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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
For combination studies, each drug was tested at the IC10, IC20 and IC40 concentrations, in the presence or absence of TNFa.
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PMC11742047
The multi-wash strategy consisted of a mixture of methanol: isopropanol (50:50, v/v) and on a wash time set at 15 s, and aqueous phase: organic phase (30:70, v/v) mixture to assist in the starting conditions.
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PMC10530622
The exposure of HK-2 cells, a proximal tubular cell line, to potassium oxalate (5 mM) also decreased the expression of antioxidant genes NQO1 and SOD1 and increased the production of hydrogen peroxide (H2O2).
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PMC11402217
In our investigation of XD23’s efficacy against metastatic OS, we developed an orthotopic mouse model by inoculating rat-derived OS cells (UMR-106) into the distal tibia bone marrow.
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PMC8701144
The following primary antibodies and dilutions were used: Tankyrase-1/2 (E10) (Santa Cruz Biotechnology; sc-365897; 1:200), AXIN1 (C76H11) (Cell Signaling Technology; #2087; 1:1000), DVL22 (30D2) (Cell Signaling Technology; #3224; 1:1000), E1B-55k (2A6) (Generous gift from P.E. Branton ; 1:5000), β-catenin (BD Biosciences, Franklin Lakes, US; BD610153; 1:5000), actin (Merck, A2066, 1:4000).
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PMC10988555
As observed in Figure S15, it seems that incubation of D2O induces a high level of circular isoform at least for complex 3.
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PMC11594641
As shown in Figure 7F,G, similarly to RAB27 KO A375 sEVs, the level of CD63 was elevated in dKO sEVs compared to vesicles from WT cells.
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PMC10587429
Efforts are needed to continue improving and tailoring these models for studying individual types of human cancer or testing specific hypothesis.
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PMC10523483
Immunoprecipitated chromatin from the first ChIP was eluted by incubating with 10 mM dithiothreitol (DTT) at 37 °C for 1 h, then diluted.
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PMC9429973
Crovalimab concentrations were stable and within the expected range over time.
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PMC11394386
To assess Wnt/β-catenin pathway activity, cells (500,000 per well) were seeded in 6-well plates and transfected with TOP and FOP flash vectors.
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PMC11459296
All p values were two tailed and statistical significance was defined as *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.
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PMC10919056
Further in vitro experiments showed that knockdown of GJA5 or GJB1 could promote the proliferation, migration and epithelial-mesenchymal transition (EMT) and inhibit apoptosis of ccRCC cells.
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PMC11763111
The results showed that 1KO CAR-T and PCDH-T cells were lysed at a higher rate, whereas 2KO, 3KO, and 4KO CAR-T cells experienced lower lysis, with 4KO-LLT1 CAR-T cells showing the least lysis (Fig. 6H).
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PMC11544122
Interestingly, when GRK2 and GRK5 were re-expressed together in the ∆Q-GRK KO cell line, SNX9 recruitment to CXCR4 was re-established when compared to re-expression of GRK2 or GRK5 alone (Fig. 6c).
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PMC11001582
eGFP and 100 codon-optimized DPRs were cloned into this vector within the BbsI and BsmBI sites to generate pMC-eGFP, pMC-(GR)100 and pMC-(PR)100.
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PMC11472569
Based on their function, ABC transporters are divided into three classes: exporters, importers, and non-transporters.
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PMC10380508
This includes a pro-tumorigenic enhancer for cyclin D1 (CCND1), which is regulated by both PAX8 and HIF2A .
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PMC11470999
However, it does not bind to the VCB complex.
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PMC11040965
The methylation intensity at each CpG site was expressed as a β value that ranged from 0 (unmethylated) to 1 (methylated) .
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PMC10965680
Additionally, we categorized ROH into four distinct ranges (0.5–1 Mb, 1–2 Mb, 2–4 Mb, and >4 Mb), and the results of LD and ROH analyses were visualized using R 3.6.1 software (Chan, 2018).
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PMC9429973
The Phase 2a Dose Expansion includes patients for emavusertib monotherapy: R/R AML with FLT3 mutation, or AML and HR-MDS R/R to HMA with U2AF1 or SF3B1 mutations.
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PMC9429973
The median number of prior lines of therapy before P-BR was 2, with most patients (63%) refractory to the last treatment.
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PMC11453018
Finally, we demonstrate that PI3K-targeting senolytics effectively eliminate iP300w-induced senescent ES cells, suggesting a novel, combined therapeutic approach.
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PMC11281366
Finally, the AB fragment corresponds to nucleotides 449-878 of the 3′ UTR of CD59 and was generated using the primers indicated in Table S1.
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PMC11802855
TT2 cohort was designated as a training set, while TT3 cohort was utilized as a validation set.
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PMC11506670
The plate was shaken vigorously using a plate reader shaker for 5 min, then incubated for 25 min at room temperature.
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PMC11753435
Recently, OpenAI released CLIP, a model that is trained to associate images and their textual descriptions by learning to rank the correct matching pairs higher than incorrect ones via contrastive learning (25, 26).
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PMC11300639
RNF26 was knocked down in A498 cells, which were subjected to RNA-seq analysis (Fig. 4a).
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PMC9429973
NX-1607 is an oral small molecule inhibitor of CBL-B that has demonstrated anti-lymphoma activity in murine models as both a single agent, and in combination with anti-CD19 monoclonal antibodies.
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PMC10933092
Currently, more than 170 modifications have been described in all classes of RNAs (Han et al., 2020), including N-methyladenosine (mA), N-methyladenosine (mA), N-methylguanosine (mG), and 5-methylcytosine (mC) (Barbieri and Kouzarides, 2020; Han et al., 2020; Haruehanroengra et al., 2020).
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PMC11770199
HCT8 and A375 cells were transfected with PCDH-GFP and PCDH-GFP-p14 plasmids with Lipofectamine 2000.
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PMC11721277
Consequently, the test compound is metabolized more rapidly in A-431 cells.
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PMC11371627
The neurological examination of our patient revealed slight weakness in abduction of the right hip (4/5), in dorsal extension and plantar flexion of both feet (4/5) and atrophy of the left calf muscle with regular muscle strength in the upper limbs.
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PMC11413393
As such, we selected MS023 as our lead compound and sought to further characterize type I PRMT inhibition in ccRCC.
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PMC11011020
The methylation level of the non-cancerous cell line MeT-5A (11.2 µA cm) is much lower than that of SKOV3 and OVCAR3, indicating hypomethylation at the promoter gene.
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PMC4277423
Genomic DNA were then extracted from CCR5/CR2 and CCR5/CR3 at 21 and 84 days post transduction along with mock-transduced TZM.bl cells and subject to PCR amplification with 12 prime pairs listed in S2 Table followed by T7 endonuclease I assay as described above.
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PMC10142392
The structure and size of micelles depend on parameters such as the size of the hydrophobic domain, the size of the polar group, ionic strength, concentration, temperature, pH, and, more specifically, on the topology of the copolymer, which will be further discussed .
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PMC5417661
Plasma samples were stored in −80°C until transportation on dry ice.
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PMC10978090
The primary indication for VA-FF-ECMO as a bridge to lung transplantation was severe hypoxemia and right heart failure.
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PMC11752767
Furthermore, CAR-engineered and CISH depletion via CRISPR/Cas9 system, leading to enhancement in IL-15 signaling, has substantially improved CAR-NK cell persistence and cytotoxic function .
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PMC9847912
Inter-group A/B recombinant.
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PMC11730311
These cleavage sites were S17-R18 and N26-F27 for the LLSR motif and the KNN motif, respectively.
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PMC10873328
Much attention has been paid on the role of hypoxia in regulating the immune microenvironment in tumor progression and metastasis.
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PMC6442998
Our data suggest that oncogenic KIT downstream pathways and YAP pathway act in parallel to drive cell survival.
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PMC10237474
Pools are scaled up after recovery from selection and are expanded a few times before initiating the large-volume production run.
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PMC9429973
There were no dose-limiting toxicities, and additional patients were enrolled in the expansion phase at this dose.
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PMC11155445
Isoniazid-based acyl thiourea (94a–d) were synthesized and characterized by Ramaswamy et al. and investigated for their antibacterial activity against Gram-positive (B. subtilis, S. aureus) and Gram-negative bacteria (E. coli, K. pneumoniae).
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PMC10253973
Studies of [Ru(η-C6H6)(DMSO)Cl2] (4), the first arene Ru(II) compound (Figure 3), revealed that it strongly inhibits topoisomerase II, which participates in DNA replication and is responsible for structural organization .
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PMC9429973
I. Weitz, M. Al-Adhami, J. Min, E. Persson, M. Yeh, J. Savage, D. Dingli Jane Anne Nohl Division of Hematology, Keck-USC School of Medicine, Los Angeles; Apellis Pharmaceuticals, Waltham, United States of America; Swedish Orphan Biovitrum AB, Stockholm, Sweden; Mayo Clinic, Rochester, United States of America Background: Thrombosis is the main life-threatening complication of paroxysmal nocturnal hemoglobinuria (PNH), a rare acquired hematologic disease.
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PMC11604015
Thus, developing CAR-T cells that target T cell-derived malignancies is a potential strategy.
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PMC10507284
p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; ns, not significant.
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PMC11267830
For statistical comparisons, we performed unpaired Student’s t tests and one-way analysis of variance (ANOVA).
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PMC11591038
Reduced aerobic glycolysis during aging may ruin cell survival mechanisms and fail to counteract neurodegenerative changes; notably, aerobic glycolysis is regulated at the transcriptional level by HIF-1α and peptidyl-prolyl cis/trans isomerase-1 (Pin1) .
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PMC11564322
Available data showed increased plasma elastase activity, and concentrations of EDPs were observed in patients with acute and chronic myeloid leukemia (CML) after hematopoietic stem cell transplantation .
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PMC11806182
Kaplan–Meier survival curves were plotted for UCEC patients stratified by high and low expression levels of the identified miRNAs.
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PMC9429973
We also performed PD1 and LAG3 immunohistochemical stains in all cases.
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PMC11731614
Samples were run through a 4–20% 12-well Mini-PROTEAN® TGX™ Precast Protein Gel (19.5 µL loaded per well; BioRad 4561095) and run for 90 min at 120V.
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PMC11585565
After chemical treatment for 2, 4, 8, 12 and 24 h, the cells were harvested for measuring the CNNM4 mRNA and protein levels.
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PMC11748363
A minority (5%–10%) with latent infection will develop active disease (World Health Organization 2022), depending on the status of health of the afflicted individual, among other factors.
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PMC11754436
DHRS4-AS1 directly interacts with miR-362-5p and represses its expression.
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PMC11564322
Interestingly, the cell co-treatment with the c-SRC inhibitor I and the VGVAPG peptide increased the mTOR mRNA expression by 27.28%, compared to the control.
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PMC11762280
Overall, this study demonstrated that UVB induces ZBP1-mediated PANoptosis in keratinocytes, which plays a crucial lethal role among diverse keratinocyte death modalities in UVB-induced skin injury.
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PMC11650848
Similar to the analysis conducted for the cognitive assessments, the data produced from MEG brain imaging was split by rs365052 genotypes and intervention groups (Fig. 5C, placebo in green, FA in purple).
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PMC11063646
Compatability studies of Andrographolide, Xanthan gum and Flaxseed oil in the emulgels to know about the interactions.
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PMC11476004
For B2, the average frequencies of SCEs had a similar distribution of values as in B1 (Table 2).
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PMC11548041
EpCAM is an attractive target for targeted therapies as it is highly expressed on cancer cells and has been implicated in tumor growth.
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PMC9429973
Mean number of MF-related symptoms declined significantly at 3 and 6 months; mean platelet count increased significantly at 6 months, from 160×10/L to 186×10/L (Table).
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PMC10887351
In another study of melanoma, our group supported the hypothesis that β3-ARs could promote immune tolerance .
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PMC11509278
Steroid hormones can also regulate the expression of transforming growth factor and epidermal growth factor receptors in endometrial cancer cells to inhibit their proliferation .
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PMC10812665
In parallel, less NAD+ is produced; it lacks therefore as a substrate of dehydrogenase reactions.
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PMC9429973
Summary/Conclusion: Our in vitro data indicate that targeting STAT3 in AML might be a strategy to enhance NK cell-mediated killing.
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PMC9429973
For pts with R/R Ph+ ALL, the primary endpoint was the CR/CRi rate.
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PMC9429973
Aims: To explore the characteristics of sCNSi in patients who participated in JCOG0601 and were considered mainly low risk according to IPI.
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PMC9429973
Now we have evidence that GFI1 is implicated in DNA repair as AML blast cells of patients carrying the GFI1-36N SNP feature more frequently complex-aberrant karyotypes and more mutations leading to an inferior prognosis.
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PMC11621493
This target list was then used with Lipid Data Analyzer (version 2.8.3_1) for peak picking and integration (20).
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PMC11279397
These findings suggest that MC has potential as a chemotherapy agent for anti-HIV infection and cytokine regulation, warranting further investigation .
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PMC11172027
On MTC-SK cells, NASeLM not only displayed caspase-3 activity but was also able to significantly reduce cell growth and mitochondrial activity, more than NALM.
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PMC11578343
Cells were dissociated with 0.25% trypsin/EDTA, rinsed with growth medium, centrifuged at 200 RCF for 5 min, re‐suspended in PBS at a concentration of 1–2 × 10 cells mL, filtered with a 20 µm filter, and placed on ice before injection into devices for measurement.
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PMC11377827
Endogenous 14-3-3 proteins were immunoprecipitated and samples were immunoblotted for USP43 (B).
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PMC9429973
Results: Up until now, 98 (56%) out of 174 eligible subjects from this institution were included, with a total follow-up of 805 patient-years.
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PMC10631132
Recent work has shown that not only GMPs, but also a multilymphoid progenitor (MLP) is capable of giving rise to macrophages and dendritic cells in addition to lymphoid cells, while being devoid of a megakaryocyte/erythroid potential .
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PMC6102174
Bge.
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PMC8303372
Our results, moreover, demonstrate the correlation between the toxic effect of the different forms and the bioavailability of the drug.
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PMC11673902
The “plug-and-play” format: the cells to be analyzed are simply loaded into a microfluidic device (AFS chip), and the chip is connected to a mobile platform to complete the measurement.
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PMC8735881
Design and characterization of GPI-anchored bifunctional inhibitors targeting gp41. (
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PMC9712534
The patients carrying H58Y did not show any signs of B-cell deficiency, suggesting that the pathogenic impact of H58Y is different from those of the missense mutations in the central catalytic domains.
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PMC11040965
7miR29b and DNMT3B expression in plasma cells from MGUS and MM patients.
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PMC7189327
Additionally, KEGG pathway enrichment analysis revealed that these genes were primarily enriched in pathways in cancer, p53 signaling pathway and BCC pathway.
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PMC9429973
Results: Here, we show that the adult adrenal gland can be transformed into a hematopoietic supportive environment.
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PMC8662250
Caco‐2 cell line was obtained from the European Collection of Cell Cultures (ECACC, Public Health England Porton Down, Salisbury, UK).
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PMC11411131
At lower Dox concentrations, the ratio of the full-length form to the truncated form of the construct was similar to that at high concentrations. (
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PMC9429973
Second malignancies occurred in 13.1% of pts in the G-chemo arm and 9.9% of pts in the R-chemo arm.
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PMC9429973
Besides, hematopoiesis arrest occurred earlier in chemoresistant AML cells.
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PMC3203927
The identification and validation for this entity or a potential three-dimensionality biomarker is necessary due to three compelling reasons.
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PMC11082662
Meanwhile, the exclusion criteria were the following: (I) concurrent malignant cancers, (II) severe liver and renal dysfunction, (III) severe immunodeficiency, and (IV) severe infectious diseases.
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PMC11064533
The antibiotics with different modes of action against E. coli were selected to stress the clumpy structure.
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PMC10956161
Analyses also found five mutations at different sites in the PRDX6 gene in lung adenocarcinoma.
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PMC10932641
In general, the faster the tumor grows and the poorer the tissue differentiates, the higher Ki67 expression will be.
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PMC11261875
The coexpression of MCT1 and its chaperone, CD147, has been implicated in the aggressiveness of GIST and correlated with reduced patient survival .
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