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PMC11768927
rVSV expressing an M protein with a deletion of methionine at position 51 (rVSV-ΔM51) has also been evaluated for its oncolytic efficacy.
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PMC11777207
Error bars indicate SEM.
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PMC11549062
The heightened expression of PDGFR‐β correlates with apoptosis in patients with vulnerable carotid plaques.
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PMC3019555
Ago2 mRNA expression by qRT-PCR after stable expression of Ago2 (shRNA; mean ± SEM; n = 2; ***, P < 0.001) or control shRNA (Neg Ctrl). (
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PMC9118379
Such a high filtration rate was also observed in the nine deep proteome data sets of cancer cell lines after applying two filtering strategies—filtration against reference proteome and chemical modification filter—to filter out unreliable identified variant peptides, as reported by Alfaro et al. based on their Additional File 4 (CL9_exom_snv).
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PMC9429973
Aims: We describe a case of a 35-year-old Caucasian female patient presenting with severe AFVI with life-threatening hemorrhages.
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PMC11545737
During the inflammasome activation, NLRP3 undergoes a second palmitoylation by zDHHC1 or zDHHC7 at Cys130 (mouse Cys126).
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PMC9429973
20% of patients required ICU admission, with a median stay of 3 days (range 1-12); 18% required vasopressors, 3% required mechanical ventilation, and 3% required dialysis.
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PMC9429973
Methods: Between 2009 and 2018, 10 patients of orbital MZBCL and we analyzed the treatment modality and outcome in our institution.
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PMC7553912
Expressions of OSM and OSMRβ in the kidney of a mouse model of renal crystal formation.
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PMC11758416
To address this, be diligent about passaging your cells and pre-incubate an excess with anti-CD3 and CFSE to ensure harvest of sufficient quantity.•Alterations to ratio: While 10:1 is the optimal ratio; we have successfully performed this assay with 5:1 and 2:1 effector cell: target L cell ratios.
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PMC11411004
Therefore, we plan to establish a stable recombinant antibody CHO cell line through stability testing and identification to ensure that the enhancing effect of I-4 on recombinant protein expression is reproducible during the long-term culture.
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PMC7602170
These drugs combined with imatinib may potentially provide a broader inhibition of pro-growth cellular mechanisms than the single-agent imatinib.
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PMC9412887
Moreover, cellular uptake of T12/P-Lipo by H1975 cells was higher than that of any other nanocarriers (Figure 7b), and the fluorescence images further verified the intensive BBB-penetrating capacity of T12/P-Lipo and enhanced cellular uptake (Figure 7c).
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PMC10040136
The culture medium used was L-DMEM containing 12% fetal bovine serum, 1 mM L-glutamine, and 100 μg/ml streptomycin (Cat No. 11885084, Life Technologies, USA).
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PMC11286266
The rectangle indicates where the FURIN indel mutation occurs, with the sgRNA/Cas9 sequence indicated in a grey rectangle. (
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PMC10142392
The CMC value ranged between 1.40 and 4.46 mg.
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PMC11782508
Ampicillin (10 mg/mL; Fisher Bioreagents) was used as a positive control, and sterile saline solution (0.9% w/v) served as a negative control.
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PMC11322866
Scale bar: 5 μm or 10 μm. (
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PMC11686380
She was proportional to her short stature and showed a high-arched palate and uvula bifida.
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PMC11301242
Classification of genes encoded on ecDNA amplicons, highlighting 38 cancer-related genes. (
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PMC11354239
The target Raji cells were seeded in 96-well plates (1.2 × 10 cells/well) and coated with RTX (10 μg/mL) via incubation for 30 min at 37 °C.
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PMC11335267
We found that the levels of noradrenaline-synthetizing enzyme tyrosine hydroxylase and the vesicular monoamine transporter 2 (VMAT2) were lower in Alx3-deficient than in control mice (Fig. 5D and E).
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PMC7348793
This amplification resulted in an identical spectrum of PCR products, although their relative intensity may have slightly changed (Figure 1, lanes 9–11).
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PMC9219615
The cytotoxicity of Tpz-1 toward individual cell lines was assessed between 24–72 h of exposure through the DNS assay.
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PMC11765678
While MDR is a leading cause of therapeutic failure and relapse in cancer patients, recent research suggest that specific inhibitors of ABC transporters can be an effective approach to overcome resistance .
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PMC8348645
They were 32 mg/mL, 3.2 mg/mL, 320 mg/mL, 160 mg/mL, 80 mg/mL, 40 mg/mL, 20 mg/mL, and 10 mg/mL. HepG-2 cell lines were procured from ATCC, stock cells were cultured in DMEM supplemented with 10% inactivated Foetal Bovine Serum (FBS), penicillin (100 IU/mL), streptomycin (100 µg/mL) in a humidified atmosphere of 5% CO2 at 37 °C until confluent.
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PMC11089031
D The KD of ZNF692 inhibited the migration of 786–0 cells.
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PMC11694625
Additionally, the molecular docking simulations performed for the selected active compound – 3b, 3c revealed that they could occupy the active site of CDK1, CDK4 and CDK8 through hydrophobic and H-bonding interactions, which were suggested to be essential for inhibitory activity.
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PMC11515150
The results indicated that the lack of IL-15 attenuated the cytotoxicity of CAR-NK cells.
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PMC9429973
These response rates are better than CysA monotherapy, especially HI-P. Also, the hematological responses are durable, although continued Epag administration might be necessary.
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PMC10936243
Now, why I don’t like using these disposable things too much, like for me I try to avoid using disposable hand towels and all that because I think that is not planet-friendly, environmentally friendly” [D072].Veterinarians reported that they needed to keep their prices down, so that their clients could afford to pay for them.
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PMC11743414
GSE12417 is the training set.
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PMC11650848
We next sought to validate using a second method the differences in cognitive development shown by the WISC-IV test.
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PMC6889484
Primers flanking A3G(DK) were used for PCR amplification with plasmid controls shown for A3G(DK) (1,864 bp) and undeleted A33G(DK) (964 bp).
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PMC11224020
N = 2, n = 6) and were analyzed by ordinary one-way ANOVA; ****P < 0.0001.
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PMC6160470
These results were corroborated by calcein accumulation assay.
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PMC11697065
No. R0901), snap frozen on dry ice and stored at −80°C before further processing.
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PMC11535726
The aligned sequences were trimmed using trimAl version 1.2 with the ‘-gt 0.6’ command (Capella-Gutiérrez et al. 2009) and multiple genes were assembled using SequenceMatrix (Vaidya et al. 2011).
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PMC8711270
Together, these developments have enabled the scalable production of viral vectors in HEK293 cells.
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PMC10440586
NIVO, Nivolumab adjuvant treatments.
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PMC10551595
Densitometry was applied for quantification of data.
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PMC8609870
Then, we constructed the lncRNA-miRNA-mRNA ceRNA network to identify their relationships based on the lncRNA, miRNA, and mRNA expression profiles, and plotted them using Cytoscape version 3.6.1.
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PMC11001582
To identify potential upstream regulators controlling the differential expression of ECM-related proteins, we conducted Ingenuity Pathway Analysis (IPA) on the polyGR, polyPR, and patient iPS cell motor neuron datasets.
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PMC11665584
On day 4 after wounding, 3 of these wounds were excised by centering 6 mm biopsies over the partially healed wounds and subsequently dissociated for scRNA-Seq.
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PMC9429973
In response to inflammation, Fpn levels are decreased by hepcidin-mediated post-translational and/or transcriptional mechanisms, depending on the type of inflammatory pathway activated.
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PMC8316344
NS non-significance; **P < 0.01; ***P < 0.001; ****P < 0.0001.
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PMC11754094
SpCas9 expression plasmids (750 ng) and sgRNA expression plasmids (250 ng) were mixed with 100 µl of Opti-MEM medium and 2 µl of Lipofectamin 2000 and incubated for 20 min at room temperature.
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PMC11805741
The genus Paracoccus is one of the known producers of rare xanthophylls with a varied carotenoids profile depending on the producing species (Maj et al. 2020).
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PMC9545714
High TEWL‐GTE (N = 18, One subject missed the 8‐week clinic visit, 4 weeks p = 0.428, 8 weeks p = 0.11, 18 weeks p < 0.001). (
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PMC11547972
The amygdalin–SFN combination diminished S-phase A498 and KTCTL-26 cells similarly to amygdalin or SFN alone.
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PMC11107915
ChatGPT can contribute to personalized care by engaging in conversations that help gather patient information, assess mental health symptoms, and provide relevant information about various psychiatric conditions.
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PMC11599565
Paraffin sections representative for n = 10 patients.
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PMC11758416
It is expected that cytotoxic capacity is less robust in not activated or unstimulated T cells so this may be indicative of intrinsic qualities of the effector cells.
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PMC9622879
The program solved the MILP optimization problem and the schedules of controllable appliances were provided to maximize the load balancing between homes using the GUROBI solver.
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PMC11531744
It was verified to be effective in the testing data.
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PMC5833712
Today this ligand is owned by Oasmia Pharmaceuticals AB (Uppsala, SE).
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PMC11774747
Two notable strategies include the use of the inducible caspase-9 (iCasp9) suicide gene and cetuximab-mediated antibody-dependent cellular cytotoxicity (ADCC).
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PMC11499955
Several therapeutic mAbs are routinely used for cancer immunotherapies, a dozen antibody–drug conjugates have been already approved by the FDA and many others are advancing through the pipeline, promising enhanced treatment options across various cancer types.
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PMC9325715
Here, the increase of absorption from 0.52 to 1.436 has occurred after Fe binding to bLTF which indicates the involvement of tyrosines and tryptophans in metal-protein interactions.
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PMC10728200
The nucleus is labeled by DAPI (blue).
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PMC11209164
Notably, one pancreatic tumor explant demonstrated the most substantial response with a fifteen-fold increase in VSVΔ51 output post-TPF pre-treatment.
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PMC11612794
This knowledge provides important insights into how functional kinetochores are established in cells.
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PMC11486946
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.
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PMC11746948
To further investigate whether 2-BP alone can stimulate ferroptosis in physiological contexts, we developed an orthotopic tumor model of colorectal cancer (CRC) using human RKO cells.
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PMC11655536
Next, we determined whether HA treatment leads to nuclear translocation of TFE3.
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PMC11802929
HPhobic% represents the percentage of strongly hydrophobic residues (A, V, L, I, F, M) in the CDR3β, excluding the first and last four amino acids.
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PMC11794847
In addition, FOXA2 belongs to the forkhead-box (FOX) protein transcription factor superfamily that is DNA-binding proteins regulating transcription .
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PMC9429973
The ZRMA regimen was well tolerated in these treatment-naïve PCNSL patients with an acceptable safety profile.
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PMC11463018
The silica gel (200–300 mesh) was purchased from Qingdao Marine Chemical Ltd. (Qingdao, China).
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PMC7185206
This cleavage produces an active sPD-L1 fragment that induces apoptosis in CD8 + T cells and compromises the killing of tumor cells by CD8 + T cells.
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PMC11365983
Multiple other anomalies (Supplemental Table 1) are prevalent in the ciliopathy spectrum, consistent with the premise that ciliary dysfunction may contribute to such ARS phenotypes.
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PMC3931643
In control OCI-LY1 cells MLN0128 caused a profound inhibition of protein synthesis, with intermediate effects of rapamycin ( Fig. 5 ).
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PMC9895440
Cells were equilibrated in the incubator at 37 °C and 5% CO2 for 30 min.
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PMC11621493
K–P) PLA2G4D-derived reaction products using an equimolar substrate mixture (0.5 mM each) of rac-18:1 MAG and sn-1-16:0-sn-2-20:4 PE, or rac-18:1 DAG and sn-1-16:0-sn-2-20:4 PE, respectively.
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PMC10291556
Proteins from control, untreated cells were loaded to lane C. (B) Quantitative data evaluation; bars represent mean ± SD from two independent experiments.
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PMC11190538
S. platensis biomass slurry was firstly washed with double distilled water to remove adhered salts then grounded manually (in the dark) in 10 mL of 0.1 M phosphate buffer solution (pH: 6.8) , and 1 mL of Tris HCl in the presence of acid-washed neutral sand, and then filtered.
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PMC9000591
Medicarpin is involved in increasing myeloid leukemia cell apoptosis .
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PMC10723784
In the present study, the increase in G0/G1 correlated with a decrease in S phase when A2780 cells were treated with CBD.
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PMC6835428
Thus, the retention of delivery systems in the peritoneal cavity can be modulated by their size.
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PMC10993311
Blocking this phospholipase can structurally disrupt the fatty acid uptake complex (Stremmel et al., 2017).
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PMC11271800
TLSs are common in localized GIST and seem to be positively correlated with better OS and lower risk of recurrence.
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PMC3995603
13-19].
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PMC11774251
To investigate the potential of Tan-I in modulating keratinocyte differentiation, we first employed immunofluorescence to assess keratin expression in mouse skin lesions.
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PMC5833712
Treatment with MG132 resulted in stabilization of the ERα protein at control levels in the presence of KB9520, suggesting that ERβ plays a role in proteasome-mediated ERα protein degradation.
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PMC11806818
Antibodies are large molecules, costly, difficult to modify at specific sites, and prone to significant batch-to-batch variability, especially in polyclonal antibodies obtained from animal blood .
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PMC11802929
Finally, we found that the likelihood that an SCT would be successfully expressed strongly agrees with prediction.
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PMC11367146
This study confirms that these residues are essential for the proper functioning of the protein, highlighting their critical role in binding energetics.
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PMC11768927
Potential concerns regarding neurotoxicity can be mitigated through genetic modifications, such as substituting the G with that of a non-neurotropic virus or utilizing attenuated mutants that preserve therapeutic potency while improving safety.
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PMC11469524
Due to the little change of total proteins we decided to only concentrate on the phosphoproteome in this study.
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PMC11306331
Overall, these data are consistent with 3xFUS condensation existing as a complex process that likely involves interaction with additional components whose levels may vary between cells.
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PMC11566417
The plasmid expresses hEST2 (hTERT) under a constitutive CMV promoter and can be selected using the AmpR gene in bacteria and the NeoR/KanR gene in mammalian models.
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PMC10605143
The mammary ductal epithelium is a bi-layered structure, which includes two types of cells: luminal and basal/myoepithelial cells.
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PMC11515150
So far, there have been a few of phase I studies (NCT03081910, NCT04689659, NCT04004637) in regard to the CAR-T cells targeting CD5 or CD7 to treat relapsed/refractory T-lymphocytic leukemia/lymphoma, but with tumor recurrence [52–54].
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PMC9429973
Moreover, the dysfunctions of BM EPCs were more severe in higher-risk than lower-risk MDS patients, manifested as more supportive ability to leukaemia cells but worse ability to normal HSCs.
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PMC10957991
Both MCF10A and 184A1 cell lines contain stem/progenitor cells as well as mature ME and LE cells.
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PMC11723947
j Percentage of spleen Foxp3 cells among anergic or non-anergic WT and HP1γ KO TCR Vβ6 Tconv 21 days after engraftment.
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PMC11763126
D KEGG pathway analysis.
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PMC6617630
In the most recent WHO revision of lymphoma classification, DHL/THL category is now recognized as "high-grade B cell lymphoma (HGBL) with rearrangements of MYC and BCL-2 and/or BCL-6 .
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PMC9370419
The CCK8 experiment results indicated that the working concentrations of drugs were much lower than the drug cytotoxic levels (Figure 1I,J).
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