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PMC9878562
Values below the dashed line are under the sensitivity level.
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PMC11461874
Knockout of TRAF7 in NIH3T3 cells have revealed that TRAF7 mediates the time-of-the-day-dependent regulation of DBP levels.
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PMC11502066
In addition, quercetin could increase also the expression of CB1R in a mouse model of induced colon cancer, inhibiting the mediators of proliferation (STAT3, p-STAT3) and inducing the markers of apoptosis [Bcl-2-associated X protein (Bax)/B cell lymphoma-2 (Bcl-2)], thereby leading to the suppression of colon carcinogenesis (Table 1).
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PMC8632470
In this study, we investigated the cytotoxicity and nephroprotective activity of the ethanol extract of A. keiskei Koidzumi on the NAPQI-induced HEK293 cell line.
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PMC9429973
In this aim we retrospectively studied the flow cytometry results obtained at the diagnosis for 673 patients explored in our center: 212 CLL/lymphocytic lymphoma, 160 lymphoplasmacytic lymphoma (LPL, including Waldenstrom Macroglobulinemia), 76 mantle cell lymphoma (MCL), 169 marginal zone lymphoma (MZL), 35 Hairy cell lymphoma (HCL) and 27 follicular lymphoma.
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PMC11098378
SacII/PacI constructs were cloned into a modified pCDNA3 vector containing SacII/PacI sites or pDGOpIE2.
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PMC10723784
p < .001 compared to control values.
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PMC10454535
Autologous stem cell transplantation (SCT) is recommended for eligible, newly diagnosed individuals without comorbidities and involves induction therapy, high-dose chemotherapy, SCT, and maintenance using the immunomodulator and angiogenesis inhibitor lenalidomide .
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PMC7553912
In the present study, OSM induced the expressions of OPN, ANXA1, and ANXA2, in RTECs isolated from the mouse model of renal crystal formation.
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PMC11782780
EBF3 expression was significantly lower in BC cells than in normal breast epithelial cells (Fig. 1B).
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PMC6889484
However, NL4-3 infection of a 20% CEMSS:80% CEMSS/D128K cell mix for each cell clone showed severely delayed kinetics, and virus production did not become detectable for 20 days after infection (Figure 5F, bottom).
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PMC11453018
Notably, this correlation demonstrates greater predictive power for survival outcomes than traditional clinical features .
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PMC9429973
In a Phase 1 study, etavopivat 300-600 mg once daily in pts with SCD not regularly transfused was well tolerated, improved hematologic markers, decreased hemolysis and improved markers of RBC health.
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PMC11422150
Moreover, the isolation of these cells also requires highly invasive procedures compared with iPS cells, and their differentiation potential decreases with increasing age (Stolzing and Scutt, 2006; Deng et al., 2018).
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PMC11637820
p < 0.05 was considered statistically significant.
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PMC11143482
Body weight was compared in control and tumour-induced mice with 1 × 10 and 3 × 10 cancer cells.
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PMC8382973
Data were collected using Rheocalc software (Brookfield Eng.
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PMC10196713
Further studies are required to clarify this.
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PMC11388384
To distinguish between these two models, we generated SHH signaling gradients on a standard laboratory shaker table to disrupt SHH movement through the tissue culture medium and found that although SHH gradients were sensitive to nutation in the presence of SCUBE1, SCUBE1 still increased the amplitude and lengthscale of gradients formed under nutation (Fig. 3E and SI Appendix, Fig. S7A).
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PMC10957991
Stiffness-dependent expression of TRPV4 as shown by Western Blots from cellular lysates from 184A1 cells, cultured on 0.2 kPa substrates or plastic dishes (rigidity around 10 000 kPa).
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PMC9429973
Upon confirmation of the recommended dose for expansion (RDE, determined for each arm separately), enrollment for the expansion phase (Part 2) will open; patients will be treated with siremadlin at the RDE in combination with venetoclax + azacitidine.
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PMC10578720
Mechanistically, HBV downregulated Sirtuin 3 (SIRT3) expression through activation of the toll-like receptor 2 (TLR2)-NF-κB-peroxisome proliferatoractivated receptor γ coactivator 1α (PGC-1α) axis in macrophages, thereby increasing the acetylation of CS/PDHC.
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PMC8806312
Forest plot of immune genes related to OS survival. (
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PMC11693599
Further studies should be conducted to explore whether exosomal CD109 levels are correlated with the clinical stage and prognosis of patients with ovarian cancer.
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PMC3681794
Statistical significance of differences was assessed using 2-tailed student’s t test or 2-way ANOVA, a p value of less than 0.05 considered significant.
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PMC11045125
These lymphomas express GC type B cell proteins that are activated in (and in some cases essential for survival of) human BLs and lack both LMP1 and EBNA2 expression.
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PMC9429973
Our sample showed OS 62% vs 54% in NPM1+ compared to NPM1- patients proving published data, however statistical significance was not reached probably due to the insufficient sample.
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PMC9429973
Patients who are eligible or candidates for ASCT may be enrolled in the study if they are not receiving ASCT at the time of enrollment.
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PMC11451940
After treatment with complexes 1 and 2, the intracellular copper levels rose slowly, with a maximum after 24 h reaching 76 and 72.5 ng 10 cells (i.e. ca.
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PMC6835428
Notably, FR overexpression is present in more than 80% of HGSOCs .
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PMC11756937
The plate was placed in an incubator and the media was exchanged daily with a growth medium equilibrated to room temperature.
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PMC11764090
In this section, we first consider cold stress in the context of the whole plant’s developmental stages, and then highlight the need to identify and evaluate the varying cold tolerance of different plants.
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PMC11704135
Compound 12 inhibited S. haemolyticus at a concentration of 7.5 mg/mL, while a concentration of 15 mg/mL was sufficient to inhibit the growth of S. epidermidis and C. albicans.
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PMC10212663
We compared RANKL expression levels between cancer and matched normal samples from multiple cancers both in advanced (Figure 1(a), (b)) and non‐advanced (Figure S1A,B) settings.
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PMC8873393
Cold methanol (1 mL) was added to the cell suspension drop-wise while vortexing the open tube at minimum speed on a Vortex-Genie 2 vortexer (Scientific industries, Inc.).
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PMC11463018
1 1 8 ∼ 120 °C.
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PMC11731161
Unpaired two-sided t-tests were used to compare two experimental groups, while one-way ANOVA tests were utilized for comparing three or more experimental groups.
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PMC10955424
The estradiol derivative 2HE2 was demonstrated to be a potent agent that restores platinum chemosensitivity to OC cells, mediated by cellular and soluble compartments of TME in-vitro systems .
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PMC9429973
The most common comorbidity was asthma (45.0%).
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PMC8984067
It has been revealed that all the products were uniformly dispersed nanoparticles (25–32 nm), which crystallized primarily as hexagonal structures, and their up-conversion fluorescence spectra were similar to that of NaYF4:20%Yb,2%Er.
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PMC11190538
Incubation was resumed for an additional 4 h. The purple formazan dye crystals were solubilized with 200 μL DMSO.
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PMC11467964
Each variable corresponds to its score one by one, and the total score serves as the summarized score of all variables in each sample.
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PMC11055510
The staining results of clone formation experiment showed that the number of clones in the ov-circMAN1A2 group was significantly higher than that in the ov-nc group.
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PMC11307990
The first lane was the reference 6HB-DONs. (
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PMC6024716
The luminescence was read using the SpectraMax microplate reader (Molecular devices, Wals, Austria) at an integration time of 250 ms.
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PMC6268318
Since the 1970s, several unusual compounds have also been isolated from Combretum species, for example, 9,10-dihydrophenanthrenes and a substituted bibenzyl from C. molle .
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PMC10582049
Lung adenocarcinoma tissue was isolated from 16 patients during tumor resection at the Vanderbilt University Medical Center (Supplementary Table T1).
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PMC11514418
In this retrospective study, all data were extracted from the medical information system, which was approved by the Ethics Committee of Zhejiang Provincial Hospital of Chinese Medicine (Ethics No. 2024-KLS-266-02).
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PMC11746948
Data are presented as mean ± SD.
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PMC11711345
Only cuminaldehyde induced a decrease in the proliferation of MDA-MB-231 (15 ± 7%) and Calu-3 (31 ± 5%) cells, but significantly only for the latter (p = 0.068 and p < 0.001, respectively, by post-hoc Dunnett´s test), corroborating the activity previously reported for another lung adenocarcinoma line in the literature .
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PMC11528603
Interestingly, the ethyl acetate and hexane extracts of S. affinins whole-fruits and seeds also demonstrated potent cytotoxicity toward HeLa cells in previous reports.
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PMC11657744
Our findings showed that AurA levels were lower at the 8-hour time point and increased after 12 h, which correlates with our cell cycle analysis (Fig. 3C).
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PMC10758402
While further dose optimization experiments will be required, the current study suggests that a combinatory approach involving the administration of DMF intratumorally ahead of HSV.n212 (5h apart), administered a total of three times every other day can be effective for tumor control.
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PMC11295144
These receptors were also expressed in HEK293 cells to create a stable cell line which was characterized using immunolabeling and voltage-clamp electrophysiology.
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PMC9622879
Our proposed community consists of 10 homes in Detroit city, Michigan, USA.
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PMC10317042
P < 0.05; **, P < 0.01 (Student t tests).
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PMC11615743
Previous studies utilized HCR‐based logic devices in D‐PBS supplemented with glucose and magnesium or conducted RCA reactions on cell membranes in Phi29 DNA polymerase reaction buffer containing 50 mM Tris‐HCl, 10 mM MgCl2, 10 mM (NH4)2SO4, and 4 mM DTT. ,
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PMC10978090
Plasma samples were then heated at 56°C for 30 minutes to inactivate traces of thrombin and were stored at −80°C for functional test.
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PMC11539788
Moreover, GSEA revealed that lower expression of RNF19A was significantly related to the mTOR signalling pathway.
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PMC11472569
Emerging evidence suggests that ABCC1 is also involved in the transfer of MDR between cells via EVs.
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PMC11301095
Continuous monitoring showed increasing levels of transaminases, urea, and creatinine, which improved upon cessation of hepatorenal toxic medications.
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PMC6114978
Trichostatin A treatment reversed expression of MST1 (58%) and MST2 (67%), indicating histone deacetylation also plays a role in silencing expression of MST1 and MST2.
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PMC11244823
Yet, the gD1 and gD4 molecules are still closely related, giving rise to cross-reacting neutralizing antibodies.
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PMC10142392
Several research organizations are studying plasma treatment strategies and chemical additives to improve membrane-to-fabric adhesion.
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PMC10538569
Cells transduced by pRRL-GPI-HA-scFv X5-2A-GFP result in internal GFP expression, marking transduced cells, while HA tagged GPI-scFvs are anchored to the outer leaflet of the plasma membrane.
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PMC9429973
The expression profile of the following inhibitory receptors (IRs): PD1, CD244, CD160, TIM3, LAG3, CTLA4 was characterized by flow cytometry in CD3+CD8+ T cells.
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PMC9429973
No differences were found between B/myeloid and T/myeloid MPAL cases.
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PMC11740207
The asymmetric division (AD) of PGCs has been well-studied in mice, although research on humans is more limited (Rossant and Tam, 2009; Bedzhov and Zernicka-Goetz, 2014).
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PMC8382973
The 5% HEC gel, 7% HEC gel, 10% HEC gel and 15% HEC gel were level 2, and their cell viability values were 79.3%, 73.53%, 65.1% and 60%, respectively.
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PMC11078693
Aspirate most of the supernatant away to leave 2–3 mL in each tube.c.
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PMC7612475
E, Quantification of ongoing forks, new origins, and stalled forks scored in CldU-labeled forks in untreated SF3B1 and SF3B1 cells with and without induction of RNAseH1 for 24 hours prior to CldU/IdU labeling.
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PMC9429973
With long term follow up the OS at 5 years is 97.3% and 87.3% for all PET3 negative vs PET3 positive pts.
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PMC11754436
Tukey’s test was used to further explore the between-group differences shown by the ANOVA results.
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PMC7917457
∗p < 0.05, ∗∗p < 0.01.
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PMC11461874
Ubiquitin has seven lysine residues, and poly-ubiquitin chains can be assembled through linkage to any of the seven residues.
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PMC9429973
Elevated Plt were found in 17.3% (680/3931).
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PMC11754436
The results suggested that overexpression of DHRS4-AS1 could upregulate Bax and caspase 3 expression and inhibit Bcl2 expression in MG63 cells.
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PMC7215832
From the increased protein expression of tumor-suppressor genes and functional activation of PCFT, we concluded that RX-3117 might have induced hypomethylation of the promotor.
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PMC11495567
The results from three independent experiments were then plotted using GraphPad Prism version 8.0 for Windows (San Diego, CA).
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PMC10387886
Our unbiased profiling revealed decreases in DUSP10 and DUSP13 expressions and increases in DUSP16, DUSP18, DUSP21, and DUSP27 expressions, which have not been reported in previous studies.
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PMC9429973
Most of the sample received an intensive treatment 42 (63.6%), however only 25 (37.9%) patients achieved CR, 2 (3%) CRi, 6 (9.1%) +MRD, 4 (6.1%) PR and 26 (39.4%) were refractory.
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PMC4816271
Chimeric Antigen Receptors (CARs) can be constructed by connecting the single-chain variable region (scFv) from a monoclonal antibody to intracellular signalling domains.
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PMC9429973
The IC50 of flumatinib was 2.4uM, and ABT-199 5.5nM in the cells treated for 48 hours.
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PMC8494202
We believe that the results of this study will provide a new target for the diagnosis and treatment of glioma, thus improving the prognosis of glioma patients.
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PMC11634027
This revealed that deletion of the D motif specifically reduces Ds-ICD association with the Fat-ICD (Fig. S8).
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PMC11724582
The data are presented as the means ± SEMs.
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PMC9878278
These data suggest that unlike shown in other cell types, these molecules do not have any direct or indirect effect on anti-ZIKV response in SC.
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PMC10530622
However, oxalate is also a driver of systemic inflammation , supporting an association between oxalate and disease beyond nephrolithiasis.
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PMC11257988
The two Cys residues in the peptide are essential for its cyclic structure and control of its binding and inhibitory activity, but the bond is cleaved under intracellular reducing conditions, limiting application.
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PMC10818062
PS keeps a balance of the tightly inter-connected phospholipidome as if it turns the interlocked gears of phospholipids.
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PMC11792090
Following the removal of cysteine, the plate was washed twice with PBS, and 200 μL of tumor cells were seeded into each well.
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PMC9454178
Next, we measured the mRNA levels of CDK4, CDK7 and CDK9 in different GIST risk groups.
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PMC9429973
The median overall survival (OS) duration was 44 months (25.8-62.1) and the 5-year OS rate was 40.2%.
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PMC11697189
Survival analysis was performed on patients in each subgroup, and heatmaps visualized clinical information and prognostic-related HSPs expression in each subgroup.
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PMC9429973
Allo-HSCT recipients were labelled TPL1, the others - TPL0.
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PMC10204952
For example, overexpression of MUC13, encoding mucin 13, enhances carcinogenesis and cancer progression .
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PMC11696659
Also, in some patients, biomarkers could inform on the prognosis of the disease at an early stage, or help assess the risk of indeterminate pulmonary nodules which are beyond the reach of biopsy techniques .
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PMC10470467
The “oncoPredict” is an R package (16) that predicts the half-maximal inhibitory concentration (IC50) of different chemotherapy drugs in each ES patient using the Cancer Therapeutics Response Portal (CTRP) and the Genomics of Drug Sensitivity in Cancer (GDSC) databases, allowing researchers to investigate the sensitivity differences of ES’s classic chemotherapeutics drugs in different risk groups.
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PMC10362265
and Pmax(V) are probabilities from the MD data, with Pmax(V), representing the most probable state.
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PMC11488203
The taxol-loaded exosomes were applied to the tumor cell lines in different dilutions (1:107; 1:427; 1:1707) and the viability was evaluated by fluoroscan assay as compared to two different taxol concentrations (0.1 nM; 1000 nM), the taxol solvent (solvent), and cell culture medium (control) as controls.
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