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PMC11727062
These activities include the inhibition of melanoma cell proliferation, the induction of apoptosis, the promotion of healthy cell metabolism, and the modulation of immune system responses.
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PMC11519583
To detect senescent cells, MPs transfected with the indicated siRNAs were cultured in DMEM supplemented with 10% (v/v) FBS for 3 days and then stained with SPiDER-βGal (Dojindo Laboratories) according to the manufacturer’s instructions.
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PMC10545062
Our custom rules-based algorithm incorporates proximal MAP and CVP as inputs (Supplemental Digital Content, Figure 2, http://links.lww.com/TA/D121).
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PMC11742231
This is likely due to the ability of deeper models to capture more complex patterns and relationships within the data.
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PMC9429973
Summary/Conclusion: our study identified 25% of patients to be categorized as suspected ALPS cases by fulfilling the primary criteria of diagnosis with association of accessory criteria which trigger in depth molecular investigation.
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PMC11786600
Kaempferol was bought from Macklin (Shanghai, China).
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PMC10891340
According to the results, we found the CCCP could inhibit the replication and intercellular transmission of DPV, mechanically we observed that the ROS and apoptosis induced by DPV can be downregulation by CCCP, meanwhile, CCCP can activate mitophagy under DPV infected condition.
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PMC11682224
In cutaneous squamous cell carcinoma, the rapid tumor growth and disrupted tissue structure often lead to hypoxic environments.
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PMC9351137
Preparations were analyzed using a computer-controlled Nikon Eclipse 50i epifluorescence microscope equipped with a CCD camera.
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PMC9429973
To date, 26 of 30 PD patient samples have been evaluated for mutations; no resistance-associated variants in BTK, PLCG2, or BCL2 were detected.
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PMC11609529
The results demonstrated that only the cells expressing the YM fusion, but not those transfected with empty vector, or YAP1 or MAML2, developed foci (Figure 3B).
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PMC11300639
Although CDK4/6 inhibitors have shown potential clinical value in the treatment of RCC, further research is still needed to determine their optimal use, including drug dosage, combination therapy, and treatment duration.
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PMC11240448
Thus, the phenotypic changes that require more time to be observed could be masked.
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PMC11791203
Thus, inhibiting the BCL-2 anti-apoptotic protein to overcome tumour cell resistance to apoptosis represents a novel therapeutic approach based on tumour pathogenesis.
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PMC11650848
Lastly and of most relevance here, the Wechsler Intelligence Scale for Children fourth edition (WISC-IV) was used for 11-year-olds .
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PMC11676169
Plasmids carrying deletion mutants of BCAT1 (N-terminal, C-terminal, and AT-IV domain) were synthesized and cloned in the pLenti-Myc-DDK-P2A-Puro vector using AsiSI and MluI restriction sites by Genewiz (ALENTA Life Sciences, Chelmsford, MA, USA).
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PMC11519077
It was discovered that the intestinal epithelium of people with IBD has a greater rate of apoptosis .
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PMC11754094
The selected cells were spread in 96-well plates and the CRISPRi HeLa single cell line was obtained.
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PMC9429973
Grade ≥3 TEAEs were reported in 10 (62.5%) participants, of which only four (25.0%) participants had treatment related events (decrease in lymphocyte count - 2 participants, decrease in neutrophil count - 1 participant and decrease in white blood cell count -1 participant).
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PMC11092382
There are different types of organ injury, such as ischemia/reperfusion injury, toxicity-induced acute organ injury, and transfusion-induced organ injury.
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PMC11765988
These histiocytes, which adopt an epithelioid morphology, manifest as well-formed granulomas .
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PMC9429973
A phase 3 trial of magrolimab/placebo + AZA (ENHANCE: NCT04313881) is ongoing.
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PMC9370419
The SBHX21 cell lines were maintained in hygromycin (150 µg/mL) containing supplemented DMEM.
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PMC9429973
Median B-cell counts decreased from baseline to 0 cells/μL (Arm A, C1 D15; Arm B, C1D8); at 6-month follow-up after EoT visit, B-cell counts had recovered to measurable levels in ~50% of patients.
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PMC9429973
Serum sIL-2R level also had a positive correlation with tumor size reduction which showed an interesting field of study for the upcoming research.
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PMC11792766
Maximum tolerable amounts of food simulants A, C, and D1 (10%, 20%, and 50% v/v ethanol) were specified at 0.5%, 1.25%, and 2.5%.
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PMC11750712
The main images show formalin-fixed, paraffin-embedded (FFPE) tissue sections of a T cell lymphoma stained by double IF with anti-CD34 (Q/BenD10), which stains RQR8 (red), and CD3 (yellow), which detects T cells.
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PMC9105697
This enables timely and non-invasive detection of tumor recurrence and monitoring of treatment response independent of the anatomic location.
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PMC11532793
Gibbs sampling involves drawing transcript counts from a posterior multinomial model (conditional on estimated transcript abundances) followed by drawing transcript abundances from a posterior gamma model (conditional on estimated transcript counts).
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PMC11670407
Our results suggest that the OTULIN-GPX4 axis plays an essential nonmutational role in cisplatin resistance.
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PMC11541409
Journal of Clinical Oncology, 2024.
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PMC9429973
Recommendations have been made that nonimmunosuppressive treatments, such as thrombopoietin (TPO) agents, be the first choice for ITP during the COVID-19 pandemic (ASH, 2020).
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PMC11656657
Indeed, the mechanisms associated with CAR-T cell efficacy are not yet fully understood, and the interaction between the TME and CAR T-cell therapy is considered a key factor that could directly influence CAR T-cell behavior and fate .
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PMC8494202
Besides, the clinical molecular characteristics of glioma are closely related to the prognosis of patients.
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PMC4355729
To evaluate whether the reduction of PIK3R1 influences the cancer stem cell phenotype of renal cancer cells, cell sphere formation assays of 786-O, 786-mut1, 786-mut2, A-704, A-704-mut1, and A-704-mut2 cells were performed.
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PMC9412887
HCl showed the strongest cytotoxicity in MCF-7/ADR cancer cells and the strongest antitumor effect in MCF-7/ADR cell-bearing mice, indicating that the knockdown of P-gp mRNA could remarkably improve the activity of DOX to efficiently realize synergistic therapeutic efficacy and this cation-free Pgp-siRNAsome@Dox.
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PMC9429973
Response rates were lower than previously reported in the MyloFrance 1 study, which included less heavily pretreated patients (i.e., patients only in first relapse; Taksin et al, Leukemia, 2007).
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PMC9118379
Results of explosive search on 320 identified variant PSMs.
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PMC6803987
After 24 h of incubation, the cells were treated with esculetin (12.5, 25, 50, 100, 200 mg/L) and Silybin (positive control () for 24 h. Then, the cells were collected and prepared in cell suspension (1 × 10 cells/mL).
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PMC10605143
All experiments were performed at least three times.
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PMC11036064
Collectively, hsa-miR-34a-5p targets RAF1 and potentiates the temozolomide anti-tumoral effect on A172 cells.
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PMC10495912
Additionally, the lowest BE from docking TQ to the CAT enzyme was -5.34 kcal/mol, and the estimated Ki was 121.33 µM. There were 9 amino acid residues in the binding site, including Pro34, Gln53, Val55, Met339, Pro340, Ile343, Glu344, Ala418, and Glu420 (Figure 1 and Table 1).
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PMC9429973
Global OS and EFS at 2 years was 32 % and 19% respectively.
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PMC11476222
Changes in ganglioside levels have been implicated in aging and neurodegenerative diseases , including Parkinson’s disease (PD) , Alzheimer’s disease (AD) , and Huntington’s disease (HD) .
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PMC11743316
However, it has been found that the average number of mtDNA copies in high-grade ovarian cancers is substantially lower than that of low-grade ovarian tumors , reflecting the enhanced mitochondrial activity associated with tumor development .
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PMC5925824
An alignment position is marked with (:) if either the mu-PD-L1 or ca-PD-L1 substitution differs from the hu-PD-L1 sequence.
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PMC11525028
Dysregulation of mA, mC, and mG modifications impact the self-renewal of tumor stem cells, proliferation, metabolic reprogramming, metastasis, and tumor angiogenesis, thereby influencing tumor progression.
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PMC8996378
According to the different structures, the MDR activities of some diterpenoids were described based on their structures.
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PMC10006224
b Box plot for the size of gained (406), lost (1029) and shared (2666) loops called at 10-kb resolution between control and NIPBL KD cells (see “Methods” and Supplementary Data 1 for genomic coordinates).
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PMC5311252
In addition to expanding the general knowledge of cancer biology, a major reason for this focus is that oncogenic drivers are tempting targets for anti-cancer therapy.
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PMC9429973
While the median duration of response was not reached, median time to first response across dosing cohorts was 1.0 month (range 0.9–2.8).
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PMC3164356
To predict genes in the CHO-K1 genome, we used a combination of de novo gene-prediction programs and homology-based methods.
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PMC11354239
Analysis was performed using the relative quantification (RQ) method and normalization versus housekeeping genes, with 18S rRNA and GAPDH serving as endogenous controls.
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PMC10507284
Similarly, the STS patients with low TROAP‐derived risk scores have an enhanced survival prognosis (Figure 3E), and the areas under the ROC curve are 0.798 (1 year), 0.812 (3 years), and 0.785 (5 years) (Figure 3G).
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PMC11515150
First, the similarity of the VHH sequence to human immunoglobulin V regions offers an important advantage in low-immunogenicity.
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PMC11719944
The interaction of PD-1 with its ligand, PDL-1, has an immunosuppressive effect on T cells through decreasing TCR signal transduction via its ITIM and ITAM motifs .
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PMC11496491
Generally, after obtaining the target gene set, it is necessary to analyze which pathways these genes participate in, what functions they have, and which pathways may play a leading role in the change of phenotype.
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PMC11422497
Dysregulated expression patterns of circRNAs in various cancer types compared to normal tissues underscore their relevance in cancer.
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PMC11420784
Abbreviations: hpi, hours postinfection; UPEC, uropathogenic Escherichia coli; WT, wild type.
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PMC11637276
MAP3K1 and PPP2R1A were top positive regulators in the screen (Fig 1D and 1E).
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PMC11411131
Truncated TrxR1 consists of amino acids 1–497 and lacks two amino acids at its active site, unlike the full-length form (amino acids 1–499).
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PMC11055323
Finally, resuspend the beads with 50ul of water and transfer to a 200ul PCR tube.
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PMC6379402
The number of clusters, k, is a key parameter.
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PMC11790599
Cellular apoptosis was analyzed with a FITC Annexin V Apoptosis Detection Kit I (BD Bioscience) by FACSAria II flow cytometry.
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PMC11790971
The feature values of the top 6 features are overlaid onto the t-SNE plots in (d).
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PMC11723947
To assess whether targeting this molecule could be of clinical interest, we next compared the transcriptomic signature induced by HP1α-deletion in murine CD4 T cells to the transcriptome of tumor-infiltrating T lymphocytes (TILs) isolated from patients with advanced melanoma.
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PMC11473750
Cell pellets were lysed with NP-40 buffer (Sigma) freshly supplemented with protease inhibitor cocktail (Sigma).
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PMC10482220
Indeed, oxidative stress has been shown to activate Ras and several receptor tyrosine kinases like EGF (Rao, 1996), and could thus lead to G3BP dephosphorylation at Ser 149, thereby promoting SG assembly.
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PMC10877303
In comparison to the inhibitor Nafamostat, the top three compounds exhibited superior binding energy, stability, and firmness, as further validated by the calculation of binding free energy.
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PMC11366496
Performing Ki‐67 IF staining to assess the proliferative tumor index showed that proliferation in the RNF122 knockdown cohorts was reduced more than in the normal cohorts (Figure 3D).
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PMC9429973
Our findings confirm the efficacy of C5-mab at treating CM-TMA.
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PMC9532503
The control experiment showed more osmolality before adding the feed additives compared to the batch after adding the feed additives on day 11.
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PMC11670407
j Quantitative analysis of OTULIN- and GPX4-positive cells (n = 6).
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PMC11266100
Additionally, we presented a proof of concept (Ruzgys et al., 2018) and published experimental data that high-frequency sub-microsecond PEF protocols can ensure high transfection efficiency and cell viability (Novickij et al., 2020; Radzevičiūtė et al., 2022b).
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PMC11711066
Targeted research is needed to optimize cardiovascular preventive effects without adverse effects.
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PMC11640476
Images of A549 cells, grown in fibrin gel and treated with resazurin, were acquired using a Zeiss Axio Observer.
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PMC11095939
The accurate transition from quiescence to the active cell cycle is crucial for the control of eukaryotic cell proliferation and adult stem cell-mediated tissue homeostasis and regeneration after injury.
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PMC9429973
However, a study highlighting telomere dysfunction in the BM-MSC of AA patients remains obscure.
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PMC11787651
D, heat map chromatogram for TIC of all 100 runs.
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PMC6133382
The regimen used in this trial involved immunization with a bivalent gp120 vaccine (AIDSVAX B/E) to stimulate an antibody response as well as immunization with a recombinant canarypox vector to stimulate a cell-mediated immune response [13–15].
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PMC9398137
Surprisingly, either unchanged or even downregulated BCL2 expression was observed in S63845-resistant lymphoma cells (Fig. 5).
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PMC11704834
The anti-apoptosis and pro-EMT function of TLE1 in part involves inhibiting the tumor suppressive Bcl-2-inhibitor of transcription 1 (Bit1) cell death pathway.
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PMC8956657
D Fluorescence polarization assay measuring the direct binding between MERS-CoV ORF4b NLS and respective IMPα isoforms.
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PMC11129910
The cells were incubated with 0.06 μg/μl of colcemid at 37°C for 2.5 hours and trypsinized with trypsin/EDTA (0.5%/0.1%).
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PMC9429973
Although the benefit of COVID-19 vaccine protection is still outweighed this risk, thalassemia patients should be educated about this possible reaction and to observe symptoms and signs of hemolysis after COVID-19 vaccination.
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PMC11277157
Among these reliable results, transcripts that were differentially expressed by log2(FC) > 0.5 (i.e., >|1.412| fold) were labeled as upregulated and downregulated transcripts.
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PMC11216402
The variation between Epi-like, Intermediate, and Mes-like GC cell lines is aligned with an axis that also explains most of the variance between stomach and fibroblast accessibility profiles.
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PMC11650848
A Detailed CpG methylation analysis of the ZFP57 alternative promoter analysed by pyrosequencing in the cord blood.
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PMC11672881
The combination treatment, however, exhibits a synergistic effect, significantly altering a wide range of genes involved in oxidative stress response, apoptosis, and cell cycle regulation.
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PMC11321678
GraphPad Prism 8 were used for statistical analysis.
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PMC8345486
Silica gel column chromatography was performed on silica gel 60 (230–400 mesh), Sigma-Aldrich (Steinheim, Germany) or Merck (Darmstadt, Germany).
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PMC11723947
Differentially accessible peaks were defined as peaks with absolute log2 fold change greater than 1 and adjusted p-value below 0.05.
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PMC10440586
MDM, marrow-derived macrophages; MG, microglia. (
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PMC11659921
A statistically significant difference is indicated by p < 0.05. *
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PMC11612626
Autologous CD8 T-cell–mediated cytotoxicity was measured by gating for CD138, annexin V, and PI cells.
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PMC11615828
As expected, light illumination halted the Rab3‐labeled synaptic vesicles in transgenic worms (Figure 6a; Video S27, Supporting Information).
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PMC11155445
The adsorption capability of PVDF/(170) composite membrane was also investigated for the adsorption of Ag and various other metal ions (Pb, Cu, Co, Ni, Zn, Mn, Cr and Na) to evaluate the selectivity of the membrane.
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PMC11782508
Breast cancer is the most common cancer among Egyptian women, representing 34.9% of total cancer cases and the leading cause of high rates of mortalities.
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PMC9412887
Cancer is among the leading causes of death worldwide.
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PMC9429973
Taking into consideration the identified cytogenetic abnormalities AML patients were classified by risk groups: the group of patients with adverse cytogenetic markers (3q21q26 rearrangements, -5, -7, t(9;22)(q34;q11), BCR/ABL1 fusion gene, multiple changes (≥3), monosomal karyotype), the intermediate risk group without significant prognostic markers and the group with favorable prognostic factors (t(8;21)(q22;q22), t(15;17)(q22;q21), t(16;16)(p13;q22)/inv(16)(p13q22), AML1/ETO, PML/RARa, CBFβ/MYH11 fusion genes).
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