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PMC9412887
Primary drug resistance refers to a complete failure of response to initial antitumor therapy in patients with cancer .
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PMC11307990
Using the TUNEL assay, we also found no TUNEL-positive cells in cells treated with DNA nanotapes, indicating that DNA nanotapes do not cause apoptosis.
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PMC10669966
Therefore, an association of frequent and high PDE3A expression and the efficacy of PDE3A modulators in MLPS was not confirmed in vitro.
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PMC11634794
Subsequently, the absorbance values at a wavelength of 450 nm were measured using a Microplate Reader (Bio-Rad, Hercules, CA).
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PMC11297139
Tested proteins include PrLD1, ARID, PrLD2, Pfam, PrLD(Y/S) mutant, and full-length ARID1A.
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PMC11787381
Lower levels of DBH activity have also been reported in early AD, followed by a gradual increase in enzymatic activity as cognitive symptoms worsen in late AD.
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PMC6948907
Determination of Apoptotic Cells by Flow Cytometry Assay To determine the apoptotic cells, the flow cytometry assay was done (Darzynkiewicz et al., 2001).
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PMC11718109
Regions of interest were selected by fluorescence light microscopy imaging and their coordinates were identified using phase contrast.
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PMC9429973
Selected safety outcomes, including cytokine release syndrome (CRS), neurological events (NE), and tocilizumab and corticosteroid use for CRS, were compared between the infused populations.
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PMC11789597
Human MM cell lines, including RPMI 8226, MM1S, and U266 cells were purchased from the China Center for Type Culture Collection (Wuhan, China) and cultured in RPMI 1640 medium (Invitrogen, Carlsbad, CA, USA) supplemented with 10% fetal bovine serum (FBS, TransGen Biotech, Beijing, China), 2mM L‐glutamine (Biological Industries, Beit HaEmek, Israel), and 100 U mL penicillin/streptomycin (Biological Industries).
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PMC11525028
Half-life time calculated using a linear model (n = 3). (
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PMC11640247
Transient expression studies in COS7 cells demonstrated that RAC3-R66W interacts with the downstream effectors PAK1, MLK2, and N-WASP but fails to activate SRF-, AP1-, and NFkB-mediated transcription.
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PMC11754436
After obtaining the potential target gene of DHRS4-AS1, the expression levels of miR-362-5p in OS cell lines and the hFOB1.19 human osteoblast cell line were first verified by qPCR.
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PMC11026382
DHFR and TYMS point mutant combinations in the selection vector were transformed into ER2566 ΔfolA ΔthyA chemically competent cells by heat shock.
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PMC11638288
It has a complex impact on the activity of NK cells .
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PMC10728200
The cell viability results were normalized to the number of cells in the control group.
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PMC9096373
Subsequently, the cell suspension was transferred into a 25 cm culture bottle and 3 mL of medium was added, followed by incubation at a constant temperature of 37 °C in an atmosphere of 5% CO2.
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PMC11536589
Mouse ductal cells identified by the gene markers Krt19 and Krt7. (
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PMC9429973
Physicians’ age, gender, tenure or clinical experience with DLBCL patients did not correlate with the decision to perform a biopsy, whereas more physicians chose to perform biopsies in relapsed compared to refractory disease cases.
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PMC8010066
The cultures were centrifuged at 200 g for 30 min, and after filtering (0.22 µm Millipore filters, Merck, Germany), the OD405 was measured.
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PMC10222971
Naphthoquinones have been known since ancient times due to their dye properties and their use in traditional medicine as wound-healing agents.
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PMC10125624
METHODS: This was a retrospective cohort investigation using Truven MarketScan Databases (2014-2017).
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PMC11407042
Replace the water in the water bath and heat the water to 100°C for 4–5 h. Wipe the incubator and other devices in the cell culture room with 70% EtOH.
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PMC9844987
Percentage of variation accounted for by each principal component is shown in brackets with the axis label. (
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PMC7841067
In this study, we observed that knockdown of AKAP4 significantly inhibited thyroid cancer cell migration and invasion.
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PMC10170482
Samples were stained with 1 μM JC-1 fluorescent probe and incubated for 30 min at 37 °C.
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PMC9436459
0.2 μg/mL (5-FU)A27808.2 μg/mL 0.7 μg/mL (5-FU)Bel-7402n.a.
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PMC9429973
Of the 4 pts who had fatal AEs unrelated to epcoritamab according to the investigator: 2 pts aged 87 y had primary refractory disease and 2 pts aged 74 y had multiple comorbidities.
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PMC2614416
10-formyl-THF is a critically needed precursor for two reactions of de novo biosynthesis of purine nucleotides .
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PMC11543853
Here we show that both endosomes and the cytoplasm of infected cos-7 cells contained full and empty particles of the studied enteroviruses (Figs. 1, 2, Supplementary Fig. 1–4, Supplementary Movie 1).
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PMC10055960
Compounds 3 and 5 showed an approximate two-fold increase in cytotoxicity in the A2780cis cell line when compared to cisplatin and carboplatin, whereas compounds 4 and 5 show the highest antiproliferative effect of the synthesized compounds in the OVCAR-3 cell line.
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PMC11194678
Quantification of the autophagosome/autolysosome ratio (redgreen puncta: red green puncta) in A. n, number of individual cells (on the top of the batch). (
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PMC11348300
The observed transients were associated with vasodynamics and oxygen resupply and diffusion in the tissue.
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PMC11411131
TrxR1 is a selenoprotein that is not influenced by the exon junction complex.
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PMC11612794
CENP-T I202, F205, and V209 are shown as sticks. (
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PMC9429973
Aims: We were wondering if metabolic modulator can rejuvenate aged HSCs, rescue loss-of-function of aged HSCs and improve overall immune response.
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PMC11354239
The precise localization of CD107a-negative events on the dot plots was assured by analyzing samples lacking RTX or Raji cells.
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PMC10213179
Cells were visualized at 60× using a Zeiss LSM 900 with an Airyscan 2 microscope (Zeiss, Oberkochen, Germany).
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PMC8662250
The presence of pyroptotic cells was also shown with DAPI staining.
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PMC7841067
The protein expression of AKAP4 was measured by Western blot. (
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PMC9065483
Bands were quantified by densitometry relative to the actin-loading control and expressed as a phosphorylated: total STAT1/2 ratio (n = 3, mean ± SD; ns = no significance, ∗∗p < 0.01 by one-way ANOVA). (
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PMC11568601
Reports have shown that triggering ER stress through the IRE1 pathway promotes tumor cell apoptosis .
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PMC11539788
Kaplan‒Meier analysis of the correlation between overall survival and RNF19A expression levels. *
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PMC10317042
C, CCS cells were treated with 0–3 μmol/L JQ1 for 48 hours, and the number of viable cells was estimated using a WST-8 assay (n = 3).
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PMC11612315
Previous studies have shown that GLP-1 analogs can prevent or improve diabetic neuropathy in animal models.
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PMC7153288
The draft genome sequence data of Streptomyces sp. SS1-1 will be useful for finding biosynthetic gene cluster(s) responsible for secondary metabolite(s) with cytotoxic activity.
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PMC11730305
FT-IR analysis of Ellagic acid and Co3O4@Glu-Ellagic acid NPs.
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PMC11742864
As indispensable FAs in the human body, LCPUFAs have emerged as a dietary supplement for cancer prevention due to their significant anti-inflammatory effects, multiple anticancer mechanisms, and non-toxicity; at the same time, LCPUFAs have also emerged as a novel combination for lung cancer treatment due to their abundant anticancer effects.
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PMC11087766
The high degree of specificity seen in protein localization to the phage nucleus has led to the hypothesis that chimalliviruses encode a selective protein trafficking system (1, 2, 4, 10, 15, 17).
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PMC3675084
It also synergistically enhances antitumor activity against human lung, colorectal, and cervical tumor xenografts when combined with cisplatin .
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PMC11350568
Determination of the superior PTK7 degradation ability of AptG-1 over other aptamers against MV-4–11 cells by flow cytometry.
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PMC8978939
To test the tumor suppressor role of the novel variants, we injected the cell lines expressing WT-VHL and P138R and L163R pVHL into male nude mice.
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PMC8992508
In vivo PK experiments in mouse and rat confirmed its in vitro potency and identified the optimal dose of ML753286 (50-300 mg/Kg orally) to inhibit Bcrp in rodents.
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PMC9429973
6/8 (75%) took 100 mg mitapivat twice daily in the FDEP, and 2/8 (25%) took 50 mg mitapivat twice daily after a single dose reduction because of transaminase increase.
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PMC11785489
Benchmarking: To benchmark these different TCR scoring functions methods, we applied them to a dataset external to training (Dataset 3), and scaled each type of TCR score to have mean 0 variance 1 prior to association testing via Equation 4.
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PMC9587298
Elderberries were cultivated in Varosa Valley (Moimenta da Beira, Portugal) and the berries were collected at the commercial ripening stage.
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PMC9739791
The ability of the Pt(IV) prodrug 28 to generate singlet oxygen was investigated using singlet oxygen trap 1,3-diphenylisobenzofuran (DPBF).
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PMC11026382
Nevertheless, the data indicated that our model can globally describe growth rate phenotypes given variation in enzyme velocity.
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PMC9429973
Image: Summary/Conclusion: We developed and validated a simple rule using CBC parameters to predict the likelihood of JAK2 mutation positivity in patients with elevated hemoglobin with demonstrated high sensitivity and negative predictive value across different JAK2 mutation testing platforms.
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PMC11661040
The volcano plot depicted the differential gene expression and the expression relationship between cell cycle-related genes, wnt pathway-related genes and CGREF1 gene. (
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PMC11401350
Unfortunately, a follow-up of the CD8 T cell expansion, the percentage of CAR + CD8 + T cells and the malignant CD4 T cell depletion by blood punction at several time-points is not possible in the mAITL mouse model.
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PMC9429973
of Copenhagen; Novo Nordisk Foundation Center for Stem Cell Biology, DanStem; The Bioinformatics Centre, Department of Biology; The Finsen Laboratory, Univ.
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PMC11730320
C PCR primer design.
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PMC11240052
Lipofectamine 3000 was used to transfect the cells according to the manufacturer's instructions (Invitrogen; Thermo Fisher Scientific, Inc.).
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PMC9454178
Interestingly, we observed that c-KIT mRNA and protein levels were significantly decreased after CDK7 knockdown (Fig. 7A, B) and THZ1 treatment (Fig. 7C–E).
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PMC10551595
Binding modes of GinA with the target proteins. (
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PMC9429973
A statistically significant (p<0.005) increase in uric acid, creatinine, LDH, WBC and platelets was observed for the interval 1-12 weeks in comparison with baseline (mean: 6.42±1.64mg/dl vs 5.48±1.6mg/dl, 0.87±0.16mg/dl vs 0.83±0.18mg/dl, 352±205mg/dl vs 204±62mg/dl, 11.78x10^9 ±5.29x10^9/L vs 10.36x10^9±4.35x10^9/L, and 450x10^9±221x10^9/L vs 415x10^9±202x10^9/L, respectively.
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PMC11502962
Immunohistochemistry and immunofluorescence were performed ( Figures 7 , 8 ).
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PMC7642379
Moreover, ID1 silencing has also been shown to significantly reduce adhesion of neural stem cells and conversely, increased ID1 expression in epithelial cells has been related to increased adhesion.
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PMC9429973
Aims: Here we examined and compared the incidence of various cellular components in specimens of patients with aggressive versus indolent B-cell non-Hodgkin’s lymphomas (B-NHLs).
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PMC11637276
Finally, α2β1 integrin and MAP3K1 expression were significantly up-regulated in pancreatic tumours and correlated with poor prognosis in pancreatic cancer patients.
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PMC8978939
Our variants were not found in the Genome Aggregation Database (gnomAD) that includes thousands of genomes and exomes; this information allows us to infer that they have a very low allelic frequency.
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PMC11775197
The tumor microenvironment (TME), which encompasses tumor cells and cancer‑associated fibroblasts, interstitial tissues, blood vessels, and a variety of inflammatory and immune cells, chemokines, and cytokines, is a complex and not yet fully understood system .
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PMC11726848
ROS may also contribute to cell cycle arrest acting as secondary messengers, participating in intracellular and intercellular signaling .
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PMC11200978
The correlation of our findings and the literature are compelling and suggest this response to be universal.
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PMC8751435
They induced cell apoptosis and inhibit proliferation according to previous research.
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PMC10759659
c The difference in lymphocyte infiltration level by ssGSEA in the two groups.
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PMC9812014
At 8 days after infection SIP-1 had an IC50 of 0.5 μM against HIV infection.
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PMC9429973
A. Kuykendall, M. Kremyanskaya, Y. Ginsburg, N. Pemmaraju, E. Ritchie, J. Gotlib, F. Valone, S. Khanna, S. Gupta, R. Hoffman, S. Verstovsek Hematology and Med Oncology, USF, Moffitt Cancer Center, Tampa; Hematology, Mt. sinai, New york; Dept of Leukemia, M.D. Anderson, Houston, Tx; Hematology, Weill Cornell medical College, New york; Hematology, school of Medicine, Stanford, Palo Alto, Ca; Clinical Research and Development, Protagonist Therapeutics, Newark, United States of America Background: Polycythemia vera (PV) patients are treated with periodic therapeutic phlebotomy (TP) and if needed, cytoreductive therapy to maintain hematocrit (HCT) <45% to reduce the incidence of thrombosis.
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PMC11732635
Imaging showed a thick duodenal wall and enlarged lymph nodes in the abdominal cavity.
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PMC11754094
Two targets were tested for each type of editing: HEK4 and HEK3 for substitution, FANCF and HEK3 for deletion, RNF2 and HEK3 for insertion.
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PMC9429973
The lower growth rate observed in the CD34CD38CLL-1 sub-population was associated with a significantly higher percentage of G₀/G1 cells than the CD34CD38CLL-1 sub-population (91% vs 49%; P=0.0001), respectively.
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PMC9429973
Secondary outcomes included overall survival (Kaplan–Meier analysis).
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PMC11300639
Furthermore, co-IP assays showed that CDK4 interacted with RNF26 in 786-O and A498 cells (Fig. 2m).
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PMC11092382
ex Baker seeds could reduce cyst weight and stimulate a specific immune response targeting T cells in protoscolex-infected mice, suggesting that the E2-a fraction may be used as a potential therapeutic agent against E. granulosus infection (Luo et al., 2018).
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PMC9429973
These PGs represent different disease stages, with both genetic and inflammatory associations, independently confirmed by orthogonal data.
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PMC6364197
Moreover, this scenario was lacking in the TCPS; that is the possible reason why the cell proliferation was significantly reduced by 144 and 168 h. With the increasing number of cells, the decrease of cell surface area for collagen type I adsorption is inevitable, leading to less area for cell attachment.
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PMC11515150
T cells were transfected with lentiviral supernatant at a MOI of 3 and supplemented with 1 µg/mL polybrene on day 2.
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PMC4695073
So far, several studies have elucidated NER factors contribute to cisplatin resistance and hamper the effect of cisplatin-based treatment [30-33].
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PMC11377827
D, E) Control or USP43 depleted HeLa cells were incubated in 21 or 1% oxygen for 6 h prior to lysis.
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PMC11730320
A novel homozygous 8kb deletion in PTCRA, encoding pTCRα, was identified.
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PMC11045125
It will be important to investigate further whether mouse lymphomas driven by LMP1/λ-Myc in transgenic mice are primarily LMP1/NF-κB-driven DLBCLs versus Myc-driven BLs.
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PMC11467964
In this study, the different risk groups showed significantly different TME infiltration features, indicating that for low‐risk STS patients, there were more stromal cells, and immune cells, and a better TME.
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PMC9592219
For cell transfection, 0.25 μM small interfering RNA (siRNA; Ribobio, Guangzhou, China) was diluted with 25 μl serum-free Opti-MEM (Gibco, Invitrogen, Carlsbad, CA, USA), gently mixed, and then incubated at 14°C for 5 min.
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PMC8469018
To evaluate DHODH-dependent toxicity, the cultures treated with teriflunomide were supplemented with uridine.
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PMC11733919
Given that the MNP core is coated with oleic acid, drugs can be adsorbed between these molecules and the hydrophobic tails of the PMAO.
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PMC11640419
In the present work, a series of hybrid molecules based on oleanolic acid and 5Z,1Z-diene fragments was synthesized.
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PMC11420784
The mechanism by which UPEC evades autophagy to recognize and form IBCs remains unclear.
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PMC9429973
The ORR was 87% with 3 pts achieving CR (20%) and 10 pts achieving marrow CR (67%).
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PMC11453018
DAPI (blue) was used to stain the nuclei.
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