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OTAR3088
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BioData-CellLine_annotated

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PMC11659734
BPA exhibited the lowest genotoxic effect after 3 h of exposure compared to BPE and BPP.
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PMC11568601
After dewaxing in xylene, the paraffin sections were rehydrated with gradient alcohol.
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PMC3765139
In general, HBL emerged as an outstanding cell line in our panel since virtually all cells expressed CD117 with relatively high intensities (Figure 1F).
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PMC10728200
The sample variation within each group was estimated to ensure that the variance is similar.
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PMC11506827
For instance, research by Obaidi et al. demonstrated that curcumin could inhibit the proliferation and cell cycle of TRAIL-resistant renal cancer cells by increasing the expression of the let-7C gene.
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PMC9429973
F. B. Askeland, A.-M. Rasmussen, A. Lysen, E. Haukås, A. Eilertsen, M. Moksnes, G. Tsykunova, A. Vik, B. D. Eiken, J. H. Sørbø, J. Rolke, K. O. Sand, R. F. Hallstensen, L. Myrseth, T. S. Slørdahl, F. Schjesvold Oslo Myeloma Center, Department of Hematology; KG Jebsen Center for B Cell Malignancies, Oslo University Hospital, Oslo; Department of Hematology and Oncology, Stavanger University Hospital, Stavanger; Department of Hematology, Akershus University Hospital, Oslo; Cancer and Hematology Center, Vestfold Hospital, Tønsberg; Department of Medicine, Haukeland University Hospital, Bergen; Department of Hematology, University Hospital of North Norway; Institute of Clinical Medicine, UiT, The Artic University of Norway, Tromsø; Department of Oncology, Hospital Østfold, Kalnes; Medical Department, Levanger Hospital, Levanger; Department of Hematology, Sørlandet Hospital, Kristiansand; Department of Medicine, Ålesund Hospital; Department of Reasearch and Innovation, Møre og Romsdal Hospital Trust; Department of Health Sciences in Ålesund, Norwegian University of Science and Technology, Ålesund; Department of Hematology, Nordland Hospital, Bodø; Department of Hematology, St. Olavs Hospital; Norwegian University of Science and Technology (NTNU), Trondheim, Norway Background: Although many new treatment modalities have become available, multiple myeloma (MM) is nevertheless considered an incurable disease.
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PMC11237030
In summary, we generated a new and efficient human CHO-K1/AQP5 cell line that could be used as tool to perform cell-based biopanning for the generation of monoclonal antibodies targeting AQP5 and to perform functional studies on AQP5 translocation (Fig. 6).
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PMC11634027
Binding between Ds and Fat is modulated by Four-jointed (Fj), a Golgi-localized kinase that phosphorylates their cadherin domains (Brittle et al., 2010; Ishikawa et al., 2008; Simon et al., 2010; Strutt and Strutt, 2002).
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PMC9429973
All tests were performed by the DiaMed tube gel system.
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PMC11756937
At the MB freeze of external hiPSCs and at the freeze recovery of QC of hiPSCs DB vials, inoculation of broth tubes was conducted in addition to sample submission for mycoplasma testing.
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PMC10656496
Briefly, we utilize a system to evaluate combinations with the aim of rapidly translating that data into clinical trials.
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PMC9429973
Contrary to what has been described in other scenarios, in our cohort, IO was not associated with worse outcomes.
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PMC11583690
Therefore, MSN's Brunauer–Emmett–Teller surface area was calculated to be 1,394.738 m/g, its pore diameter was approximately 2.909 nm, and its pore volume was 1.577 cm³/g based on the Barrett–Joyner–Halenda theory.
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PMC11546117
Primary cultures also offer the possibility of representing natural population variability through true biological replicates, or the use of pooled cultures of multiple subjects.
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PMC9429973
Ig use was not associated with overall survival benefit (HR=0.72, 0.46-1.14, p=0.16).
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PMC11411131
Cos-7 cells expressing FLAG-TrxR1-HA were treated with 6 µM MeHg for 24 h in the presence or absence of 50 µg/ml cycloheximide (Chx), a protein synthesis inhibitor.
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PMC10728200
STUB1, also known as the C terminus of HSP 70 interacting protein (CHIP), contains a tetratricopeptide repeat and a U-box, which is a ubiquitin E3 ligase targeting various oncogene-encoded proteins (such as p53, c-Myc, PTEN, AR-V7, and EGFR) [19–22].
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PMC11795610
The relative expression levels of mRNA of each targeted gene were normalized to the β-actin.
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PMC11419566
In a study conducted by Cheng et al PA was shown to induce apoptosis in pancreatic cancer cells by promoting ER stress and improving XBP-1s, ATF4, CHOP, and p-eIF2α.
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PMC8711270
However, as HEK293 cells were generated using sheared AdV genomic DNA, the E1 gene carried DNA sequences with high homology to wild-type AdVs.
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PMC11680578
Our findings reveal that the ratio of red to green fluorescence was notably lower in cells treated with PTX + RGZ compared to those treated with only RGZ or PTX, suggesting a potential involvement of programmed cell death through the intrinsic apoptosis pathway.
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PMC11461025
MMP-9 contributes to cell invasion and is expressed in various malignant tumors.
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PMC8658661
At the same time, the observed changes are similar to processes in hepatoblastoma and hepatocellular carcinoma cells, which justifies the use of the HepG2 cell line to study the metabolism of anticancer drugs and tumor processes.
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PMC11401350
Analysis of the FACS data was performed using MACSquantify Version 2.11 (Miltenyi) and FlowJo Software.
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PMC10698968
To avoid contamination and damage to the embryo, the window was kept closed with a piece of parafilm and opened only in case of direct intervention or imaging.
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PMC11758416
Stop trypsin EDTA process by pipetting detached cells into tube containing fresh L cell media.h.
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PMC9429973
Methods: Peripheral blood mononuclear cells (PBMC) from 55 CLL patients and 50 healthy donors (HD) were used for the study.
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PMC10969097
Additionally, the study found that CAFs trigger a process called epithelial–mesenchymal transition (EMT) in PC3 cells, which is associated with drug resistance.
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PMC11297139
ARID1A LLPS-dependent dysregulated cREs were identified by applying DESeq2 to the read counts on the merged accessible regions (FDR < 0.05).
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PMC10810426
The efficiency of amplification was determined for each primer pair by generating a standard curve with 10-fold serial dilutions of a known concentration of DNA.
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PMC11394730
Quercetin has also increased G1 phase cells and caused apoptosis, promoting PARP cleavage and nuclear fragmentation.
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PMC11334037
The top 10 downregulated genes were ATP4B, GKN1, MT1G, GKN2, ATP4A, SPINK1, TSPAN8, TFF1, KCNE2, and REG1A (Supplementary Table 1).
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PMC11742864
However, patients often have esophagitis, appetite loss or other medical conditions after radio-chemotherapy, and these can impair the patient’s nutrition and lower their life quality.
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PMC11747949
In agreement with that, 143B tumors from our experiment had pronounced expression of hypoxia‐induced protein CAIX by flow and IHC (Figure 3H,I) (McDonald and Dedhar 2014).
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PMC11472639
Shoji Leach: Investigation.
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PMC7724160
Fig. 1 illustrates one of the differences we observed over time in glutamine levels.
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PMC6222726
B. schlechtendalii (synonyms: Bursera jonesii Rose, Elaphrium jonesii (Rose) Rose, Terebinthus jonesii (Rose) Rose, and Terebinthus schlechtendalii (Engl.)
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PMC10812665
The up-regulation of several intermediates (DHAP, PEP and GAP, see Figure 11) may indicate that glycolysis is up-regulated.
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PMC11543885
Remove the blocking reagent and incubate the cells with 100 μL diluted anti-flag or anti-NLRP3 antibody (1: 1000 dilution for both antibodies) for 2 h at 25°C or 16 h at 4°C.
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PMC10772747
The cells were then measured using flow cytometry (FACS Calibur, BD Biosciences, USA).
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PMC7642379
HEK293 cell lines have been reported to have a pseudotriploid genome with the adenoviral DNA inserted on chromosome 19.
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PMC10507284
As shown in Figures 1G–I, the STS patients with low TROAP expression have an enhanced survival rate compared with STS patients with high TROAP expression levels, whether overall survival (OS) or progression‐free interval (PFI).
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PMC9429973
Of these 19 (13%) (RIT 8, ASCT 11) did not receive the planned consolidation due to 7 PD, 4 AE, 1 medical decision, 2 poor mobilization, 2 withdrawals, 1 poor compliance, 2 protocol breaches, while 63 (89%) received RIT and 59 (84%) ASCT.
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PMC11683240
After the incubation, the MTS reagent was added to the cells and incubated for 45 min at 37 °C.
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PMC10878518
All tissue samples were assessed by the averaged threshold method (ATM), as reported previously .
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PMC7987994
A–D) represent the different conditions used: (A) compares two concentrations of FBS, (B) compares two types of media, (C) compares two ways of exposition, and (D) compares two cell types.
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PMC11522251
The intrinsic ATPase activity of the RAS gene is impaired by point mutations in exon 2 codons 12 and 13 of the KRAS gene, which results in persistent activation of the MAPK pathway against EGFR inhibition .
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PMC11629143
Modifying the activities of epigenetic modifiers, such as histone deacetylases (HDACs) and histone acetyltransferases (HATs), provides opportunities to manipulate the epigenetic landscape.
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PMC9429973
L. A. Carvajal, B. Robinson, Y. Kosaka, T. Jacob, J. Lee, T. Hood, K. Baker, A. Kaempf, S. N.-A. Amara, J. Pucilowska, E. Lind, C. Tognon, J. Tyner, P. Kumar, T. Vu, J. DiMartino Kronos Bio, Inc., San Mateo; Oregon Health & Science University (OHSU), Portland, United States of America Background: Spleen tyrosine kinase (SYK) acts as a key integrator of signals from cell surface receptors containing an immunoreceptor tyrosine-based activation motif to boost cellular proliferation.
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PMC11643491
In this study, it was hypothesized that elongated particles might be preferentially taken up by deformable, aggressive cancer cells compared to normal cells.
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PMC6803987
By consulting the literature, it was found that esculetin could inhibit tumor cells , enhance the body′s defense ability and inhibit the expression of inflammatory cytokines .
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PMC2247071
A partially purified fraction of the water soluble photosensitive dye sulphonated aluminium phthalocyanine (AlSPc) was encapsulated in liposomes which were then linked to a targeting monoclonal antibody 791T/36 using a heterobifunctional linking agent.
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PMC9412887
First of all, due to the rapid development and wide application of nanomedicines or nanomaterials, the research on their potential toxicity has not been fully determined.
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PMC10840195
WB results showed that the protein expression levels of PCNA, Ki-67, MMP2 and MMP9 in oe-Twist were significantly higher than those in oe-NC, and the results were still consistent after sunitinib was added.
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PMC11583010
Recovery animals were included in the vehicle and ETx-22 groups and sacrificed after a 4-week treatment-free period.
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PMC6771295
In summary, silencing of SIRT1 led to increased U2OS cell viability in all conditions tested and SIRT5 silencing resulted in decreased cell viability in etoposide treated U2OS cells.
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PMC11705630
Tumorigenic cells display hyperactive synthesis and use of nucleotides so as to support the uncontrolled proliferation and metastasis 10.
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PMC10958426
DEGreg has low CNV-expression correlation and enriched in cytokine signaling genes, while DEGCNV has high CNV-expression correlation enriched in housekeeping genes and adhesion signaling genes.
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PMC11087766
and “.”
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PMC11679033
A total of 40 mL of blood was drawn by venepuncture into lithium heparin (LH 170 I.U.)-coated tubes (BD vacutainer, Becton Dickinson: BD-Plymouth, Roborough, Plymouth PL6 78P, UK).
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PMC9429973
Results: The peer support intervention was feasible and safe, and participants reported very high satisfaction with the support (75%).
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PMC10605143
HSF1 overexpression or inhibition also affects the phenotype of triple-negative cancer cells, mainly their invasiveness in 3D culture.
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PMC11541241
In the absence of glucose, ABL1 could inhibit TOR activity, which sheds new light on the inhibitory signals of the TOR pathway.
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PMC9429973
Myelofibrosis (MF) (n=140, 45.4%) was the most prevalent baseline malignancy, with 18 MF patients (12.9%) reporting 3 or more comorbidities.
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PMC11774251
In this study, Tan-I was shown to induce G1 phase cell cycle arrest and inhibit TNF-α-induced apoptosis in HaCaT cells.
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PMC11186948
In addition, HDAC2 total protein abundance resulted altered in patient, and we found that newly identified variant in HDAC2 affects also acetylation levels, with significant difference in acetylation pattern among patient #249, HD and RSTS cells and in expression of a known molecular target.
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PMC11412721
The portion of the Trp53 gene encoding the DNA Binding domain (DBD), most frequently mutated in cancers, was sequenced for 14 tumors from Trp53 (WT) Eμ-myc males and 18 tumors from Trp53 (ΔAS) Eμ-myc males, and Trp53 mutations were found in 3/14 and 1/18 tumors, respectively. (
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PMC9429973
DIC score (Taylor et al., 2001) was calculated for 107 patients with laboratory data fully available and resulted in overt DIC (≥ 5) in 45.2%.
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PMC11413393
P-values are calculated by one-way ANOVA with Sidak’s multiple comparisons test.
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PMC11541241
The TOR pathway also played a conserved role in U. maydis: promoting ribosomal synthesis and repressing autophagy.
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PMC9429973
Acalabrutinib, a BTKi, is approved in MCL, and mAbPD showed clinical activity in R/R MM.
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PMC11543853
Fig. 2Release of rhinovirus 2 from endosomes into the cytoplasm.
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PMC11775197
By now, the pathogenesis of CRC is complex and not fully understood.
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PMC9512971
SAS version 9.4 (SAS Institute, Cary, NC, USA) was used for all statistical analyses.
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PMC11185260
Seven days after treatment, the cells were fixed and stained using a Senescence β-Galactosidase Staining Kit (Cell Signaling Technology), according to the manufacturer’s protocol.
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PMC11413393
Labeled proteins were purified by high-affinity streptavidin precipitation and identified by mass spectrometry.
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PMC11576293
1H, SCH2CH = CH2, J = 1.5 and 17.1 Hz), 4.01 (d., 2H, SCH2CH = CH2, J = 6.9 Hz) 3.92 (overlap singlets, 6H, 2 OCH3), 1.55 (d, 6H, SCH(CH3)2, J = 6.9 Hz); C NMR (75 MHz, CDCl3) δ (ppm) = 171.5, 164.3, 164.3, 162.1, 160.1, 138.5, 134.2, 129.8, 129.2, 128.8, 119.6, 117.4, 116.6, 114.2, 112.5, 107.4, 55.5, 34; HRMS (ESI+) calcd.
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PMC11607638
SK2 was found more effective than SK1 (Figure 3); this was corroborated in functionally expressed SKR in CHO‐K1 cells (Figure 6).
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PMC9429973
CD8+ T cell counts recovered more rapidly, also during treatment.
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PMC11478724
This is crucial for maintaining cell energy and metabolic homeostasis.
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PMC11794588
After the plants were completely dried, a fine powder was made and preserved.
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PMC11763111
Subsequently, we used the Hu-PBL-SCID model generated by injecting human peripheral blood mononuclear cells (PBMCs).
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PMC10729469
While each proved successful at reducing plaque burden and cognitive defects in animals, [5–7] human trials showed limited success with adverse reactions following immunizations.
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PMC8584319
Next, we investigated whether other MAPKs, p38 and JNK , exert similar effects.
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PMC11721587
Consistent with Fu being required for converting Ci into labile Ci in response to high levels of Hh (8), full-length Ci was up-regulated in A-compartment cells abutting the A/P boundary in fu discs (Fig. 1E).
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PMC8068766
In parallel, we also used the HBV-integration effect gene lists to draw heat maps for the comparative expression levels of these DEGs in 8 different hepatocellular cancer cell lines taken from Cancer cell line encyclopedia databasehttps://portals.broadinstitute.org/ccle.
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PMC10968586
Despite being considered as a T-ALL cell line, Jurkat cells are immunophenotypically different from T-ALL cells; thus, results obtained in this cell model retain modest reliability .
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PMC11128598
We demonstrate that CQ induces DNA DSBs dependent on ROS production and also that the repair of these lesions is inhibited by LBH, which avoids HR, or by NU-7026 and KU-57788, that inhibit the NHEJ repair pathway, which explains the observed synergies.
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PMC6222726
The loss of the essential oils and the oxidation and polymerization processes transform copal into amber.
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PMC2777936
The levels of Wnt ligands in RA-treated and control cells are presented in Figure 2a.
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PMC11720107
Interestingly, the current study revealed that the Morado cultivar did not contain catechins.
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PMC11502327
The results show that compared to other polymer drug delivery systems, Poly(DL-lactic acid-co-glycolic acid) (PLGA) nanoparticles incorporating kaempferol can reduce the vitality of OC cells without altering normal ones, indicating that it had cytoselective toxicity and could be a promising candidate for the prevention and treatment of OC.
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PMC9429973
Inter-patient comparisons of bone marrow samples (n=31) revealed a higher MHC-I expression in CD9+ AML (P<0.001).
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PMC11470999
In vivo imaging results showed rapid growth of intracranial melanoma, while PF greatly inhibited brain metastasis growth and exhibited a slightly better activity than TMZ (Figure 2C,E,G).
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PMC11740207
Disruptions in AD have been linked to cancerous growth due to unchecked cell division (Hansen and Pelegri, 2021).
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PMC2777936
p < 0.05, **p < 0.005).
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PMC11727145
It is, therefore, interesting to study this fluid as a potential tool for improving cellular wound healing potential, although only a few scientific studies have examined its proliferative, migratory, or adhesion effects on cutaneous cells .
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PMC11453018
There is a crucial partnership in ES, where P300/CBP is dynamically localized to interact with the activation domain of the EWS::FLI1 fusion protein.
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PMC11515150
NK cells have been utilized as effector cells without dependent on major histocompatibility complex (MHC), accompanied by limited risk of GVHD and cytokine release syndrome (CRS) .
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PMC11357960
Previous studies have suggested an association between epigenetic abnormalities such as methylation and clinical response to anti-PD-1 immunotherapy, while the role of SUMOylation in resistance to anti-PD-1 antibody immunotherapy is still unclear.
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