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BioData-CellLine_annotated

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PMC9844987
Transcriptional regulation is the main process controlling how genome-encoded information is translated into phenotypes.
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PMC6222726
B. morelensis (synonym: Elaphrium morelense (Ramírez) Rose) is widely distributed in Mexico , where it is commonly known as coabinillo .
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PMC5025404
This hypothesis was indirectly confirmed by measuring HC/LC ratio in the supernatants by SDS-PAGE.
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PMC9429973
However, the management of such patients is challenging due to the lack of clear recommendations.
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PMC11700523
Inhibitors of the renin-angiotensin system and add-on therapy with mineralocorticoid receptor (MR) antagonists can help reduce proteinuria and suppress CKD progression.
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PMC11506670
Notably, mice carrying a Cre-dependent activated allele of NRAS (G12D) did not induce hyperproliferation, while KRAS G12D did, which manifested as chronic intestinal hyperplasia in the colonic epithelium .
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PMC11732523
Table 1Laboratory examination of the patient.
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PMC9429973
Results: Of 155 apheresis, 71 (45.81%) were performed through CVC, and 84 (54.19%) through PV.
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PMC9621239
However, in the presence of CPT, the proportion of cells labelled with annexin V-PE in the HCC cell lines stably expressing HBx-TM was significantly higher than in the HCC cell lines stably expressing HBx-WT (Figures S9B and S9D), indicating that HBx-T81P/S101P/L123S is likely to increase the genomic instability in HCC cells compared with wild-type HBx.
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PMC11695623
The results showed that glucose uptake decreased significantly (Fig. 6A) after down-regulation of DCUN1D5.
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PMC6163708
Our results recognize the sensitivity of tumor cell types to GANT61 in cell culture and support a critical role for GLI factors in tumor progression through restraining apoptosis.
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PMC11474209
Anterograde signaling regulates oxidative phosphorylation (OXPHOS) and the biogenesis of mitochondria in exposure to environmental cues acquired by the nucleus.
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PMC11781181
Meanwhile, after treatment with the autophagy inhibitors 3-MA, only the NCOA4 and FTH1 expression levels have been significantly restored (P < 0.01) (Fig. S6E).
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PMC9429973
The blood tests reveald that anemia was normocytic in 43 cases and macrocytic in 64 cases.
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PMC10993311
Microarrays of DNAm have identified epigenetically regulated lipid-related genes in obese patients with hypercholesterolemia (Płatek et al., 2020).
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PMC11741577
The human mast cell line HMC-1 was treated with the TLR2/6 agonist FSL-1, and the conditioned medium (CM) was collected from untreated cells (HMC-1 CM) and FSL-1-stimulated cells (FSL-1-HMC-1 CM).
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PMC4360730
To annotate biosamples in the tissue and whole organism categories, we use Uberon (http://uberon.org), which is an anatomical ontology that includes structural, functional and developmental relationships with emphasis on cross-species integration (11).
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PMC10203589
With the expression and stimulation of endogenous or exogenous FGF18, it can significantly promote the development of malignant phenotypes such as proliferation, migration and invasion of most tumors ( Table 2 ).
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PMC6892818
Equal loading for human epithelial cell lysate was confirmed by CK18 detection (see Methods).
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PMC11537649
The results showed that the wild-type binding sequence of Lnc NEAT1 was co-transfected with the miR-152-3p inhibitor, luciferase activity was increased.
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PMC11248911
Found: C, 63.21; H, 6.99; N, 17.08; S, 13.04.
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PMC9454852
Histologically MPM can be classified in two variants, namely epithelioid and sarcomatoid subtypes, but some tumors display characteristics of both types and are thus classified as biphasic .
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PMC8140214
These results are compatible with the Dave et al. study in which hyperglycemia decreased CAT and GPx activity in both types of diabetes (Dave and Kalia, 2007 ▶).
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PMC11721587
Hh morphogen controls pattern formation in a concentration and time-dependent manner through a largely conserved signal transduction cascade that culminates in the conversion of the latent transcription factors Ci/Gli from transcriptional repressors (Ci/Gli) to activators (Ci/Gli) (1, 5–7).
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PMC11144382
Cellular localisation and functional studies of MSS mutants.
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PMC11547917
The antioxidant capacity of the extract was evaluated by five in vitro chemical-based assays, proving that ABTS assay was a better method for this type of evaluation showing an IC50 of 160.89 ± 0.21 µg/mL. Furthermore, the cytotoxic effects of the extract were established by an IC50 of 216 µg/mL for 24 h by MTT assay, followed by a cell-based assay on Caco-2 cells by the ABTS method.
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PMC10253553
For RPPA (N = 22), log2 fold changes were determined by taking the log2 expression in the tumor minus the log2 expression in the normal for each patient and then taking the mean of those.
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PMC7612475
SF3B1 and SF3B1 K-562 cells were grown in suspension cultures.
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PMC3274243
We have previously reported the principles of an electrochemical biosensor, ‘Oncoprobe’, for passively recording the Electrochemical open circuit potential (OCP) of confluent cell monolayers on gold sensors in vitro and its application in anticancer drug testing [1–3].
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PMC7802142
Interestingly, the highest fold change is observed for miR-100 with a 6.0-fold change compared with 1.4 for let-7i and 1.3 for let-7b.
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PMC10998613
Single-stranded DNA oligos CXCR4.1-sso and ADRB2.1-sso were designed against the sense strand to promote gene knockout (AAG > TAG) edit, CXCR4.2-sso and ADRB2.2-sso were designed against the antisense strand (TGG > TAG) edit, whereas CXCR4.3-sso and ADRB2.3-sso oligos were designed against the sense strand (TTC > TAG) edit.
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PMC8270637
Cells were harvested and washed twice with phosphate-buffered saline (PBS).
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PMC11774747
In the following section, we will summarize these findings, highlighting the differences in signaling outcomes between CAR and TCR activation.
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PMC10988555
Comparing the results of cobalt internalization after 12 h of exposure to the complexes at 37 and 4 °C (Table 1), it is possible to observe that even at 4 °C more than 45% of complex 2, 62% of complex 3 and 69% of complex 4 are internalized in the cellular fraction despite the values are lower compared to 37 °C, being complex 2 the one with the lower % of internalization by passive diffusion and more % of complex internalized by an active process compared to 3 and 4.
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PMC3730428
Indeed, we found that FLIP silencing did not promote formation of complex IIb formation either in response to SMC or TNFα treatment (Supplementary Figure 4C).
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PMC11271800
CCL: CC ligand; CXCL: CXC ligand; miRNA: MicroRNA; ncRNA: Non-coding RNA; TAM: Tumor-associated macrophage.
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PMC9250505
Thus, phosphorylation of BADS99 is increased in EOC and predicts poor survival outcomes for patients.
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PMC9429973
Patients who have received a prior BCMA CAR-T or BCMA-antibody-drug conjugates therapy are included, whereas those with prior treatment with BCMA-CD3 bispecifics are excluded.
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PMC9429973
Informed consent was obtained.
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PMC10759659
For the first time, we reported that ARID1A deficiency was correlated with the increased expression of TIM-3.
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PMC11742047
Heatmap plots show a general decrease in lipid levels, except for triglycerides and diglycerides (Fig. 4).
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PMC9065483
Related gene lists for each respective transcription factor were obtained from the published TFactS catalogue.
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PMC3730428
Scrambled control (SCR), c-FLIP and XIAP targeting siRNAs were obtained from Dharmacon (Chicago, IL, USA).
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PMC11572213
However, the change was significant only in HL60 shTET2-1 cells (Figure 5A).
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PMC11694066
Mycoplasma testing was performed bimonthly using the MycoAlert Mycoplasma Detection Kit (Lonza).
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PMC9429973
We used 3D-structures of Drosha and Dicer for molecular dynamics (MD) simulations for 200 and 300 ns, respectively (Schrödinger Suite 2020-4, Schrödinger, LLC, New York, NY, USA, 2020).
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PMC11721295
The first experimental group (Ccsp-rtTa;TetO-Kras with or without Trp53) was given dox, but not ad-Cre, to induce expression of KRAS but not mutant p53.
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PMC6627640
For Western analysis cells were lysed in radioimmune precipitation buffer.
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PMC9429973
Ten (41.7%) pediatric ALL patients achieved MRD negativity.
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PMC10748106
The higher electron density over the aldehydic group and the hydroxyl group in C8 allows a better interaction with the possible target of these iridoids.
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PMC9220170
Values were given in the work as the mean ± standard deviation of at least three independent experiments.
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PMC11194678
Moreover, the finding that the LLPS-deficient 5KE mutation could efficiently reduce STAU1-induced abnormal accumulation of pathological protein aggregates (Figs. 6 and 7; and S5) provides a new insight for the treatment of STAU1 overabundance-related neurodegenerative disorders.
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PMC9429973
Image: Summary/Conclusion: This is the first study to highlight telomere shortening in the BM-MSC of AA patients.
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PMC9429973
In 25/71 febrile episodes (35%), pathogens were detected by NGS-based diagnostic only and the corresponding conventional diagnostics remained negative.
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PMC9429973
Data was extracted from subgroup analysis of each study.
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PMC11743414
Using GSEA analysis, we identified that FHL1 is involved in cell differentiation, the regulation of pathways (such as Notch and Wnt signaling pathway), protein transfer, and development of chronic myeloid leukemia.
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PMC8711270
HEK293 cells exhibit a greater capacity for γ-carboxylation of glutamic acid and sulfation of tyrosine residues as compared to CHO cells.
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PMC11144200
These mechanisms include positive regulation, which activates the immune system to attack the tumor, and negative regulation, which weakens the activity of immune cells, which together determine the development or suppression of the tumor.
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PMC9429973
F. Bernaudin, C. Arnaud, A. Kamdem, C. Pondarré, I. Hau, N. Bayani, M. Kuentz, E. Gluckman, R. Peffault de Latour, N. Dhédin, H. Lezeau, J.-H. Dalle Pediatrics, Referral Center for SCD, CHIC Hospital; Pediatrics; Hematology, CHIC Hospital; Transplant unit, Mondor Hospital, Creteil; Transplant Unit, St-Louis Hospital, Paris; Pediatric Surgery, CHIC Hospital, Creteil; Transplant Unit, Debré Hospital, Paris, France Background: The presence of Howell-Jolly bodies (HJB) is associated with splenic dysfunction that appears progressively during aging or after splenectomy in patients with sickle cell disease (SCD).
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PMC7185206
Supernatants were isolated from cell culture by ultracentrifugation.
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PMC11476004
As a result of poorly functioning checkpoints and repair systems, the error goes unnoticed or is incorrectly repaired, which leads to the formation of a tumour .
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PMC11659921
In conjunction with the results from the Friend analysis, we identified TNFSF11 as the most crucial gene for the prognosis of OV patients among those related to angiogenesis and stemness.
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PMC7642379
All elements with copy number gain of > 1 log2 fold-change common to all progenitor cells are located in this region (Supplementary Table S3).
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PMC10810426
ns, not significant.
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PMC11643491
The entrapment efficiency was calculated by the following equation:% Entrapment Efficiency=Amount of entrappped drugTotal drug added×100 To assess the viability of cells treated with paclitaxel-loaded nanoparticles and investigate whether ellipsoidal particles demonstrate enhanced selectivity towards aggressive cancer cells compared to spherical particles, positive and negative A375 cells were seeded in a 96-well plate at a density of 5 × 10 cells/well and incubated for 48 h. The treatments (drug-free and paclitaxel-loaded spherical and ellipsoidal PLGA particles) were introduced at identical particle concentrations and the plates were incubated for an additional 24 h. After incubation, MTT (Sigma-Aldrich, USA) was added (0.5 mg/mL) into each well for viability detection and incubated at 37 °C and 5% CO2 for 40 min.
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PMC9118379
Table S1 in the Supporting Information shows the numbers of spectra and peptides in the four spectral groups and four peptide FASTA sets, respectively.
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PMC11367939
The liquid-like properties of the condensates formed by ATG9A and synapsin or synaptophysin and synapsin suggest that the liquid–liquid phase separation (LLPS) principle could account for the clustering of two different types of vesicles.
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PMC11740573
MacConkey Agar (Oxoid, UK) was used for EC, Bile Esculin Agar (Oxoid, UK) for EF, and Columbia Agar (Difco, USA) with 5% sheep blood for GBS.
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PMC10587429
Image the mice according to the manufacturer’s instructions.
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PMC9352806
Upon the above, we followed to determine the effects of BMS on the lipophagy and its potential mechanism.
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PMC11674834
Briefly, pFRT/lacZeo plasmid was transfected into nucleotide excision repair-deficient UV5 cell lines to generate a UV5 cell line containing a single integrated FRT site (UV5FRT).
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PMC11518702
Upon ligation, BCR upstream signaling ( Figure 1B , left panel) is initiated via LYN phosphorylation of ITAMs within BCR alpha and beta chains (42, 43).
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PMC11461833
STXBP5 and STXBP6 are marked with arrows.
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PMC9587298
Linkage of a glucose residue at the C5 position (A-ring) did not change the atomic charge of cyanidin-3,5-diglucoside significantly compared to cyanidin-3-glucoside and cyanidin-3-sambubioside-5-glucoside, when compared to cyanidin-3-sambubioside in the carbinol pseudo base form.
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PMC11683240
The Amberlite XAD column was washed with 25%, 50%, 75%, and 100% acetonitrile (J. T. Baker) to generate pools E5, E6, E7, and E8, respectively.
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PMC11754436
Tunel detection of apoptosis in MG63 cells after co-transfection with DHRS4-AS1 and miR-362-5p mimic. *
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PMC11352666
MERTK is a protein found in leukemia, melanoma, lung cancer, and other cancer types where it promotes cancer cell survival and resistance to therapies.
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PMC11547972
This concurs with an earlier investigation where amygdalin concentrations of 10 mg/mL were required to significantly suppress RCC cell growth in vitro .
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PMC8750422
One limitation of our study may be that the tail vein injection model is not an accurate in vivo model for the study of lung cancer metastasis.
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PMC11361748
A431 cells (KRT17 WT and KRT17 KO) were lysed using NP-40 lysis buffer as described before.
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PMC11799620
This system consisted of a vacuum degasser, an autosampler, and a binary pump with a maximum pressure of 400 bar; Agilent 1260, Agilent Technologies, Germany equipped with a reversed-phase C18 analytical column of 4.6 × 100 mm and 3.5 μm particle size (Zorbax Eclipse XDB C18).
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PMC10743717
appeared to disregard the basic enzymology concept of the initial velocity , a much more significant problem here is the inconsistency between published data and the reported experimental procedures, no matter whether the reported experimental procedures of the JBC article are scientifically rational or not.
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PMC11066331
In total 175 mass spectra acquired from seven different mixtures of SKOV3scrambled shRNA and SKOV3TUSC3 shRNA in five technical replicates recorded in five different days were used.
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PMC9429973
Eastern cooperative oncology group performance score (ECOG-PS) was ≥2 in 54.1% of patients.
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PMC9429973
In our cohort, 46.5% (33/71) of cases were assigned to a specific molecular cluster on the LN biopsy and 40.3% (27/67) on the liquid biopsy.
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PMC11644761
This aligns with the results of Fernández-Santiago et al. (2019) , who reported global DNA hypermethylation in dopaminergic neurons from patients with PD.
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PMC10891340
The scale bar is 100 μm. (
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PMC9429973
Gene editing of T cells isolated from patients with CTLA4 insufficiency restored CTLA4 expression and rescued transendocytosis of CD80 and CD86 in vitro.
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PMC11786600
Consequently, developing novel dressings to achieve effective DFU treatment is urgently needed.
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PMC9429973
Conference abstracts from 2017 to September 2021 were also searched.
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PMC7215832
Methylation of the MGMT promoter is a favorable predictive factor in the treatment of glioma patients with temozolomide .
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PMC11098378
E. coli BL21 cells transformed with His6x-TEV-Ceg10 were grown in LB medium supplemented with kanamycin (50μg/ml).
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PMC11740573
Control refers to cells which received no bacteria and calcitriol over the culture period.
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PMC8973085
Orange solid (81%); mp: 170–172 °C (EtOH); IR (KBr, v, cm): 3454 (NH), 3252 (NH), 2229 (CN), 1644 (C=O); H NMR (DMSO-d6): δ 2.51 (s, 3H, CH3), 3.76 (s, 3H, OCH3), 3.85 (s, 3H, OCH3), 7.13–8.32 (m, 7H, CH-Ar), 9.60 (bs, 1H, NH), 10.10 (bs, 1H, NH); C NMR (DMSO-d6): δ 23.21, 56.03, 56.81, 113.11, 113.37, 113.56, 116.79, 120.36, 121.32, 121.82, 121.87, 143.12, 153.16, 153.46, 192.65; MS m/z (%): 423 [M] (95).
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PMC11541409
Oncoproteins regulate key enzymes in metabolic pathways, providing energy and materials essential for cell proliferation through mechanisms involving AKT kinase and the transcription factor c-MYC [94–96].
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PMC11024707
A previous postmortem brain study revealed that mi-RNA-106a-5p is lower in the brain tissue of individuals with autism compared to those without autism .
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PMC6450504
The possibility of co-loading siRNA along with an anticancer drug and the transfection ability of these new formulations was also investigated.
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PMC9118379
MSFragger: peptide tolerance = 500 Da, fragment ion tolerance = 0.01 Da, fixed modification = carbamidomethylation (+57), variable modifications = methionine oxidation and acetylation of protein N-term, missed cleavages = 2, protease = trypsin.
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PMC10812665
NeuriTox assesses acute neurotoxicity and DNT by quantifying the impairment of neurite outgrowth in differentiating dopaminergic neurons.
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PMC10823017
Previous Molecular Docking studies proved that ICA-1 worked as an inhibitor of PKC-ι (31).
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