet factor 4; TPE, therapeutic plasma exchange. | [
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PMC11365427 | CETSA method for studying the interaction between phenylalanine and VAPB protein. ( | [
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PMC10743717 | Since it can catalyze the β-oxidation of branched-chain fatty acyl-CoAs (see Figure 2), 17β-HSD10 belongs to the HADII family so it has an alternative name as SDR5C1 . | [
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PMC10135767 | These results indicate that the adhesion of RPMI 8226 cells to MAdCAM-1-coating substrates was specifically mediated by the interaction between MAdCAM-1 and its receptor integrin α4β7 expressed on RPMI 8226 cells. | [
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PMC10890307 | The change of glucose to lactate increased cell death (p < 0.001). | [
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PMC10976516 | Dias et al.Capsid-modified, Ad5-derived virusIntravenousMesenchymal stem cells (MSCs)MSCs loaded with modified Ad5 homed primarily to lungs in orthotopic xenotransplanted NSCLC cell line model. | [
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PMC9429973 | Altogether, our data suggest that FLT3-ITD cell lines have less ER stress, reflected by lower levels of chaperones and UPR proteins, possibly because they rely on more efficient protein folding mechanisms. | [
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... |
PMC11657695 | The packages used for the analyses are detailed in Table S4. | [
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PMC11092382 | The antitumor activity of sophocarpine is mainly achieved by interfering with multiple signaling pathways in tumor cells. | [
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"tokens": [
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PMC10589262 | Authorization for the use of these tissues for research purposes was obtained from the Institutional Review Board of Yonsei University, College of Medicine (IRB 4-2015-0227). | [
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"tags": [
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PMC11126803 | We set our sights on oncogenes that may be directly involved in the regulation of VM formation. | [
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PMC10204952 | As shown in Fig 3, S1P caused morphological alteration of nuclei in both normal mammary gland epithelial MCF-12A cells and breast cancer MDA-MB-231 and HCC1937 cells; however, the effect was much stronger towards the cancer cells. | [
{
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PMC11632064 | To characterize the mitochondrial protein expression patterns associated with resistance to PLK1 inhibition in melanoma cell lines, we performed correlation analyses between transcript expression levels (CCLE) and the impact of PLK1-targeting approaches on cell proliferation (DepMap). | [
{
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PMC6684588 | However, ACE-083 treatment increased ankle dorsiflexion torque in the treated limb by 137%, as determined in vivo under isometric conditions, compared to that in vehicle-treated CMT mice (Fig. 4g). | [
{
"tags": [
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PMC5833712 | p ≤ 0.05Fig. | [
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"tokens": [
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