OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11413393	Our data supports PRMT1 as a target in ccRCC and informs a mechanism-based strategy for translational development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "supports", "PRMT1", "as", "a...
PMC9516447	Whole cell lysate was subjected to Western blot analysis for KRAS protein level with GAPDH serving as loading control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole", "cell", "lysate", "was", ...
PMC11290772	Considering these findings, it is imperative to develop more effective immunotherapy strategies targeting ROBO1 in clinical ovarian cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Considering", "these", "findings", ...
PMC9429973	Aims: To estimate the cumulative incidence (CI) of cardiac events in a large series of unselected pts with AML in a single Spanish institution, and to identify risk factors associated with their development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10523483	Similarly, H1.2 overexpression increased nuclear levels of NRF2 in A549 and H1975 cells (SI Appendix, Fig. S9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly",...
PMC8873393	Here we sought to capture the transcription shutdown and restart and isolate the set of lncRNAs that are likely to function at the chromatin interface by using biochemical fractionation of the cellular compartments coupled to RNA-seq.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8662250	Nowadays, the role of the ACE‐2 receptor as the interaction site between SARS‐CoV‐2 SP and the host cells is well known.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nowadays", "...
PMC6948907	Histone deacetylase inhibitors (HDACi) are anti-cancer drugs which induce chromatin remodelling and alter gene transcription by which induces tumor cell apoptosis, cell cycle arrest, cell differentiation, modulation of immune responses and altered angiogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743316	The relationship between the amounts of ROS and cell metabolism is tightly controlled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relationship", "between", "the", "amounts", "of", "ROS", "and", ...
PMC10761571	6Magnetic saturation curve of Fe3O4@Glu-Gingerol NPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "6Magnetic", "saturation", "curve", "of", "Fe3O4@Glu-Gingerol", "NPs", "." ] } ]
PMC11599565	RNA integrity was ascertained using the 2100 Bioanalyzer (Agilent, Santa Clara, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "integrity", "was", "ascertained", "using", "the...
PMC11786156	However, adhesion between tumor cells and tumor-infiltrating lymphocytes via CD54 and LFA1 may not always be beneficial for tumor cells, because it may also enhance antitumor immune response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2196094	The RBL-1 cell line was originally established from cells of a rat with basophilic leukemia (27).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RBL-1", "cell", "line", ...
PMC9848491	IC50 of JNK.9L in high and low risk groups. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IC50", "of", "JNK.9L", "in", "high", "and", "low", "risk", "groups", ".", "(" ] } ]
PMC9429973	Summary/Conclusion: Compared with chemotherapy plus DLI, donor-derived CD19 CAR-T is more effective and safe in the treatment of recurrent B-ALL after allogeneic HSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11190062	In line with previously published data (22, 25, 27–29), we found that both cell proliferation ( Figure 1C ) and cell viability ( Figures 1D, E ) were increased following LPS and CpG treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10907726	Scale bar: 1 mm for B and 500 μm for C. (D) Western blot was employed to measure the expression levels of E-cad, N-cad, MMP-2, Snail and Vimentin in OS cells. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11695623	3The relationship between DCUN1D5 and the prognosis of LUAD. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3The", "relationship", "between", "DCUN1D5", "and", "the", "prognosis", "of", "LUAD", ".", ...
PMC11798926	Information on all constructs used in this study are described in greater detail in Supplementary Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Information", "on", "all", "constructs", "used", ...
PMC9429973	Prior to infusion of ARU-1801, all patients received a single IV dose of RIC melphalan (140 mg/m).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "to", "infusion", ...
PMC9351137	Scale bar = 10 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "10", "μm", "." ] } ]
PMC11627133	These self‐labeling and genetically encodable protein tags covalently attach the fluorophores to the POI within the cell.[ , ]	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "self‐labeling", "an...
PMC11543935	The CT image was acquired using a Siemens SOMATOM X.cite with the following parameters: Collimation, 38.4 × 0.6 mm; Voltage, 70 kV; Tube current 28 mA; Slice thickness 2 mm; Pitch factor 0.8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10870498	IF staining was used to verify the relationship between KIF23 and SIRT7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IF", "staining", "was", "used", "to", "verify", "the", "relationship", "between"...
PMC11741906	This literature may suggest the oncogenic role of hsa-miR-200b-3p in ovarian cancer, but this requires validation using functional studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "literature", "may", ...
PMC11736898	Despite reduced vitamin D receptor expression in keloid epidermis in vivo, keloid keratinocytes are able to respond to vitamin D stimulation in vitro with upregulation of target genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8873393	This observation has been further confirmed by immunostaining of p-H3S10 protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "observation", "has", "been", "further", "confirmed", "by", "immunostaining", "of", ...
PMC7039683	In each replicate, we isolated 20,000 peridermal and non-peridermal cells from Tg(krt4:GFP) embryos at the 4-somite stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "each", "replicate", ",", ...
PMC11486946	Using an automated system for a fast large-scale single-molecule analysis, we screen for epidermal growth factor receptor (EGFR) from 1134 of FDA approved drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Although the immune ADC is still in the initial stage of development and has not yet achieved satisfactory clinical results, the immune-modulating ADC has the potential to greatly broaden the treatment window of the ADC, improve its anti-tumor activity, and have ideal safety and efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087055	Authentic PS morphogenesis under disrupting authentic polonaise movements. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Authentic", "PS", "morphogenesis", "under", "disrupting", "authentic", "polonaise", "movements", ".", "(" ...
PMC11640419	Therefore, hybrid molecule 9a, which is based on oleanolic acid and the 1Z,5Z-diene fragment, affects all phases of the cell cycle, but it has a particularly pronounced effect on G1, pre-G0, and G2 phases (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266	Representative BLI signals depicting the interaction of rat (r) CRT (analyte) with different forms of cgATF6α_LD (from HEK293T cells) immobilised on streptavidin biosensors: ATF6α_LD in red, ATF6α_LD in yellow, and ATF6α_LD in blue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "...
PMC11583010	In brief, mAbs in PBS 1×, 1 mmol/L EDTA, were reduced with 14 mol/L equivalents of TCEP for 2 hours at 37°C, after which the buffer was exchanged (Amicon ultra 30 kDa) to 100 mmol/L KPO4, 1 mmol/L EDTA, pH 7.4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766309	Since there are few or no normal tissue samples in the TCGA database, a comparison was made between the expression levels of tumors and normal tissues in various cancerous tissues by combining TCGA and GTEx data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938377	The A2780cisR cell line was routinely treated with cisplatin (2 μM) in the media to maintain cisplatin resistance.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "A2780cisR", ...
PMC9844987	For all box-and-whisker plots, central band: median; boundaries: first and third quartiles; whiskers:+/-1.5 IQR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "all", "box-and-whisker", "...
PMC11401358	β-Sheet structures could form β-crystallite by orderly arrangement and then form nanofibril structures .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-Sheet", "structures", "could", "form", "β-crystallite", "by", "orderly", ...
PMC10362265	Altogether, these findings suggested that the initial conformation of the surface region between 68 and 81 that affects the dynamics of the IL18-IL18BP complex through stabilization of the IL18 structure by two salt bridge interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012313	Further statistical analysis demonstrates that these changes in phospho-4E-BP1 are statistically significant (Figure 5C,D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "statistical", "analysis", "demons...
PMC11711063	Comparison of ZG16B‐induced cell migration in ER‐positive (MCF7, T47D) and ER‐negative (MDA‐MB‐231, MDA‐MB‐468, HCC1143) breast cancer cell lines using scratch assays. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", ...
PMC8414691	In the case of SRCAP isoforms, post-translational modifications may occur which could affect migration differences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "case", "of", "SRCAP", "isoforms", "...
PMC11495567	After 24 h, treatment media were refreshed followed by incubation for a further 24 h. The cells were fixed with 4% formaldehyde, permeabilized with 0.5% Triton X-100 and stained using a mixture of 1X Alexa Fluor568 phalloidin (cat# A12380) and 1X Hoechst stain (DAPI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9611901	As known, for each new material or newly developed technological process various safety issues must be known before it is put into widespread use.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9143157	In vivo antitumor effect of P-THP was investigated by using xenograft models in mice, as compared with commonly used chemotherapeutic drugs for gynecological malignancies, i.e., THP, cisplatin, and paclitaxel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459	All these compounds were isolated from the bark of Brosimum rubescens by Shirota et al. , and they share the same cis–trans configuration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11607638	p < .0001. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", ".0001", ".", "(" ] } ]
PMC11635087	The φII image was obtained using the following equation: φII=(Fm′−F)/Fm′ The blanks (Fn and Fm′n, respectively) for F and Fm′ of CHO-K1 cells without chloroplasts were measured and excluded from the data for chloroplasts incorporated into CHO-K1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC9509578	This nanoformulation was revealed to cause significant inhibition of tumor growth in female nude mice with negligible distribution in healthy tissues and organs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11657695	p < 0,05; : p < 0,01 and *: p < 0,001 (Mann–Whitney tests) The regulation of KCNA2 expression was then studied using RT-qPCR and Western blot assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11348300	Twenty-one mice were injected with 250 mg/kg ALA and imaged at 1, 2, 3, 4, 6, 8, 18, and 24 h postinjection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10919056	Afatinib. (	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Afatinib", ".", "(" ] } ]
PMC8389560	Since in our experiments SeNP induce both Ca transients and Ca oscillations, which is then accompanied by the induction of an early stage of apoptosis, it can be assumed that this mechanism is activated as well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6948907	This compound has anticancer property and activates tumor suppressor genes by modulating chromatin configuration and DNA methylation (Banerjee et al., 2008; Kikuno et al., 2008; Sarkar et al., 2003).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4360730	Lastly, the ‘Available data’ facet describes the data file types that are available for download from the ENCODE portal. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lastly"...
PMC9429973	After the start of treatment, the different QLQ-C30 scales were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the", "start", "of", "treatment", ",", "the", "different", "QLQ-C30", ...
PMC11790971	Moreover, within-cell-line heterogeneity was evident across passages, complicating the visual assessment of differences among cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "within-cell-line", "heterog...
PMC9512971	The ordinal scale was grade 3 (hospitalized, no oxygen therapy) in most patients during the study period because all patients were hospitalized for SARS-CoV-2 testing; outpatients were not enrolled due to the risk of transmission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	Here, we have discussed the mechanisms associated with MC-LR exposure-related signaling pathways and sensing methods for detecting MC-LR in the water sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ...
PMC11247842	The red horizontal line indicates the genome-wide significance level [− log10(p) = 8.5]Table 1Lead SNPs for QTL for clinical mastitis (CM) and somatic cell score (SCS), along with the nearest gene and the functional annotation of the SNPsBTABase pairQTLrsid− log10(p)Analysis methodNearest geneAnnotation1131,393,761131,144,131–131,643,847NA11.23MR-MEGA_SCSSOX14Intergenic variant1131,399,037131,149,079–131,649,130rs2092620969.15MR-MEGA_CMSOX14Intergenic variant1131,508,931131,259,179–131,758,987rs13364577419.16MTAG_SCSSOX14Intergenic variant1143,908,907143,660,512–144,160,344rs432822799.08MR-MEGA_SCSAGPAT3Intergenic variant1145,932,212145,682,433–146,182,333rs4699473989.05MTAG_SCSMCM3APIntron variant2127,010,295126,760,970–127,260,998rs1098613389.11MR-MEGA_CMTRIM63Intergenic variant2127,199,316126,949,469–127,449,526rs1339142628.92MTAG_CMPAQR7Intergenic variant324,114,90423,865,017–24,365,480rs3850259338.87MTAG_CMTBX15Intergenic variant332,937,62432,688,826–33,188,877rs433361909.29MR-MEGA_CMCYMIntergenic variant332,991,79332,741,957–33,241,801rs433361358.97MTAG_CMPROK1Intron variant333,085,26232,835,778–33,356,862rs4333546111.06MTAG_SCSRBM15Downstream variant410,207,0919,958,314–10,457,519rs21131775917.71MR-MEGA_SCSENSBTAG00000051416Downstream variant556,290,20456,040,322–56,542,938rs10984876012.68MTAG_CMLRP1Intron variant556,332,71556,082,869–56,583,125rs20835890919.19MTAG_SCSSTAT6Synonymous variant588,406,86187,673,289–88,657,962rs2098937729.50MR-MEGA_CMABCC9Intron variant686,940,86386,690,963–87,191,548rs21037393633.58MR-MEGA_CMGCIntergenic variant686,991,63086,741,866–87,268,801rs43653257622.14/19.43MTAG_CM, MTAG_SCSGCIntron variant687,000,65486,752,563–87,280,573rs10895212822.27MR-MEGA_SCSGCIntron variant910,451,70510,202,576–10,702,351rs21077070717.59MR-MEGA_SCSOGFRL1Intergenic variant910,457,30410,207,394–10,707,412rs13316426223.63MR-MEGA_CMbta-mir-30fIntergenic variant910,510,02010,260,034–10,760,190rs10933544316.73MTAG_CMOGFRL1Intergenic variant910,672,83310,423,069–10,923,737rs10971803825.51MTAG_SCSENSBTAG00000048046Intergenic variant1087,184,30886,811,104–87,436,082rs4224853215.37MR-MEGA_SCSTTLL5Intron variant1112,078,91111,079,809–12,329,170NA8.73MR-MEGA_SCSEXOC6BIntron variant1185,622,20685,372,220–85,872,367rs38261516110.51MTAG_SCSTRIB2Intergenic variant1356,890,47256,012,401–57,140,946rs416964369.22MR-MEGA_SCSPHACTR3Intron variant1379,482,64578,816,883–79,738,951NA13.03MR-MEGA_SCSATP9AIntron variant14528,726283,062–778,739rs1104189609.70MTAG_CMENSBTAG00000053637Intron variant14559,962311,166–885,752rs21023076710.75MR-MEGA_CMADCK5Intron variant1625,160,03424,910,289–25,411,234rs37974267311.42MTAG_CMDUSP10Intergenic variant1625,189,02224,941,012–25,440,400rs11006112413.03MTAG_SCSDUSP10Intron variant1625,190,38924,953,782–25,460,899rs1092742159.12/MR-MEGA_CM, MR-MEGA_SCSDUSP10Intron variant1843,707,61043,463,418–43,957,639rs37969907710.52MR-MEGA_CMENSBTAG00000049393Intergenic variant1844,354,88343,674,933–44,605,086NA10.49MR-MEGA_SCSENSBTAG00000050669Intron variant1865,188,61364,939,546–65,442,597rs4190175117.65MTAG_SCSLOC100124497Intron variant1865,288,69265,038,910–65,539,395NA9.24MR-MEGA_CMENSBTAG00000038715Intergenic variant197,358,4807,109,618–7,610,867NA16.86MR-MEGA_SCSNOGIntergenic variant197,371,2117,122,553–7,622,923rs10918424510.25MR-MEGA_CMNOGIntergenic variant1931,532,43631,282,440–31,782,555rs44352717010.84MR-MEGA_SCSENSBTAG00000052541Intergenic variant1940,053,28839,502,431–40,303,655rs13440207512.25MR-MEGA_SCSPGAP3Intron variant1954,626,23254,376,382–54,900,608rs13469340511.63MR-MEGA_SCSSEPTIN9Intron variant1956,012,40155,763,067–56,483,191rs1357907659.81MR-MEGA_CMLLGL2Intron variant2022,385,79121,933,562–22,635,895rs11032306113.09MR-MEGA_SCSMAP3K1Intron variant2022,386,42522,141,590–22,636,468rs38094437421.22MR-MEGA_CMMAP3K1Intron variant2022,422,29922,172,873–22,673,171rs20910356919.42MTAG_CMMAP3K1Upstream variant2022,428,45522,180,220rs20828083715.14MTAG_SCSMAP3K1Intergenic variant2039,502,43139,252,645–39,766,694rs426639679.40MR-MEGA_SCSRAI14Intron variant2157,144,70456,895,032–57,394,726rs37825594016.51MR-MEGA_CMSLC24A4Intron variant2162,941,83362,691,932–63,192,091rs13684406217.55MR-MEGA_SCS5S_rRNAIntergenic variant2163,051,72062,801,824–63,302,337rs13352412912.53MTAG_SCSBCL11BIntergenic variant2252,947,79052,698,116–53,199,688rs13584515114.17MR-MEGA_SCSLTFUpstream variant2253,007,16852,757,454–53,257,174rs3853931728.58MTAG_SCSCCRL2Intron variant2339,530,19639,295,040–39,780,965rs13685750713.02MTAG_SCSKIF13AIntron variant2460,882,42060,633,040–61,132,920rs4157120711.74MR-MEGA_SCSZCCHC2Intergenic variant2460,883,69660,633,830–61,133,857NA9.37MR-MEGA_CMZCCHC2Intergenic variant2538,531,21437,561,390–38,781,883rs3837199168.54MTAG_SCSLOC618542Intron variant299,486,0409,236,161–9,736,089NA9.68MR-MEGA_SCSPICALMIntergenic variant2946,577,85946,074,605–46,834,864rs3782682279.36MR-MEGA_SCSENSBTAG00000050252Intergenic variantThe list of lead SNPs, their annotation and nearest genes for all the meta-analyses used and implemented in MR-MEGA and MTAG .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Additionally, we isolated DNA of fibroblasts or remission material of each pediatric patient as matching non-tumor control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "we", "isolated", ...
PMC10197932	In addition, no increase in senescence or apoptosis events is observed in RBC following US-treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "no", "increase", "in", "s...
PMC11539788	P < 0.05, P < 0.01, and *P < 0.001 RNF19A regulated the activation of AKT/mTOR signalling via ILK. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742431	HE staining of the principal organs of nude mice in the control and experimental groups, including heart, liver, spleen, lung, kidney, and pancreas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657744	The asterisks (*) indicate the primary cilia. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "asterisks", "(", "*", ")", "indicate", "the", "primary", "cilia", ".", "(" ] ...
PMC9429973	We further prove the impact of using an LNP delivery system to improve therapeutic potential of siRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "prove", "the", "impact", "...
PMC11794847	Given this backdrop, we hypothesized that manipulating HVEM expression could provide insights into the intricate dynamics of T cell functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "this", "...
PMC11515150	PE-conjugated CD56 and FITC-conjugated CD3 antibodies were used to label primary NK cells and T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PE-conjugated", "CD56", "and", "FITC-conjugated", "CD3", ...
PMC10998613	The measured values of fc = 0.13 ± 0.11 (median fc = 0.09) in COS-7 cells and fc = 0.11 ± 0.14 (median fc = 0.07) in MDA-MB-231 (Fig. 3C and SI Appendix, Table S2) indicate that similar levels of β2AR homodimerization exist in both COS-7 and MDA-MB-231 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	Additionally, we assessed the role of metastatic and relapse state in patient prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "we", "assessed", "the", "role", "of", "meta...
PMC10142392	Additionally, researchers have developed oxygen carriers for potential use in treating ischemic tissues, using PEO-PCL copolymer vesicles loaded with either human or bovine hemoglobin that demonstrate good oxygen binding and release .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352746	Since neurite length quantification depends on the visualization of individual neurites, it was intuitive that these publications would gravitate toward low-density cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since",...
PMC11745823	The collection process adhered to ethical guidelines and regulations, and all patients signed informed consent before the surgical operations, permitting both the intervention and the anonymized scientific analysis of their diseased tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	n = 3 independent biological replicates, one-way ANOVA, Bonferroni’s multiple comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", "independent", "biological", "replicates", ",", "o...
PMC11626627	We previously found that ERβ, as a TF, can bind to the response elements in the promoter region of the circATP2B1 parent gene ATP2B1, thereby suppressing the expression of circATP2B1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673060	The statistical significance was –log10 transformed (y-axis) and plotted against the t-test difference (x-axis).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "statistical", "significance", "was", ...
PMC11033180	A template of concentric circles distant from 60 and 100 μm from the ganglion center was overlaid on the ganglion using Fiji software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC7917457	As we have previously shown the superior anti-tumor efficacy of PeptiCRAd using an unarmed adenovirus within the platform as compared to the unarmed adenovirus alone, here, we set up to test whether the combination of virus-encoded OX40L and CD40L has an effect on the efficacy of PeptiCRAd.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5035325	Color figure online) Co-expression of EGFR and NeuGcGM3 ganglioside in human non-small cell lung cancer (poorly differentiated ductal adenocarcinoma).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Color", "fig...
PMC11543885	Elute the biotinylated proteins via boiling the beads in 60 μL 3 x Laemmli loading buffer (supplemented with 2 mM biotin and 20 mM DTT) at 98°C for 10 min.c.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540611	Moreover, the effect of the AuNP14-siBCL-xL complexes on the CEM-SS cell line became discernible.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "effect", "of", "the", "AuN...
PMC9429973	E. Tanzi, S. M Di Modica, J. Bordini, V. Olivari, M. Pettinato, A. Pagani, A. Campanella, L. Silvestri, A. Nai Division of Genetics and Cell Biology, Ospedale San Raffaele; University of Milan Bicocca; Division of Experimental Oncology, Ospedale San Raffaele; Vita-Salute San Raffaele University, Milan, Italy Background: β-thalassemia is a disorder due to mutations in the β-globin gene, characterized by ineffective erythropoiesis (IE), anemia, and iron overload, whose treatment still requires improvement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10907726	Fig. 7DATS inactivated EGFR/PI3K/AKT/mTOR pathway. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "7DATS", "inactivated", "EGFR/PI3K/AKT/mTOR", "pathway", ".", "(" ] } ]
PMC11704834	To the best of our knowledge, this is the first study to implicate the TLE1 corepressor in drug sensitivity and resistance in human lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5963610	Statistical differences are indicated: p<0.001, p<0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "differences", "are", "indicated", ":", "p<0.001", ",", "p<0.05", "." ] } ]
PMC11760643	Data represented as mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represented", "as", "mean", "±", "SEM", "." ] } ]
PMC10820104	Following a bioassay-guided strategy for the isolation of presumable drugs or drug-led structures originating from a natural source for use against the human pancreatic adenocarcinoma cell line PANC-1, several indole diketopiperazine alkaloids, including a new triprenylated alkaloid, named rubrumline P (1), together with other known prenylated derivatives (2–7) were obtained from rice culture supplemented with 3.5% NaCl of the marine sediment-derived fungus, Aspergillus chevalieri.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "...
PMC10094712	Relatively recently, a similar cytotoxic effect of selenium nanoparticles was demonstrated .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relatively", "recently", ",", "a", "similar", "cytotoxic", "effect", "of", "sele...
PMC6102174	This result revealed the anti-HBV active constituents of A. capillaris and provided valuable information for the potential use of chlorogenic acid analogues as novel non-nucleoside anti-HBV candidates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10507284	Manuscript writing: Binfeng Liu and Chao Tu.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Manuscript", "writing", ":", "Binfeng", "Liu", "and", "Chao", "Tu", "." ] } ]
PMC11794588	Fig. 6Cytotoxic activity of most active fractions of Cestrum aurantiacum against hela cell line using a twofold dilution protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "6Cytotoxic", "activity...
PMC11365427	Cell viability was assessed by a CCK-8 Kit (Beijing Livning Biotechnology Co., Ltd., Beijing, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "was", ...
PMC11786704	This approach of enhancing polyphenol bioavailability and preserving their biological activity over the long term may offer a promising strategy for the treatment of chronic diseases, particularly as demonstrated by its potential in managing diabetic chronic wounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694066	The combination of PARPi and ATRi elicits a cGAS–STING–mediated cell-autonomous immune response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "of", "PARPi", "and", "ATRi", ...
PMC9429973	Methods: We differentiated IPSCs that contain wildtype GFI1B or GFI1B into megakaryocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "differentiated", "IPSCs", "that", "contain", "wildtyp...
PMC11481779	While they are extremely useful for the prediction of the genetic landscape, they are responsible for the smoothening effect, which makes the output highly informative but very distinct from the real heatmaps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10812665	This points to a broad set of metabolic reverberations due to disturbances of primary metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "points", "to", "a", "broad", "set", "of", "me...
PMC11012012	The expression of SLAMF5/CD84 was found to be regulated by macrophage migration inhibitory factor (MIF) and its receptor, CD74.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expre...
PMC8992508	Bifendate (DDB) (38) [Figure 8] is an analogue of schizandrin C, used for the treatment of chronic viral hepatitis B in China.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	p < 0.05; p < 0.01; *p < 0.001 (boxes indicate the first and third quartiles—and the median inside—of the different measures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11413393

Our data supports PRMT1 as a target in ccRCC and informs a mechanism-based strategy for translational development.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "supports", "PRMT1", "as", "a...

PMC9516447

Whole cell lysate was subjected to Western blot analysis for KRAS protein level with GAPDH serving as loading control.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole", "cell", "lysate", "was", ...

PMC11290772

Considering these findings, it is imperative to develop more effective immunotherapy strategies targeting ROBO1 in clinical ovarian cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Considering", "these", "findings", ...

PMC9429973

Aims: To estimate the cumulative incidence (CI) of cardiac events in a large series of unselected pts with AML in a single Spanish institution, and to identify risk factors associated with their development.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10523483

Similarly, H1.2 overexpression increased nuclear levels of NRF2 in A549 and H1975 cells (SI Appendix, Fig. S9).

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PMC8873393

Here we sought to capture the transcription shutdown and restart and isolate the set of lncRNAs that are likely to function at the chromatin interface by using biochemical fractionation of the cellular compartments coupled to RNA-seq.

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PMC8662250

Nowadays, the role of the ACE‐2 receptor as the interaction site between SARS‐CoV‐2 SP and the host cells is well known.

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PMC6948907

Histone deacetylase inhibitors (HDACi) are anti-cancer drugs which induce chromatin remodelling and alter gene transcription by which induces tumor cell apoptosis, cell cycle arrest, cell differentiation, modulation of immune responses and altered angiogenesis.

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PMC11743316

The relationship between the amounts of ROS and cell metabolism is tightly controlled.

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PMC10761571

6Magnetic saturation curve of Fe3O4@Glu-Gingerol NPs.

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PMC11599565

RNA integrity was ascertained using the 2100 Bioanalyzer (Agilent, Santa Clara, CA).

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PMC11786156

However, adhesion between tumor cells and tumor-infiltrating lymphocytes via CD54 and LFA1 may not always be beneficial for tumor cells, because it may also enhance antitumor immune response.

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PMC2196094

The RBL-1 cell line was originally established from cells of a rat with basophilic leukemia (27).

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PMC9848491

IC50 of JNK.9L in high and low risk groups. (

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PMC9429973

Summary/Conclusion: Compared with chemotherapy plus DLI, donor-derived CD19 CAR-T is more effective and safe in the treatment of recurrent B-ALL after allogeneic HSCT.

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PMC11190062

In line with previously published data (22, 25, 27–29), we found that both cell proliferation ( Figure 1C ) and cell viability ( Figures 1D, E ) were increased following LPS and CpG treatment.

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PMC10907726

Scale bar: 1 mm for B and 500 μm for C. (D) Western blot was employed to measure the expression levels of E-cad, N-cad, MMP-2, Snail and Vimentin in OS cells. *

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PMC11695623

3The relationship between DCUN1D5 and the prognosis of LUAD. (

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PMC11798926

Information on all constructs used in this study are described in greater detail in Supplementary Table 1.

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PMC9429973

Prior to infusion of ARU-1801, all patients received a single IV dose of RIC melphalan (140 mg/m).

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PMC9351137

Scale bar = 10 μm.

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PMC11627133

These self‐labeling and genetically encodable protein tags covalently attach the fluorophores to the POI within the cell.[ , ]

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PMC11543935

The CT image was acquired using a Siemens SOMATOM X.cite with the following parameters: Collimation, 38.4 × 0.6 mm; Voltage, 70 kV; Tube current 28 mA; Slice thickness 2 mm; Pitch factor 0.8.

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PMC10870498

IF staining was used to verify the relationship between KIF23 and SIRT7.

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PMC11741906

This literature may suggest the oncogenic role of hsa-miR-200b-3p in ovarian cancer, but this requires validation using functional studies.

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PMC11736898

Despite reduced vitamin D receptor expression in keloid epidermis in vivo, keloid keratinocytes are able to respond to vitamin D stimulation in vitro with upregulation of target genes.

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PMC8873393

This observation has been further confirmed by immunostaining of p-H3S10 protein.

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PMC7039683

In each replicate, we isolated 20,000 peridermal and non-peridermal cells from Tg(krt4:GFP) embryos at the 4-somite stage.

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PMC11486946

Using an automated system for a fast large-scale single-molecule analysis, we screen for epidermal growth factor receptor (EGFR) from 1134 of FDA approved drugs.

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PMC10547921

Although the immune ADC is still in the initial stage of development and has not yet achieved satisfactory clinical results, the immune-modulating ADC has the potential to greatly broaden the treatment window of the ADC, improve its anti-tumor activity, and have ideal safety and efficacy.

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PMC11087055

Authentic PS morphogenesis under disrupting authentic polonaise movements. (

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PMC11640419

Therefore, hybrid molecule 9a, which is based on oleanolic acid and the 1Z,5Z-diene fragment, affects all phases of the cell cycle, but it has a particularly pronounced effect on G1, pre-G0, and G2 phases (Figure 2).

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PMC11286266

Representative BLI signals depicting the interaction of rat (r) CRT (analyte) with different forms of cgATF6α_LD (from HEK293T cells) immobilised on streptavidin biosensors: ATF6α_LD in red, ATF6α_LD in yellow, and ATF6α_LD in blue.

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PMC11583010

In brief, mAbs in PBS 1×, 1 mmol/L EDTA, were reduced with 14 mol/L equivalents of TCEP for 2 hours at 37°C, after which the buffer was exchanged (Amicon ultra 30 kDa) to 100 mmol/L KPO4, 1 mmol/L EDTA, pH 7.4.

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PMC11766309

Since there are few or no normal tissue samples in the TCGA database, a comparison was made between the expression levels of tumors and normal tissues in various cancerous tissues by combining TCGA and GTEx data.

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PMC10938377

The A2780cisR cell line was routinely treated with cisplatin (2 μM) in the media to maintain cisplatin resistance.

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PMC9844987

For all box-and-whisker plots, central band: median; boundaries: first and third quartiles; whiskers:+/-1.5 IQR.

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PMC11401358

β-Sheet structures could form β-crystallite by orderly arrangement and then form nanofibril structures .

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PMC10362265

Altogether, these findings suggested that the initial conformation of the surface region between 68 and 81 that affects the dynamics of the IL18-IL18BP complex through stabilization of the IL18 structure by two salt bridge interactions.

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PMC11012313

Further statistical analysis demonstrates that these changes in phospho-4E-BP1 are statistically significant (Figure 5C,D).

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PMC11711063

Comparison of ZG16B‐induced cell migration in ER‐positive (MCF7, T47D) and ER‐negative (MDA‐MB‐231, MDA‐MB‐468, HCC1143) breast cancer cell lines using scratch assays. (

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PMC8414691

In the case of SRCAP isoforms, post-translational modifications may occur which could affect migration differences.

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PMC11495567

After 24 h, treatment media were refreshed followed by incubation for a further 24 h. The cells were fixed with 4% formaldehyde, permeabilized with 0.5% Triton X-100 and stained using a mixture of 1X Alexa Fluor568 phalloidin (cat# A12380) and 1X Hoechst stain (DAPI).

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PMC9611901

As known, for each new material or newly developed technological process various safety issues must be known before it is put into widespread use.

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PMC9143157

In vivo antitumor effect of P-THP was investigated by using xenograft models in mice, as compared with commonly used chemotherapeutic drugs for gynecological malignancies, i.e., THP, cisplatin, and paclitaxel.

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PMC9436459

All these compounds were isolated from the bark of Brosimum rubescens by Shirota et al. , and they share the same cis–trans configuration.

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PMC11607638

p < .0001. (

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PMC11635087

The φII image was obtained using the following equation: φII=(Fm′−F)/Fm′ The blanks (Fn and Fm′n, respectively) for F and Fm′ of CHO-K1 cells without chloroplasts were measured and excluded from the data for chloroplasts incorporated into CHO-K1 cells.

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PMC9509578

This nanoformulation was revealed to cause significant inhibition of tumor growth in female nude mice with negligible distribution in healthy tissues and organs.

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PMC11657695

p < 0,05; **: p < 0,01 and ***: p < 0,001 (Mann–Whitney tests) The regulation of KCNA2 expression was then studied using RT-qPCR and Western blot assays.

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PMC11348300

Twenty-one mice were injected with 250 mg/kg ALA and imaged at 1, 2, 3, 4, 6, 8, 18, and 24 h postinjection.

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PMC10919056

Afatinib. (

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PMC8389560

Since in our experiments SeNP induce both Ca transients and Ca oscillations, which is then accompanied by the induction of an early stage of apoptosis, it can be assumed that this mechanism is activated as well.

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PMC6948907

This compound has anticancer property and activates tumor suppressor genes by modulating chromatin configuration and DNA methylation (Banerjee et al., 2008; Kikuno et al., 2008; Sarkar et al., 2003).

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PMC4360730

Lastly, the ‘Available data’ facet describes the data file types that are available for download from the ENCODE portal. (

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PMC9429973

After the start of treatment, the different QLQ-C30 scales were analyzed.

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PMC11790971

Moreover, within-cell-line heterogeneity was evident across passages, complicating the visual assessment of differences among cell lines.

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PMC9512971

The ordinal scale was grade 3 (hospitalized, no oxygen therapy) in most patients during the study period because all patients were hospitalized for SARS-CoV-2 testing; outpatients were not enrolled due to the risk of transmission.

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PMC11474209

Here, we have discussed the mechanisms associated with MC-LR exposure-related signaling pathways and sensing methods for detecting MC-LR in the water sample.

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PMC11247842

The red horizontal line indicates the genome-wide significance level [− log10(p) = 8.5]Table 1Lead SNPs for QTL for clinical mastitis (CM) and somatic cell score (SCS), along with the nearest gene and the functional annotation of the SNPsBTABase pairQTLrsid− log10(p)Analysis methodNearest geneAnnotation1131,393,761131,144,131–131,643,847NA11.23MR-MEGA_SCSSOX14Intergenic variant1131,399,037131,149,079–131,649,130rs2092620969.15MR-MEGA_CMSOX14Intergenic variant1131,508,931131,259,179–131,758,987rs13364577419.16MTAG_SCSSOX14Intergenic variant1143,908,907143,660,512–144,160,344rs432822799.08MR-MEGA_SCSAGPAT3Intergenic variant1145,932,212145,682,433–146,182,333rs4699473989.05MTAG_SCSMCM3APIntron variant2127,010,295126,760,970–127,260,998rs1098613389.11MR-MEGA_CMTRIM63Intergenic variant2127,199,316126,949,469–127,449,526rs1339142628.92MTAG_CMPAQR7Intergenic variant324,114,90423,865,017–24,365,480rs3850259338.87MTAG_CMTBX15Intergenic variant332,937,62432,688,826–33,188,877rs433361909.29MR-MEGA_CMCYMIntergenic variant332,991,79332,741,957–33,241,801rs433361358.97MTAG_CMPROK1Intron variant333,085,26232,835,778–33,356,862rs4333546111.06MTAG_SCSRBM15Downstream variant410,207,0919,958,314–10,457,519rs21131775917.71MR-MEGA_SCSENSBTAG00000051416Downstream variant556,290,20456,040,322–56,542,938rs10984876012.68MTAG_CMLRP1Intron variant556,332,71556,082,869–56,583,125rs20835890919.19MTAG_SCSSTAT6Synonymous variant588,406,86187,673,289–88,657,962rs2098937729.50MR-MEGA_CMABCC9Intron variant686,940,86386,690,963–87,191,548rs21037393633.58MR-MEGA_CMGCIntergenic variant686,991,63086,741,866–87,268,801rs43653257622.14/19.43MTAG_CM, MTAG_SCSGCIntron variant687,000,65486,752,563–87,280,573rs10895212822.27MR-MEGA_SCSGCIntron variant910,451,70510,202,576–10,702,351rs21077070717.59MR-MEGA_SCSOGFRL1Intergenic variant910,457,30410,207,394–10,707,412rs13316426223.63MR-MEGA_CMbta-mir-30fIntergenic variant910,510,02010,260,034–10,760,190rs10933544316.73MTAG_CMOGFRL1Intergenic variant910,672,83310,423,069–10,923,737rs10971803825.51MTAG_SCSENSBTAG00000048046Intergenic variant1087,184,30886,811,104–87,436,082rs4224853215.37MR-MEGA_SCSTTLL5Intron variant1112,078,91111,079,809–12,329,170NA8.73MR-MEGA_SCSEXOC6BIntron variant1185,622,20685,372,220–85,872,367rs38261516110.51MTAG_SCSTRIB2Intergenic variant1356,890,47256,012,401–57,140,946rs416964369.22MR-MEGA_SCSPHACTR3Intron variant1379,482,64578,816,883–79,738,951NA13.03MR-MEGA_SCSATP9AIntron variant14528,726283,062–778,739rs1104189609.70MTAG_CMENSBTAG00000053637Intron variant14559,962311,166–885,752rs21023076710.75MR-MEGA_CMADCK5Intron variant1625,160,03424,910,289–25,411,234rs37974267311.42MTAG_CMDUSP10Intergenic variant1625,189,02224,941,012–25,440,400rs11006112413.03MTAG_SCSDUSP10Intron variant1625,190,38924,953,782–25,460,899rs1092742159.12/MR-MEGA_CM, MR-MEGA_SCSDUSP10Intron variant1843,707,61043,463,418–43,957,639rs37969907710.52MR-MEGA_CMENSBTAG00000049393Intergenic variant1844,354,88343,674,933–44,605,086NA10.49MR-MEGA_SCSENSBTAG00000050669Intron variant1865,188,61364,939,546–65,442,597rs4190175117.65MTAG_SCSLOC100124497Intron variant1865,288,69265,038,910–65,539,395NA9.24MR-MEGA_CMENSBTAG00000038715Intergenic variant197,358,4807,109,618–7,610,867NA16.86MR-MEGA_SCSNOGIntergenic variant197,371,2117,122,553–7,622,923rs10918424510.25MR-MEGA_CMNOGIntergenic variant1931,532,43631,282,440–31,782,555rs44352717010.84MR-MEGA_SCSENSBTAG00000052541Intergenic variant1940,053,28839,502,431–40,303,655rs13440207512.25MR-MEGA_SCSPGAP3Intron variant1954,626,23254,376,382–54,900,608rs13469340511.63MR-MEGA_SCSSEPTIN9Intron variant1956,012,40155,763,067–56,483,191rs1357907659.81MR-MEGA_CMLLGL2Intron variant2022,385,79121,933,562–22,635,895rs11032306113.09MR-MEGA_SCSMAP3K1Intron variant2022,386,42522,141,590–22,636,468rs38094437421.22MR-MEGA_CMMAP3K1Intron variant2022,422,29922,172,873–22,673,171rs20910356919.42MTAG_CMMAP3K1Upstream variant2022,428,45522,180,220rs20828083715.14MTAG_SCSMAP3K1Intergenic variant2039,502,43139,252,645–39,766,694rs426639679.40MR-MEGA_SCSRAI14Intron variant2157,144,70456,895,032–57,394,726rs37825594016.51MR-MEGA_CMSLC24A4Intron variant2162,941,83362,691,932–63,192,091rs13684406217.55MR-MEGA_SCS5S_rRNAIntergenic variant2163,051,72062,801,824–63,302,337rs13352412912.53MTAG_SCSBCL11BIntergenic variant2252,947,79052,698,116–53,199,688rs13584515114.17MR-MEGA_SCSLTFUpstream variant2253,007,16852,757,454–53,257,174rs3853931728.58MTAG_SCSCCRL2Intron variant2339,530,19639,295,040–39,780,965rs13685750713.02MTAG_SCSKIF13AIntron variant2460,882,42060,633,040–61,132,920rs4157120711.74MR-MEGA_SCSZCCHC2Intergenic variant2460,883,69660,633,830–61,133,857NA9.37MR-MEGA_CMZCCHC2Intergenic variant2538,531,21437,561,390–38,781,883rs3837199168.54MTAG_SCSLOC618542Intron variant299,486,0409,236,161–9,736,089NA9.68MR-MEGA_SCSPICALMIntergenic variant2946,577,85946,074,605–46,834,864rs3782682279.36MR-MEGA_SCSENSBTAG00000050252Intergenic variantThe list of lead SNPs, their annotation and nearest genes for all the meta-analyses used and implemented in MR-MEGA and MTAG .

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PMC9429973

Additionally, we isolated DNA of fibroblasts or remission material of each pediatric patient as matching non-tumor control.

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PMC10197932

In addition, no increase in senescence or apoptosis events is observed in RBC following US-treatment.

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PMC11539788

P < 0.05, **P < 0.01, and ***P < 0.001 RNF19A regulated the activation of AKT/mTOR signalling via ILK. (

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PMC11742431

HE staining of the principal organs of nude mice in the control and experimental groups, including heart, liver, spleen, lung, kidney, and pancreas.

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PMC11657744

The asterisks (*) indicate the primary cilia. (

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PMC9429973

We further prove the impact of using an LNP delivery system to improve therapeutic potential of siRNA.

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PMC11794847

Given this backdrop, we hypothesized that manipulating HVEM expression could provide insights into the intricate dynamics of T cell functions.

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PMC11515150

PE-conjugated CD56 and FITC-conjugated CD3 antibodies were used to label primary NK cells and T cells.

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PMC10998613

The measured values of fc = 0.13 ± 0.11 (median fc = 0.09) in COS-7 cells and fc = 0.11 ± 0.14 (median fc = 0.07) in MDA-MB-231 (Fig. 3C and SI Appendix, Table S2) indicate that similar levels of β2AR homodimerization exist in both COS-7 and MDA-MB-231 cells.

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PMC11453018

Additionally, we assessed the role of metastatic and relapse state in patient prognosis.

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PMC10142392

Additionally, researchers have developed oxygen carriers for potential use in treating ischemic tissues, using PEO-PCL copolymer vesicles loaded with either human or bovine hemoglobin that demonstrate good oxygen binding and release .

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PMC11352746

Since neurite length quantification depends on the visualization of individual neurites, it was intuitive that these publications would gravitate toward low-density cultures.

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PMC11745823

The collection process adhered to ethical guidelines and regulations, and all patients signed informed consent before the surgical operations, permitting both the intervention and the anonymized scientific analysis of their diseased tissue.

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PMC11001582

n = 3 independent biological replicates, one-way ANOVA, Bonferroni’s multiple comparison.

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PMC11626627

We previously found that ERβ, as a TF, can bind to the response elements in the promoter region of the circATP2B1 parent gene ATP2B1, thereby suppressing the expression of circATP2B1.

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PMC5673060

The statistical significance was –log10 transformed (y-axis) and plotted against the t-test difference (x-axis).

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PMC11033180

A template of concentric circles distant from 60 and 100 μm from the ganglion center was overlaid on the ganglion using Fiji software.

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PMC7917457

As we have previously shown the superior anti-tumor efficacy of PeptiCRAd using an unarmed adenovirus within the platform as compared to the unarmed adenovirus alone, here, we set up to test whether the combination of virus-encoded OX40L and CD40L has an effect on the efficacy of PeptiCRAd.

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PMC5035325

Color figure online) Co-expression of EGFR and NeuGcGM3 ganglioside in human non-small cell lung cancer (poorly differentiated ductal adenocarcinoma).

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PMC11543885

Elute the biotinylated proteins via boiling the beads in 60 μL 3 x Laemmli loading buffer (supplemented with 2 mM biotin and 20 mM DTT) at 98°C for 10 min.c.

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PMC8540611

Moreover, the effect of the AuNP14-siBCL-xL complexes on the CEM-SS cell line became discernible.

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PMC9429973

E. Tanzi, S. M Di Modica, J. Bordini, V. Olivari, M. Pettinato, A. Pagani, A. Campanella, L. Silvestri, A. Nai Division of Genetics and Cell Biology, Ospedale San Raffaele; University of Milan Bicocca; Division of Experimental Oncology, Ospedale San Raffaele; Vita-Salute San Raffaele University, Milan, Italy Background: β-thalassemia is a disorder due to mutations in the β-globin gene, characterized by ineffective erythropoiesis (IE), anemia, and iron overload, whose treatment still requires improvement.

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PMC10907726

Fig. 7DATS inactivated EGFR/PI3K/AKT/mTOR pathway. (

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PMC11704834

To the best of our knowledge, this is the first study to implicate the TLE1 corepressor in drug sensitivity and resistance in human lung cancer.

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PMC5963610

Statistical differences are indicated: p<0.001, p<0.05.

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PMC11760643

Data represented as mean ± SEM.

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PMC10820104

Following a bioassay-guided strategy for the isolation of presumable drugs or drug-led structures originating from a natural source for use against the human pancreatic adenocarcinoma cell line PANC-1, several indole diketopiperazine alkaloids, including a new triprenylated alkaloid, named rubrumline P (1), together with other known prenylated derivatives (2–7) were obtained from rice culture supplemented with 3.5% NaCl of the marine sediment-derived fungus, Aspergillus chevalieri.

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PMC10094712

Relatively recently, a similar cytotoxic effect of selenium nanoparticles was demonstrated .

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PMC6102174

This result revealed the anti-HBV active constituents of A. capillaris and provided valuable information for the potential use of chlorogenic acid analogues as novel non-nucleoside anti-HBV candidates.

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PMC10507284

Manuscript writing: Binfeng Liu and Chao Tu.

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PMC11794588

Fig. 6Cytotoxic activity of most active fractions of Cestrum aurantiacum against hela cell line using a twofold dilution protocol.

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PMC11365427

Cell viability was assessed by a CCK-8 Kit (Beijing Livning Biotechnology Co., Ltd., Beijing, China).

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PMC11786704

This approach of enhancing polyphenol bioavailability and preserving their biological activity over the long term may offer a promising strategy for the treatment of chronic diseases, particularly as demonstrated by its potential in managing diabetic chronic wounds.

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PMC11694066

The combination of PARPi and ATRi elicits a cGAS–STING–mediated cell-autonomous immune response.

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PMC9429973

Methods: We differentiated IPSCs that contain wildtype GFI1B or GFI1B into megakaryocytes.

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PMC11481779

While they are extremely useful for the prediction of the genetic landscape, they are responsible for the smoothening effect, which makes the output highly informative but very distinct from the real heatmaps.

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PMC10812665

This points to a broad set of metabolic reverberations due to disturbances of primary metabolism.

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PMC11012012

The expression of SLAMF5/CD84 was found to be regulated by macrophage migration inhibitory factor (MIF) and its receptor, CD74.

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PMC8992508

Bifendate (DDB) (38) [Figure 8] is an analogue of schizandrin C, used for the treatment of chronic viral hepatitis B in China.

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PMC11706776

p < 0.05; **p < 0.01; ***p < 0.001 (boxes indicate the first and third quartiles—and the median inside—of the different measures.

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