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PMC11704135
Similarly, the addition of a phenyl group elevates radical scavenging efficacy owing to the aromatic nature of the phenyl group, which bolsters the compound's stability and reactivity towards radicals.
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PMC11473750
Scale bar: 20 μm.
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PMC11337594
Following p53 knockout, the alterations in BAX and FAS expression resulting from TER treatment were no longer evident, indicating that p53 is a prerequisite for the observed upregulation of these genes (Fig. 3B).
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PMC9429973
Image: Summary/Conclusion: In patients with MF previously treated with RUX, these analyses suggest treatment with FEDR was associated with a greater proportion of patients achieving a spleen response compared with NAV+RUX.
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PMC11473843
Notably, the signaling pathways that were found to be altered by concomitant ERK5 and CDK5 inhibition have been previously reported to be affected by FAK suppression, confirming that ERK5 and CDK5 inhibition recapitulate, at least in part, FAK inhibition (Pylayeva et al, 2009; Zhang et al, 2016).
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PMC11574029
2NOTCH3 promotes tumor growth and metastasis in BLCA.A, B The knockdown efficiency of NOTCH3 in T24 and 5637 cells was determined by qRT-PCR and Western blot analysis.
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PMC11676670
Morphologically, OVAR79 cells are medium-sized and adherent, characterized by the formation of rounded colonies prior to reaching confluency (Figure 1B).
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PMC9429973
Summary/Conclusion: Several ncRNAs processed from KDM genes seem to be closely related to the responsiveness of MDS/AML-MRC patients to AZA treatment.
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PMC11478724
Cell viability was assessed in A549 cells using a colorimetric assay.
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PMC6222726
The ethanol extract from the dried exudate of Bursera fagaroides showed significant cytotoxic activity against the HT-29 (human colon adenocarcinoma) cell line.
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PMC11640555
LPS from E. coli (0111:B4) was obtained from Sigma-Aldrich (St. Louis MO, USA) (Cat# L3012-5MG).
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PMC10907726
Notably, PIK3R2 exhibited prominent expression in the volcano map (Fig. 3B).
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PMC9454852
Unless specified, all reagents were purchased from Merck (Milan, Italy).
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PMC11740399
Quantitative analysis of the PKM2, FASN, Bax, Bcl-2, and Cleaved Caspase-3 proteins (E).
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PMC9693627
The mitochondria were solubilized 20 min on ice and debris was removed by 1 h centrifugation at 4 °C and 25,000× g. Coomassie dye (5% Coomassie Blue G-250 dye stock solution, suspended 500 mM 6-aminohexanoic acid) was added to the supernatant to give a detergent/dye ratio of 8, and the samples were subjected to electrophoresis in a 4–14% gradient gel.
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PMC9429973
Although SMZL genomic profile has been largely investigated, the genetic mechanisms leading to this transformation are still unknown.
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PMC10033453
TCID50 values per mL were determined by the Spearman-Kärber algorithm.
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PMC9895440
Mean and SD are shown.
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PMC11188874
G, Shown are gene accession numbers for the top 20 peptides most downregulated by bortezomib treatment.
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PMC9429973
Group-1 consisted of 180 and Group-2 of 118 pts.
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PMC11805741
B Cell morphology under the light microscope.
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PMC9436459
Subsequently, Mascarello et al. found that among the four MDAAs chalcomoracin (5), kuwanon G (92), kuwanon H (93), and kuwanon L (118), compounds 92 (IC50 = 0.83 μM) and 93 (IC50 = 0.36 μM) were the two most potent Mtb PtpB inbibitors with Ki values of 0.39 and 0.20 μM, respectively.
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PMC7759933
To our knowledge, the present study is the first where a comprehensive characterisation of the HepG2 3D cell model was performed.
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PMC11740207
In cancer research, a subset of SCs has also been identified.
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PMC9532503
The purified anti-CD20 antibody (Sample Number: P2-CRD-1508) was used for further functional characterization.
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PMC11680578
Following treatment with PTX + RGZ, there was a notable increase in the number of condensed nuclei compared to that of control (P < 0.001), PTX alone (P < 0.001), and RGZ alone (P < 0.001) (Fig. 4).
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PMC9910796
Our present results indicate that pEP84R provides a guiding cue for the correct membrane targeting of the core shell polyproteins.
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PMC9429973
Both groups reported high levels of concern about COVID, and this level was higher in MM; 50% of MM patients reported they were “extremely concerned”.
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PMC11569208
Moreover, we demonstrated its ability to increase tagged VSVd51-GFP expression by florescence microscopy (Fig. 2E) and VSV-M RNA expression by qPCR, both indicating increased VSV∆51 viral titer (Fig. 2F).
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PMC11726183
This collective information (both statistical and energy) from molecular dynamics study revealed that stable interactions and higher binding free energy for the complex 23 made it the most potent agent to inhibit the EGFR kinase domain target protein.
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PMC11705484
Overall, this study elucidates the molecular mechanisms via which NF‐κB increases the transcription of TRMT61A, which accelerates mA modification of HMOX2 mRNA and enhances its stability via a YTHDF1‐dependent mechanism, ultimately promoting BLCA progression.
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PMC11025866
The function of SLC7A11 as an antiporter releasing glutamate is intriguing in the context of studying valpromide as a drug used to treat neurological disorders since glutamate is a neurotransmitter.
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PMC9429973
All reported AEs will be graded as per the Common Terminology Criteria for AEs (CTCAE) v5.0.
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PMC11741906
Cell cultures were maintained in a humidified atmosphere with 5 % CO2 at 37 °C (Binder, Germany).
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PMC11127909
Then, we treated these cells with cisplatin and assessed the apoptosis rate by Annexin V/PI staining.
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PMC9429973
OS and EFS were studied with the Kaplan-Meier method and log-rank test, cumulative incidence and Grey test were used to estimate relapse risk (CIR) and non-relapse mortality (NRM).
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PMC10858941
Thanks to the 3D organisation, a complex tumour microenvironment was recreated, characterised by a hypoxic zone in the centre of the device, a starved zone in between and a zone with high viability due to high nutrient availability at the periphery (Fig. 1).
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PMC11785489
HEK-293T cells were engineered to express HLA-A2 and authenticated by flow cytometry as described previously.
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PMC11502962
Targeted therapy is the first choice for the patients with metastatic disease and those with intermediate or high recurrence risk (4).
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PMC10878518
These samples were divided into the OBP-401 infection group and the control PBS group (n = 3 each) on 96-well plates with a culture medium.
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PMC11307990
Negatively charged DNA origami nanostructure interacting with positively charged chitosan forms DNA nanotapes through electrostatic interaction.
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PMC10988555
The normal conformation of the pDNA is the supercoiled isoform and when both of the chains are cleaved the pDNA adopts a linear isoform.
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PMC11806182
Gene co-expression analysis identified five distinct co-expression modules (Fig. 5F).
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PMC10470467
The GO and KEGG analysis results are shown in Figures 3A,B. And we also found that NRGs enriched in some immune-related signaling pathways, such as PD-L1 expression and PD-1 checkpoint pathway in cancer, T cell receptor signaling pathway, and B cell receptor signaling pathway (Supplementary Table S1).
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PMC8316344
TFRC was measured by IB in Bel-7404 cells with single or double knockout (DKO) of TRIB2 and PSMB5 or in SK-Hep1 cells with or without TRIB2 overexpression, in the presence or absence of PSMB5 knockout.
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PMC9429973
Summary/Conclusion: Tolinapant has demonstrated varying cytotoxic effects against a range of TCL lines as a single agent.
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PMC10073922
Several mechanisms may involve in suppressing effects of NDRG2 on MMPs expression, notably inhibition of nuclear factor kappa B activity and phosphoinositide 3-kinase (PI3K)/AKT signaling pathway .
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PMC10728200
K Computational molecular docking simulation analyses of STUB1 and GPX4.
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PMC10993311
The KLRK1 module was related to 36 biological processes and 3 diseases, targeting susceptibility to natural killer cell-mediated cytotoxicity, leukocyte mediated immunity and innate immune response and diseases involving infection.
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PMC11461874
The quantified band intensity of DBP relative to GFP was shown in the bottom.
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PMC11478724
There are no conflicts of interest.
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PMC11464609
Immunohistochemistry demonstrates only a few scattered JC virus-positive cells.
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PMC9429973
Finally, the efficacy of BL-IPI was tested in our patient population.
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PMC11707832
Aberrations in enzymes involved in glycosylation have been linked to lysosomal storage disorders (LSDs), immune intercellular receptor–ligand interactions, congenital disorders and tumour progression [3-9].
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PMC10898159
Nintedanib, first approved by FDA for idiopathic pulmonary fibrosis, overcame not only resistance induced by KIT mutations, but also ERK-reactivation-mediated resistance induced by FGF upregulation .
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PMC11092382
A properly regulated inflammatory response can effectively shield the body against external stimuli, whereas an excessive inflammatory response can exacerbate the initial injury and consequently mediate a range of pathophysiological processes (Dinarello, 2010).
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PMC6600253
A recent study has shown that the TH1 cytokines interferon gamma (IFN-γ) and tumor necrosis factor (TNF) induce senescent growth arrest in vitro that is accompanied by restoration of functional p16/pRb .
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PMC11388384
To plot timepoints after the end of a trajectory, we measured the fluorescence at the site of the particle’s last detected position.
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PMC7171147
Collagen type XI alpha 1 (COL11A1), a minor fibrillar collagen crucial for skeletal development and collagen fiber assembly, is a novel biomarker associated with poor survival and chemoresistance in several cancer types including ovarian cancer.
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PMC8336407
Finally, 6 ml potassium acetate was added and OD was measured after 40 min at 415 nm .
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PMC11655498
P, phosphorylation; Ub, ubiquitination; UFM, UFMylation. (
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PMC11674441
The other four patients were diagnosed with early-stage breast cancer and underwent curative total mastectomy and sentinel lymph node biopsy.
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PMC11742047
The analysis of the altered compounds in various cell lines reveals consistent trends across different lipid families, regardless of the cell line.
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PMC9454178
All statistical analyses were performed with Prism 8.0 (GraphPad Software).
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PMC11279397
The criteria for the Rule of Five (Ro5) are as follows: LogP should be less than or equal to 5, molecular weight (MW) should be less than or equal to 500 Da, the number of hydrogen bond acceptors (n-ON) should be less than or equal to 10, and the number of violations in terms of hydrogen bond donors (n-OHNH) should be less than or equal to 5.
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PMC11785489
It is now clear that a TCR sequence conveys two types of information: transcriptional fate bias and antigen specificity.
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PMC6379402
We uncover functional regions in iCells using spatial analysis of functional enrichment (SAFE) framework, a systematic and quantitative method for annotation of network regions of genes with enriched functionality.
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PMC6487404
Due to the barrier role of P-gp in limiting the intestinal absorption of wide class of drugs, down-regulation, bypassing or inhibition of P-gp at the intestine has been considered as a strategy to improve oral drug bioavailability of known substrates.
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PMC9429973
Methods: Eligible pts were ≥18 y of age, had LR-MDS requiring regular red blood cell (RBC) transfusions, and were ineligible/intolerant or refractory to ESAs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
At 24 hr post-dose, CD41 cell ploidy was increased, suggesting RKER-050 may promote MK maturation.
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PMC10604092
Proinflammatory cytokines induce both muscle atrophy and lipid mobilization .
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PMC11155445
Compounds (120a) and (119a) showed hydrogen bonding interaction with Gly368 and Arg369 and hydrophobic affinity toward Leu365 and Arg369, these four interactions were responsible for the best docking scores (Fig. 50).
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PMC11732628
In colon cancer, miR-490-3p alleviates the Warburg effect and inhibits cell proliferation (22).
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PMC11487720
3Calcium influx and NO production during UV/cold shock-mediated nuclear bubbling.
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PMC11521786
These results are consistent with previous reports that highlight HER3 as a relevant trigger in the acquisition of a resistance-competent phenotype in lung and, more recently, prostate carcinoma.
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PMC11678130
Similarly, Tang et al. demonstrated the ability of QUE to reverse the chemoresistance of HCT116 and HCT116-R colorectal cancer (CRC) cells to 5-FU, with the association between these agents resulting in a synergistic interaction .
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PMC10344560
The highest prevalence of fungal peritonitis was reported in India (14.3%–23.8% of all peritonitis episodes).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "highest", "prevalence", "of", "...
PMC11551844
The intensity of the absorbance of AuNPs-contignasterol was higher than that of AuNPs-ansellone A due to the higher concentration of HAuCl4·3H2O used.
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PMC9847912
CA/SP1 mutant HIV-2ROD9 M3 was constructed using the pROD9 molecular clone and reagents from a QuikChange II XL Site-directed Mutagenesis Kit (Agilent Technologies).
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PMC10778532
We also asked whether VHL-C162F mutation interferes with the proliferative potential in conditions of a single cell culture by sorting (Figure 1C) and to form colonies at low dilution (Figure 1E).
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PMC9429973
In line with these observations, MLL-AF9 positive human cell lines expressed HMX3 (eg.
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PMC11758416
Following incubation with anti-CD3 antibodies, the L cells “present” anti-CD3 antibodies to effector CD8 T cells via CD32, allowing for TCR activation and possible subsequent killing of the antigen presenting L cell (Figure 1).
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PMC6617630
a, b DHL and THL cell lines were treated with BET bromodomain inhibitors I-BET, JQ1, and OTX, and RT-PCR was performed using MYC- and BCL-6-specific primers.
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PMC11389534
UFMylation controls adaptive immunity through modulating PD‐1/PD‐L1 checkpoint and B‐cell development and function.
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PMC10547921
Importantly, this significant efficacy cannot be achieved through a 1:1 combination of MMAF ADC and MMAE ADC alone.
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PMC11472639
SSC-A, side scatter-area; FSC-A, forward scatter-area; FSC-H, forward scatter-height; SMM, smouldering multiple myeloma.
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PMC11659734
For the first time, multiple genotoxicity endpoints were evaluated in vitro in liver spheroids, including DNA strand breaks and oxidised base lesions using the enzyme‐modified comet assay as well as clastogenicity and aneugenicity assessed by the micronucleus assay, in conjunction with cytotoxicity.
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PMC11682224
MMPs (e.g., MMP2 and MMP9) enhance the ability of tumour cells to migrate through remodelling of the extracellular matrix and modulation of cellular adhesion molecules, which are essential for tumour spread and metastasis.
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PMC11741906
Fig. 5).
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PMC9024365
After 30 min, lysates were centrifuged at 12,000 rpm for 10 min at 4C.
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PMC9429973
More deaths occurred among patients who received treatment reduction/modification than standard treatment (55.6% vs. 18.8%, χ=9.72, p=0.002, n=68).
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PMC11787355
To investigate the therapeutic potential of the PTPRZ1 TCR in vivo, we first inoculated U87 TMG cells subcutaneously (s.c.)
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PMC10055960
No observable change in the electronic spectra (Figure S8) was noted for complex 8 in DMSO, thus supporting the spectral data and the stability of the Rh-Npyridyl bond under these conditions.
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PMC9429973
Results: Of 249 adult patients in the post-HCT population treated with defibrotide, 22 (9%) underwent auto-HCT.
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PMC10969097
These findings underline the necessity for further research and clinical trials to fully explore the capabilities of mushroom extracts in combating cancer and enhancing outcomes for cancer patients.
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PMC11323699
p < 0.05, ***p < 0.001 TAX2 efficacy in a metastatic mouse model of ovarian cancer.
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PMC10669128
Sarcoma cell lines have a central role in cancer research, as they can be easily employed to develop new potential drugs, allowing rapid identification of compounds with anti-cancer activity.
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PMC8978939
Inhibition of proteasome by 5 µg/ml MG 132 for cell lines expressing WT, and P138R and L163R pVHL variants.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "of", "proteaso...
PMC9429973
In pediatric pts (all ever-transfused), median Hb at enrollment was 8.3 g/dL (6.8–10.8).
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PMC9429973
Further studies are warranted to characterize the biological relationship between IBDs, CH, and HMs.
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