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OTAR3088
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BioData-CellLine_annotated

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PMC11186948
Statistical analysis on both western blot and RT-qPCR data was performed using Student t-test, considering significance for p value < 0.05.
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PMC11343332
After treatment, fewer cells were present, and those that were there shrank and showed cytoplasmic membrane blebbing.
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PMC11599565
A population of giant, mono- or binucleated cells (A) undergoing progressive cytoplasmic/cytoskeletal structural changes (A-H) and forming “branches” (white arrows, B-D) which ultimately give the cells a multipolar neuron-like appearance.
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PMC11473843
Understanding these mechanisms may provide ways for overcoming FAK drug resistance and greatly improve cancer treatment.
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PMC10955424
Compounds were identified using the mZcloud database.
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PMC11802929
For SCTs that captured cells, polar and charged residues such as Threonine (T) and Arginine (R) were enriched in non-anchor positions (Fig. 2c right top).
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PMC11597291
The nCGO-PEG/PCT nanoparticles exhibited sustained, pH-responsive drug release properties, having a significantly higher drug release at pH 6.0 compared to the physiological pH 7.4.
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PMC10761571
4Fig.
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PMC11789597
Here, it is found that caveolin‐1 (CAV1), a primary component of membrane lipid rafts and caveolae, is highly expressed in MM cells and is associated with MM progression and drug resistance.
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PMC11402217
Mouse body weight fluctuations during the experiment. (
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PMC8358006
b Top ten TF-binding motifs enriched in H3K4me3, H3K4me1, and H3K27ac peaks of upregulated GSDs marked genes.
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PMC9429973
Within the sample preparation, DNA from 1-2 mL of bone marrow (BM) samples were isolated and concentrated to allow up to 20 µg DNA as the input for the downstream PCR.
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PMC11545737
HrpA acts as a manganese-dependent cell lysin and mediates the bacterial escape from the internalization vacuole .
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PMC11453018
The data represent the mean ± SEM, p< 0.05, by t-test.
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PMC9780037
This includes patients from low-income countries, whose clinical facilities may have limitations in refrigeration equipment.
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PMC11705067
For genes positively associated with FDX1 and DLAT, the functional analysis demonstrated that acetyl-CoA biosynthetic process, respiratory electron transport chain, lipid oxidation, mitochondrial respiratory chain, active ion transmembrane transporter activity and acetyl-CoA metabolic process were severely affected.
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PMC11742431
However, the degradation platform established in this study was in the form of a protein that directly controlled the degradation of the target protein and introduced the concept of tumor microenvironment‐mediated site‐specific cleavage, allowing the protein to spontaneously exert the degradation of the target protein in the ubiquitin‐proteasome system within the tumor cell.
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PMC11471157
It was observed that when boiled, dried fish retained its structure, resisting complete melting.
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PMC11615101
P ≤0.05, ** P ≤0.01, *** P ≤0.001).Abbreviations: WB, Western blot; ns, non-significant; NS, non-specific Si-RNA; TNF-α, tumor necrosis factor-α; VC, vehicle control; UT, untreated; kDA, kilo Dalton; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; Il-6, Interleukin-6; IL1β, Interleukin-1-β; nM, Nano molar; ng, Nano gram; mL, milliliter.
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PMC8540692
Sodium butyrate (NaBu), a salt of short chain fatty acid, is one of the main products of the anaerobic fermentation of indigestible polysaccharides such as dietary fiber and resistant starch produced by the microbiota in the large intestine .
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PMC11363012
However, to fully understand natural product biosynthesis in plants, the corresponding products and biosynthetic intermediates must also be mapped at the single-cell level.
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PMC11257988
Sun et al. demonstrated that the clinical outcomes of KRAS-mutant NSCLC patients varied in response to ICI-based first-line treatment to some extent with different KRAS mutation subtypes and co-mutations.
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PMC11397654
Yilmaz and co-workers synthesised two fluorescent calixarenes bearing 4-sulfo-1,8-naphtalimide moieties linked at the lower rim through hydrazide (33a) or aminopropyl (33b) chains (Figure 9).
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PMC9429973
In the multivariate analysis, there were significant associations of OS with CCI (p=0.043, relative risk [RR] 0.36, 95% confidence interval [CI]= 0.13-0.97) and age (p=0.048, RR 0.60, 95%CI= 0.36-0.97).
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PMC11536589
The bioinformatics analysis and transcriptome sequencing showed that ferroptosis was involved in the resistant effect of the KRAS inhibitor treatment, and MGST1 was the key molecule against MRTX1133-induced ferroptosis.
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PMC11449273
Then the resultant values for mutant p53- (175, 273) transfectants were normalized to p53-WT cells, whereas the values for PG-p53 transfectants to their p53 only expressing counterparts.
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PMC9592219
We screened nine drugs that act on TOP2A to evaluate the receptor-ligand binding conformation and affinity through molecular docking.
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PMC11519788
To examine the role of SPOP in UBC, we analyzed the frequency of SPOP genetic alterations in TCGA-BLCA dataset containing 127 samples with genetic information, and found that only 2.4% of UBC patients had genetic alterations, including X27 splicing and E210Q (within the BTB domain; Figure S1A-B).
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PMC11474209
In East Asia, HABs have been found on the shores of Japan, China, eastern Russia, and Korea .
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PMC11795610
Subsequently, the effects of myricetin on differentiation were evaluated by examining the proliferation/differentiation markers and formation of tight junctions, and the mechanism was explored based on TRPV4 channel.
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PMC11680391
It is, of course, easy to point at the herd veterinarian, who must be proactive in providing the service.
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PMC9250505
A similar synergy between NPB in combination with Rucaparib or Talazoparib to stimulate apoptotic cell death was also observed in CAOV2 cells.
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PMC11746948
Fluorescence images were obtained on a confocal laser-scanning microscope (Carl Zeiss Confocal LSM980).
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PMC9243326
Subsequently, primers, barcodes, poly A tails, and concatemers of full passes were removed to obtain full-length non-chimeric (FLNC) reads.
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PMC11714165
Osteosarcoma, a highly aggressive bone cancer, primarily affects children and young adults.
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PMC6627640
Hence, understanding mechanisms of acquired resistance in TGCTs may shed light on mechanisms that account for resistance avoidance and chemosensitivity of TGCTs, which is currently poorly understood.
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PMC10094992
Recently, an analysis of 84 MPM patients from the TGCA database revealed that high ALDH1A3 expression is significantly associated with worse prognosis .
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PMC11026382
We randomly shuffled the catalytic parameters (kcat and Km) among mutations for both DHFR and TYMS, refit all free model parameters, and calculated the RMSD and R values between the best fit model and the shuffled data.
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PMC11483468
The results showed that Hela and PLC-PRF-5 cells treated with TAT-LPTS39 grew more slowly than cells treated with PBS (Figure 6A).
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PMC10988555
Interestingly, the % of internalization of complex 4 is higher compared to the % of internalization of complex 3, which seems to correlate with its higher cytotoxicity, but when compared to complex 2 both show a similar % of internalization, while complex 4 cytotoxicity is higher (Figure 6 and Table 1).
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PMC11265931
There are several mechanisms by which the p53 and pRb1 pathways can be inhibited in human cancers (Alshatwi et al., 2016).
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PMC11767725
Hypertriglyceridemia and reduced HDL in HS patients reflect a pro-atherogenic lipid profile, while inconsistent findings on LDL and total cholesterol levels highlight the need for further research.
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PMC9429973
T cells are considered the gold standard immune effector cells for CAR therapy, but they show toxicities that could be overcome using other cells such as activated and expanded natural killer cells (NKAE), that can be used in an allogeneic context with no GvHD, have natural anti-tumor properties and a short lifespan within the organism.
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PMC11412752
In addition to type I IFN signaling, bacterial infection can directly activate ISG15 expression through the STING pathway .
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PMC11725127
Identifying USP2 as a DUB of KRAS renders USP2 a promising target in MM treatment.
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PMC9429973
Results: We found a significant increase in the percentage of HLA-DR+ cells (median 1.25 vs 1.90%, p<0.0001), mDC (median 0.20 vs 0.28%, p<0.01), pDC (median 0.10 vs 0.15%, p<0.01) and a significant decrease in PD-1 expression on mDC cells (median 35.81 vs 32.23%, p=0.03) in 3 months after treatment discontinuation.
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PMC9429973
Percentage apoptosis calculated at 24h time point using Piperine, Ascorbic acid and Fludarabine alone and in combination.
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PMC11683240
Bars graphs depict a representative group of n ≥ 4 mice for experiments performed two times.
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PMC9429973
Bcl-xL appears to be up-regulated in MPN patients and we previously showed that its modulation correlates with the clinical severity of MPN subgroups.
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PMC9960565
FTIR (KBr pellet): ν = 1581 cm (amide II, N-H and C-N), 1647 cm (C=O), 2844 cm (C-H), 2963 cm (C-H), 3263 cm (NH3), and 3423 cm (N-H).
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PMC8632470
Nephrotoxicity is indicated by changes in glomerular filtration rate (normal GFR in young adults is 120 mL/minute), proximal tubular cell toxicity, inflammation, etc.,
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PMC8584319
Although both p38 and JNK were phosphorylated by AZD8055 treatment, the phosphorylation pattern of p38, but not JNK, was regulated in a manner similar to that of ERK1/2 (Figure 3a).
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PMC11653533
It also highlights advanced analytical techniques, including LC-MS and NMR spectroscopy, that have improved the accuracy of bioactive compound identification, which previous reviews may not have emphasized in depth.
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PMC9960565
C 31.08, H 5.26, N 13.71, found: C 35.63, H 6.98, N 12.56 (hygroscopic compound).
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PMC10938336
This network sheds light on the synergistic effects of compounds when used in treating cancer.
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PMC11347429
Pathway analysis for DEGs between infected patients and healthy controls revealed that the top up-regulated genes were ‘Defense response to bacterium’, ‘Regulation of viral process’, ‘Response to virus’, ‘Response to biotic stimulus’, ‘Nuclear division’ ( Figure 2B ) and the top down-regulated genes were ‘B cell proliferation’, ‘Adaptive immune response’, ‘Lymphocyte differentiation’, and ‘Axonogenesis’ ( Figure 2C ).
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PMC6034753
Rabbit anti-mouse was isotype control in (A) and mouse anti-Myc was isotype control in (C).
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PMC9143157
Moreover, the IC50 values in the 3 h following P-THP were 1.5–10 times higher than those at 72 h, though the intracellular uptake of P-THP in all cells were 2–10-fold less than THP.
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PMC9919300
The percentage of the positive area/field at ORO staining was quantified using ImageJ as indicated, as described by Pratelli et al. .
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PMC11098378
An advantage of using a Y2H approach is that we can identify direct IpaH4-substrate interactions whereas UBAIT techniques tend to identify both direct and indirect IpaH-host interactions.
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PMC11377827
Instead, the 14-3-3ζ/ε isoforms control the nuclear pool of the HIF-1 complex.
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PMC11723947
S4c-e).
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PMC11655498
After hypoxia-induced DNA damage response in B cells, ATM activation suppresses EBV lytic gene expression and reduces viral load.
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PMC10874773
Currently, there are limited reports on the isolation of these compounds from Illicium plants.
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PMC11770130
Notably, the knocking-down of CerS2 also increased the level of UPR-related factors in the primary adipocytes with Ntsr2 depletion (Supplementary information, Fig. S7d) and prevented the NTS-induced elevation of UPR-related factors (Supplementary information, Fig. S7e).
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PMC11469524
Interestingly, this coefficient path corresponds to the cross talk from p38 to RAF/MEK/ERK, and the underlying data shows that the effect is only notable in the presence of α-IgM stimulus but not when p38 inhibitor is applied without stimulation (Fig 2F).
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PMC11139449
The results demonstrated that CHO-KO cells exhibited higher viability compared to CHO-K1 cells due to CASP8AP2 knockout when they were exposed to NaBu.
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PMC9429973
Mean PPPM all-cause costs were $17,061 and $1,889 in the on- and off-treatment phases, respectively.
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PMC9646302
For the LAPTM5-overexpressed plasmids, the full-length LAPTM5 cDNA was cloned into the lentiviral vector of pHAGE using cytomegalovirus promoter and FLAG antibodies.
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PMC10772747
Activation of these receptors triggers the activation of the protein PI3K (Phosphatidylinositol 3-Kinase).
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PMC7022782
The results reported in the present research work demonstrated that the PECA-NPs previously proposed can be a promising carrier to load and stabilize ICG.
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PMC11381192
Meanwhile, CSI was closely associated with immune cell infiltration level and immune checkpoint gene expression.
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PMC4485648
Firstly, SFN was often evaluated in high concentrations that cannot be reached in vivo (10,12,26).
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PMC11190538
Table 8 shows that increasing the content of free C-phycocyanin, T1 and T2, marginally enhanced mean total solids compared to control samples.
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PMC9817179
Halo-tagged proteins are ligated with the JFX549 Halo ligand before imaging.
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PMC11536589
Experimental scheme.
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PMC11740399
Dio-Lipo and Dil-Mem were evaluated by co-localization analysis via an Axio Vert.
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PMC9429973
Most patients were prescribed an initial voxelotor dose of 1500 mg (n=187, 86.6%), and 68.1% (n=147) of patients used hydroxyurea concomitantly.
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PMC9587866
The product of fusion gene gives rise to EWSR1/FLI1 which activates the activity of Eyes absent homolog 3 (EYA3) which causes tumor growth and angiogenesis.
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PMC11756937
However, the factors that contribute to reprogramming success are still not well understood.
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PMC5261804
Current technologies focus on silencing of single genes in large-scale shRNA screens; however, shRNA silencing of a single gene effectively disrupts multiple PPIs and masks the contributions of individual PPIs to the overall protein essentiality.
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PMC9429973
When exposed to different PI than during resistance generation period MM1S/R BTZ cells were resistant to CFZ (IC50=43.5 nM) whereas MM1S/R CFZ cells were similarly sensitive to BTZ as MM1S WT (IC50=24.0 nM).
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PMC10551595
PRIMA‐1 and MIRA‐1 were selected as control reactivators of P53R175H and P53R248Q, respectively, according to published data. , ,
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PMC11697189
With the exception of CD274, CD200, TNFSF18, TNFSF15, NRP1, and KIR3DL1, most immune checkpoint genes (28/34) were highly expressed in the high-risk score group (Fig. 6F).
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PMC11536589
7 hub genes were identified with connectivity degrees exceeding 9.
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PMC11757131
The mechanism by which 3-HIB regulates cellular fatty acid transport remains unclear.
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PMC11770130
Raw data of fastq format were firstly processed through in-house perl scripts.
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PMC11792740
These metabolic disorders not only impact the energy supply for T cells but also interfere with signaling and gene expression, leading to T-cell dysfunction.
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PMC10926885
The results showed that compared with NC group, transfection of miR‐520a‐5p and miR‐525‐5p significantly down‐regulated NDE1 mRNA level in T24 cells.
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PMC9388315
ErbB2 calls PI3K and then AKT and mTOR through the signaling cascade it activates.
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PMC11759543
∗∗∗p < 0.001 and ∗ p < 0.05 compared to control, ##p < 0.01).
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PMC11470381
Nucleofection of Piezo1-mCherry and actin-GFP plasmids Pre-equilibrate post-nucleofection RPMI media (see Recipe 2) at 37 °C/5% CO2 in tissue-culture-treated 6-well plates.
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PMC11544122
We show that SNX9 is recruited to phosphorylated CXCR4 at the plasma membrane and mediates agonist-stimulated endocytosis of CXCR4.
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PMC11574271
Cells at 2 × 10 per well in a serum-free media were seeded for 48 h in the upper chamber with filters coated with BD Matrigel.
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PMC9927933
We found that KO in the lung of Ube2c, but not Ube2s, substantially reduced the tumor burden and prolonged mouse lifespan, indicating that Ube2c is a Kras-cooperative gene, largely required for Kras-induced lung tumorigenesis.
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PMC7709199
This has the advantage that the preservation of a single mannose unit maintains the solubility of the glycoprotein.
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PMC11047729
Research on non-APL AML blasts shows the synergy between ATRA and rhIGFBP, which binds to growth factor independent 1 transcriptional repressor protein (GFI1), causing its down-regulation, and leading to cell death.
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PMC11748335
D The left stacked bar chart shows the genomic distribution across 109 samples.
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PMC10988555
Cells were plated in 96-well plates at 7.5 × 10 cells/mL and incubated at 37 °C with 5% (v/v) CO2.
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PMC11352746
In addition, the prevalence of IncuCyte systems in neuroscience has shown significant growth over the past decade, as evidenced by the consistent increase in the number of publications mentioning their use in neurite outgrowth assays (Figure 2B).
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