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OTAR3088
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BioData-CellLine_annotated

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PMC11258145
Then, determining safe concentrations of curcumin at the cellular level is extremely important.
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PMC10631132
Both cell lines were created using a Sendai virus reprogramming kit .
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PMC9429973
B. Atef, S. El-Ashwah, L. M. Saleh, H. Gawish, M. Nasr Hematology Unit, Internal Medicine Department; Hematology Unit, Clinical Pathology Department; Diabetes & Endocrinology Unit, Internal Medicine Department, Faculty of Medicine Mansoura University, Mansoura, Egypt Background: In chronic myeloid leukemia (CML), BCR-ABL1 oncoprotein induces overexpression of STAT5 and its target genes.
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PMC7022782
Data were analyzed using an unpaired t-test and the analysis of variance (one-way ANOVA) was followed by Tukey’s multiple comparison test.
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PMC8557138
Natural hydrogels such as matrigel, collagen, fibrin, and gelatin have been extensively used in vascular tissue engineering.
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PMC9429973
Results: In summary, 75% of HL patients were treated with ABVD and 10.8% with 6-8 BEACOPP.
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PMC11766309
Distinct gene mutation, methylation, and CNA patterns for YKT6 were found in certain types of cancers.
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PMC11763126
Lentivirus-infected A498 and 786-O cell lines were selected with 10M puromycin for a duration of one week to establish stable cell lines.
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PMC10698968
On day 5 post-fertilization, 2-3 ml of albumen were removed, and a window was opened on the eggs’ shell.
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PMC9429973
Several early trials are showing promise with novel epigenetic agents for B-cell and T-cell lymphomas.
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PMC9429973
The JAK/STAT alterations represent about 7% of the ‘Philadelphia-like’ cases.
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PMC2944824
Similarly, capsase-3 activity was lower and the decrease in mitochondrial membrane potential was smaller in cultures of adult cerebellar granule neurons from wild type mice compared to Hr knockout mice induced to undergo apoptosis.
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PMC11285179
However, cytotoxic effects were observed at higher concentrations, which exceed pharmacologically relevant levels in the body necessary to support essential cellular functions.
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PMC11286266
Right histograms indicate the transfected, gated cells 72 hr post-transfection (red rectangles). (
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PMC9429973
Among subgroups, including those with high-risk mutations, no significant factor was found to be associated with OS in the matched patients (Figure).
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PMC8193813
The temperature and relative humidity (RH) operating range is 0 to +50 °C and 15% to 90% RH, respectively.
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PMC9429973
MFC analysis was performed on a DxFLEX cytometer (Beckman Coulter), using CD19 (20-291) protein-FITC (ACRO Biosystems).
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PMC7153288
They were the gene clusters for ectoine (with the ectoine gene cluster of Streptomyces anulatus), melanin (with the melanin gene cluster of Streptomyces coelicolor A3(2)), terpene (with the albaflavenone gene cluster of Streptomyces coelicolor A3(2)), terpene/butyrolactone (with the gamma-butyrolactone gene cluster of Streptomyces acidiscabies), terpene (with the isorenieratene gene cluster of Streptomyces argillaceus).
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PMC11188874
A, Number of peptides eluted from human MHC-I molecules at each indicated peptide lengths (range = 6 to 15 amino acids).
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PMC9429973
Moreover, this research on the influence of treatment duration and outcomes such as survival has mainly focused on MM, while it has hardly been investigated in monoclonal gammopathies treated with similar therapeutic approaches, such as systemic AL amyloidosis.
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PMC11683240
Subsequently, recombinant PTS1 (84 nM) and biotin-labeled NAD (1 μM; R&D Systems) were added for labeling of the ADP-ribosylation of Gαi during the 40 min incubation at room temperature.
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PMC11186948
After washing, membranes were incubated with goat anti-rabbit or anti-mouse IgG horseradish peroxidase (HRP)-conjugated antibody (#1706515 or 1706516, Bio-Rad, RRID: AB_11125142 or RRID: AB_2921252) diluted in 5% milk in TBS-T for 1 h at RT, they were washed again and chemiluminescence signals were detected through ECL (#1705061 Bio-Rad) incubation and captured by Chemidoc Imaging System.
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PMC5673060
Activation of IGF-1R signalling is a well-established bypass mechanism of resistance to many kinase inhibitors including EGFR, HER2, MEK and BRAF inhibitors , , , , .
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PMC11727145
In addition, further experiments using primary human keratinocytes, combinations of keratinocytes and fibroblasts, and longer culture periods would be of interest to evaluate the presence of K14 to approach what may be seen in normal human skin.
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PMC7192625
Despite the probable differences between primary B cells and the B cell derived cell line, we could see similar values of ChAs for all epigenomic marks on the Hi-C networks and the PP PCHi-C subnetwork (Figure 5A), with only the H3K27me3 and H3K9me3 marks having lower assortativity in Hi-C compared to PCHi-C (see Supplementary Figure S9 for other comparisons).
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PMC10092581
It should be mentioned that Se(ICy) and Se(IAd) are the only ligands with alkyl substitution on the nitrogen atom, with the former being the smallest ligand of the two and of the whole ligand series.
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PMC11306019
PC1 represents size, shape, and polarizability; PC2 represents aromatic and conjugation-related properties; and PC3 represents lipophilicity, polarity, and hydrogen bond capacity.
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PMC11665555
Cells were treated for 72 hours with PBS or 0.01 μM gemcitabine and were at 70% confluency at the time of extraction.
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PMC11806182
C–E Gene Ontology (GO) biological processes and pathway enrichment analyses for up-regulated and down-regulated genes.
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PMC11772585
Cells were cultured in 6-well plates and transfected with the specified constructs as outlined above.
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PMC9596868
Supplementary Fig. 3.
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PMC9429973
The cutoff values of cystatin C ≥ 16.03 and ≥ 13.2 (ng/mL) could detect subclinical cardiac dysfunction risk among SCD and b-thalassemia patients respectively.
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PMC11742431
Given these advantages, we fused them with conventional PROTACs to obtain a PROTACs‐like degradation system that used membrane‐penetrating peptides to enter cells, used the tumor microenvironment to mediate exposure of degron sequences, and used nanobodies to target intracellular proteins.
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PMC5673060
The following peptide bond cleavages: arginine or lysine followed by any amino acid (a general setting referred to as Trypsin/P) and up to two missed cleavages were allowed.
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PMC10669966
No. HPA014492, Sigma-Aldrich) and monoclonal rabbit anti-SLFN12 (1:500, Cat.
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PMC9429973
Fms-like tyrosine kinase 3 (FLT3) gene mutations are found in approximately 30% of the general AML population and are often secondary events associated with leukemic transformation.
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PMC9792775
Briefly, 10% SDS-PAGE gel was applied for separating the 30 μg total protein, and then proteins were electrophoretically transferred to PVDF membranes (Millipore; Burlington, MA, United States).
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PMC11726848
When tagged with a fluorescent dye, such damaged DNA is seen as a comet, where the tail contains leading ends of migrating fragments .
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PMC9429973
RNA sequencing provides a functional snapshot that we propose will provide rapid diagnostic information for most ALL subtypes and deep biological insight to guide diagnostic efforts of atypical cases.
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PMC9429973
S. Li, Z. Yuan, L. Liu, Y. Li, S. Martina, J. Liu, Z. Li, X. Wang, J. He, W. Zhao, L. Shen, X. Zhang, S. Wang 920th Hospital, Kunming; Gracell Biotechnologies Ltd, Shanghai; The Second Affiliated Hospital of Army Medical University, Chongqing, China Background: CD19 targeted autologous CAR-T therapies have been approved for the treatment of r/r B-ALL and greatly improved outcome.
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PMC11502443
Other differences, such as the differential expression of GLP-1 and GIP receptors in adipocytes, the effect of accessory proteins and other signaling should be considered.
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PMC11752767
ACT has undoubtedly revolutionized the management of hematologic malignancies, whereas its usage in solid tumors remains largely unexploited.
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PMC10421378
For instance, a comparison of patients with IBD and healthy individuals showed that some strains of Lactobacillus ssp.
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PMC10114490
Filled bars: NES > 0, enriched in PD.
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PMC11676674
It has been shown to be able to inhibit cancer cell proliferation and to modulate inflammatory signaling pathways .
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PMC7294030
The closure of gap distance was examined by (A) photographs and (B) calculated the percentage of migration area. **
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PMC11047729
The extent of hTERT mRNA expression strongly corresponds to cellular telomerase activity.
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PMC11593084
A novel CasMab against PDPN, PMab-117-mG2a possesses a superior reactivity to cancer cells, but not to normal cells.
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PMC6468656
In particular, MMP10 is significantly upregulated and required for the ghrelin-Aurora A axis to promote ccRCC invasion.
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PMC9454178
3THZ1 suppresses the proliferation and induces the apoptosis of GIST cells in vitro.
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PMC6461034
Algorithm to calculate kinase impact score from (1) cell line INKA, KARP or INKA components normalized kinase activity ranking KASi, (2) normalized drug −logIC50 values ej, and (3) a drug–kinase relationship table gij.
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PMC9429973
We speculate that in GATA2 deficiency syndrome, STAG2 mutations could induce a mechanism of indirect Somatic Genetic Rescue (SGR) by compensating the loss of GATA2 activity induced by the mutated allele.
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PMC11155445
Variation of metal ions strongly influences the antiparasitic activity of complexes and thus complexes of platinum (65a) and (65b) show better activity against trypomastigote and less active against amastigote compared to the palladium and nickel complexes (Fig. 13).
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PMC9599726
YAP and TFRC expression (p-value < 0.0001), YAP activity, and TFRC expression were correlated (p-value = 0.00017) (Table 2).
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PMC9325715
Instead, the addition of a reducing agent causes the breaking of disulfide bonds and loss of the globular structure of the protein and thus should influence the metal binding ability.
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PMC11596967
Therefore, further experiments were conducted using the 8 Gy dosage.
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PMC10944868
The synthesis, employing a cutting-edge organocatalytic cyanovinylation methodology, not only underscores the accessibility but also highlights the versatility of these compounds in the pursuit of effective antiproliferative interventions.
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PMC11394386
For the detection of HOTAIR using in situ hybridization, 60,000 cells were seeded into 12-well plates.
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PMC11496728
In CHO-WT cells, the fluorescence of pCMV-eGFP-1 and pCMV-eGFP-2 was stronger than that of pCMV-eGFP, and the green fluorescence of each group was remarkably enhanced in CHO-KO cells compared with CHO-WT (Fig. 6).
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PMC11228511
Children with HGPS develop disease phenotypes in multiple tissues (e.g., bone, connective tissue, skin, hair, heart, vasculature) and typically die during their teenage years from atherosclerotic cardiovascular disease (2).
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PMC9429973
On the other hand, since MPN develop in the same way in JAK2V617F-only and in JAK2V617F/TP53KO mouse, this suggests that JAK2V617F-specific pathways also found differentially expressed in JAK2V617F/TP53KO are linked to the MPN phenotype.
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PMC10882807
Cell migration and invasion abilities were determined by transwell assays in HCCLM3 cells transfected with siNC, si1 and si2 (Magnification, 20X; Scale bars, 200 μm). (
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PMC11026382
The thyA gene (encoding TYMS) was amplified by PCR from E. coli MG1655 and cloned into the vector pET24A using XbaI/Xho restriction sites.
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PMC5025404
According to the manufacturer’s instructions, subsequent selection of the transfected clones was performed as shown in the schematic representation below (Fig. 1).Fig.
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PMC11015054
It is thought that most liver cancers are caused by hepatocellular carcinomas (HCC).
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PMC9429973
Whereas in T593 and T856, expanding clones at relapse were showed up with completely different gene signatures from the diagnostic ones, but dominant clones at diagnosis and relapse were surprisingly presented with identical TCR repertoires.
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PMC11718817
We speculate that this is mediated by multiple factors, among them increased expression of PD-L1, decreased expression of CD80 and CD86, and alteration of surface MHC-I expression.
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PMC11790599
This heightened pace of vacuole formation, coupled with rapid vacuole fusion, overwhelms the cells’ capacity to manage these structures effectively.
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PMC10170482
The fluorescence intensity of both dyes was measured at the respective time points and was normalized to total fluorescence.
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PMC9786247
Different from the situation in bovine MDMs, infected epithelial cells respond to Cb30/14 infection rather late, i.e., days after the invasion process, and therefore presumably do not engage cell surface receptors.
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PMC10878518
To evaluate the expression levels of CAR and hTERT in bone and soft-tissue sarcoma tissues, clinical tumor specimens from 68 patients were analyzed by immunohistochemistry.
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PMC11750696
Research has shown that proteasome activators can boost the antitumor immunity of TILs through mitigating the activation of PERK-p-eIF2α (85).
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PMC11740573
We used heat-killed bacteria for the study, so the evaluation of the immune response was conducted at longer time points (24 h, 48 h, 72 h).
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PMC9243326
A total of 57 Gb reads were generated from the SMRT library.
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PMC8973085
Anal.
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PMC11144200
With the construction of PDX mouse model completed (Supplementary Fig. S6A, B), our data confirmed that liposome as a vector can load DOX and transport it to the tumor site to induce apoptosis of tumor cells.
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PMC9429973
Aims: To decipher and target tissue-selective pharmacological targeting of tumor intrinsic F2 expression using an integrated genetic reporter system Methods: By using an innovative newly generated knock-in reporter mouse model combined with non-invasive molecular imaging, extra-hepatic expression of F2 in tumors was discovered, recapitulating findings in cancer patients.
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PMC11594641
The gels were treated with 0.2 mg/mL sodium thiosulfate for one minute and washed twice in distilled water.
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PMC10033453
Interpolated time point at which 50% of maximal cell death occurs compared between viruses from the data in (C).
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PMC6600592
When R=H, all oximes in the four groups decreased inhibitions of HBsAg in 505.7, 257.4, 489.3, and 352.4μM, respectively, HBeAg in 375.0, 283.7, 404.7, and 373.4 μM, respectively, and elevated cytotoxicity than their relative ethers.
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PMC11766174
Briefly, cells were stained for viability at 4 °C for 20 min using BD Horizon Fixable Viability Stain 700 (BD Biosciences, Franklin Lakes, NJ, USA) and blocked for 10 min at RT with Human TruStain FcX (Biolegend) prior to surface staining.
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PMC11092418
Cells were seeded into the top layer of a 96-well cell migration assay plate in 0.5% FBS DMEM together with TKIs at IC50 concentrations, while 10% FBS DMEM (chemoattractant) was added to the bottom layer.
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PMC11718109
Scale bars, 500 nm.
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PMC6642070
Lactate production in A-204 cells exogenously expression of β-enolase (n = 3). (
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PMC9429973
The telomere length and the expression of genes associated with telomere maintenance, DNA damage responses, and cell senescence of the BM-MSC of AA patients were analyzed by real-time quantitative-PCR (RT-qPCR).
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PMC9429973
The mean age of the patients was 53.03±17.78.
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PMC11407042
Shake the dish gently and observe under the inverted microscope to ensure cells have spread evenly.
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PMC11802855
ELISA was utilized to assess the levels of CXCL7 extracellular secreted protein in the CXCCL7-OE and NC H929 (J)/RPMI8226 (K) cell lines.
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PMC10890307
In contrast, normal differentiated cells are exposed to control systems that prevent aberrant individual cell proliferation .
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PMC10502403
RNA microarray analysis was performed by Agilent Technologies, Inc. Briefly, the RNA integrity of the samples was determined using an Agilent 2100 Bioanalyzer and Agilent RNA 6000 Pico Kit.
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PMC7812570
cell-cell transmission was monitored by quantifying the production of the luciferase reporter in the TZM-bl cells.
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PMC9545714
Two experiments were performed to test the effects of rich tomato extract (Golden Tomato Extract, GTE) on human skin.
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PMC11499381
NA – not applicable because we were testing the effect of fusing V1–154 to CTR in the absence of RAMP1.
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PMC5673060
Line thickness portrays the STRING calculated association confidence.
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PMC11247842
Consistent with previous studies [18–20, 22], the most significant signal was located on BTA6 at 86,940,863 bp (rs210373936) and is an intergenic SNP close to the GC gene.
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PMC11441402
Error bars represent the standard error of the mean from n = 3 biological replicates.
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PMC9429973
Methods: An outpatient service specifically dedicated to follow-up of COVID-19 survivors was set up at our Institution.
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PMC11438317
In HS1, both Tyr are required for the interaction with LP-DACS.
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PMC11720808
Quantification of OS cell proliferation shown in (C). (
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PMC11481779
We have calculated the Pearson correlation coefficient and SCCs for all the predictions and FID scores for all chromosomes.
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