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OTAR3088
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BioData-CellLine_annotated

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PMC11757230
Bioluminescence images of lungs taken from xenotransplantation mouse models treated with different doses of cADSCs. (
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PMC6892818
For activation of CD40 by soluble agonist, epithelial cells were treated with G28-5 mAb cross-linked with goat anti-mouse IgG antibody (Sigma).
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PMC11641630
For measuring the activity of secreted matrix metalloproteinases (MMPs), conditioned media were obtained from mycobacteria-infected and non-infected T24 and 5637 cells incubated for 72 h in FBS-free medium.
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PMC11673902
EFC combines microfluidic technology and electroporation to enable the detection of cellular deformations through the following steps (Figure 2):i.
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PMC11201245
Hybridization takes place overnight at 37 °C.
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PMC9596868
C, D) Percentage cell viability after combination treatment with quercetin and MST-312 in A2780 cells. (
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PMC9429973
Summary/Conclusion: High or low myeloid skewing is a common finding in the general population, and not restricted to individuals >60 years.
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PMC11742431
With the same concentration of the working protein, only the high level of PD‐L1 expression on the cell surface could make the working proteins enter intracellularly in large amounts and then exercise the subsequent functions.
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PMC11786704
Quantitative result of p-p38 in wound skin. (
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PMC9429973
Venetoclax was administered at the dose of 400 mg daily after a short ramp-up.
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PMC9429973
H. Erba, D. Pollyea, M. Sekeres, G. Garcia-Manero, K. Seiter, I. DeGutis, P. Kiselev, A. McBride, E. Yu, G. Roboz Duke University, Durham; University of Colorado, Aurora; Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami; The University of Texas MD Anderson Cancer Center, Houston; New York Medical College, Valhalla; Bristol Myers Squibb, Princeton; Weill Cornell Medicine; New York-Presbyterian Hospital, New York, United States of America Background: Pts with AML in RCTs often do not reflect the population seen in clinical practice due to strict eligibility criteria.
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PMC11569208
To further exploit this mechanism for therapeutic gain, we encoded a short-hairpin RNA (shRNA) against ACP2 into oncolytic vesicular stomatitis virus (VSV∆51) under a miR-30 promoter.
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PMC11706776
A similar decrease of KCNN1 expression at the mRNA level was obtained after 7 days of doxycycline treatment (Supplementary Fig. 5B).Fig.
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PMC11765879
This was supported by our results that revealed suppression of p38 MAPK and upregulation of NF-κB after exposure to ZSC extract.
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PMC9429973
According to the European Research Initiative on CLL recommendations, IgHV mutational status was determined by amplifying the IgHV transcript by PCR, sequencing the gene through Sanger sequencing, and comparing the transcript to known germline genes available in immunoglobulin databases.
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PMC11794588
The results showed that fractions 31–38 consistently exhibited cytotoxic activity, suggesting the presence of a potent active antitumor component.
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PMC7504302
In conclusion, executing data curation based on different selection criteria can effectively provide scientists with distinct results that would complement their research interests.
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PMC9261184
This paper begins to fill this critical knowledge gap by conducting the first total methane and CO2 emissions measurement campaign for an LNG carrier.
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PMC11532793
In the lung adenocarcinoma cell lines data, this phenomenon was observed for transcripts HABP2-201 and HABP2-203 of the tumor suppressor gene HABP2 (24).
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PMC11612508
Regular harvesting was done using a solution of trypsin–EDTA (0.25%).
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PMC11694109
In this respect, TCL offer unique challenges.
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PMC11721064
The resulting LNCs were plated on Matrigel-coated well plates and further purified using MESCM.
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PMC11721064
Studies have suggested that niche cells can secrete various chemotactic factors to activate receptors on the cell surface, thereby altering cell developmental pathways.
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PMC9429973
Compared to fit patients, the HRs for all-cause mortality for prefrail and frail patients were: 1.6 (1.3-1.9), and 3.6 (2.9-4.4) in ET; 1.3 (1.1-1.5) and 2.7 (2.1-3.4) in PV, and 1.2 (1.0-1.5) and 2.0 (1.5-2.7) in MF.
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PMC11206251
Moreover, Western blot results showed that the PEIM could induce apoptosis of HepG2 cells due to upregulation of P53, P21, cytochrome-C, caspase-9, and caspase-3, as well as downregulation of cyclinD1, CDK, MDM2, and Bcl-2 expression.
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PMC11756514
Langerin and MGL are both type II transmembrane proteins found on antigen-presenting cells.
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PMC11310713
The micro-sized hydrogel beads were designed to mimic ovarian structures, such as the distribution of ovarian follicles within the ovary.
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PMC9429973
The myocardial extracellular volume (ECV) by CMR has been introduced as a surrogate marker of diffuse interstitial myocardial fibrosis, significantly associated with MIO.
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PMC9429973
The new method has superior interobserver concordance at low plasma cell densities.
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PMC9019892
GIST‐5R, GIST‐T1‐T670I and GIST‐T1 cell lines were cultured in Dulbecco's Modified Eagle Medium (DMEM; Corning, Manassas, VA, USA) with 10% FBS (ExCell Bio, Guangzhou, China).
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PMC11768927
Thus, these viruses present safer alternatives to WT VSV for oncolytic applications .
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PMC11224020
cPLA2 is in gray, and nuclei are in red; scale bar, 10 µm.
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PMC11711663
Optimal model (minimum λ) has 5 degrees of freedom.
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PMC10605143
The EMT plays an important role in breast development.
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PMC10454535
In relation to cleaved caspase-3 expression, the protein expression from the combination treatment was significantly greater than the expression from 5 nM BTZ alone, which is the more potent component of the treatment versus the 5 μM PIN component (Figure 5a).
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PMC11206502
The HB effects on autophagy induction were considered at the gene transcription level as well.
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PMC11144382
Thus, the fibroblast and in vitro expression studies confirmed that frameshift mutations in NFIX exons 6-8 generate transcripts that escape NMD and encode truncated NFIX proteins.
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PMC10656496
Gene-level expression was quantified using HTSeq v0.6.1 based on the RefSeq gene model downloaded from USCS Table Browser.
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PMC11511922
Labeled samples of exo-N and exo-S2 were incubated with different cancer cell lines at 4 °C or 37 °C.
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PMC11714165
For the LDH assay, different concentrations of peptides were added to 143B cells as described above.
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PMC10965680
After aligning the clean reads with the Capra Hircus reference genome (GCA_001704415.2), we obtained 4.08 million reads with an average mapping rate of 98.37% and coverage depth of 12.39× (Supplementary Table S2).
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PMC7504302
Further studies are therefore needed for a thorough understanding of the biological basis of MPM, especially in the context of genetic, epigenetic, and transcriptomic alterations.
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PMC11769522
In addition, IL-4 and IL-13 stimulation on keratinocytes has been reported to downregulate the process of epidermal barrier formation in vitro .
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PMC11680562
In another study, Dulta et al. found that 77 nm-sized green CuO NPs produced using Carica papaya leaf extract showed anticancer properties on HeLa cells, with an IC50 value of 139.6 μg/mL measured .
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PMC11180402
For example, SOX2 reportedly promotes the invasion of MIBC cells .
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PMC11564405
This intricate compilation serves as a comprehensive repository, enabling users to not only conduct efficient analyses but also to visually dissect the dynamic nuances inherent in the realm of anticancer immunity.
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PMC9429973
These data support the need to incorporate blood count into risk stratification and treatment strategies for pts with PV in clinical practice and to move beyond the conventional risk model.
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PMC11786704
All quantitative data are expressed as mean ± standard error (SD), n = 3.
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PMC9429973
Results: Of the 50 randomized patients, 49 patients received the study treatment and 46 patients completed the study.
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PMC11013014
Column chromatography was performed on silica gel 60 (230–400 mesh, 0.040–0.063 mm).
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PMC6742971
Hundred microliter of BCIP/NBT buffer was added to every well and the plates were incubated for 5–15 min, monitoring spot formation visually throughout the incubation period for sufficient color development.
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PMC5308810
The cell suspension was strained through a 40 μm cell strainer (BD Biosciences).
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PMC11637284
The TAC and the spindle are both filament-based structures and extend, although in opposite directions, from the same type of microtubule (MT)-organizing centers: the BB (in case of the TAC) and the centriole (in case of the spindle).
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PMC11747885
A lack of the methyl group for compound 26 or the exchange to a trifluoromethyl group at the C6 position group has no effect on the inhibition.
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PMC11731161
As shown in Fig. 5B, C, the relative expression levels of USP7 mRNA and protein in U266 and RPMI-8226 cells were significantly higher compared to those in NCI-H929 and MM.1S cells.
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PMC11078693
Wipe each cover glass dry with a lens cleaning tissue and lay it on parafilm.
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PMC11033180
Whole-mount myenteric plexus of distal colons were immunolabeled for Sema5A, Plexin A1, or Plexin A2 in combination with markers of neuronal cell bodies (Hu), axonal fibers (β3-tubulin), and glial cells (S100β).
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PMC11711127
Although treatment with CAR T cells has produced remarkable clinical responses with certain subsets of B cell leukaemia or lymphoma, many challenges limit the therapeutic efficacy of CAR T cells in solid tumours and other haematological malignancies.
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PMC11661024
If required, any additional data will be available from the corresponding author upon request.
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PMC9275501
The inappropriate proportion of drugs may cause antagonism of combined drug administration and reduce the therapeutic effect.
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PMC10538569
To test whether restriction of R5-tropic HIV-1 in the iDC-T cell co-cultures is due to blocking of cell-cell transmission to CD4 T cells expressing GPI-scFv X5, we co-cultured iDCs-HIV-1 Yu-2 with or without CEMss-CCR5-GPI-scFv X5 or AB65 or CEMss-CCR5-CR2N cells.
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PMC10237474
All cells were incubated in a 37°C humidified shaker at 120 rpm with 5% CO2 and split twice a week.
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PMC9429973
no CBFB::MYH11, PML::RARA or RUNX1::RUNX1T1 fusion, no ASXL1, CEBPA, FLT3, NPM1, RUNX1 or TP53 mutation) (Figure 1A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC3675084
The purified DNA and loading dye was subjected to 1% agarose gel electrophoresis at 50 V for 10 min and 100 V for 1 hour.
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PMC11670954
Specifically, BA increases TEER, reduces FD-4 flux, and maintains barrier integrity.
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PMC9275501
Meng et al. (2016b) encapsulated PTX and BCL in nanoemulsion (PTX/BA NM) to treat breast cancer.
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PMC8973725
CCK8 and colony formation assays were performed to estimate the effect of ZNF677 on cell proliferation.
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PMC8540692
No changes in DNA methylation level of SFRP1 were, however, detected in U-138 MG cell line.
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PMC9429973
Summary/Conclusion: Our study confirmed the findings of previous studies that the use of ibrutinib in the treatment of R/R MCL was effective and reliable.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973
No relapses or deaths were reported within this subgroup.
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PMC10877303
Kihadanin B (486.51 g/mol) with 1 hydrogen bond donor and 9 hydrogen bond acceptors, Robustaflavone (538.46 g/mol) with 6 hydrogen bond donors and 10 hydrogen bond acceptors, and 3-beta-O-(trans-pCoumaroyl) maslinic acid (618.84 g/mol) with 3 hydrogen bond donors and 6 hydrogen bond acceptors meet the drug-likeness criteria.
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PMC11075223
The structure–activity relationship of these compounds need to be strengthened so as to carry out more in-depth research.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "structure", "–", ...
PMC11286266
Cells were washed twice with prechilled phosphate-buffered saline (PBS) on ice, and whole-cell extracts were scrapped out in 1 mM EDTA (Ethylenediaminetetraacetic Acid)–PBS, pelleted at 370 × g for 10 min at 4°C and incubated in Nonidet P40 (NP-40) lysis buffer (150 mM NaCl, 50 mM Tris–HCl pH 7.5, 1% (vol/vol) NP-40) supplemented with 2× protease inhibitor cocktail (Roche Applied Science) for 30 min.
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PMC11790971
Recent studies have employed various approaches to uncover these connections, such as statistical analysis linking intracellular metabolites to mAb productivity and ML approaches predicting cell line performance based on the temporal evolution of metabolic phenotypes at early process timepoints.
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PMC6337547
The flavonoids in Chinese Salvia species should be analysed using modern analytical techniques, such as liquid chromatography-tandem mass spectrometry to supplement current knowledge on the chemical composition of phenolic acids.
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PMC10582049
In conclusion, we showed that ADH1B CAFs deficiency in early-stage LUADs is associated with tumor aggressive behavior.
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PMC11544122
d, e SNX9 binding to CXCR4 was examined by microscale thermophoresis (MST).
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PMC9429973
Cell cycle analysis showed G1 arrest and increased sensitivity of venetoclax.
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PMC11012313
This motif is responsible for binding and activating Syk kinase that subsequently activates downstream pathways that promote both proliferation and survival.
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PMC5600151
By associating the PLL dendrimers with DOX, they attempted to combine the anti-cancer effect of the drug and antiangiogenic effect of the carrier .
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PMC9429973
All patients were symptomatic.
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PMC9429973
Likewise, PFS was significantly shorter in del(1p32) patients (18.1 and 29.1 months, respectively, P < 0.0001).
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PMC10728535
Gene Ontology (GO) and pathway enrichment analysis were performed for DEGs through the web‐based enrichment analysis tool, Enrichr (https://maayanlab.cloud/Enrichr/), containing >180 000 curated gene sets in multiple categories from >100 gene set libraries.
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PMC11718109
Following recovery from high K stimulation, the majority of SVs were positive for HRP, indicating that the large pool of newly-formed SVs originated from the large vacuoles induced by high K stimulation (Supplementary Fig. 2F–H).
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PMC11680578
Error bars represent the mean ± SEM of three independent experiments. ***
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PMC5415764
The data was presented as the mean and standard deviation of 6 replicates.
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PMC11087055
The initiation of the polonaise movements was set as Time 0 (t=0).
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PMC11354225
Then, cells were washed with DPBS 1X and fixed with cold methanol.
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PMC9429973
All patients were treated COVID-19 in accordance with the current guidelines for the prevention, diagnosis and treatment of COVID-19 (interleukin 6 inhibitor, anticoagulant and antibacterial therapy, glucocorticoids (GCs), human immunoglobulin (IG) against COVID-19).
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PMC11791264
Each bar represents the mean ± SD (n = 3).
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PMC11297139
Scale bar: 5 μm.
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PMC11732628
P<0.01, ***, P<0.001.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P<0.01", ",", "*", "*", "*", ",", "P<0.001", "." ] } ]
PMC10582049
Expression of ECM proteins in the samples with low (n = 105), intermediate (n = 209), and high (n = 105) expression of ADH1B (TCGA dataset).
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PMC9429973
However, only a subset of ABC-DLBCL respond well to ibrutinib-containing regimen (Wilson et al., 2021, Cancer Cell 39, 1643–1653).
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PMC11725127
Other than developing small-molecule inhibitors, a potential approach could be to promote the degradation of KRAS.
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PMC11078693
If imaging with an oil lens, carefully aspirate PBS and slowly add mounting medium in an amount sufficient to cover the cells.
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PMC9429973
We speculate that adding a FLT3-ITD inhibitor could improve the complete remission (CR) and overall survival (OS) rates in this setting.
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PMC11591052
Importantly, 20E-induced expression of metabolic genes was not concentration-dependent, and the effect was observed in the whole range of concentrations (0.1–100 µM) tested.
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PMC11190238
In both the stem cell differentiation model (Fig. 4a) and the cancer EMT cell line model, the A/B compartments housing EMT genes displayed dynamic changes and conservation across different EMT transitional phases.
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PMC11587606
F-I) The (F) protein and (G) mRNA levels of p-PKCζ and PKCζ in (F, G) MCF10A/GFP and MCF10A/RH, and (H, I) Dox-treated TetON-RH in 3D acini cultures (n = 3). (
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