OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11750161	LH, luteinizing hormone; CGR, choriogonadotropin receptor; cAMP, cyclic adenosine monophosphate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LH", ",", "luteinizing", "hormone", ";", "CGR", ",", ...
PMC10440586	QWC contributed to the data processing of the Fudan PGx cohort and manuscript revision.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "QWC", "contributed", "to", "the", "data", "processing", "of", "t...
PMC3681794	24 hours after exposure to SRB IC50 doses of cytotoxic for 1 hour lysates were assessed for total p53, p53 pS15, p21, PUMA and NOXA by western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11025866	Transcript abundance counts were quantified using Salmon (v0.12.0) in Anaconda with the hg38.95 human reference transcriptome following the process in this Bioconductor vignette .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11758416	Note: Other cell dyes including CellTrace Violet (Thermo Fisher Scientific, cat: C34557) or CellTrace FarRed (Thermo Fisher Scientific, cat: C34564) can be used to identify the L cells if CFSE is not a good option.a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506670	Neither the three novel NRAS mutants nor the canonical NRAS Q61K mutant promoted cell migration in NIH3T3 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Neither", "the", "three", ...
PMC9429973	The objectives were to compare overall survival (OS), relapsed free survival (RFS), non-relapse mortality (NRM), relapse, grade II-IV acute graft vs host disease (aGVHD), chronic GVHD (cGVHD), mucositis and gastrointestinal (GI) toxicity based on Mel mg/kg dosing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774251	These findings confirm that Tan-I effectively disrupts abnormal apoptosis while modulating the inflammatory mediators implicated in the pathogenesis of psoriasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "confirm...
PMC11224020	Data were analyzed by Kruskal–Wallis test; ****P < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", "by", "Kruskal", "–", ...
PMC11634794	Correlation analysis revealed significant associations between LAMP1 expression in cancer tissues and sex(P<0.001), age(P<0.001) and T stage(P=0.039), however, no correlations were observed with M stage, clinical stage, or nuclear grade.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	Scale bar = 1 cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "1", "cm", "." ] } ]
PMC2614415	Data represents fold enrichment in carcinoma patients versus adenoma patients. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represents", "fold", "enrichment", "in", "carcinoma", "patients", "versus", "adenom...
PMC11478724	Our results were consistent with the results of Zhang et al. (2016) and the up-regulation of hsa-MiR-320a had inversely related to the expression of VDAC1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9776316	However, the excessive apoptosis with degradation of DNA will readily cause the detection of γH2AX by immunofluorescence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "excessive", "ap...
PMC11772449	Next, we investigated the synergistic anti-tumor effect of pirfenidone and Sora in BEL-7404 tumor xenografts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "investigated", "the", "syn...
PMC5330095	In general, with regard to antiviral activity, medical Cannabis was reported to be used as an accompanying remedy by HIV/AIDS patients to alleviate neuropathic pain, wasting, nausea, and vomiting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	The information about food intake was collected via a three-day 24-h dietary recall, and the nutrient composition was analyzed according to China Food Composition Tables by two independent investigators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11381192	Relative infiltration levels of immune cells in the MM microenvironment were characterised by single sample gene set enrichment analysis (ssGSEA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "...
PMC9622879	Let be the energy cost of the community in time slot t. From (20), the optimization problem of the community that minimizes the daily energy cost of the community can be formulated as21[12pt] $$&min _^ C_(t)= min _^ P(t) E_(t) \\& = min _^P(t) ( _^E_^(t) - _^E_^(t) ), $$∑t=1TCCom(t)=min∑t=1TP(t)·ECom(t)=min∑t=1TP(t)·(∑i=1NEi,Combuy(t)-∑i=1NEi,Comsell(t)),where22[12pt] $$ P(t) = P_(t) & _^E_^(t) > _^E_^(t) \\ P_(t) & _^E_^(t) < _^E_^(t) . }	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The treatment consisted of four 28-day cycles of KRd (carfilzomib 36 mg/m day 1,2,8,9,15 and 16 (except 20 mg/m day 1 and 2 first cycle), lenalidomide 25 mg day 1-21 all cycles and dexamethasone 40 mg day 1,8,15 and 22 all cycles).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11128598	Cell lines were seeded into 96-well plates (from 2,000 to 4,000 cells/well, depending on the cell lines used) and were treated with different concentrations of CQ, LBH, KU-57788 or NU-7026 for 24, 48 or 72 h. Cell proliferation was determined using 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyl-2H-tetrazolium bromide (MTT) (Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502962	Such a phenomenon was also found in MIF expression and CXCR4 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "a", "phenomenon", "was", "also", "found", "in", "MIF", "expression", ...
PMC9429973	Aims: To conduct a retrospective audit to determine the total number of FVL and FII tests requested by clinicians and the prevalence of FII mutations at Tygerberg hospital, and screen a novel gain of function mutation, Prothrombin Yukuhashi, in exon 14 of the FII gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3915447	The differential expression of FR in blood and other cancers makes it an attractive marker and target molecule for diagnosis and therapy of the disease (Low et al., 2008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11648299	The local cohort included 13 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "local", "cohort", "included", "13", "patients", "." ] } ]
PMC11387401	HIV-1 infection of SupT1 cells prior to RIPseq was done with VSV-G pseudotyped NL4.3 HSA-IRES-Nef dEnv labstrain virus by spinoculation for 90 min (2300 rpm, 32 °C).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	We observed weak light-induced dissolution upon mCherry recruitment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "observed", "weak", "light-induced", "dissolution", "upon", "mCherry", "recruitment", "." ] } ]
PMC11682525	This study investigated the impact of hypoxic preconditioning on the survival and oxidative stress tolerance of nestin-expressing hair follicle stem cells (hHFSCs) and SH-SY5Y neuroblastoma cells, two crucial cell types for central nervous system therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC2777936	WNT3, WNT4, WNT6, and WNT10A were significantly up-regulated after 96 hours of RA-treatment and WNT5B and WNT9A were significantly down-regulated by this treatment (Figure 2a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640419	Apoptosis may be initiated by the cell itself when it detects damage through a number of intracellular sensors, a process known as the intrinsic pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10887351	In canine pulmonary arteries, the β3-ARs vasodilating effects were coupled with increased cAMP levels .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "canine", "pulmonary", "arteries", ",", "the", "β3-ARs...
PMC11188874	A homogeneous fluorescent assay was used that measures proteasome ChT-like activity in cultured cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "homogeneous", "fluorescent", "assay", "was", "used", "that", ...
PMC10719213	Mitochondrial protein synthesis was analyzed by metabolic labeling with S methionine/cysteine, as described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mitochondrial", "protein", "synthesis", "was", "analyzed", "by", "meta...
PMC9429973	Data from developed countries has shown that CALR mutated patients have higher platelet count and lower thrombotic risk compared to JAK2 mutated patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", ...
PMC11092382	Furthermore, sophocarpine exhibits great benefits in agriculture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "sophocarpine", "exhibits", "great", "benefits", "in", "agriculture", "." ] } ]
PMC9065483	The use of VSVΔ51-FLuc allowed us to simultaneously measure the impact of treatments on virus output via a secondary assay measuring viral expression unit output from supernatants (viral expression units, akin to viral titer), as well as cellular metabolic activity by resazurin assay (Alamar blue), a surrogate for detection of cell viability and cytopathic effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7762347	In contrast, after prolonged exposure of 72 h to CYN (0.5 µg/mL) alone and in combination with MCLR (1 µg/mL) a significant decrease in cell viability of up to 50% compared to solvent control was determined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11155445	Naphthoquinone based iminothiazoline derivatives (14a–e) synthesized by Efeoglu et al. were found as effective inhibitors of carbonic anhydrase I and II, and acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7802142	Unfortunately, all of these treatments have limitations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "all", "of", "these", "treatments", "have", "limitations", "." ] } ]
PMC10529414	Subsequently, they were fixed with 4% paraformaldehyde for 15 min and permeabilized with 0.2% Triton X-100 for 15 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ...
PMC11252553	After 24 hours of incubation, different concentrations of Taurine (25, 50, 100, 200, 300, 400, 500, and 1000 mM) were added to the plates with eight replicates each.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485786	Real-time PCR-based detection of various immune markers in tumor homogenates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Real-time", "PCR-based", "detection", "of", "various", "immune", "markers", "in", "tumor", "homo...
PMC11451940	calcd. (%)	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "calcd", ".", "(", "%", ")" ] } ]
PMC8345486	The cumulative percentage of cells in different phases of apoptosis and necrosis revealed a significant increase in resistance to all drugs for “+2 cells” (Figure 9A,B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: We undertook to discuss what matters most to people living with MDS and provide feedback on discussions in patient support programmes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ...
PMC7553912	Furthermore, Taguchi et al. demonstrated that colony stimulating factor-1 (CSF-1)-deficient mice had marked increase in renal crystal deposition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "Taguchi", "et...
PMC9429973	11 of these patients had a carbapenem exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "11", "of", "these", "patients", "had", "a", "carbapenem", "exposure", "." ] } ]
PMC11747949	ELISA analysis for differences in CCL2 secretion of 143B cells grown in normoxia or hypoxia, without/with (−/+) IFNγ. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ELISA", ...
PMC11541409	Pimitespib shows efficacy against imatinib-sensitive and -insensitive GIST cells with KIT mutations, both in vitro and in vivo .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pimitespib", "shows", "efficacy", ...
PMC9429973	The median age at diagnosis was 68.5 years (range 1-85 years).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "at", "diagnosis", "was", "68.5", ...
PMC7685376	Furthermore, we also found that MCM protein (Figure 4D) and mRNA expression (Figure 4E) were inhibited by Huaier in Bel-7404 and SK-Hep1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC11045125	The two major EBV oncoproteins, EBNA2 and LMP1, mimic constitutively-active Notch and CD40 signaling, respectively, and are essential for EBV transformation of B cells in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11483468	The Western blot results indicated that the GST-TAT-LPTS39 fusion protein was rapidly introduced into the cell and could be detected in the cell after two hours of incubation and remained stable for at least 24 hours (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	Volcano plot of differential expressed proteins. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Volcano", "plot", "of", "differential", "expressed", "proteins", ".", "(" ] } ]
PMC11545737	The most highly inflammatory LOS is also the greatest inducer of miR-146a .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "highly", "inflammatory", "LOS", "is", "also", "the", "greatest", ...
PMC11240052	Mapping on the reverence genome was done by Top Hat (GRCH37.p13 NCBI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mapping", "on", "the", "reverence", "genome", "was", "done", "by...
PMC11578343	In contrast to the untreated control cells, we observed a decrease in elastic G′ in Lat‐A treated cells for all measured frequencies, indicating that they had become more compliant (Figure 2C; Figure S3A, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	Overall, production of oxalate might arise from different pathways (Figure 1), and several gaps still exist, including the contributions of several precursors, cofactors, enzymes, and transporters in different cells/tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697189	Fig. 8Association of risk signatures with tumor mutational burden (TMB). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "8Association", "of", "risk", "signatures", "with", "tumor", "mutati...
PMC9429973	In contrast, mutated DUSP2 indicated longer survival (PFS: HR 0.28; p=.002; OS: HR 0.15; p=.011) (Fig1d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11711871	On a HSD, 10 week-old GR rats exhibited an increased number of the less active forms of fatty acids compared to wild-type rats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10605143	The regulation of its activity is complex, can be cell-type specific and is not yet fully understood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "regulation", "of", "its", "acti...
PMC9872547	After 48 hours, the cells were stained with annexin V/PI (propidium iodide) apoptosis detection kit according to the manufacturer’s instruction (Ebioscience, Thermo Fisher Company).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	Then, the beads were thoroughly washed with HEG50 buffer [25 mM Hepes (pH 7.6), 50 mM KCl, 0.1 mM EDTA, and 10% glycerol] twice and resuspended in the same buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	ACYP1 and ACYP2 are isoforms that consist of 60% identical sequence and display identical substrate specificity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ACYP1", "and", "ACYP2", "are", "isoforms", ...
PMC9473868	The PI3K/Akt/mTOR signaling pathway was significantly activated in RA synovial cells and attenuated RA development by modulating the PI3K/Akt/mTOR signaling pathway .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PI3K/Akt/mTOR", ...
PMC11365983	2Altered levels of Foxc1 are associated with changes to cilia length in three cell types. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2Altered", "levels", "of", "Foxc1", "are", "associated...
PMC9424261	Bel-7402 and Bel-7404 were treated with CA for 1 h, and then supplemented with ferroptosis inducer erastin or RSL3.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bel-7402", "and"...
PMC11699465	Having confirmed that the plasmids work well, we tested whether the transcription factors mentioned above affect CD274 mRNA expression levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Having", "confirmed", ...
PMC9429973	MYC-IGH patients were younger and had more EN site involvement as MYC-non-IGH, but no differences in EFS and OS were noted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MYC-IGH", "p...
PMC10470467	These pieces of evidence suggest that necroptosis plays a complex role in cancer development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "pieces", "of", "evidence", "suggest", "that", "necroptosis", ...
PMC10443665	Bassorin and tragacanthin showed a remarkable and concentration-dependently cytotoxic effect on sensitive and resistant CCRF-CEM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Bassorin", "and", "tragacanthin", "showed", "a", ...
PMC11224020	Regulation of CCR7 expression might thus be critical to define the balance between tolerance and immunity at steady state or during infection and cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Further studies are ongoing to elucidate the exact mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "are", "ongoing", "to", "elucidate", "the", "exact", "mechanism", "." ] } ]
PMC11680982	Furthermore, the anti-HER inhibitor neratinib was administered to enhance the effectiveness of CDK4/6 inhibitor combined with endocrine therapy in HR/HER2-low breast cancer by inhibiting the HER2 pathway and lowering HER2 mRNA expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A. M. Spanjaart, E. Pennings, P. Mutsaers, S. van Dorp, M. Jak, J. van Doesem, J. de Boer, J. Vermaat, A. Sijs-Szabo, M. van der Poel, I. Kuipers, M. Chamuleau, I. Nijhof, M. Minnema, P. Lugtenburg, T. van Meerten, M. J. Kersten Dept.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10204952	At 1000 nM S1P, nucleic alteration was decreased from 66.3% in complete media to 59.6% in AD-CM and 42.7% in CAA-CM, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11264242	Spheroid size was quantified with ImageJ. For cellular and molecular assays, statistically significant differences were determined by two-tailed Student’s t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spheroid", "...
PMC10877303	In this study, 2369 phytoconstituents from Japanese medicinal plants were identified through extensive literature mining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "2369", "phytoconstituents"...
PMC11739504	Scale bar: 2 μm Right graph showed fluorescence intensity of Smo within primary cilia. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "2", "μm", "Right", "graph",...
PMC9919300	In this perspective, the Italian Health Ministry discouraged, since July 2019, curcumin administration in cases of hepatic function alterations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this",...
PMC11672617	Furthermore, the ionic compounds 5a and 5b exhibited reliable differences between themselves with regard to the phases of apoptosis induction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", ...
PMC9429973	From an international perspective this result can have major implications given the fact that proton pump inhibitors may frequently be the only realistic therapy for many patients without access to or not tolerating iron chelators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014	Dengue hemorrhagic fever and dengue shock syndrome are induced by four DENV serovars (DENV1-4), all of which are potentially deadly .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11357960	These data might provide effective circulating biomarkers for predicting the efficacy of anti-PD-1 immunotherapy, and uncovered a novel regulatory mechanism of resistance to anti-PD-1 immunotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11730311	These metabolites were not identified for hαCGRP8-37N25K-C20DA-γGlu, which suggests that positioning the C20DA-γGlu conjugation at N25K offer greater protection against cleavage at the KNN motif.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	Compared to the 143B-EFHD1-cisplatin group, we observed a considerable decrease in tumor volume (Fig. 6B) and tumor weight (Fig. 6C) in the 143B-EFHD1-cisplatin-CATR group.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: Here, we report the health-related quality of life (HRQoL) outcomes from an interim analysis of the SEQUOIA trial.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ...
PMC11321678	After comparing the gene activity scores and motif deviation scores of TFs, we identified 26 positive TF regulators (Figure 3D) and most of them are subgroup‐specific (Figure 3E; Figure S5C, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11495567	For FACS analysis, harvesting and centrifugation after PCAIs treatment is necessary to obtain cells for sorting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "FACS", "analysis", ",", "harvesting", ...
PMC9429973	One of the three main driver mutations known to cause MPN (JAK2, MPL or CALR mutation) was found in nine patients, eight of whom carrying a JAK2 V617F mutation (ET, N=5; PV, N=3; female, N=5; male, N= 3) and the patient with PMF harbored a CALR type 1 mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594588	Hemostasis is achieved by a careful balance of platelet interactions with vascular components, cytokine mediators, fibrinolytic agents, and plasma-clotting mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hemosta...
PMC2196094	Peritoneal cells from Sprague-Dawley rats (females, 10–15 wk old) were collected by peritoneal washing with 0.025 M Tris-HCl, pH 7.6, containing 0.12 M NaCl and 0.01 M EDTA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	To capture the functioning of a cell, we use the following sets of biological annotations: the pathway annotations from KEGG (collected on the 14 June 2016), the pathway annotations from REACTOME (collected on the 14 June 2016), and the experimentally validated GO-BP annotations from NCBI’s web server (collected on the 14 June 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	Importantly, addition of glycine dramatically reversed the fixation effect on the LLPS behavior of DsRed2-TAF15(IDR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "addition", "of", "glycine", ...
PMC11708541	A vast array of biological and pharmacological effects can result from the interaction of aminopyridine rings with different enzymes and receptors, due to their unique structural properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727062	Furthermore, patients with advanced melanoma not only face treatment challenges and low response rates but are also prone to tumor drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further...
PMC11699042	For the analysis of long-term cultured EwS cell lines we performed DGEA on the top 60% expressed genes included in the raw count matrix (N = 27,143, all EwS cell line samples were analyzed in one batch).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	GPRC5D has limited expression in healthy human tissue but is highly expressed on malignant plasma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GPRC5D", "has", "limited", "expression", "in", "health...
PMC11033180	Previous studies have shown that mice expressing a Sema5A deletion mutant defecate more than wildtype mice, suggesting that deficiency in Sema5A affects gut motility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11750161

LH, luteinizing hormone; CGR, choriogonadotropin receptor; cAMP, cyclic adenosine monophosphate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LH", ",", "luteinizing", "hormone", ";", "CGR", ",", ...

PMC10440586

QWC contributed to the data processing of the Fudan PGx cohort and manuscript revision.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "QWC", "contributed", "to", "the", "data", "processing", "of", "t...

PMC3681794

24 hours after exposure to SRB IC50 doses of cytotoxic for 1 hour lysates were assessed for total p53, p53 pS15, p21, PUMA and NOXA by western blotting.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11025866

Transcript abundance counts were quantified using Salmon (v0.12.0) in Anaconda with the hg38.95 human reference transcriptome following the process in this Bioconductor vignette .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11758416

Note: Other cell dyes including CellTrace Violet (Thermo Fisher Scientific, cat: C34557) or CellTrace FarRed (Thermo Fisher Scientific, cat: C34564) can be used to identify the L cells if CFSE is not a good option.a.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11506670

Neither the three novel NRAS mutants nor the canonical NRAS Q61K mutant promoted cell migration in NIH3T3 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Neither", "the", "three", ...

PMC9429973

The objectives were to compare overall survival (OS), relapsed free survival (RFS), non-relapse mortality (NRM), relapse, grade II-IV acute graft vs host disease (aGVHD), chronic GVHD (cGVHD), mucositis and gastrointestinal (GI) toxicity based on Mel mg/kg dosing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11774251

These findings confirm that Tan-I effectively disrupts abnormal apoptosis while modulating the inflammatory mediators implicated in the pathogenesis of psoriasis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "confirm...

PMC11224020

Data were analyzed by Kruskal–Wallis test; ****P < 0.0001.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", "by", "Kruskal", "–", ...

PMC11634794

Correlation analysis revealed significant associations between LAMP1 expression in cancer tissues and sex(P<0.001), age(P<0.001) and T stage(P=0.039), however, no correlations were observed with M stage, clinical stage, or nuclear grade.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11127909

Scale bar = 1 cm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "1", "cm", "." ] } ]

PMC2614415

Data represents fold enrichment in carcinoma patients versus adenoma patients. *

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represents", "fold", "enrichment", "in", "carcinoma", "patients", "versus", "adenom...

PMC11478724

Our results were consistent with the results of Zhang et al. (2016) and the up-regulation of hsa-MiR-320a had inversely related to the expression of VDAC1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9776316

However, the excessive apoptosis with degradation of DNA will readily cause the detection of γH2AX by immunofluorescence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "excessive", "ap...

PMC11772449

Next, we investigated the synergistic anti-tumor effect of pirfenidone and Sora in BEL-7404 tumor xenografts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "investigated", "the", "syn...

PMC5330095

In general, with regard to antiviral activity, medical Cannabis was reported to be used as an accompanying remedy by HIV/AIDS patients to alleviate neuropathic pain, wasting, nausea, and vomiting.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11770130

The information about food intake was collected via a three-day 24-h dietary recall, and the nutrient composition was analyzed according to China Food Composition Tables by two independent investigators.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11381192

Relative infiltration levels of immune cells in the MM microenvironment were characterised by single sample gene set enrichment analysis (ssGSEA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "...

PMC9622879

Let be the energy cost of the community in time slot t. From (20), the optimization problem of the community that minimizes the daily energy cost of the community can be formulated as21[12pt] $$&min _^ C_(t)= min _^ P(t) E_(t) \\& = min _^P(t) ( _^E_^(t) - _^E_^(t) ), $$∑t=1TCCom(t)=min∑t=1TP(t)·ECom(t)=min∑t=1TP(t)·(∑i=1NEi,Combuy(t)-∑i=1NEi,Comsell(t)),where22[12pt] $$ P(t) = P_(t) & _^E_^(t) > _^E_^(t) \\ P_(t) & _^E_^(t) < _^E_^(t) . }

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The treatment consisted of four 28-day cycles of KRd (carfilzomib 36 mg/m day 1,2,8,9,15 and 16 (except 20 mg/m day 1 and 2 first cycle), lenalidomide 25 mg day 1-21 all cycles and dexamethasone 40 mg day 1,8,15 and 22 all cycles).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11128598

Cell lines were seeded into 96-well plates (from 2,000 to 4,000 cells/well, depending on the cell lines used) and were treated with different concentrations of CQ, LBH, KU-57788 or NU-7026 for 24, 48 or 72 h. Cell proliferation was determined using 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyl-2H-tetrazolium bromide (MTT) (Sigma-Aldrich).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11502962

Such a phenomenon was also found in MIF expression and CXCR4 expression.

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PMC9429973

Aims: To conduct a retrospective audit to determine the total number of FVL and FII tests requested by clinicians and the prevalence of FII mutations at Tygerberg hospital, and screen a novel gain of function mutation, Prothrombin Yukuhashi, in exon 14 of the FII gene.

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PMC3915447

The differential expression of FR in blood and other cancers makes it an attractive marker and target molecule for diagnosis and therapy of the disease (Low et al., 2008).

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PMC11648299

The local cohort included 13 patients.

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PMC11387401

HIV-1 infection of SupT1 cells prior to RIPseq was done with VSV-G pseudotyped NL4.3 HSA-IRES-Nef dEnv labstrain virus by spinoculation for 90 min (2300 rpm, 32 °C).

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PMC11306331

We observed weak light-induced dissolution upon mCherry recruitment.

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PMC11682525

This study investigated the impact of hypoxic preconditioning on the survival and oxidative stress tolerance of nestin-expressing hair follicle stem cells (hHFSCs) and SH-SY5Y neuroblastoma cells, two crucial cell types for central nervous system therapies.

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PMC2777936

WNT3, WNT4, WNT6, and WNT10A were significantly up-regulated after 96 hours of RA-treatment and WNT5B and WNT9A were significantly down-regulated by this treatment (Figure 2a).

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PMC11640419

Apoptosis may be initiated by the cell itself when it detects damage through a number of intracellular sensors, a process known as the intrinsic pathway.

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PMC10887351

In canine pulmonary arteries, the β3-ARs vasodilating effects were coupled with increased cAMP levels .

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PMC11188874

A homogeneous fluorescent assay was used that measures proteasome ChT-like activity in cultured cells.

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PMC10719213

Mitochondrial protein synthesis was analyzed by metabolic labeling with S methionine/cysteine, as described .

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PMC9429973

Data from developed countries has shown that CALR mutated patients have higher platelet count and lower thrombotic risk compared to JAK2 mutated patients.

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PMC11092382

Furthermore, sophocarpine exhibits great benefits in agriculture.

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PMC9065483

The use of VSVΔ51-FLuc allowed us to simultaneously measure the impact of treatments on virus output via a secondary assay measuring viral expression unit output from supernatants (viral expression units, akin to viral titer), as well as cellular metabolic activity by resazurin assay (Alamar blue), a surrogate for detection of cell viability and cytopathic effect.

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PMC7762347

In contrast, after prolonged exposure of 72 h to CYN (0.5 µg/mL) alone and in combination with MCLR (1 µg/mL) a significant decrease in cell viability of up to 50% compared to solvent control was determined.

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PMC11155445

Naphthoquinone based iminothiazoline derivatives (14a–e) synthesized by Efeoglu et al. were found as effective inhibitors of carbonic anhydrase I and II, and acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).

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PMC7802142

Unfortunately, all of these treatments have limitations.

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PMC10529414

Subsequently, they were fixed with 4% paraformaldehyde for 15 min and permeabilized with 0.2% Triton X-100 for 15 min.

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PMC11252553

After 24 hours of incubation, different concentrations of Taurine (25, 50, 100, 200, 300, 400, 500, and 1000 mM) were added to the plates with eight replicates each.

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PMC4485786

Real-time PCR-based detection of various immune markers in tumor homogenates.

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PMC11451940

calcd. (%)

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PMC8345486

The cumulative percentage of cells in different phases of apoptosis and necrosis revealed a significant increase in resistance to all drugs for “+2 cells” (Figure 9A,B).

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PMC9429973

Aims: We undertook to discuss what matters most to people living with MDS and provide feedback on discussions in patient support programmes.

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PMC7553912

Furthermore, Taguchi et al. demonstrated that colony stimulating factor-1 (CSF-1)-deficient mice had marked increase in renal crystal deposition.

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PMC9429973

11 of these patients had a carbapenem exposure.

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PMC11747949

ELISA analysis for differences in CCL2 secretion of 143B cells grown in normoxia or hypoxia, without/with (−/+) IFNγ. (

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PMC11541409

Pimitespib shows efficacy against imatinib-sensitive and -insensitive GIST cells with KIT mutations, both in vitro and in vivo .

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PMC9429973

The median age at diagnosis was 68.5 years (range 1-85 years).

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PMC7685376

Furthermore, we also found that MCM protein (Figure 4D) and mRNA expression (Figure 4E) were inhibited by Huaier in Bel-7404 and SK-Hep1 cells.

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PMC11045125

The two major EBV oncoproteins, EBNA2 and LMP1, mimic constitutively-active Notch and CD40 signaling, respectively, and are essential for EBV transformation of B cells in vitro.

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PMC11483468

The Western blot results indicated that the GST-TAT-LPTS39 fusion protein was rapidly introduced into the cell and could be detected in the cell after two hours of incubation and remained stable for at least 24 hours (Figure 2A).

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PMC11365427

Volcano plot of differential expressed proteins. (

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PMC11545737

The most highly inflammatory LOS is also the greatest inducer of miR-146a .

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PMC11240052

Mapping on the reverence genome was done by Top Hat (GRCH37.p13 NCBI).

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PMC11578343

In contrast to the untreated control cells, we observed a decrease in elastic G′ in Lat‐A treated cells for all measured frequencies, indicating that they had become more compliant (Figure 2C; Figure S3A, Supporting Information).

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PMC10530622

Overall, production of oxalate might arise from different pathways (Figure 1), and several gaps still exist, including the contributions of several precursors, cofactors, enzymes, and transporters in different cells/tissues.

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PMC11697189

Fig. 8Association of risk signatures with tumor mutational burden (TMB). (

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PMC9429973

In contrast, mutated DUSP2 indicated longer survival (PFS: HR 0.28; p=.002; OS: HR 0.15; p=.011) (Fig1d).

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PMC11711871

On a HSD, 10 week-old GR rats exhibited an increased number of the less active forms of fatty acids compared to wild-type rats.

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PMC10605143

The regulation of its activity is complex, can be cell-type specific and is not yet fully understood.

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PMC9872547

After 48 hours, the cells were stained with annexin V/PI (propidium iodide) apoptosis detection kit according to the manufacturer’s instruction (Ebioscience, Thermo Fisher Company).

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PMC11721587

Then, the beads were thoroughly washed with HEG50 buffer [25 mM Hepes (pH 7.6), 50 mM KCl, 0.1 mM EDTA, and 10% glycerol] twice and resuspended in the same buffer.

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PMC11391695

ACYP1 and ACYP2 are isoforms that consist of 60% identical sequence and display identical substrate specificity.

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PMC9473868

The PI3K/Akt/mTOR signaling pathway was significantly activated in RA synovial cells and attenuated RA development by modulating the PI3K/Akt/mTOR signaling pathway .

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PMC11365983

2Altered levels of Foxc1 are associated with changes to cilia length in three cell types. (

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PMC9424261

Bel-7402 and Bel-7404 were treated with CA for 1 h, and then supplemented with ferroptosis inducer erastin or RSL3.

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PMC11699465

Having confirmed that the plasmids work well, we tested whether the transcription factors mentioned above affect CD274 mRNA expression levels.

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PMC9429973

MYC-IGH patients were younger and had more EN site involvement as MYC-non-IGH, but no differences in EFS and OS were noted.

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PMC10470467

These pieces of evidence suggest that necroptosis plays a complex role in cancer development.

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PMC10443665

Bassorin and tragacanthin showed a remarkable and concentration-dependently cytotoxic effect on sensitive and resistant CCRF-CEM cells.

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PMC11224020

Regulation of CCR7 expression might thus be critical to define the balance between tolerance and immunity at steady state or during infection and cancer.

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PMC9429973

Further studies are ongoing to elucidate the exact mechanism.

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PMC11680982

Furthermore, the anti-HER inhibitor neratinib was administered to enhance the effectiveness of CDK4/6 inhibitor combined with endocrine therapy in HR/HER2-low breast cancer by inhibiting the HER2 pathway and lowering HER2 mRNA expression.

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PMC9429973

A. M. Spanjaart, E. Pennings, P. Mutsaers, S. van Dorp, M. Jak, J. van Doesem, J. de Boer, J. Vermaat, A. Sijs-Szabo, M. van der Poel, I. Kuipers, M. Chamuleau, I. Nijhof, M. Minnema, P. Lugtenburg, T. van Meerten, M. J. Kersten Dept.

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PMC10204952

At 1000 nM S1P, nucleic alteration was decreased from 66.3% in complete media to 59.6% in AD-CM and 42.7% in CAA-CM, respectively.

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PMC11264242

Spheroid size was quantified with ImageJ. For cellular and molecular assays, statistically significant differences were determined by two-tailed Student’s t-test.

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PMC10877303

In this study, 2369 phytoconstituents from Japanese medicinal plants were identified through extensive literature mining.

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PMC11739504

Scale bar: 2 μm Right graph showed fluorescence intensity of Smo within primary cilia. (

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PMC9919300

In this perspective, the Italian Health Ministry discouraged, since July 2019, curcumin administration in cases of hepatic function alterations.

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PMC11672617

Furthermore, the ionic compounds 5a and 5b exhibited reliable differences between themselves with regard to the phases of apoptosis induction.

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PMC9429973

From an international perspective this result can have major implications given the fact that proton pump inhibitors may frequently be the only realistic therapy for many patients without access to or not tolerating iron chelators.

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PMC9812014

Dengue hemorrhagic fever and dengue shock syndrome are induced by four DENV serovars (DENV1-4), all of which are potentially deadly .

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PMC11357960

These data might provide effective circulating biomarkers for predicting the efficacy of anti-PD-1 immunotherapy, and uncovered a novel regulatory mechanism of resistance to anti-PD-1 immunotherapy.

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PMC11730311

These metabolites were not identified for hαCGRP8-37N25K-C20DA-γGlu, which suggests that positioning the C20DA-γGlu conjugation at N25K offer greater protection against cleavage at the KNN motif.

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PMC11127909

Compared to the 143B-EFHD1-cisplatin group, we observed a considerable decrease in tumor volume (Fig. 6B) and tumor weight (Fig. 6C) in the 143B-EFHD1-cisplatin-CATR group.

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PMC9429973

Aims: Here, we report the health-related quality of life (HRQoL) outcomes from an interim analysis of the SEQUOIA trial.

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PMC11321678

After comparing the gene activity scores and motif deviation scores of TFs, we identified 26 positive TF regulators (Figure 3D) and most of them are subgroup‐specific (Figure 3E; Figure S5C, Supporting Information).

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PMC11495567

For FACS analysis, harvesting and centrifugation after PCAIs treatment is necessary to obtain cells for sorting.

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PMC9429973

One of the three main driver mutations known to cause MPN (JAK2, MPL or CALR mutation) was found in nine patients, eight of whom carrying a JAK2 V617F mutation (ET, N=5; PV, N=3; female, N=5; male, N= 3) and the patient with PMF harbored a CALR type 1 mutation.

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PMC11594588

Hemostasis is achieved by a careful balance of platelet interactions with vascular components, cytokine mediators, fibrinolytic agents, and plasma-clotting mechanisms.

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PMC2196094

Peritoneal cells from Sprague-Dawley rats (females, 10–15 wk old) were collected by peritoneal washing with 0.025 M Tris-HCl, pH 7.6, containing 0.12 M NaCl and 0.01 M EDTA.

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PMC6379402

To capture the functioning of a cell, we use the following sets of biological annotations: the pathway annotations from KEGG (collected on the 14 June 2016), the pathway annotations from REACTOME (collected on the 14 June 2016), and the experimentally validated GO-BP annotations from NCBI’s web server (collected on the 14 June 2016).

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PMC9817179

Importantly, addition of glycine dramatically reversed the fixation effect on the LLPS behavior of DsRed2-TAF15(IDR).

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PMC11708541

A vast array of biological and pharmacological effects can result from the interaction of aminopyridine rings with different enzymes and receptors, due to their unique structural properties.

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PMC11727062

Furthermore, patients with advanced melanoma not only face treatment challenges and low response rates but are also prone to tumor drug resistance.

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PMC11699042

For the analysis of long-term cultured EwS cell lines we performed DGEA on the top 60% expressed genes included in the raw count matrix (N = 27,143, all EwS cell line samples were analyzed in one batch).

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PMC9429973

GPRC5D has limited expression in healthy human tissue but is highly expressed on malignant plasma cells.

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PMC11033180

Previous studies have shown that mice expressing a Sema5A deletion mutant defecate more than wildtype mice, suggesting that deficiency in Sema5A affects gut motility.

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