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PMC11387401
The beads were collected magnetically, washed six times, and resuspended in 55 µL lysis buffer.
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PMC11785489
We quantify the extent of these features through our TCR scoring function “TCR-mem.”
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PMC11244823
The data were examined using Scaffold 4.4.2.
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PMC11703992
Five hypotheses (H0–H4) were configured in the colocalization analysis for posterior probabilities calculation (Fig. S4A).
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PMC9429973
Overall survival (OS) and progression free survival (PFS) were estimated by the Kaplan-Meier method and compared by the log rank test.
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PMC11337594
As illustrated in Fig. 3C and S2A, cleavage of PARP1, CASP3, and GSDME was evident in both BAX- and FAS-overexpressing cells.
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PMC7570809
Additionally, there is substantial evidence for interplay between αv integrins and tissue growth factor (TGF-beta) during the pathological epithelial-to-mesenchymal transition that occurs in many types of cancer , which is the reason why anti-integrin therapeutics are indeed under development as treatment for TGF-beta-related disorders .
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PMC11401358
Structural characterization of (GAGSGA)2 exhibited β-sheet conformations.
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PMC11629461
After plasmid transfection the DUOX2 expression was markedly increased in DUOX2–CHO‐K1 cells (Figure 6).
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PMC8701144
The search criteria for Mascot searches were: trypsin digestion with two missed cleavage allowed, carbamidomethyl (C) as fixed modification and acetyl (N-term), Gln->pyro-Glu (N-term Q), and oxidation (M) as dynamic modifications.
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PMC11618052
This combination has also demonstrated encouraging outcomes in BRAF colorectal cancer.
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PMC11185260
N = 6/group. (
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PMC9545474
To confirm the hypothesis of induction of oxidative stress by complexes 6 and 8, based on the potential mechanism of action observed for complex 3, the intracellular production of ROS in A2780 cells exposed to the complexes was investigated using the fluorescent DCFH2‐DA assay with the analysis performed by flow cytometry.
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PMC11770199
mMSCs-GFP (2 × 10), mMSCs-p14 (2 × 10), or normal saline was administrated intratumorally into these mice.
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PMC11347429
A few samples were taken from a repository (seasons 2008/2009 until 2013/2014, total of 5 samples, collected at the Otto-von-Gericke University Magdeburg, Germany).
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PMC10243817
Indeed, we found that MEX3B knockdown with siMEX3B significantly increased TGF-β2–induced SMAD2 phosphorylation in ALI-cultured HNECs (Figure 6, A and B).
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PMC11703992
Jurkat cells were utilized to explore the specific function of DDIT4 in T cells.
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PMC7823217
These are important factors to consider and monitor as part of the process of bioengineering tumour constructs by bioprinting.
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PMC10788478
LGR6, leucine‐rich repeat‐containing G protein‐coupled receptor 6; NSCLC, non‐small cell lung cancer; SCLC, small cell lung cancer.
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PMC8956657
Next, we quantitatively measured the direct binding interaction with MERS-CoV ORF4b NLS to respective IMPα isoforms using fluorescence polarization.
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PMC10891340
The relative gene expression was calculated using the mean values obtained with the arithmetic formula ∆∆Ct.
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PMC11656657
The absolute number of PMN-MDSC (left side panel), or Mo-MDSC (right side panel) before (day 0) and after three days of cell–cell contact (C) and cell-free experiments (D) with medium and OS cell lines.
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PMC11144200
Chemotherapy alone is unable to completely and permanently destroy the tumor microenvironment .
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PMC11525028
Additionally, protein synthesis, PRPP, and adenosine levels were also restored by ASNS-OE or supplementation with Asn in ATF4-KD cells (Figures S3E–S3G).
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PMC11342785
Recovery fluorescence intensities were recorded for the indicated time, then quantified, and normalized by using Fiji.
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PMC10376064
Neutral pH was important to avoid the degradation of DMF .
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PMC11740508
42,966, Sigma-Aldrich®), and 84% PBS.
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PMC5941560
GATK also uses split-reads, but its detection of variants relies on an assembly-based method that is limited to small sequence differences between the reads and the reference genome.
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PMC11680391
They allocated the questions based on the headline for the construct and added the question where they agreed it was truthful.
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PMC11474209
Its neurotoxic properties are frequently linked to red tides because of marine dinoflagellates such as (Gymnodinium sp., Pyrodinium sp., and Alexandrium sp).
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PMC11087766
One of the chimeras generated between PhiKZ gp104 and its homolog PhiPA3 gp108 (PhiPA3gp108-[PhiKZ gp104(113-162)]-sfGFP) revealed a stalled transport intermediate that was targeted to the PhiKZ import machinery, but failed to be transported.
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PMC10870498
Moreover, a previous study shows that overexpressing SIRT7 promotes the proliferation and invasion of tumor tissues through its-related signaling pathway, which is similar with our results .
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PMC6835762
Additionally, Korupp et al. and Iglesias et al. produced PGA using adipic acid as a starting material; as with DMA, the molecular weight of the PGA produced was significantly lower than that seen by the Garnett group when producing PGA with DVA .
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PMC11659921
The Kyoto Encyclopedia of Genes and Genomes (KEGG) serves as a useful tool for examining gene functions and provides high‐level information related to the genome. ,
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PMC10165258
Combination drug treatments aim, beyond the simple addition of the individual drugs, to identify synergies between the different drugs that provide therapeutic advantages over single treatments.
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PMC11769522
tt.
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PMC11763111
T-cells were isolated from peripheral blood using CD3-positive selection microbeads (STEMCELL, 17851).
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PMC11650848
Taking into consideration the previous analysis at 7 years that showed FA-supplemented participants from the FASSTT study scored higher in verbal IQ and observational data correlating maternal folate deficiency in pregnancy with lower language abilities in the children , a language task was designed to assess the underlying neurophysiological basis of language processing for the age 11 years assessment using MEG.
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PMC9429973
Results: A total of 203 subjects were invited to participate in the study, 163 (80.3%) responded and were included in this analysis.
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PMC10551595
Here, 2–5 mL of heparinized peripheral or bone marrow blood samples were collected from nine newly diagnosed ALLs who were referred to Sayed‐ol‐Shohada Hospital (Isfahan, Iran) for 7 months (Table S1).
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PMC11575040
We also examined the role of lncRNA-miRNAs (LINC00094/miR-1270) and relevant novel pathways in the proliferation and motility of a BRAF-mutated melanoma cell line after metformin treatment.
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PMC11085211
Indeed, imatinib mainly promotes partial response or stable disease in most patients, while complete response is only observed in 5% of patients .
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PMC11655536
P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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PMC10748106
In vitro cytotoxicity activity of Geniposide and Genipin was measured using the sulforhodamine B (SRB) (MP Biomedicals, Irvine, CA, USA) protein staining assay , using three different cervical cancer cell lines CaSki, CaLo, and INBL; and the immortalized keratinocytes HaCaT, as a non-tumorigenic cell line.
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PMC10203589
In a geneticmodel, the FGF18 SNP rs3806929 was significantly associated with treatment response to OC after platinum-based chemotherapy (90).
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PMC11295144
Synaptic contact formation in co-culture of α2β2γ2-GABAAR/mCherry-NL2/GFP–expressing HEK293 cells and embryonic medium spiny neurons in the presence of (A) SF9 cell extracts, (B) α2 subunit ECD, (C) β2 subunit ECD or (D) γ2 subunit ECD.
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PMC11477621
The IC50 value of the compounds was calculated using GraphPad 7.0 software.
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PMC9429973
As for the frequency of VOC admission in the preceding 12 months, a decrease of 2.28 points in HRQoL was observed for every additional admission (p=0.012).
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PMC10890307
Table 1, Table 2, Table 3 and Table 4 summarize the kinetic parameters calculated during the exponential growth phase for each cell line and each condition.
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PMC9444294
PLA indicates proximity ligation assay.
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PMC11739484
Relative mRNA expression levels were determined utilizing the 2 method.
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PMC11594074
As visualized in the dose–response curves of the two selected drug candidates in the four cancer cell lines, only compound 4 displayed significant cytotoxic effects (Figure 6).
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PMC11770130
By crossing Ntsr2 mice with an Adipoq-cre mouse, the Ntsr2 AKO mouse model was established and phenotypically characterized (Fig. 1b).
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PMC10968586
Instead, the role of redox homeostasis in HT-dependent cytotoxicity is less clear in the context of HCC.
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PMC11512230
For each SP, n and x were pooled over all sarcoma cells, followed by calculation of the ratio with indices 1 and 2 corresponding to different SP:AER=x1n1x2n2 From a mathematical point of view, xi positive adsorption events out of ni observations represent the sample from the binomial distribution with adsorption probability pi.
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PMC9429973
Overall survival (OS) was measured as the time from diagnosis until death or the last follow-up.
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PMC11489351
Importantly, we confirmed these results using two independent pHi manipulation methods and performed confirmatory experiments across various human and canine epithelial cell models.
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PMC10671321
ColQ is a collagen that is expressed and concentrated at cholinergic synapses .
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PMC9429973
According to TKO data, a decreased constitutive VLA-4 activation was observed in CLL cells collected at pre-treatment and at day 14, 30, 60 and 90 from patients on IB, confirming an IB-dependent impairment of VLA-4 activation via BCR signal.
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PMC8526701
The inhibition of cellular expression by reduced expression of BRD9 has yet to be fully studied; hence, there are only a few available reports.
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PMC11337594
Three combinations (dabrafenib plus trametinib, vemurafenib plus cobimetinib, and encorafenib plus binimetinib) have been observed to elicit a high initial response rate, with evidence of tumour regression in nearly all patients [11–13].
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PMC6160470
After 72 hours of incubation, only attached cells were collected and washed with blocking solution (2% BSA in PBS).
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PMC11783017
Then, the cells were incubated with Alexa Fluor 488-conjugated anti-CRT antibody (10 μg/mL, 30 min).
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PMC11610461
Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to explore the biological function of PSENEN and investigate its relevance with the immune microenvironment of patients with KIRC.
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PMC9592219
After washing with PBS, the tissue slices were incubated at RT for 1 hour with a secondary antibody that had been conjugated with anti-rabbit or anti-mouse horseradish peroxidase.
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PMC11599565
Then gDNA was removed prior to the WTA process.
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PMC11753949
Our findings reveal the evolutionary conservation of synaptopodin and of the spine apparatus from Drosophila melanogaster to mammals.
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PMC11537649
It can regulate gene expression through chromatin modification, transcriptional regulation, posttranscriptional regulation, and other mechanisms, and participate in the process of many diseases, including tumors.
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PMC10734950
Caspase activity begins upon activation, and this is followed by nucleic acid cleavage.
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PMC11767817
To identify the cell death pathways involved in 2a and 2a-B anticancer activity, we investigated the apoptosis and necrosis activation in response to compounds 2a and 2a-B. In this assay, we used a dye that binds to the PS, indicating apoptotic cells, and a second cell-impermeant, fluorescent DNA dye, which detects necrosis.
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PMC10522430
This protocol was replicated six times.
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PMC11021472
Significance was determined by mixed model analysis; ***p < 0.001. (
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PMC11802929
We assigned each cell an antigen only if their UMI count was >25 and the UMIs specific for that dextramer occupied >25% of that cells’ dextramer reads.
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PMC11799978
NIH3T3 cells were seeded into 6-well plates at a density of 1 × 10 cells per well.
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PMC11489351
For D, significance was determined using ANOVA with Tukey’s multiple comparisons correction.
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PMC11650848
In light of the important role of ZFP57 in regulating imprinted genes, which often have neurodevelopmental effects, as well as the colocalization of methylation differences with the upstream promoter, we have further investigated this region in our maternal–offspring cohort to look for associations between the methylation status and cognitive outcomes.
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PMC11746948
p < 0.05, **p < 0.01, ***p < 0.001, and **** p < 0.0001 were considered statistically significant, while ns was considered not statistically significant.
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PMC11704834
In addition to promoting cell-cell adhesion, the tumor suppressor E-cadherin may also induce apoptosis in several cellular models (16,23,24).
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PMC11033180
Subsequently, we assessed AP parameters after a current injection set at +30 pA above the rheobase.
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PMC6771295
Regulation of autophagy by SIRT family members (GFP-LC3 punctate staining). (
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PMC11725127
Subsequently, the eluted protein was applied to a size exclusion chromatography column (Superdex 75, HiLoad 26/60, Amersham) equilibrated with 45 mmol/L potassium phosphate (pH 6.0) and 300 mmol/L NaCl.
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PMC6617630
Cells were washed with FACS buffer and re-suspended in 500 μL FACS buffer, and data were acquired on a FACSCalibur flow cytometer (BD Biosciences).
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PMC11349530
In addition to PD-L1/2, these ligands include galectin-3, galectin-9, and others (80).
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PMC9429973
However, the molecular programs governing HSC stemness become dysregulated during culture, compromising HSC self-renewal and engraftment ability.
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PMC11802929
Adjusted p-values are generated by EnrichR. a Each TCR beta chain was split into V, CDR3βmer, and J regions, and then encoded by the physicochemical properties of amino acids at each residue position for overlay on the GEX-UMAP.
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PMC10165258
On the right side of each plot, a boxplot represents the viability of the control group, subjected to either DMSO or NaCl. (
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PMC11377827
14-3-3ζ has been implicated in influencing HIF-1α expression (Tang et al, 2015; Xue et al, 2016), but we did not observe any changes in HIF-1α levels.
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PMC11310713
NRecon (Bruker, Belgium, V1.7.0.4) and micro-CT (μCT; SkyScan, Bruker, Belgium, V1.17.7.2+) were employed for image reconstruction and CT analysis.
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PMC11394227
Following the addition of HRP-Goat Anti-Human IgG (H + L) (Proteintech, Wuhan, China) and incubation for 1 h at room temperature, the TMB substrate solution (Solarbio) was added.
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PMC5415764
Compared to PTX drug sensitive A2780 cells, A2780/PTX cells demonstrated high drug resistance against PTX, with a 48.5-fold increase in the IC50.
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PMC11478724
After 24 h of treatment, the concentration of PMX that resulted in 50 percent cell survival was found to be 4.653 (a).
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PMC11700523
Treatment with IS (10-500 μmol/L) increased MR-driven luciferase activity without ligand stimulation, and IS concentrations >150 μmol/L significantly enhanced MR transcriptional activity (Figure 2B).
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PMC9895440
Representative of n = 3 experiments.
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PMC10329074
However, the underlying mechanism of how the YBX3 gene promotes the development of ccRCC remains unclear and requires further exploration.
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PMC11252033
FTMAP has been shown as a powerful tool for identifying druggable hot spots in proteins (Brenke et al., 2009; Kozakov et al., 2015), as it correlates pocket druggability with propensity to bind clusters of small organic compound fragments.
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PMC11740573
When exposed to a bacterial infection, autophagy-induced proteins such as Beclin1 and microtubule-associated protein 1 light chain 3 (LC3B) are activated.
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PMC11551844
One-way ANOVA for multiple groups, followed by Tukey's test for multiple comparisons, was used for determining statistical significance.
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PMC11317131
PE functions in both dividing and non-dividing cells and efficiently inserts sequences <50 bp while minimizing DSBs (1).
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PMC11612794
Scale bar, 10 μm.(D) Localization of GFP-Dsn1.
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PMC10978090
Three days after admission, she was placed on veno-arterial femoro-femoral ECMO (VA-FF-ECMO) support and anticoagulation with UFH was started (Day 1, D1).
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