OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11641630	However, migration also plays a critical role in tumor formation and dissemination, including in BC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "migration", "also", "plays", ...
PMC11363012	Untargeted scMS was performed on approximately 200 cells from each of the five tissue samples (Table S5 and Figures S6–S10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Untargeted", ...
PMC11089031	B ZNF692 mRNA expression across histological stages of ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "ZNF692", "mRNA", "expression", "across", "histological", "stages", "of", "ccRCC", "." ] } ]
PMC8759873	Digest the cells with 0.25% trypsin, centrifuge, inoculate 0.5 × 104 cells/well in a 96-well culture plate, 200 cell suspension per well, 3%, 5% CO2 incubator incubate overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6468656	The cells were lysed at 4 °C in RIPA buffer containing 50 mM Tris-HCl (pH 7.4), 150 mM NaCl, 1% Triton X-100, 0.25% sodium deoxycholate, 5 mM EDTA (pH 8.0), and 1 mM EGTA supplemented with protease and phosphatase inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707832	Deficiency in MAN2B1 leads to impaired lysosomal function and compromised glycoprotein degradation, resulting in the gradual accumulation of mannose-rich oligosaccharides in cells and tissues, culminating in α-lysosomal storage disease .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Recombinant CTPS1 and CTPS2 enzymatic activity was assessed by quantitating cytidine triphosphate by RapidFire Mass Spectrometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Recombinant", "CTPS1", ...
PMC11468365	In challenging diseases, targeting multiple biochemical pathways within a cell with a single drug is often inefficient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "challenging", "diseases", ",", "...
PMC11266100	The role of Ca ions in the EP buffer has also been reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "role", "of", "Ca", "ions", "in", "the", "EP", "buffer", ...
PMC5839394	p < 0.05 was considered significant; p < 0.01 was considered highly significant and p < 0.001 was considered very highly significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", ...
PMC11759751	There was no significant difference in tumor size between the Vehicle group and the Chidamide group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "no", "significant", "difference", "in"...
PMC10890307	We found that compared to Jurkat cells, lung cancer cell lines had a doubling time that ranged from 18 h to 30 h in media containing 10 mM glucose.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Thus R/R MM constitutes a significant unmet medical need.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", "R/R", "MM", "constitutes", "a", "significant", "unmet", "medical", "need", "." ] } ]
PMC11657744	Schematic model depicting the functional specialization of DA proteins during ciliary dynamics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "model", "depicting", "the", "functional", "specialization", "of", "DA", ...
PMC11201245	As a positive control for OC-FISH test, we used three primary ovarian cancer cultures and ovarian cancer cell lines OVCAR 3, OVCAR 8, and SKOV 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "I-...
PMC11706491	Rep2 promotes START by MBF activation and Cdc25 promotes mitosis entry by activating the CDK Cdc2. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rep2", "promotes", "START", "by", "MBF", "a...
PMC11714165	In addition, laser scanning confocal microscopy (LSCM, Leica SP8, Germany) was used to confirm the co‐localization of NBD‐F and D‐NBD‐F in the co‐assembled nanoparticles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470999	In conclusion, our study provides compelling evidence that PF can be repositioned as an effective therapeutic agent for melanoma and its brain metastasis by promoting CIP2A degradation and restoring PP2A activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11381192	Although the prognostic value of CSI is apparent, further verification through large‐scale multicenter studies is necessary.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "prognostic", "value", "of", ...
PMC7685376	A–F) The mRNA levels of cell cycle related genes in SK-Hep1 cell lines treated with Huaier (0 and 15 mg/mL) for 24 h with or without a knockdown of indicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11467964	Differences in risk score between the two subtypes. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differences", "in", "risk", "score", "between", "the", "two", "subtypes", ".", "(" ] } ]
PMC11786767	To confirm that the labeling of biotin-DHPE was lipid dependent, 100% methanol or 100% acetone were added separately into PFA-fixed cells for 10 min at 20°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193046	Compounds 16–25 were screened at 10 µM in calcein AM (ABCB1 and ABCC1) as well as pheophorbide A (ABCG2) fluorescence accumulation assays using either ABCB1-overexpressing A2780/ADR, ABCC1-overexpressing H69AR, or ABCG2-overexpressing MDCK II BCRP cells, respectively, as reported earlier , , , , .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739484	Fig. 10The effects of MMP7 knockdown on A375 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Fig.", "10The", "effects", "of", "MMP7", "knockdown", "on", "A375", "cells", ".", ...
PMC11489275	The mortality rate of class 2 and class 3 patients was significantly higher than that of the normal lymphocyte group (Table 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11269933	The results in Figure 3D showed that the density of water molecules near the K279 core catalytic site in the S11 phosphorylated system is higher than that in the wild-type system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	All manipulations were approved by the Medical Science Ethics Committee of SJTU-SM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "manipulations", "were", "approved", "by", "the", "Medical", "Science", "E...
PMC9429973	Results: Interviewed HCPs (n=219) were composed of 48% hematologists, 37% hematologist-oncologists, 11% pediatric hematologists, 1% pediatricians, 1% internists, and <1% general or family practitioners.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10158546	These inocula have been used in an unrelated, ongoing in vivo mouse experiment and display the expected amount of infectivity (J. Myskiw et al, unpublished data).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11547917	Other classes of compounds were identified by gas-chromatography analyses from A. tagala leaves extracted in different types of solvents, hydroalcoholic and methanolic, showing the most diverse biologically potent compounds (e.g., alkaloids, flavonoids) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803918	Further local laser irradiation to the tumor lesions will activate photosensitizers to eradicate tumor tissue via ROS generation without impacting normal tissue and to induce immunogenic cell death (ICD) for long-term antitumor immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Replication kinetics of CCR5-tropic subtype C clone MJ4 in parental PM1 cells, with no detectable virus in PM1/D128K cells 26 days post-infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", ...
PMC11705547	A preclinical study showed that cisplatin down-regulates the transcription factor c-Myc in human ovarian carcinoma cells by inhibiting miR-145, which increases PD-L1 expression and leads to the apoptosis of CTLs, eventually resulting in cisplatin resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11707832	Recently, a seven-month-old dog displaying progressive neurological symptoms and brain atrophy was euthanised, and microscopic examination confirmed a lysosomal storage disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recentl...
PMC10926885	The top 8 miRNAs targeting NDE1 were displayed in Targetscan database. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top", "8", "miRNAs", "targeting", "NDE1", "were", "displayed", "in", ...
PMC9341513	The data showed trends which were generally consistent with the simulations: the CCND1 probe volume was, on average, 30% larger in U266 compared to GM12878, and the MYEOV probe was, on average, 23% larger.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9096373	RT, radiotherapy; DDPs, cisplatin; APA, apatinib; Ki-67, proliferating cell nuclear antigen; γ-H2AX, histone H2AX family member; IHC, immunohistochemistry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11576293	The replacement of the di-aryl pyrimidine group at the 4 and/or 6-positions is essential for activity and is another area of interest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "repla...
PMC9429973	To analyze the association between exposure variables and thromboembolic events, logistic regression models were used to estimate unadjusted and adjusted odds ratios (ORs) with their 95% confidence intervals (CI 95%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730320	Both pipelines were based on the b37 genome reference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "pipelines", "were", "based", "on", "the", "b37", "genome", "reference", "." ] } ]
PMC11443022	45,X/46,XY mosaicism is a rare anomaly in sexual differentiation, presenting with diverse phenotypes and often leading to infertility due to abnormal gonadal development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9096373	Our study demonstrated that the extent of apoptosis in tumor cells within the APA + RT group was significantly higher compared with the control, RT, and DDPs + RT groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11597291	The yield of the nCGO-PEG conjugates was in the range of 14–32% wt, depending on the MW of the mPEG-NH2 polymers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11269792	pcDNA 3.1-circAPP and si-CDV3 were co-transfected, (A) Expression changes of miR-6838-5p, (B) Expression changes of CDV3, (C and D) Colony formation and EdU assays to assess cell proliferation, (E) Flow cytometry to analyze apoptosis, (F) Cellular glucose consumption, lactate production, and ATP levels, (G) ATP/ADP ratio and NAD/NADH ratio, (H) Western blot to evaluate cellular HK2 and PKM2 protein expression; data are expressed as mean ± SD (n = 3). *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502443	FBS (50%) in pERK1/2 and pAKT or 50 μM forskolin in pCREB assays were used as positive controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FBS", "(", "50", ...
PMC11474209	Cytotoxicity45HepG2 cells0.01, 0.1 and 1 µg/mLFpg, AraC and HUPP1, PP2ADNA damage, oxidative pyrimidine DNA damage, ROS productionInitiate tumorAbbreviations: Bcl-2: B-cell leukemia/lymphoma 2 protein; cdc2: Cell division control 2; cdc25C: Cell division cycle 25; cGAS: Cyclic GMP-AMP synthase; cGAS-STING signaling pathway: Cyclic GMP–AMP synthase-stimulator of interferon gene signaling pathway; c-Myc: Cellular Myc; COX2: Cyclooxygenase enzyme; CTNNB1: Ctenin Beta 1; ERα: Estrogen receptors alpha; FAK: Focal adhesion kinase; FOXM1: Forkhead box M1; GS: Glycogen synthase; GSK-3: Glycogen synthase kinase 3; GSK3β: Glycogen synthase kinase 3 β; GSK3β: Glycogen synthase kinase 3 β; HAVSMCs: Human aortic vascular smooth muscle cells; HCC: Hepatocellular carcinoma; HIF-1α: Hypoxia-inducible factor 1-alpha; HL7702 cell: Human normal liver cells; HSP27: Heat shock protein 27; Hsp90: Heat shock protein 90; HUC-1 cells: Human uroepithelial cells-1 cells; HUVECs: Human umbilical vein endothelial cells; INS: Insulin; IRS1: Insulin receptor substrate 1; JAK2: Janus kinase 2; Krt16: Keratin 16; MAPK: Mitogen-activated protein kinases; MLC: Myosin light chain; MMP: Mitochondrial membrane potential; MMP7: Matrix metalloproteinase-7; mTOR: Mammalian target of rapamycin; P53: Tumor protein 53; PI3K: Phosphatidylinositol-3 kinase; PI3K: phosphoinositide 3-kinase; ROCK: Rho-associated protein kinase; ROS: Reactive oxygen species; S6K1: Ribosomal protein S6 kinase beta-1; SGC-7901 cells: Human gastric cancer cell line; STAT3: signal transducer and activator of transcription 3; VASP: vasodilator-stimulated phosphoprotein; VEGFCyclin D1: Vascular endothelial growth factor Cyclin D1; PPI3/AKT: phpsphoinositide 3-kinase/protein kinaseB; HL7702: Human normal liver cell line; OATP1B1: Organic anion transporting polypeptide 1B1; OATP1B3: Organic anion transporting polypeptide 1B3; L02: Human normal liver cell line; HepG2: Human hepatoma cell line; RWPE-1: Epithelial cell derived cell line; LX-2: Human hepatic stellate cell line; NCM460: Human normal intestinal epithelium cell line; HepG2: Human hepatoma cell line; L02: Human normal liver cell line: CaCo2: Cancer coli-2 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721064	To further assess the efficacy of our approach in reconstructing the cornea, future corneal wound healing experiments will need to be conducted to evaluate the therapeutic outcomes on the ocular surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10142392	An analysis of the literature shows that the field has undergone a major expansion from a small group to a growing list of researchers, as reflected by the number of publications in recent years (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11764090	ex A. Juss.)	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "ex", "A.", "Juss", ".", ")" ] } ]
PMC9429973	Key inclusion criteria were newly diagnosed AML, age ≥60 years, eligible for IC, WHO performance status 0-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Key", "inclu...
PMC11791432	For in vivo studies, 1 × 10 luciferase-expressing U87 cells (both NC and shANXA1 groups) were intracranially injected into the right caudate nucleus of BALB/c mice using a stereotactic apparatus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516401	In contrast to HEPV, the mechanism through which, both C. colocynthis and P. oleracea extracts could induce anti-diabetic effects has been well-established in previous studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	We speculate that deSUMOylation is required for the breakdown of interdimer SUMO-SIM interaction to free mature Fu from the condensates, whereas re-SUMOylation may create new intradimer SUMO-SIM interaction to facilitate Fu conformational maturation through molecular cross-linking (Fig. 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11751675	Collectively, these results highlight brevilin A and related SLTs as encouraging candidates for further development in influenza therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ",", "these", "res...
PMC11742670	The proposed CNN architecture.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "The", "proposed", "CNN", "architecture", "." ] } ]
PMC11574271	B The tumor growth was assessed daily and represented in a line chart.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "The", "tumor", "growth", "was", "assessed", "daily", "and", "rep...
PMC5025404	After amplification, subcloning was carried out with three prospective mini-pools using limiting dilutions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "amplification", ",", "subcloning", "was", "carried", "out", ...
PMC9429973	The second most discussed stage of patient journey was treatment (44%); blood transfusions was the most mentioned treatment (34%), which was generally found to be effective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10958426	By integrating the 10x Genomics scRNA-seq data from Lee et al. , we obtained scRNA-seq data of 36 samples from 12 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "integr...
PMC9429973	It often affects males with a median age between 55 and 60 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "often", "affects", "males", "with", "a", "median", "age", "betw...
PMC7305184	According to our results PEF treatment can thus be used for repeated treatments with similar efficiency as the initial treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "our", ...
PMC9429973	The proportions of patients with high-risk cytogenetic abnormalities (HRCAs), defined as amplification 1q21, deletion 17p, t(4,14) and t(14,16), were lower in L-MT without ASCT and I-MT with ASCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11641630	Both mycobacteria inhibited individual cell migration across all BC lines, while collective migration was only reduced in intermediate-grade cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "mycobacteria", "inhi...
PMC10587429	Spin to collect the cells and resuspend in 200 μL DPBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spin", "to", "collect", "the", "cells", "and", "resuspend", "in", "200", "μL", ...
PMC11434983	On the other hand, lapatinib induces A431 cell line arrest in the G2/M phase .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "lapatinib", "in...
PMC5025404	For the best clones, production batches were carried out in the different media.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "best", "clones", ",", "production", "batches", "we...
PMC2944824	DNA damage, ER and other types of stresses induce apoptosis through a p53-dependent mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "damage", ",", "ER", "and", "other", "types", "...
PMC11350568	Subsequently, western blot analysis was employed to scrutinize alterations in the target protein on the cell membrane, with AptG-1, AptG-2, Sgc8c ∼ lib, and HG1–9 individually co-incubated with CCRF-CEM cells at 37 °C for 1 h. As illustrated in Figure 4a,b, the cells treated with AptG-1 displayed a notable reduction in PTK7 levels on the cell membrane compared to those treated with AptG-2 and Sgc8c ∼ lib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine"...
PMC11568601	Scale bar = 25 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "25", "μm", "." ] } ]
PMC10243817	These CRS subtypes demonstrate considerable differences in inflammatory and tissue remodeling features, associated with distinct responses to medical and surgical treatments (19–22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6803987	Furthermore, HBx protein was detected by western blot and the esculetin significantly inhibited the expression of HBx protein, and its inhibitory effect was stronger than with 3TC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496491	GO enrichment analysis results show the top 10 Term analysis charts that are most significant in terms of biological processes. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", "enrichment", ...
PMC10605143	On the other hand, the down-regulation of HSF1 in MCF12A cells was accompanied by increased CDH1 expression and a slight reduction in the SNAI2 level, while the VIM and CTNNB1 levels were not changed (Figure 3a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540692	Since current GBM treatments are ineffective, finding new therapeutic options are of great importance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "current", "GBM", "treatments", "are", "ineffective", ...
PMC11806106	Therefore, the lower efficacy of buprenorphine compared to the other agonists might be responsible for this effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "lower", "effi...
PMC11487720	UV/cold shock downregulated WWOX, TRAF2 and α-Tubulin proteins by ~ 50%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UV/cold", "shock", "downregulated", "WWOX", ",", "TRAF2", "and", "α-Tubulin...
PMC10452486	Dulberger et al. pointed out that there are ten conserved a.a residues that are critical for the architecture of the peptide-binding groove and for binding with specific peptide residues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705547	Cell-cell interactions in the TIME are also key determinants of cisplatin resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell-cell", "interactions", "in", "the", "TIME", "are", "also", "key", "determin...
PMC11055510	The localization of circMAN1A2 was consistent with that of the positive control GAPDH, which was mainly expressed in the cytoplasm (Fig. 1E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	BV+len showed promising clinical activity in a Phase 1 trial with a 57% overall response rate (ORR), 10.2-month median progression-free survival, and 14.3-month overall survival (Ward 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	All data were imported into GraphPad Prism (www.graphpad.com) for analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "were", "imported", "into", "GraphPad", "Prism", "(", "www.graphpa...
PMC11240448	Even large mTORi doses cannot move the MDA-MB-231 cell state from oncogenic to normal DPDonc scores, whereas high PKCi doses can.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11342785	Microtubule lattices were directly visualized with SiR-tubulin (green).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Microtubule", "lattices", "were", "directly", "visualized", "with", "SiR-tubulin", "(", "green", ...
PMC10667689	Interestingly, a significant rising trend was observed in glucose consumption and lactate release within 72 h of the experiment compared to the control and PMA groups in both cell lines ( Tables 2 , 3 , Figure 3 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190538	C-phycocyanin's mode of action wes investigated to fully understand its inhibitory effects on the HCoV-229E virus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C-phycocyanin", "'s", "mode", "of", "action", ...
PMC11519077	A calibrator sample was chosen from the control group, which received no treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "calibrator", "sample", "was", "chosen", "from", "the", "con...
PMC11680391	As a result, the dairy veterinarian of today needs a comprehensive soft-skills toolbox with a variety of skills that may be very different from the traditional veterinary college curriculum to have an impact on the bulk tank somatic cell count (BTSCC) as a measure of udder health .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Although these markers have been associated to an increased inflammatory state in cancer patients; other factors such as poor nutritional status, and advanced disease stage due to delayed access to specialized cancer care in our region may have contributed to the observed outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301095	Fig. 2 Appearances of cerebrospinal fluid and microscopic observations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2", "Appearances", "of", "cerebrospinal", "fluid", "and", "microscopic", "observations", "." ] ...
PMC11633763	Furthermore, HK2's major function in controlling energy metabolism serves as the foundation for its control of tumour growth .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "HK2", ...
PMC10165258	24 h later, spheroids are exposed to cisplatin and imaged.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "24", "h", "later", ",", "spheroids", "are", "exposed", "to", "cisplatin", "and", ...
PMC10965315	The results are expressed as means ± standard deviation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "are", "expressed", "as", "means", "±", "standard", "deviation", "." ] } ]
PMC11627133	This work introduces a novel protein labeling method based on bifunctional aptamers for super‐resolution imaging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "work", "introduces", "a", "novel", "protein", "labe...
PMC11467964	As a result, from 1 to 9, k = 2 exhibited to be the best selection, that is, categorizing the STS patients into two clusters (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	BM samples from AML patients are provided by the Laboratory for Leukemia Diagnostics, LMU University Hospital.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BM", "samples", "from", "AML", "patients", ...
PMC11757131	The PMECs were conducted exactly as previously described (15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PMECs", "were", "conducted", "exactly", "as", "previously", "described", "(", ...
PMC11656657	GD2 expression was detected in 55% of the primary tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GD2", "expression", "was", "detected", "in", "55", "%", "of", "the", "primary", ...
PMC11257988	Ghimessy et al. analyzed the effect of the KRAS mutation subtype on bevacizumab (vascular endothelial growth factor inhibitor) and found that BEV had lower activity in KRAS-mutant tumors, especially in KRASG12D-mutant stage III–IV LUAD patients than in non-KRAS-mutant LUAD patients .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422150	While inflammation after SCI can have some beneficial effects, the excessive infiltration of immune cells is a primary driver of neural degeneration (Glaser et al., 2004; Garcia et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10652261	Mp 115–116 °C.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Mp", "115–116", "°", "C", "." ] } ]

PMC11641630

However, migration also plays a critical role in tumor formation and dissemination, including in BC .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "migration", "also", "plays", ...

PMC11363012

Untargeted scMS was performed on approximately 200 cells from each of the five tissue samples (Table S5 and Figures S6–S10).

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PMC11089031

B ZNF692 mRNA expression across histological stages of ccRCC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "ZNF692", "mRNA", "expression", "across", "histological", "stages", "of", "ccRCC", "." ] } ]

PMC8759873

Digest the cells with 0.25% trypsin, centrifuge, inoculate 0.5 × 104 cells/well in a 96-well culture plate, 200 cell suspension per well, 3%, 5% CO2 incubator incubate overnight.

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PMC6468656

The cells were lysed at 4 °C in RIPA buffer containing 50 mM Tris-HCl (pH 7.4), 150 mM NaCl, 1% Triton X-100, 0.25% sodium deoxycholate, 5 mM EDTA (pH 8.0), and 1 mM EGTA supplemented with protease and phosphatase inhibitors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11707832

Deficiency in MAN2B1 leads to impaired lysosomal function and compromised glycoprotein degradation, resulting in the gradual accumulation of mannose-rich oligosaccharides in cells and tissues, culminating in α-lysosomal storage disease .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Methods: Recombinant CTPS1 and CTPS2 enzymatic activity was assessed by quantitating cytidine triphosphate by RapidFire Mass Spectrometry.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Recombinant", "CTPS1", ...

PMC11468365

In challenging diseases, targeting multiple biochemical pathways within a cell with a single drug is often inefficient.

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PMC11266100

The role of Ca ions in the EP buffer has also been reported.

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PMC5839394

p < 0.05 was considered significant; p < 0.01 was considered highly significant and p < 0.001 was considered very highly significant.

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PMC11759751

There was no significant difference in tumor size between the Vehicle group and the Chidamide group.

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PMC10890307

We found that compared to Jurkat cells, lung cancer cell lines had a doubling time that ranged from 18 h to 30 h in media containing 10 mM glucose.

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PMC9429973

Thus R/R MM constitutes a significant unmet medical need.

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PMC11657744

Schematic model depicting the functional specialization of DA proteins during ciliary dynamics.

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PMC11201245

As a positive control for OC-FISH test, we used three primary ovarian cancer cultures and ovarian cancer cell lines OVCAR 3, OVCAR 8, and SKOV 3.

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PMC11706491

Rep2 promotes START by MBF activation and Cdc25 promotes mitosis entry by activating the CDK Cdc2. (

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PMC11714165

In addition, laser scanning confocal microscopy (LSCM, Leica SP8, Germany) was used to confirm the co‐localization of NBD‐F and D‐NBD‐F in the co‐assembled nanoparticles.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11470999

In conclusion, our study provides compelling evidence that PF can be repositioned as an effective therapeutic agent for melanoma and its brain metastasis by promoting CIP2A degradation and restoring PP2A activity.

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PMC11381192

Although the prognostic value of CSI is apparent, further verification through large‐scale multicenter studies is necessary.

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PMC7685376

A–F) The mRNA levels of cell cycle related genes in SK-Hep1 cell lines treated with Huaier (0 and 15 mg/mL) for 24 h with or without a knockdown of indicate.

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PMC11467964

Differences in risk score between the two subtypes. (

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PMC11786767

To confirm that the labeling of biotin-DHPE was lipid dependent, 100% methanol or 100% acetone were added separately into PFA-fixed cells for 10 min at 20°C.

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PMC8193046

Compounds 16–25 were screened at 10 µM in calcein AM (ABCB1 and ABCC1) as well as pheophorbide A (ABCG2) fluorescence accumulation assays using either ABCB1-overexpressing A2780/ADR, ABCC1-overexpressing H69AR, or ABCG2-overexpressing MDCK II BCRP cells, respectively, as reported earlier , , , , .

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PMC11739484

Fig. 10The effects of MMP7 knockdown on A375 cells. (

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PMC11489275

The mortality rate of class 2 and class 3 patients was significantly higher than that of the normal lymphocyte group (Table 3).

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PMC11269933

The results in Figure 3D showed that the density of water molecules near the K279 core catalytic site in the S11 phosphorylated system is higher than that in the wild-type system.

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PMC11725127

All manipulations were approved by the Medical Science Ethics Committee of SJTU-SM.

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PMC9429973

Results: Interviewed HCPs (n=219) were composed of 48% hematologists, 37% hematologist-oncologists, 11% pediatric hematologists, 1% pediatricians, 1% internists, and <1% general or family practitioners.

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PMC10158546

These inocula have been used in an unrelated, ongoing in vivo mouse experiment and display the expected amount of infectivity (J. Myskiw et al, unpublished data).

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PMC11547917

Other classes of compounds were identified by gas-chromatography analyses from A. tagala leaves extracted in different types of solvents, hydroalcoholic and methanolic, showing the most diverse biologically potent compounds (e.g., alkaloids, flavonoids) .

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PMC11803918

Further local laser irradiation to the tumor lesions will activate photosensitizers to eradicate tumor tissue via ROS generation without impacting normal tissue and to induce immunogenic cell death (ICD) for long-term antitumor immunity.

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PMC6889484

Replication kinetics of CCR5-tropic subtype C clone MJ4 in parental PM1 cells, with no detectable virus in PM1/D128K cells 26 days post-infection.

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PMC11705547

A preclinical study showed that cisplatin down-regulates the transcription factor c-Myc in human ovarian carcinoma cells by inhibiting miR-145, which increases PD-L1 expression and leads to the apoptosis of CTLs, eventually resulting in cisplatin resistance .

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PMC11707832

Recently, a seven-month-old dog displaying progressive neurological symptoms and brain atrophy was euthanised, and microscopic examination confirmed a lysosomal storage disease.

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PMC10926885

The top 8 miRNAs targeting NDE1 were displayed in Targetscan database. (

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PMC9341513

The data showed trends which were generally consistent with the simulations: the CCND1 probe volume was, on average, 30% larger in U266 compared to GM12878, and the MYEOV probe was, on average, 23% larger.

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PMC9096373

RT, radiotherapy; DDPs, cisplatin; APA, apatinib; Ki-67, proliferating cell nuclear antigen; γ-H2AX, histone H2AX family member; IHC, immunohistochemistry.

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PMC11576293

The replacement of the di-aryl pyrimidine group at the 4 and/or 6-positions is essential for activity and is another area of interest.

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PMC9429973

To analyze the association between exposure variables and thromboembolic events, logistic regression models were used to estimate unadjusted and adjusted odds ratios (ORs) with their 95% confidence intervals (CI 95%).

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PMC11730320

Both pipelines were based on the b37 genome reference.

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PMC11443022

45,X/46,XY mosaicism is a rare anomaly in sexual differentiation, presenting with diverse phenotypes and often leading to infertility due to abnormal gonadal development.

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PMC9096373

Our study demonstrated that the extent of apoptosis in tumor cells within the APA + RT group was significantly higher compared with the control, RT, and DDPs + RT groups.

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PMC11597291

The yield of the nCGO-PEG conjugates was in the range of 14–32% wt, depending on the MW of the mPEG-NH2 polymers.

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PMC11269792

pcDNA 3.1-circAPP and si-CDV3 were co-transfected, (A) Expression changes of miR-6838-5p, (B) Expression changes of CDV3, (C and D) Colony formation and EdU assays to assess cell proliferation, (E) Flow cytometry to analyze apoptosis, (F) Cellular glucose consumption, lactate production, and ATP levels, (G) ATP/ADP ratio and NAD/NADH ratio, (H) Western blot to evaluate cellular HK2 and PKM2 protein expression; data are expressed as mean ± SD (n = 3). *

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PMC11502443

FBS (50%) in pERK1/2 and pAKT or 50 μM forskolin in pCREB assays were used as positive controls.

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PMC11474209

Cytotoxicity45HepG2 cells0.01, 0.1 and 1 µg/mLFpg, AraC and HUPP1, PP2ADNA damage, oxidative pyrimidine DNA damage, ROS productionInitiate tumorAbbreviations: Bcl-2: B-cell leukemia/lymphoma 2 protein; cdc2: Cell division control 2; cdc25C: Cell division cycle 25; cGAS: Cyclic GMP-AMP synthase; cGAS-STING signaling pathway: Cyclic GMP–AMP synthase-stimulator of interferon gene signaling pathway; c-Myc: Cellular Myc; COX2: Cyclooxygenase enzyme; CTNNB1: Ctenin Beta 1; ERα: Estrogen receptors alpha; FAK: Focal adhesion kinase; FOXM1: Forkhead box M1; GS: Glycogen synthase; GSK-3: Glycogen synthase kinase 3; GSK3β: Glycogen synthase kinase 3 β; GSK3β: Glycogen synthase kinase 3 β; HAVSMCs: Human aortic vascular smooth muscle cells; HCC: Hepatocellular carcinoma; HIF-1α: Hypoxia-inducible factor 1-alpha; HL7702 cell: Human normal liver cells; HSP27: Heat shock protein 27; Hsp90: Heat shock protein 90; HUC-1 cells: Human uroepithelial cells-1 cells; HUVECs: Human umbilical vein endothelial cells; INS: Insulin; IRS1: Insulin receptor substrate 1; JAK2: Janus kinase 2; Krt16: Keratin 16; MAPK: Mitogen-activated protein kinases; MLC: Myosin light chain; MMP: Mitochondrial membrane potential; MMP7: Matrix metalloproteinase-7; mTOR: Mammalian target of rapamycin; P53: Tumor protein 53; PI3K: Phosphatidylinositol-3 kinase; PI3K: phosphoinositide 3-kinase; ROCK: Rho-associated protein kinase; ROS: Reactive oxygen species; S6K1: Ribosomal protein S6 kinase beta-1; SGC-7901 cells: Human gastric cancer cell line; STAT3: signal transducer and activator of transcription 3; VASP: vasodilator-stimulated phosphoprotein; VEGFCyclin D1: Vascular endothelial growth factor Cyclin D1; PPI3/AKT: phpsphoinositide 3-kinase/protein kinaseB; HL7702: Human normal liver cell line; OATP1B1: Organic anion transporting polypeptide 1B1; OATP1B3: Organic anion transporting polypeptide 1B3; L02: Human normal liver cell line; HepG2: Human hepatoma cell line; RWPE-1: Epithelial cell derived cell line; LX-2: Human hepatic stellate cell line; NCM460: Human normal intestinal epithelium cell line; HepG2: Human hepatoma cell line; L02: Human normal liver cell line: CaCo2: Cancer coli-2 cell line.

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PMC11721064

To further assess the efficacy of our approach in reconstructing the cornea, future corneal wound healing experiments will need to be conducted to evaluate the therapeutic outcomes on the ocular surface.

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PMC10142392

An analysis of the literature shows that the field has undergone a major expansion from a small group to a growing list of researchers, as reflected by the number of publications in recent years (Figure 1).

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PMC11764090

ex A. Juss.)

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PMC9429973

Key inclusion criteria were newly diagnosed AML, age ≥60 years, eligible for IC, WHO performance status 0-2.

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PMC11791432

For in vivo studies, 1 × 10 luciferase-expressing U87 cells (both NC and shANXA1 groups) were intracranially injected into the right caudate nucleus of BALB/c mice using a stereotactic apparatus.

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PMC9516401

In contrast to HEPV, the mechanism through which, both C. colocynthis and P. oleracea extracts could induce anti-diabetic effects has been well-established in previous studies.

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PMC11721587

We speculate that deSUMOylation is required for the breakdown of interdimer SUMO-SIM interaction to free mature Fu from the condensates, whereas re-SUMOylation may create new intradimer SUMO-SIM interaction to facilitate Fu conformational maturation through molecular cross-linking (Fig. 8).

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PMC11751675

Collectively, these results highlight brevilin A and related SLTs as encouraging candidates for further development in influenza therapy.

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PMC11742670

The proposed CNN architecture.

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PMC11574271

B The tumor growth was assessed daily and represented in a line chart.

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PMC5025404

After amplification, subcloning was carried out with three prospective mini-pools using limiting dilutions.

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PMC9429973

The second most discussed stage of patient journey was treatment (44%); blood transfusions was the most mentioned treatment (34%), which was generally found to be effective.

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PMC10958426

By integrating the 10x Genomics scRNA-seq data from Lee et al. , we obtained scRNA-seq data of 36 samples from 12 patients.

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PMC9429973

It often affects males with a median age between 55 and 60 years.

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PMC7305184

According to our results PEF treatment can thus be used for repeated treatments with similar efficiency as the initial treatment.

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PMC9429973

The proportions of patients with high-risk cytogenetic abnormalities (HRCAs), defined as amplification 1q21, deletion 17p, t(4,14) and t(14,16), were lower in L-MT without ASCT and I-MT with ASCT.

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PMC11641630

Both mycobacteria inhibited individual cell migration across all BC lines, while collective migration was only reduced in intermediate-grade cells.

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PMC10587429

Spin to collect the cells and resuspend in 200 μL DPBS.

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PMC11434983

On the other hand, lapatinib induces A431 cell line arrest in the G2/M phase .

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PMC5025404

For the best clones, production batches were carried out in the different media.

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PMC2944824

DNA damage, ER and other types of stresses induce apoptosis through a p53-dependent mechanism.

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PMC11350568

Subsequently, western blot analysis was employed to scrutinize alterations in the target protein on the cell membrane, with AptG-1, AptG-2, Sgc8c ∼ lib, and HG1–9 individually co-incubated with CCRF-CEM cells at 37 °C for 1 h. As illustrated in Figure 4a,b, the cells treated with AptG-1 displayed a notable reduction in PTK7 levels on the cell membrane compared to those treated with AptG-2 and Sgc8c ∼ lib.

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PMC11568601

Scale bar = 25 μm.

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PMC10243817

These CRS subtypes demonstrate considerable differences in inflammatory and tissue remodeling features, associated with distinct responses to medical and surgical treatments (19–22).

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PMC6803987

Furthermore, HBx protein was detected by western blot and the esculetin significantly inhibited the expression of HBx protein, and its inhibitory effect was stronger than with 3TC.

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PMC11496491

GO enrichment analysis results show the top 10 Term analysis charts that are most significant in terms of biological processes. (

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PMC10605143

On the other hand, the down-regulation of HSF1 in MCF12A cells was accompanied by increased CDH1 expression and a slight reduction in the SNAI2 level, while the VIM and CTNNB1 levels were not changed (Figure 3a).

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PMC8540692

Since current GBM treatments are ineffective, finding new therapeutic options are of great importance.

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PMC11806106

Therefore, the lower efficacy of buprenorphine compared to the other agonists might be responsible for this effect.

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PMC11487720

UV/cold shock downregulated WWOX, TRAF2 and α-Tubulin proteins by ~ 50%.

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PMC10452486

Dulberger et al. pointed out that there are ten conserved a.a residues that are critical for the architecture of the peptide-binding groove and for binding with specific peptide residues.

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PMC11705547

Cell-cell interactions in the TIME are also key determinants of cisplatin resistance .

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PMC11055510

The localization of circMAN1A2 was consistent with that of the positive control GAPDH, which was mainly expressed in the cytoplasm (Fig. 1E).

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PMC9429973

BV+len showed promising clinical activity in a Phase 1 trial with a 57% overall response rate (ORR), 10.2-month median progression-free survival, and 14.3-month overall survival (Ward 2021).

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PMC11489351

All data were imported into GraphPad Prism (www.graphpad.com) for analysis.

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PMC11240448

Even large mTORi doses cannot move the MDA-MB-231 cell state from oncogenic to normal DPDonc scores, whereas high PKCi doses can.

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PMC11342785

Microtubule lattices were directly visualized with SiR-tubulin (green).

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PMC10667689

Interestingly, a significant rising trend was observed in glucose consumption and lactate release within 72 h of the experiment compared to the control and PMA groups in both cell lines ( Tables 2 , 3 , Figure 3 ).

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PMC11190538

C-phycocyanin's mode of action wes investigated to fully understand its inhibitory effects on the HCoV-229E virus.

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PMC11519077

A calibrator sample was chosen from the control group, which received no treatment.

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PMC11680391

As a result, the dairy veterinarian of today needs a comprehensive soft-skills toolbox with a variety of skills that may be very different from the traditional veterinary college curriculum to have an impact on the bulk tank somatic cell count (BTSCC) as a measure of udder health .

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PMC9429973

Although these markers have been associated to an increased inflammatory state in cancer patients; other factors such as poor nutritional status, and advanced disease stage due to delayed access to specialized cancer care in our region may have contributed to the observed outcome.

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PMC11301095

Fig. 2 Appearances of cerebrospinal fluid and microscopic observations.

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PMC11633763

Furthermore, HK2's major function in controlling energy metabolism serves as the foundation for its control of tumour growth .

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PMC10165258

24 h later, spheroids are exposed to cisplatin and imaged.

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PMC10965315

The results are expressed as means ± standard deviation.

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PMC11627133

This work introduces a novel protein labeling method based on bifunctional aptamers for super‐resolution imaging.

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PMC11467964

As a result, from 1 to 9, k = 2 exhibited to be the best selection, that is, categorizing the STS patients into two clusters (Figure 2B).

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PMC9429973

BM samples from AML patients are provided by the Laboratory for Leukemia Diagnostics, LMU University Hospital.

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PMC11757131

The PMECs were conducted exactly as previously described (15).

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PMC11656657

GD2 expression was detected in 55% of the primary tumors.

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PMC11257988

Ghimessy et al. analyzed the effect of the KRAS mutation subtype on bevacizumab (vascular endothelial growth factor inhibitor) and found that BEV had lower activity in KRAS-mutant tumors, especially in KRASG12D-mutant stage III–IV LUAD patients than in non-KRAS-mutant LUAD patients .

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PMC11422150

While inflammation after SCI can have some beneficial effects, the excessive infiltration of immune cells is a primary driver of neural degeneration (Glaser et al., 2004; Garcia et al., 2016).

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PMC10652261

Mp 115–116 °C.

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