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PMC8623816
Mycelial plugs were cut at random from the regenerated colonies and transferred to fresh PDA plates.
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PMC11266100
After 24 h cell viability was assessed using PrestoBlue cell viability reagent (Thermo Fisher Scientific, Waltham, MA, United States).
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PMC9429973
Methods: Patients with SMM presenting to Memorial Sloan Kettering Cancer Center between the years 2000 and 2019 and who identified as either AA or white were included in this retrospective study.
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PMC11172027
Furthermore, NASeLM, the selenium-containing form of NALM, showed similar results on Jurkat cells, with caspase-3 activity being increased.
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PMC11727062
By inhibiting this pathway, toadflax endolipids may reverse drug resistance in melanoma.
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PMC11670954
Procyanidins have been shown to preserve normal intestinal barrier functions by inhibiting MLCK, similar to the effects of a MLCK inhibitor observed in a study involving acrylamide-induced Caco-2 cell monolayers .
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PMC11754784
h Confocal imaging of CEM cells treated with cage-Nb, cage-Nb-sgc4f, cage-Nb-sgc8c and DNP2.
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PMC11792740
Therefore, future research must focus on developing combination therapeutic strategies that target multiple pathways involved in T-cell depletion to enhance tumor immunotherapy.
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PMC7823217
with creative commons attribution (CC BY) license.
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PMC11585994
The percentage of apoptotic cells was detected by flow cytometry (left panel), with quantification shown in the right panel. (
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PMC11574029
In this study, we confirmed that NOTCH3 is highly expressed and is associated with poor prognosis in BLCA patients.
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PMC11087055
Despite the disturbed cell flow, PS extension was preserved along both authentic and induced midline axes (Figure 4).
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PMC11513011
In 5637, the expression of E-cadherin was not increased by administration of DIB.
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PMC9429973
36 (54%) patients had PV, 25 (37%) ET, and 6 (9%) PMF.
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PMC9096373
The positive expression of γ-H2AX was obviously increased compared with the control and RT groups (P<0.05), whereas the apoptosis rate in the APA + RT group was obviously increased compared with the control, RT, and DDPs + RT groups (P<0.05).
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PMC11424574
Several studies suggest that MTA2 is highly expressed in human cancers and is directly associated with malignancy, metastasis, drug resistance, and a poor cancer prognosis .
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PMC11361748
Lysis buffer was added, and cells were scraped off from the plate and rotated at 4°C for 1 h. Supernatants were collected after centrifugation (12,000 × g, 20 min) and total protein levels were measured using Pierce BCA Protein Assay Kits (Thermo Scientific #23227).
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PMC9429973
However, many studies were conducted prior to widespread immunisation and availability of effective antiviral strategies.
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PMC10024132
Moreover, T cells that secrete CD19-T cell-engaging bsAbs may be superior to CD19-CAR T cells in terms of long-term anti-leukemia activities, as these cells can overcome CAR-mediated CD19 downregulation that often leads to leukemia cell escape and disease relapse .
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PMC7917457
FlowJo software v.10 (FlowJo) was used for the data analysis.
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PMC10571053
Results from one of three independent experiments are shown; (B) Three-day cytotoxicity assays were performed on OVCAR8 and NCI/ADR-RES cells with imidazole ketone erastin, piperazine erastin, FIN56 or erastin.
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PMC9429973
Summary/Conclusion: In conclusion, we found a JAK2-dependent down-regulation of SHP1 expression which is related to the resistance of JAK2V617F cells to the antiproliferative effect of TGFβ explaining clonal selection of mutant stem cells in myelofibrosis S. Bianchi, G. Palumbo, V. Filipponi, N. Monaco, G. Pileggi, R. Maglione, M. Rousseau, M. L. Moleti, F. Giona Translational and Precision Medicine, Sapienza, University of Rome, Rome, Italy Background: Mutations in the JAK2, MPL and CALR driver genes are reported in over 90% of adults with BCR-ABL1-negative chronic myeloproliferative neoplasms (MPNs) and in 22-40% of children, where inherited forms, such as familial erythrocytosis (FE) and hereditary thrombocytosis (HT), are common.
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PMC9429973
In contrast, URD Cords and MMRD showed a marked increase (+14% and +15%) In children, auto-HCT showed an unexpected marked increase (21%) with no variation in allo-HCT.
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PMC11748335
Upon the loss of short LOCKs in CGI promoters, the group acquiring active markers and showing activated expression contains a higher proportion of poised promoters.
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PMC10545062
The feasibility of ACC has been proposed by some, while others have focused on computational modeling of ACC systems with the majority focusing on single therapeutic interventions and not parallel interventions.
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PMC11621493
Using untargeted HPLC-MS, we analyzed 296 different lipid species.
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PMC9429973
Methods: Clinical laboratory and demographic data were summarized for HCL patients who performed PET CT during follow up in 2 medical centers in Israel.
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PMC11190062
p-Values were calculated using one-way ANOVA and Sidak’s multiple comparisons test.
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PMC5916734
FIX activity also depends on the degree of γ-carboxylation of the Glu residues in the Gla domain.
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PMC8041314
This is a special finding given the fact that screenings usually do not provide compounds with very high activities.
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PMC10890055
Therefore, the difference in toxicity of the extract in MEM and DMEM/Ham’s F-12 is less evident.
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PMC11155445
Anti-bacterial activity of acyl thioureas and thiosemicarbazides was investigated by Kholodniak et al. N-substituted acyl thioureas (96a, 96b, 96c, 96e, 96j, and 96l) were found to exhibit poor inhibitory activity towards DHFR but showed moderate antibacterial activity against E. coli (MIC 100 μg mL, MBC 200 μg mL), Ps.
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PMC9429973
Serum cystatin C is a well-known marker of nephropathy in sickle cell disease (SCD) and b-thalassemia patients that has recently emerged as a strong predictor of cardiovascular dysfunction in patients with and without kidney disease.
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PMC11098378
Data in B-C are means ± SD; n = 3.
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PMC11499955
Although the experiments carried out are preliminary and need to be confirmed by further investigations, the results are encouraging.
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PMC10454535
In these 6-well Transwell plates, HS-5 cells were added at 2.5 × 10 cells per well in 2.5 mL of media and allowed to adhere to the basal chamber for 24 h. Then, RPMI 8226 cells were added to the apical chamber of the Transwell insert at 5 × 10 cells per well in 1.5 mL of media, to which the drugs were added.
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PMC6163708
Generally, all HH proteins were expressed.
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PMC11787381
Rabbit polyclonal antibody anti-synaptophysin (SYN) at the dilution of 1/100 in PBS containing 1% fetal calf serum and 0.1% of saponin.
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PMC11604768
Coupling promoter activity to the production of barcoded mRNAs affords the ability to quantify activity in response to stimuli in a sensitive and high-throughput manner via next-generation sequencing (NGS).
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PMC11180402
Fig. 4miR-129 induced by ISO destabilizes SOX2 mRNA by interacting with its 3′UTR.
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PMC6642070
Lactate production in A-204 cells exogenously expression of β-enolase (n = 3). (
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PMC9739791
Such prodrugs are non-toxic towards normal cells that are not irradiated, while they are simultaneously highly efficient against malignant cells in vitro and in vivo in the presence of irradiation.
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PMC11575040
Fig. 8In silico identification of miR-1270 target genes.
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PMC9014716
The results showed that the number of clones was significantly increased in the O + M group as compared with cells without the miR-224-5p inhibitor (the O group).
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PMC9164404
To track the nanoparticles through fluorescence signal, Abplatin was labelled with Cy7.5, and i.v.
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PMC11640419
This is of particular significance for cells that have mutated p53, which are the cells of most malignant tumors.
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PMC11701801
The number of mutated and deleted alleles was then summed up to calculate the number of altered alleles.
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PMC9429973
One patient did not received treatment due to lack of T-cell expansion.
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PMC11679033
It has to be mentioned, indeed, the group median value of tail intensity we detected in CIT-treated sample was below 10%, pointing to a rather low overall level of DNA damage .
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PMC11387401
The interaction network, combined with gene ontology (GO) enrichment analysis performed on the set of interacting RNAs for each HIV-1 protein, revealed a variety of RNA clusters for which the protein products are involved in specific biological processes (Fig. 4A; Appendix Table S6).
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PMC11591038
HIF-1α is also critical for B cell development and enhances the expression of interleukin (IL)-10 and CD11b, which may exert anti-inflammatory action .
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PMC8193813
The NO2-D4 sensor showed higher drift (average 8.6%) at one location for the highest concentration of its calibration gas (10.4 ppm).
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PMC11507371
However, Keap1 abundance was heightened after CAP treatment (+81%), similar to HaCaT cells (+54%).
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PMC11711663
Progression-free survival (PFS) encompasses the duration from the start of treatment to either the progression or death for any reason, with patients lost during follow-up treated as censored observations, contributing less weight to the survival analysis.
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PMC11055443
Prostaglandin E2 (PGE2) and some inflammatory cytokines induced cAMP production that resulted in cystic fibrosis transmembrane conductance regulator (CFTR) opening, dysfunction of ion channels and increases in intestinal secretion.
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PMC11788920
The TransIT-X2:RNP complexes were added dropwise to various regions of the well after a 15-min room temperature incubation period.
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PMC11365427
Briefly, a total of 4 × 10 cells/well were plated in 96-well plates, with each well supplemented with 10% FBS in a volume of 100 μL medium.
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PMC9429973
The median (range) time to CRS onset was 2 days (1–6) and median duration was 2 days (1–9).
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PMC10898159
In this figure we describe several inhibitors targeting KIT expression and function.
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PMC11551844
DMSO (100 μL) was added to each experimental well to lyse the cells and the plate was placed on the orbital shaker for 3 min to dissolve formazan crystals.
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PMC11188874
In contrast to the proteasome activators (Fig. 1A), proteasome inhibitors significantly reduced cell viability (Supplementary Fig. S5A and S5B).
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PMC9429973
Overall, the average hospitalization length after the infusion was 17 days (median=16) for group 2 and 14 days (median=13) for group 1 (p=0.059).
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PMC11222184
The ERCC3 and ERCC5 gene is a central component of the nucleotide excision repair pathway .
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PMC9429973
Irreversible and covalent nature of GB5121 was evaluated using enzymatic assays compared to analogs that lacked an active covalent warhead.
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PMC10055960
Serial dilutions were carried out in such a way as to obtain the final concentration of compounds over the 0.1–100 µM concentration range with corresponding DMSO concentrations of 0.016–1%.
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PMC6182045
Assays were performed in duplicate and error bars indicate Standard Deviation (SD).
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PMC11320834
The characteristics of TLL and OLL are presented in Table 1.
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PMC10758402
This tumor tropism is derived from the aberration of anti-viral responses commonly found within tumor cells.
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PMC9429973
Duration of PN was similar for both treatments.
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PMC8751435
In other words, CME‐induced damaged DNA stimulates caspase‐3 and afterward caspase‐3/PARP, which is followed cascade of apoptosis.
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PMC9844987
The architecture is composed of one convolutional layer with 128 hidden units, followed by global average pooling and two dense layers with 128 and 2 nodes, respectively. (
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PMC11737091
In tumors, abnormal cell cycle activity drives tumor growth.
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PMC9503669
Introduction of a bulky benzimidazole or related substituent in place of the thioamide present in B9 greatly enhanced Nef binding affinity in many cases.
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PMC11470381
A. A cell ROI is fitted into an ellipse and its shape parameters are measured.
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PMC11453018
Our assumption was that simultaneous overexpression of LMNB1 and knockdown of P15 would delay the senescence.
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PMC11575040
Among the actions of metformin, the most extensively studied mitochondrial action is the inhibition of Complex I in the respiratory chain, which inhibits the production of ATP .
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PMC10547921
Dongke Yu obtained a novel HER2-targeting ADC DS-8201a by conjugating DXd to trastuzumab.
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PMC11701801
Specifically, the following methods were used to determine the genotype of SMARCB1, ARID1A, PBRM1, SMARCA4, SMARCA2, or SS18–SSX in terms of the number of altered allele(s) with mutations and/or CN deletions.
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PMC10092581
After 24 h, the cells were washed twice with PBS and, following 48 h of treatment with IC50 doses of the tested compound, cells were stained for 5 min with 10 μg/mL of Hoechst 33258 (20‐(4‐hydroxyphenyl)‐5‐(4‐methyl‐1‐piperazinyl)‐2,50‐bi‐1H‐benzimidazole trihydrochloride hydrate, Sigma‐Aldrich, St.Louis, MI, USA) in PBS.
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PMC11754784
White arrows indicate macrophages that phagocytized cancer cells.
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PMC11441402
After 24 h settling period, cell number accuracy and Tz plates were analyzed using each of the four assays described below.
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PMC10529414
The qPCR primers used to evaluate the TALAM promoter region are listed in Supplementary Table S1.
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PMC11224206
Draw up a model which combines the various factors under different physiological conditions and incorporates intrinsic cellular defence mechanisms to counteract heat (not considered in this Opinion piece).
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PMC4485648
Hypoxia affects the phenotype of ovarian cancer cells by inducing stem-like properties (17), migration and invasion (28) and reduced sensitivity to drugs (29,30).
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PMC7039683
Genes flanking elements meeting both criteria are strongly enriched for those expressed in periderm.
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PMC11380329
The network is represented as a pie chart, where nodes correspond to parent masses of the metabolites.
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PMC10976516
Further to this, MSC-derived carriers have shown great promise for cancer therapy based on the results obtained in a variety of preclinical tumor models (Table 2, ICOVIR-5/CELYVIR).
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PMC11768281
Figure 2 outlines the search and screening process.
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PMC2196094
This sequence corresponds to an internal portion of RMCP-1 starting at Asn82 (numbering according to Le Trong et al., 1987), indicating a cleavage at the Tyr81-Asn82 bond.
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PMC10898159
The fundamental chaperoning role of HSPs is subverted, especially heat-shock protein of 90 KD (HSP 90), leading to the maintenance of mutant proteins with its gain-of-function of protecting cancer cells from onco-stress .
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PMC11680562
Early diagnosis of cervical cancer may lead to more favorable treatment outcomes .
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PMC9386809
At this point, we reasoned thate Cl2Zr–BPC complex 2 could be a valuable catalyst in the synthesis of medicinally useful bis(indolyl)methanes.
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PMC11718817
Possible candidates include CD80, CD86, and PD-L1 on myeloid cells.
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PMC8540692
Interestingly, in our study, even Aza, the positive control with DNMT inhibitory properties, was not found to be effective in causing complete demethylation of CpG sites under consideration, suggesting the promoter regions to be resistant towards hypomethylating effects.
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PMC9786247
Some genetic diversity of C. burnetii isolates was also described in different Spanish bulk tank samples .
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PMC6379402
d The distribution of distances between iCell and ER networks (in pink) and the distribution of distances between ER networks (in blue) are significantly non-overlapping (MWU p value ≤ 5%), indicating that the ER model does not fit the iCell, i.e., that the structure (topology) of iCell is not random Then, we examine the iCells to assess how well they capture the functional organization of cells, as described by reactome pathway (RP) annotations.
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PMC11401350
SINHIV-PGK-GFP and SINHIV-EF1a-GFP lentiviral vector constructs are available upon request from E. Verhoeyen.
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PMC11401358
Therefore, we chose (GAGSGA)2-8 h as a representative polypeptide for studying the antioxidant mechanism on SF.
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PMC10823017
Effect of aPKC inhibitors ICA-1, BYL719 and combination therapy on c-Myc regulation in Caki-1 and 786-0 Cells (A) Western blot analysis and the effect of ICA-1,BYL719 and BYL719 combined with ICA-1 following three days of treatment on p-Akt1, Akt1, p-ERK1/2, ERK1/2, and c-Myc. (
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PMC11401350
Of note, AITL Tfh CD4 cells show very high similarity to healthy Tfh cells, also in their T-B-cell interaction through ICOS-ICOSL binding .
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