OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11799620	The full factorial design (2) was used to determine the impact of time of extraction, temperature, and liquid-solid ratio on the phenolic extraction yield.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770746	Four-week-old female BALB/cAnNTac mice weighing 16–18 g were purchased from InVivos (Singapore).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four-week-old", "female", "BALB/cAnNTac", "mice", "weighing", "16–1...
PMC10890055	We have shown that hFOB 1.19 cell line was less sensitive to Zn than L929, recommended by the ISO-10993 standard .	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We...
PMC8777939	Images and measurements of fluorescence signals were acquired and analyzed using NEOimage FOBI software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "and", "measurements", "of", "fluorescence", "signals", "were...
PMC11488203	Each experiment represents the mean ± s.d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experiment", "represents", "the", "mean", "±", "s.d", "." ] } ]
PMC9046263	Figure 1Among all investigated HERVs, certain HERV superfamilies demonstrated high degrees of dysregulation in the A172, M059J, and H4 cell lines in (A). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: We sought to identify stress response mechanisms associated with adverse prognosis and PI resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "We", "sought", "to", "identify", "s...
PMC11802855	However, the exact mechanisms by which CXCLs influence tumors remain unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "exact", "mechanisms", "by", "which", "CXCLs", "influence"...
PMC11774251	RNA seq revealed that Tan-I downregulated several immune and inflammation-related genes, including TREM2, IL-17C, CXCL2, CXCL5, CXCL8, CCL3, S100A7, and IL-1β, thereby further elucidating its potent anti-inflammatory effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10380508	These genes are regulated in a temporal and spatial manner, and expression patterns of PAX2 and PAX8 are typically downregulated in the kidneys during fetal development as they undergo terminal differentiation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10502403	OCR and ECAR were measured with a Seahorse XF HS Mini Analyzer using a Seahorse XF Cell Mito Stress Test Kit (Agilent Technologies Inc., Santa Clara, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	On contrary, SNUPN, responsible for transport of spliceosomal snRNPs, and UQCRC1, involved in cytochrome c regulation and oxidative phosphorylation, were found to be essential for SF3B1-mutated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10734950	The fluorescent cationic probe (5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide JC-1) is able accumulate inside the mitochondria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fluorescent", "cationic", "probe", "(", "5′,6,6′-tetrachlo...
PMC11155445	Jin et al. developed an ion-imprinted membrane (IIM) and utilized it as an adsorbent for the removal of Ag ions from an aqueous medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11487720	The zinc finger domain of TRAF2 blocked the function of WWOX/p53 in inducing BCD at low temperatures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "zinc", "finger", "domain", "of", "TR...
PMC11267036	DHM can inhibit cell proliferation, motivate apoptosis, and regulate redox balance in liver cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DHM", "can", "inhibit", "cell", "proliferation", ...
PMC11013014	High-resolution mass spectra (HRMS) were obtained on a Maxis Bruker 4G (Bruker, Billerica, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High-re...
PMC9684669	Calculated CI values are presented below the plots. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calculated", "CI", "values", "are", "presented", "below", "the", "plots", ".", "(" ] } ]
PMC9429973	Results: Unsupervised multi-dimensional scaling analysis of GEP clearly separated T-LGLL from CTR samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Unsupervised", "multi-dimensional", "scaling", "analysis", ...
PMC5600151	They used this system to deliver different types of siRNA, and effectively knocked down GAPDH, PEPCK (a rate-limiting enzyme for gluconeogenesis), and organic cation transporter 1 (OCT1), reducing the glucose production of rat hepatoma H4IIEC3 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	In conclusion, we have identified phenylalanine metabolism as a characteristic feature of MM metabolic remodeling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "we", "have", "identified", ...
PMC7612475	However, treatment with either etoposide or olaparib significantly reduced the volume of the SF3B1-mutant tumors, but had little effect on the volume of SF3B1 tumors (Fig. 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10900886	At 24 hpi, we detected EV-D68/A- (mean 3% ± SEM 0.9) and EV-D68/B2- (3% ± 0.7) but not for EV-D68/A2-infected cells, based on intracellular expression of EV-D68 capsid protein VP1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	MDS pathogenesis is complex and depends on the interaction between HSPC and microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MDS", "pathogenesis", "is", "complex", "and", "depends", "on", "the", ...
PMC11683240	However, the lack of specific treatment options against pertussis presents a critical challenge in managing and mitigating its impact.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", ...
PMC10502403	Frequency of human CD8NE1-tetramer cells in human CD45 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frequency", "of", "human", "CD8NE1-tetramer", "cells", "in", "human", "CD45", "cells", "." ] } ]
PMC11711066	Mechanistically, although there are no reports of the E2‐like actions of AS‐IV, E2‐like effects have been reported in Radix Astragali.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanistically", ...
PMC9429973	An essential component of these regimens is pegaspargase, here incorporated into a national treatment program for patients 18-65 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "essent...
PMC9429973	I. Serrano-Gonzalo, L. López de Frutos, I. Arévalo-Vargas, M. Á. Fernández-Galán, M. Morales-Conejo, M. V. Calle-Gordo, I. Vitoria-Miñana, P. Correcher-Medina, A. Madinaveitia-Ochoa, J. Á. Hernández-Rivas, J. García-Frade, D. Ibarretxe-Gerediaga, F. Delgado-Mateos, M. D. M. Tormo-Díaz, M. Á. Ruíz-Guinaldo, E. Mora-Casterá, M. S. Noya-Pereira, A. Albarracín-Arraigosa, M. López-Dupla, J. Balanzat-Muñoz, M. L. Lozano-Almela, F. Labbadia, M. Andrade-Campos, P. Giraldo FEETEG; Grupo de Investigación de Enfermedad de Gaucher (GIIS-012), Instituto de Investigación Sanitaria de Aragón (IISA); Grupo Español de Enfermedades de Depósito Lisosomal (GEEDL), Sociedad Española de Hematología y Hemoterapia, Zaragoza; Servicio de Hematología, Hospital Virgen del Puerto, Plasencia; Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid; Servicio de Hematología, Hospital de Torrecardenas, Almería; Unidad de Nutrición y Metabolopatías, Hospital Universitari i Politècnic La Fe, Valencia; Servicio de Hematología, Hospital Comarcal de Albarracín, Teruel; Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca; Servicio de Hematología, Hospital Universitario Río Hortega, Valladolid; Unitat de Medicina Vascular i Metabolisme, Hospital Universitari San Joan, Reus; Servicio de Hematología, Hospital Punta de Europa, Cádiz; Servicio de Hematología, Hospital Clínico Universitario de Valencia; Servicio de Hematología, Hospital Comarcal Francesc de Borja; Servicio de Hematología, Hospital Universitari i Politècnic La Fe, Valencia; Servicio de Hematología, Hospital Teresa Herrera, A Coruña; Servicio de Medicina Interna, Hospital Serranía de Ronda, Málaga; Servicio de Medicina Interna, Hospital Universitari Joan XXIII, Tarragona; Servicio de Hematología, Hospital Can Misses, Ibiza; Servicio de Hematología, Hospital General Universitario Morales Meseguer; Servicio de Hematología, Hospital de la Vega Lorenzo Guirao, Murcia; Servicio de Hematología, Hospital del Mar, Barcelona; Servicio de Hematología, Hospital QuirónSalud, Zaragoza, Spain Background: Eliglustat (Cerdelga®, Sanofi-Genzyme), is a substrate reduction therapy approved in European Union in 2015 for Gaucher disease type-1 (GD1) adult patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549062	Subsequently, cells were washed three times with PBST for 10 min each.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "cells", "were", "washed", "three", "times", "with", ...
PMC9429973	Hemoglobin was under 9 g/dL in 75%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hemoglobin", "was", "under", "9", "g/dL", "in", "75", "%", "." ] } ]
PMC11544771	Apart from its broad-spectrum antifungal and antibacterial activity, CPX also shows anticancer activity against a spectrum of human tumors, which is related to its inhibition of cell proliferation, induction of apoptosis, suppression of cell migration and invasion, and inhibition of angiogenesis and lymphangiogenesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	No bubble formation was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "bubble", "formation", "was", "observed", "." ] } ]
PMC8316344	We found that TRIB2 was expressed at a higher level in Bel-7404 cells than that in SK-Hep1 cells (Fig. 2A), suggesting that lower expression of TRIB2 in SK-Hep1 cells might be critical for higher sensitivity to the induction of ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11656657	Two-way ANOVA was applied for the analysis. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-way", "ANOVA", "was", "applied", "for", "the", "analysis", ".", "*" ] } ]
PMC11190062	Their main mode of action is to inhibit proteasomal protein degradation, which leads to the accumulation of misfolded proteins, activation of the unfolded protein response (UPR), and subsequent apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10391797	A combination of VPA pre-treatment and CAR-T against AML exhibits synergic effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "combination", "of", "VPA", "pre-treatment", "and", "CAR-T", "against", "AML...
PMC11680391	The first author verified the answers but did not address potential missing values at the visit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "first", "author", "verified", "the", "answers",...
PMC9429973	We estimate a sample of 100 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "estimate", "a", "sample", "of", "100", "patients", "." ] } ]
PMC11767817	Several studies showed that curcumin is a compound capable of inhibiting the progression of bladder cancer cells by triggering apoptosis, inhibiting the PI3K/Akt pathway, blocking the Yes-associated protein (YAP) and/or WW domain–containing transcription regulator 1 (TAZ) pathway, affecting the cell cycle, and suppressing Extracellular signal-regulated kinase 1/2 (Erk1/2) and NF-κB signaling pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11590870	At 300 µg/mL, a soybean peptide reduced Caco-2 cell proliferation by around 70% .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "300", "µg/mL", ",", "a", "soybean", "peptide...
PMC11473843	The combination index (CI) showing the synergistic effect of combination of the 2 drugs is indicated; n = 3. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9812014	In immunofluorescence staining, emetine also inhibited the MR766 ZIKV strain along with the ZIKV PRVABC59 strain by targeting the synthesis of the E-protein in the SNB-19 cell line with an IC50 concentration of 29.8 nM and confidence intervals of 24.4 to 35.0 nM. Moreover, a ZIKA virus titer assay performed in Vero cells showed complete inhibition of the viral replication with an IC50 of 8.74 nM and confidence intervals of 7.4–10.7 nM. The CC50 of emetine for the HEK293 and SNB-19 cell lines was 180 nM and 86 nM respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9918897	The mice receiving unfortified ethanol had significantly higher liver weights compared to the other groups (medium combined size effect of the absence of XN fortification and the ethanolic liquid ηp = 0.096; p > 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574029	Data are presented as the mean ± SEM of three independent experiments, p < 0.05, p < 0.01, p < 0.001, **p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759543	Table 1The effects and CI values of doxorubicin and vorinostat combination in 5637 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Table", "1The", "effects", "and", "CI", "values", "of", ...
PMC11495567	NCI-H23 cells were suspended in complete medium, seeded at a density of 2.5 x10 cells/mL in 96U Nunclon Sphera plates (Thermo Scientific, Waltham, MA), and incubated at 37°C/5% CO2 for 72 h to form spheroids.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11477621	RPMI-8226 cells were seeded in six-well plates and treated with compounds for 24 h. Cells were lysed with 1× SDS loading buffer (50 mM Tris pH 6.8, 100 mM DTT, 2% SDS, 0.1% bromophenol blue, 10% glycerol), and then centrifuged at 12,000 rpm for 5 min at 4 °C.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	n.s.,	[ { "tags": [ "O", "O", "O" ], "tokens": [ "n.s", ".", "," ] } ]
PMC6461034	Lyse cells at room temperature by adding 6 ml lysis buffer to the pellet, pipetting up and down a few times, and vortexing 30 s at maximum speed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10729469	A Representative flow cytometric gating strategy for quantification of total Treg frequencies (CD4+ CD25+ FoxP3+).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Representative", "flow"...
PMC10253553	The 786-0 cell line was chosen because it is defective in VHL expression and thus is a good cell line model of ccRCC, given that VHL is inactivated in approximately 80% of ccRCC cases .	[ { "tags": [ "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC8345486	The measurement was performed at ambient temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "measurement", "was", "performed", "at", "ambient", "temperature", "." ] } ]
PMC10940855	Multiple myeloma cells were treated with si-EPHB1 or si-Control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multiple", "myeloma", "cells", "were", "treated", "with", "si-EPHB1", "or", "si-Control", "." ] } ]
PMC11708541	This is a therapeutic agent for treatment of Parkinson disease (Fig. 12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "a", "therapeutic", "agent", "for", "treatment", "o...
PMC11471176	Optical density was compared to control optical density for each measurement, allowing the calculation of the average % survival for the three triplicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10547921	The ideal PDC peptide should have strong target binding affinity, high stability, low immunogenicity, high internalization rate, and a relatively long plasma half-life.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680578	The media was then removed, and formazan crystals that had formed were dissolved in 100 µl of DMSO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "media", "was", "then", ...
PMC10988808	Recent research has implicated several CCDC proteins in cancer development and progression, suggesting that members of this family may serve as valuable therapeutic targets [8–10].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10631132	These engineered iRANK cells have been shown to be effective in applications involving the controlled resorption of heterotopic ossifications , necrotic bone and even more potential applications can be envisioned.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11708541	4-AP is linked to MS patients for improved motor function, improved vision, and reduced fatigue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4-AP", "is", "linked", "to", "MS", "patient...
PMC11703992	After dimensional reduction, the cell differentiation tracks were visualized .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "dimensional", "reduction", ",", "the", "cell", "differentiation", "tracks", "were", "vi...
PMC9429973	Summary/Conclusion: Oral thalidomide, cyclophosphamide and dexamethasone are effective and safe regimen for recurrent/refractory LCH patients, particularly for patients with risk organ involvement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11352746	From this, significantly more information can be extracted compared to the historic fashion of disclosing datasets, which are often processed and presented in tablature form.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890307	Additionally, this study includes, as controls, the breast cancer cell line MCF-7 because it consumes lactate without glucose and the MRC-5 fibroblasts as proliferative non-transformed cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657695	In (C, D, E and G), bars indicate means ± SD of the different values.*:	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "(", ...
PMC9780037	In newly diagnosed non-small lung cell cancer patients, serum cyt c levels were about three-fold lower than in healthy individuals .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "newly", "di...
PMC11684821	CD69 upregulation by MC.7.G5 (P = 0.0003), MC.27.759S (P = 0.0008), K8T-1 (P = 0.001), and K8T-2 (P = 0.002) TCRs was at its maximum in the absence of endogenous TRBC1 (collective P value of 0.00049), with only K8T-1 showing some reactivity in WT Jurkat cells toward the C1R cells overexpressing MR1*01 in the absence of TRBC1 KO (Figure 7B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11320084	The adhesion ability of tumor cells undergoing EMT is significantly weakened, with N‐cadherin and vimentin upregulation, and E‐cadherin downregulation being a key factor in the occurrence of EMT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10671321	Nuclei were visualized with DAPI (Invitrogen, Waltham, MA, USA) diluted 1:5000 in PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nuclei", "were", "visualized", "with", ...
PMC9429973	S. Zhou, M. xiong, G. wang, W. ling, J. zhu BeiJing Ludaopei Hospital, BeiJing; Hebei yanda Ludaopei Hospital, hebei, China Background: Antithymocyte Globulin (ATG) are often used as a component of the preparative regimen in allogeneic HSCT to reduce the incidence and severity of GVHD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160	Given the results from the Raji cell and 3t3 cell trans-infectivity assays, we were left to conclude that, at the very least, no variant of Griffithsin (WT-Grft, Q-Grft, and GLG-3A) exhibited any appreciable ability to act as an inhibitor of DC-SIGN-mediated capture of SARS-CoV-2 pseudotyped lentivirions.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11240571	AG-CN2-0416).	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "AG-CN2", "-", "0416", ")", "." ] } ]
PMC9960565	= 1023.27, m/z found = 1023.27 [M+2Na] C46H96N18Na2O20Pt4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "=", "1023.27", ",", "m/z", "found", "=", "1023.27", "[", "M+2Na", "]", "C46H96N...
PMC11092382	The therapeutic application of sophocarpine in these two conditions involves modulation of the NF-κB pathway and ultimately aims to reduce inflammatory mediators such as IL-6 and IL-1β (Yang et al., 2021a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10759659	For clone formation, 2000 cells were seeded into a six-well plate and cultured for 2 weeks or more.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "clone", "formation", ",", ...
PMC11634027	Ds staining in clones of homozygous ds cells was slightly weaker than that of neighboring heterozygous cells (Fig. S5A), which could explain the mild phenotype induced by this allele.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	Ikbkb-knockout mice were from the laboratory of T. Lawrence (Centre d’Immunologie de Marseille-Luminy, Marseille, France), as described in Baratin et al.. WASp mice on a C57BL/6 (CD45.2) genetic background were from the laboratory of F.B. Experiments were performed using homozygous WASp mice as knockout animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11796104	Fig. 1Characterization of circRNAs identified in male osteoporosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1Characterization", "of", "circRNAs", "identified", "in", "male", "osteoporosis", "." ] } ]
PMC9429973	The second most common listed diagnosis was for asthma (J45909).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "second", "most", "common", "listed", "diagnosis", "was", "for", "asthma",...
PMC10976516	Since the FDA recently approved a modified HSV strain, talimogene laherpaprevec (T-vec), for the treatment of melanoma, oncolytic virotherapy has become more accepted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718817	This is linked to a network of filamentous actin with the leading edge being particularly sensitive to the engagement of T cell antigen and chemokine receptors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9220170	At the same time, ER stress induced by MSA or SeNPs induced a more pronounced pro-apoptotic effect in SELENOT knockdown cells through suppression of the expression of selenium-containing antioxidant proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878278	Profiling of ZIKV-specific response in the SC at the transcriptomics and proteomics level revealed that peak virus replication was associated with induction of TLRs and RLRs, and the type I IFN signaling pathway (Strange et al., 2018a, 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607638	Knockingdown sulfakinin and sulfakinin receptor gene expression in the female A. aegypti results in increased blood meal intake, but microinjection in the thorax of the sulfakinin peptide 1 and 2 both inhibits dose dependently blood meal intake (and delays the time course of blood intake), which is reversible with receptor antagonist.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10978090	Abbreviations: Anti-PF4/H, anti-PF4-heparin; HIPA, heparin-induced platelet activation; IgG, immunoglobulin G; ND, not determined; OD, optical density; PF4, platelet factor 4; TPE, therapeutic plasma exchange.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	CETSA method for studying the interaction between phenylalanine and VAPB protein. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CETSA", "method", "for", "studying", "the", "interaction", "between", "phenylalanine",...
PMC10743717	Since it can catalyze the β-oxidation of branched-chain fatty acyl-CoAs (see Figure 2), 17β-HSD10 belongs to the HADII family so it has an alternative name as SDR5C1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10135767	These results indicate that the adhesion of RPMI 8226 cells to MAdCAM-1-coating substrates was specifically mediated by the interaction between MAdCAM-1 and its receptor integrin α4β7 expressed on RPMI 8226 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10890307	The change of glucose to lactate increased cell death (p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "change", "of", "glucose", "to", "lactate", "increased", "...
PMC10976516	Dias et al.Capsid-modified, Ad5-derived virusIntravenousMesenchymal stem cells (MSCs)MSCs loaded with modified Ad5 homed primarily to lungs in orthotopic xenotransplanted NSCLC cell line model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Altogether, our data suggest that FLT3-ITD cell lines have less ER stress, reflected by lower levels of chaperones and UPR proteins, possibly because they rely on more efficient protein folding mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657695	The packages used for the analyses are detailed in Table S4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "packages", "used", "for", "the", "analyses", "are", "detailed", "in", "Table",...
PMC11092382	The antitumor activity of sophocarpine is mainly achieved by interfering with multiple signaling pathways in tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "antitumor", "activity", "of", "sophocarpin...
PMC10589262	Authorization for the use of these tissues for research purposes was obtained from the Institutional Review Board of Yonsei University, College of Medicine (IRB 4-2015-0227).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11126803	We set our sights on oncogenes that may be directly involved in the regulation of VM formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "set", "our", "sights", "on", "oncogen...
PMC10204952	As shown in Fig 3, S1P caused morphological alteration of nuclei in both normal mammary gland epithelial MCF-12A cells and breast cancer MDA-MB-231 and HCC1937 cells; however, the effect was much stronger towards the cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC11632064	To characterize the mitochondrial protein expression patterns associated with resistance to PLK1 inhibition in melanoma cell lines, we performed correlation analyses between transcript expression levels (CCLE) and the impact of PLK1-targeting approaches on cell proliferation (DepMap).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	However, ACE-083 treatment increased ankle dorsiflexion torque in the treated limb by 137%, as determined in vivo under isometric conditions, compared to that in vehicle-treated CMT mice (Fig. 4g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5833712	p ≤ 0.05Fig.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "p", "≤", "0.05Fig", "." ] } ]

PMC11799620

The full factorial design (2) was used to determine the impact of time of extraction, temperature, and liquid-solid ratio on the phenolic extraction yield.

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PMC11770746

Four-week-old female BALB/cAnNTac mice weighing 16–18 g were purchased from InVivos (Singapore).

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PMC10890055

We have shown that hFOB 1.19 cell line was less sensitive to Zn than L929, recommended by the ISO-10993 standard .

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PMC8777939

Images and measurements of fluorescence signals were acquired and analyzed using NEOimage FOBI software.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "and", "measurements", "of", "fluorescence", "signals", "were...

PMC11488203

Each experiment represents the mean ± s.d.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experiment", "represents", "the", "mean", "±", "s.d", "." ] } ]

PMC9046263

Figure 1Among all investigated HERVs, certain HERV superfamilies demonstrated high degrees of dysregulation in the A172, M059J, and H4 cell lines in (A). (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Aims: We sought to identify stress response mechanisms associated with adverse prognosis and PI resistance.

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PMC11802855

However, the exact mechanisms by which CXCLs influence tumors remain unclear.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "exact", "mechanisms", "by", "which", "CXCLs", "influence"...

PMC11774251

RNA seq revealed that Tan-I downregulated several immune and inflammation-related genes, including TREM2, IL-17C, CXCL2, CXCL5, CXCL8, CCL3, S100A7, and IL-1β, thereby further elucidating its potent anti-inflammatory effects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10380508

These genes are regulated in a temporal and spatial manner, and expression patterns of PAX2 and PAX8 are typically downregulated in the kidneys during fetal development as they undergo terminal differentiation .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10502403

OCR and ECAR were measured with a Seahorse XF HS Mini Analyzer using a Seahorse XF Cell Mito Stress Test Kit (Agilent Technologies Inc., Santa Clara, CA, USA).

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PMC9429973

On contrary, SNUPN, responsible for transport of spliceosomal snRNPs, and UQCRC1, involved in cytochrome c regulation and oxidative phosphorylation, were found to be essential for SF3B1-mutated cells.

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PMC10734950

The fluorescent cationic probe (5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide JC-1) is able accumulate inside the mitochondria.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fluorescent", "cationic", "probe", "(", "5′,6,6′-tetrachlo...

PMC11155445

Jin et al. developed an ion-imprinted membrane (IIM) and utilized it as an adsorbent for the removal of Ag ions from an aqueous medium.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11487720

The zinc finger domain of TRAF2 blocked the function of WWOX/p53 in inducing BCD at low temperatures.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "zinc", "finger", "domain", "of", "TR...

PMC11267036

DHM can inhibit cell proliferation, motivate apoptosis, and regulate redox balance in liver cancer cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DHM", "can", "inhibit", "cell", "proliferation", ...

PMC11013014

High-resolution mass spectra (HRMS) were obtained on a Maxis Bruker 4G (Bruker, Billerica, MA, USA).

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PMC9684669

Calculated CI values are presented below the plots. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calculated", "CI", "values", "are", "presented", "below", "the", "plots", ".", "(" ] } ]

PMC9429973

Results: Unsupervised multi-dimensional scaling analysis of GEP clearly separated T-LGLL from CTR samples.

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PMC5600151

They used this system to deliver different types of siRNA, and effectively knocked down GAPDH, PEPCK (a rate-limiting enzyme for gluconeogenesis), and organic cation transporter 1 (OCT1), reducing the glucose production of rat hepatoma H4IIEC3 cells .

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PMC11365427

In conclusion, we have identified phenylalanine metabolism as a characteristic feature of MM metabolic remodeling.

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PMC7612475

However, treatment with either etoposide or olaparib significantly reduced the volume of the SF3B1-mutant tumors, but had little effect on the volume of SF3B1 tumors (Fig. 4B).

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PMC10900886

At 24 hpi, we detected EV-D68/A- (mean 3% ± SEM 0.9) and EV-D68/B2- (3% ± 0.7) but not for EV-D68/A2-infected cells, based on intracellular expression of EV-D68 capsid protein VP1.

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PMC9429973

MDS pathogenesis is complex and depends on the interaction between HSPC and microenvironment.

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PMC11683240

However, the lack of specific treatment options against pertussis presents a critical challenge in managing and mitigating its impact.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", ...

PMC10502403

Frequency of human CD8NE1-tetramer cells in human CD45 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frequency", "of", "human", "CD8NE1-tetramer", "cells", "in", "human", "CD45", "cells", "." ] } ]

PMC11711066

Mechanistically, although there are no reports of the E2‐like actions of AS‐IV, E2‐like effects have been reported in Radix Astragali.

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PMC9429973

An essential component of these regimens is pegaspargase, here incorporated into a national treatment program for patients 18-65 years.

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PMC9429973

I. Serrano-Gonzalo, L. López de Frutos, I. Arévalo-Vargas, M. Á. Fernández-Galán, M. Morales-Conejo, M. V. Calle-Gordo, I. Vitoria-Miñana, P. Correcher-Medina, A. Madinaveitia-Ochoa, J. Á. Hernández-Rivas, J. García-Frade, D. Ibarretxe-Gerediaga, F. Delgado-Mateos, M. D. M. Tormo-Díaz, M. Á. Ruíz-Guinaldo, E. Mora-Casterá, M. S. Noya-Pereira, A. Albarracín-Arraigosa, M. López-Dupla, J. Balanzat-Muñoz, M. L. Lozano-Almela, F. Labbadia, M. Andrade-Campos, P. Giraldo FEETEG; Grupo de Investigación de Enfermedad de Gaucher (GIIS-012), Instituto de Investigación Sanitaria de Aragón (IISA); Grupo Español de Enfermedades de Depósito Lisosomal (GEEDL), Sociedad Española de Hematología y Hemoterapia, Zaragoza; Servicio de Hematología, Hospital Virgen del Puerto, Plasencia; Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid; Servicio de Hematología, Hospital de Torrecardenas, Almería; Unidad de Nutrición y Metabolopatías, Hospital Universitari i Politècnic La Fe, Valencia; Servicio de Hematología, Hospital Comarcal de Albarracín, Teruel; Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca; Servicio de Hematología, Hospital Universitario Río Hortega, Valladolid; Unitat de Medicina Vascular i Metabolisme, Hospital Universitari San Joan, Reus; Servicio de Hematología, Hospital Punta de Europa, Cádiz; Servicio de Hematología, Hospital Clínico Universitario de Valencia; Servicio de Hematología, Hospital Comarcal Francesc de Borja; Servicio de Hematología, Hospital Universitari i Politècnic La Fe, Valencia; Servicio de Hematología, Hospital Teresa Herrera, A Coruña; Servicio de Medicina Interna, Hospital Serranía de Ronda, Málaga; Servicio de Medicina Interna, Hospital Universitari Joan XXIII, Tarragona; Servicio de Hematología, Hospital Can Misses, Ibiza; Servicio de Hematología, Hospital General Universitario Morales Meseguer; Servicio de Hematología, Hospital de la Vega Lorenzo Guirao, Murcia; Servicio de Hematología, Hospital del Mar, Barcelona; Servicio de Hematología, Hospital QuirónSalud, Zaragoza, Spain Background: Eliglustat (Cerdelga®, Sanofi-Genzyme), is a substrate reduction therapy approved in European Union in 2015 for Gaucher disease type-1 (GD1) adult patients.

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PMC11549062

Subsequently, cells were washed three times with PBST for 10 min each.

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PMC9429973

Hemoglobin was under 9 g/dL in 75%.

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PMC11544771

Apart from its broad-spectrum antifungal and antibacterial activity, CPX also shows anticancer activity against a spectrum of human tumors, which is related to its inhibition of cell proliferation, induction of apoptosis, suppression of cell migration and invasion, and inhibition of angiogenesis and lymphangiogenesis .

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PMC11487720

No bubble formation was observed.

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PMC8316344

We found that TRIB2 was expressed at a higher level in Bel-7404 cells than that in SK-Hep1 cells (Fig. 2A), suggesting that lower expression of TRIB2 in SK-Hep1 cells might be critical for higher sensitivity to the induction of ferroptosis.

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PMC11656657

Two-way ANOVA was applied for the analysis. *

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PMC11190062

Their main mode of action is to inhibit proteasomal protein degradation, which leads to the accumulation of misfolded proteins, activation of the unfolded protein response (UPR), and subsequent apoptosis.

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PMC10391797

A combination of VPA pre-treatment and CAR-T against AML exhibits synergic effects.

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PMC11680391

The first author verified the answers but did not address potential missing values at the visit.

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PMC9429973

We estimate a sample of 100 patients.

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PMC11767817

Several studies showed that curcumin is a compound capable of inhibiting the progression of bladder cancer cells by triggering apoptosis, inhibiting the PI3K/Akt pathway, blocking the Yes-associated protein (YAP) and/or WW domain–containing transcription regulator 1 (TAZ) pathway, affecting the cell cycle, and suppressing Extracellular signal-regulated kinase 1/2 (Erk1/2) and NF-κB signaling pathways .

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PMC11590870

At 300 µg/mL, a soybean peptide reduced Caco-2 cell proliferation by around 70% .

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PMC11473843

The combination index (CI) showing the synergistic effect of combination of the 2 drugs is indicated; n = 3. (

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PMC9812014

In immunofluorescence staining, emetine also inhibited the MR766 ZIKV strain along with the ZIKV PRVABC59 strain by targeting the synthesis of the E-protein in the SNB-19 cell line with an IC50 concentration of 29.8 nM and confidence intervals of 24.4 to 35.0 nM. Moreover, a ZIKA virus titer assay performed in Vero cells showed complete inhibition of the viral replication with an IC50 of 8.74 nM and confidence intervals of 7.4–10.7 nM. The CC50 of emetine for the HEK293 and SNB-19 cell lines was 180 nM and 86 nM respectively.

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PMC9918897

The mice receiving unfortified ethanol had significantly higher liver weights compared to the other groups (medium combined size effect of the absence of XN fortification and the ethanolic liquid ηp = 0.096; p > 0.05).

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PMC11574029

Data are presented as the mean ± SEM of three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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PMC11759543

Table 1The effects and CI values of doxorubicin and vorinostat combination in 5637 cells.

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PMC11495567

NCI-H23 cells were suspended in complete medium, seeded at a density of 2.5 x10 cells/mL in 96U Nunclon Sphera plates (Thermo Scientific, Waltham, MA), and incubated at 37°C/5% CO2 for 72 h to form spheroids.

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PMC11477621

RPMI-8226 cells were seeded in six-well plates and treated with compounds for 24 h. Cells were lysed with 1× SDS loading buffer (50 mM Tris pH 6.8, 100 mM DTT, 2% SDS, 0.1% bromophenol blue, 10% glycerol), and then centrifuged at 12,000 rpm for 5 min at 4 °C.

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PMC11095939

n.s.,

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PMC6461034

Lyse cells at room temperature by adding 6 ml lysis buffer to the pellet, pipetting up and down a few times, and vortexing 30 s at maximum speed.

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PMC10729469

A Representative flow cytometric gating strategy for quantification of total Treg frequencies (CD4+ CD25+ FoxP3+).

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PMC10253553

The 786-0 cell line was chosen because it is defective in VHL expression and thus is a good cell line model of ccRCC, given that VHL is inactivated in approximately 80% of ccRCC cases .

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PMC8345486

The measurement was performed at ambient temperature.

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PMC10940855

Multiple myeloma cells were treated with si-EPHB1 or si-Control.

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PMC11708541

This is a therapeutic agent for treatment of Parkinson disease (Fig. 12).

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PMC11471176

Optical density was compared to control optical density for each measurement, allowing the calculation of the average % survival for the three triplicates.

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PMC10547921

The ideal PDC peptide should have strong target binding affinity, high stability, low immunogenicity, high internalization rate, and a relatively long plasma half-life.

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PMC11680578

The media was then removed, and formazan crystals that had formed were dissolved in 100 µl of DMSO.

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PMC10988808

Recent research has implicated several CCDC proteins in cancer development and progression, suggesting that members of this family may serve as valuable therapeutic targets [8–10].

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PMC10631132

These engineered iRANK cells have been shown to be effective in applications involving the controlled resorption of heterotopic ossifications , necrotic bone and even more potential applications can be envisioned.

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PMC11708541

4-AP is linked to MS patients for improved motor function, improved vision, and reduced fatigue.

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PMC11703992

After dimensional reduction, the cell differentiation tracks were visualized .

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PMC9429973

Summary/Conclusion: Oral thalidomide, cyclophosphamide and dexamethasone are effective and safe regimen for recurrent/refractory LCH patients, particularly for patients with risk organ involvement.

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PMC11352746

From this, significantly more information can be extracted compared to the historic fashion of disclosing datasets, which are often processed and presented in tablature form.

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PMC10890307

Additionally, this study includes, as controls, the breast cancer cell line MCF-7 because it consumes lactate without glucose and the MRC-5 fibroblasts as proliferative non-transformed cells.

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PMC11657695

In (C, D, E and G), bars indicate means ± SD of the different values.*:

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PMC9780037

In newly diagnosed non-small lung cell cancer patients, serum cyt c levels were about three-fold lower than in healthy individuals .

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PMC11684821

CD69 upregulation by MC.7.G5 (P = 0.0003), MC.27.759S (P = 0.0008), K8T-1 (P = 0.001), and K8T-2 (P = 0.002) TCRs was at its maximum in the absence of endogenous TRBC1 (collective P value of 0.00049), with only K8T-1 showing some reactivity in WT Jurkat cells toward the C1R cells overexpressing MR1*01 in the absence of TRBC1 KO (Figure 7B).

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PMC11320084

The adhesion ability of tumor cells undergoing EMT is significantly weakened, with N‐cadherin and vimentin upregulation, and E‐cadherin downregulation being a key factor in the occurrence of EMT.

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PMC10671321

Nuclei were visualized with DAPI (Invitrogen, Waltham, MA, USA) diluted 1:5000 in PBS.

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PMC9429973

S. Zhou, M. xiong, G. wang, W. ling, J. zhu BeiJing Ludaopei Hospital, BeiJing; Hebei yanda Ludaopei Hospital, hebei, China Background: Antithymocyte Globulin (ATG) are often used as a component of the preparative regimen in allogeneic HSCT to reduce the incidence and severity of GVHD.

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PMC10747160

Given the results from the Raji cell and 3t3 cell trans-infectivity assays, we were left to conclude that, at the very least, no variant of Griffithsin (WT-Grft, Q-Grft, and GLG-3A) exhibited any appreciable ability to act as an inhibitor of DC-SIGN-mediated capture of SARS-CoV-2 pseudotyped lentivirions.

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PMC11240571

AG-CN2-0416).

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PMC9960565

= 1023.27, m/z found = 1023.27 [M+2Na] C46H96N18Na2O20Pt4.

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PMC11092382

The therapeutic application of sophocarpine in these two conditions involves modulation of the NF-κB pathway and ultimately aims to reduce inflammatory mediators such as IL-6 and IL-1β (Yang et al., 2021a).

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PMC10759659

For clone formation, 2000 cells were seeded into a six-well plate and cultured for 2 weeks or more.

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PMC11634027

Ds staining in clones of homozygous ds cells was slightly weaker than that of neighboring heterozygous cells (Fig. S5A), which could explain the mild phenotype induced by this allele.

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PMC11224020

Ikbkb-knockout mice were from the laboratory of T. Lawrence (Centre d’Immunologie de Marseille-Luminy, Marseille, France), as described in Baratin et al.. WASp mice on a C57BL/6 (CD45.2) genetic background were from the laboratory of F.B. Experiments were performed using homozygous WASp mice as knockout animals.

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PMC11796104

Fig. 1Characterization of circRNAs identified in male osteoporosis.

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PMC9429973

The second most common listed diagnosis was for asthma (J45909).

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PMC10976516

Since the FDA recently approved a modified HSV strain, talimogene laherpaprevec (T-vec), for the treatment of melanoma, oncolytic virotherapy has become more accepted.

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PMC11718817

This is linked to a network of filamentous actin with the leading edge being particularly sensitive to the engagement of T cell antigen and chemokine receptors .

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PMC9220170

At the same time, ER stress induced by MSA or SeNPs induced a more pronounced pro-apoptotic effect in SELENOT knockdown cells through suppression of the expression of selenium-containing antioxidant proteins.

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PMC9878278

Profiling of ZIKV-specific response in the SC at the transcriptomics and proteomics level revealed that peak virus replication was associated with induction of TLRs and RLRs, and the type I IFN signaling pathway (Strange et al., 2018a, 2021).

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PMC11607638

Knockingdown sulfakinin and sulfakinin receptor gene expression in the female A. aegypti results in increased blood meal intake, but microinjection in the thorax of the sulfakinin peptide 1 and 2 both inhibits dose dependently blood meal intake (and delays the time course of blood intake), which is reversible with receptor antagonist.

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PMC10978090

Abbreviations: Anti-PF4/H, anti-PF4-heparin; HIPA, heparin-induced platelet activation; IgG, immunoglobulin G; ND, not determined; OD, optical density; PF4, platelet factor 4; TPE, therapeutic plasma exchange.

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PMC11365427

CETSA method for studying the interaction between phenylalanine and VAPB protein. (

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PMC10743717

Since it can catalyze the β-oxidation of branched-chain fatty acyl-CoAs (see Figure 2), 17β-HSD10 belongs to the HADII family so it has an alternative name as SDR5C1 .

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PMC10135767

These results indicate that the adhesion of RPMI 8226 cells to MAdCAM-1-coating substrates was specifically mediated by the interaction between MAdCAM-1 and its receptor integrin α4β7 expressed on RPMI 8226 cells.

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PMC10890307

The change of glucose to lactate increased cell death (p < 0.001).

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PMC10976516

Dias et al.Capsid-modified, Ad5-derived virusIntravenousMesenchymal stem cells (MSCs)MSCs loaded with modified Ad5 homed primarily to lungs in orthotopic xenotransplanted NSCLC cell line model.

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PMC9429973

Altogether, our data suggest that FLT3-ITD cell lines have less ER stress, reflected by lower levels of chaperones and UPR proteins, possibly because they rely on more efficient protein folding mechanisms.

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PMC11657695

The packages used for the analyses are detailed in Table S4.

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PMC11092382

The antitumor activity of sophocarpine is mainly achieved by interfering with multiple signaling pathways in tumor cells.

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PMC10589262

Authorization for the use of these tissues for research purposes was obtained from the Institutional Review Board of Yonsei University, College of Medicine (IRB 4-2015-0227).

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PMC11126803

We set our sights on oncogenes that may be directly involved in the regulation of VM formation.

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PMC10204952

As shown in Fig 3, S1P caused morphological alteration of nuclei in both normal mammary gland epithelial MCF-12A cells and breast cancer MDA-MB-231 and HCC1937 cells; however, the effect was much stronger towards the cancer cells.

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PMC11632064

To characterize the mitochondrial protein expression patterns associated with resistance to PLK1 inhibition in melanoma cell lines, we performed correlation analyses between transcript expression levels (CCLE) and the impact of PLK1-targeting approaches on cell proliferation (DepMap).

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PMC6684588

However, ACE-083 treatment increased ankle dorsiflexion torque in the treated limb by 137%, as determined in vivo under isometric conditions, compared to that in vehicle-treated CMT mice (Fig. 4g).

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PMC5833712

p ≤ 0.05Fig.

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