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OTAR3088
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BioData-CellLine_annotated

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PMC11537649
Melanoma has become a major tumor that threatens human life and health.
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PMC11388384
We confirmed that upon SHH stimulation, the receiver cells expressed canonical SHH targets Ptch1 and Gli1, and did not exhibit positive feedback on Hedgehog ligand gene expression, suggesting that the only source of Hedgehog ligand is the engineered sender cells (SI Appendix, Fig. S1).We expressed a membrane-anchored mTurquoise2 to label the sender cell membrane and found that NIH3T3 cells formed tube-like protrusions consistent with previous descriptions of cytonemes (Fig. 1C) (10, 12).
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PMC11727907
Samples were analyzed spectrophotometrically before and after the addition of 4 μg of purified LDH.
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PMC11727145
In detail, the timing of optimal delivery of cells and their combinations for optimal repair of the tegument could be assessed.
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PMC11547972
Attenuation of oncogenic pathways along with an increase in tumor suppressor proteins under SFN have been shown in clinical trials .
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PMC11469524
The negative quantification of the PI3K-> AKT link in BL-41 cells can be attributed to the weak AKT signal found in that cell line (cf.
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PMC11486946
The side of the image corresponds to the z-direction of the shift of the objective from the in-focus position.
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PMC9429973
After applying the DREAMM-2 eligibility criteria to patients from the intent-to-treat population of MajesTEC-1, IPD from MajesTEC-1 were weighted to match the aggregated DREAMM-2 baseline patient characteristics.
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PMC11637276
In agreement with our previous observations, α2 integrin could be detected in collagen I-positive vesicles (Fig 3C), indicating that p38 promotes the internalisation of ECM-bound α2β1 integrin. (
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PMC4695073
b. RT, radiotherapy.
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PMC11622247
The lower performance of probes in lysate has been observed previously.
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PMC3681794
Data are representative of 3 independent experiments.
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PMC10818062
An increase in the levels of phosphatidylinositol (PI), the precursor of PI4P and PI(4,5)P2, in PTDSS1 KO cells motivated the authors to test another lipid exchanger, Nir2/3, which transport PI from the ER to the PM and phosphatidic acid (PA) in the opposite direction.
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PMC9503541
The alignment result was then normalized and transformed into a comma-separated value (.csv) format to be uploaded in MetaboAnalyst, along with the TIC-peak intensities obtained from the MS-DIAL run.
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PMC11049548
In the case of cell culture media, all the samples were thawed and analyzed together using an automatic refrigerated sample changer (SampleJet, Bruker BioSpin, Rheinstetten, Germany).
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PMC11666785
Actin3315.315.315.2(nm)Tubulin3117.817.617.4Mitochondria3320.920.319.4SBRActin2.443.144.033.83Tubulin3.43.44.24.5Mitochondria2.464.574.84.75#N/Mol.
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PMC11742290
However, LGR5 overexpression was associated with reduced migration in ovarian cancer cells (OVCAR-3 and SNU-8) .
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PMC9727330
Together, these data suggest that NNDAsp can restore the expression of P53 and stimulate the expression of Casp3 TET3 in both RNA and protein levels to produce programmed cells death in treated cells (PCD) in infected cells.
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PMC10723784
Mitochondrial membrane potential assay on A2780 cells treated with (a) CBD and (b) CBG.
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PMC11806106
10M*min (Fig. 4F).
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PMC7039683
Color of curves corresponds to SVM scores. (
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PMC11742047
The blue color indicates lower levels of lipids in the CBD-treated condition compared to the control and red higher levels in CBD-treated samples.
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PMC8735881
As shown, TZM-bl cells transduced with secretory scFvs could not effectively block HIV-1 infection (Table S1).
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PMC9429973
Univariate analysis of 2- and 5-year outcomes after transplantation are given in Table 1.
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PMC11155445
N,N-Di(trimethoxysilylpropyl)-N′-benzoylthiourea was synthesized and then immobilized on the surface of silica gel to prepare novel silica-anchored acyl thiourea adsorbent (Fig. 98).
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PMC11545737
Moreover, some pathogens have evolved virulence factors that directly interfere with pyroptosis pathways, like Yersinia pestis YopM and Shigella flexneri IpaH7.8.
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PMC11055510
Early screening strategies cannot reduce the OC morbidity or mortality (Modugno & Edwards, 2012), owing to a lack of diagnostic markers for OC.
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PMC7917457
APCs were pulsed with tumor antigen-containing peptides, with or without the polylysine modification.
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PMC9429973
Patients achieved overall response were divided into three groups (R1: 30-49, R2: 50-99, R3: ≥100 × 10⁹/L) according to platelet counts, which was used to analyze the potential predictors of response and successful discontinuation.
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PMC11740399
3025@ML and compound 3 K reduced the levels of FASN in T24 and 5637 cells and increased the anti-tumor activity of OXA.
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PMC10577955
While the expression of miRNA-21 level was statistically lowered in all treated cells when compared to untreated cells, but there was no significant difference between all treated cells as shown in Table 5 and Fig. 4.
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PMC11591038
the resultant ROS cause oxidative damage to lipids, proteins, and DNA, thus leading to cell death and affecting Aβ misfolding along with plaque aggregation .
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PMC11789597
RPMI 8226, MM1S, LP‐1, or U266 cells were transduced with lentivirus and after 48 h, cells were treated with 1 µg mL puromycin (Beyotime Biotechnology, Shanghai, China) and amplified in the presence of puromycin for extra 14 days.
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PMC8481254
Upon initial exploration of the relationship between this gene and hepatocellular carcinoma cell (HCC), we observed that YAP, OGT, SLC5A3, and Nudt9 expression in HCC tissues was upregulated relative to that in normal liver tissues (Supplementary Fig. 4A–D) through The Cancer Gene Atlas (TCGA) online visualization website.
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PMC8170755
The effect of VPA (0-16 Mm) on the cell viability of A549 cells after 24, 48 and 72 h incubation.
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PMC10114490
However, these strategies are accompanied by genomic instability, phenotypic changes, and altered growth requirements , which are not present when hTERT is used .
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PMC11706297
Lapatinib, a potential EGFR and HER2 inhibitor, was used as a standard agent.
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PMC11637284
Cell debris was removed by centrifugation (20 minutes, 13’000 g at 4°C).
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PMC9429973
According to the results of immunohistochemical examination the expression of proteins-products of oncogenes have been revealed in most patients (12 of 13) in plasma cells of bone marrow and bone plasmacytomas, wherein in half of the patients (patients 7-12) the expression of proteins-products of oncogenes coincides in bone marrow and bone plasmacytoma.
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PMC9429973
I. Avivi, D. H vesole, J. Dávila Valls, L. Usnarska-Zubkiewicz, V. Milunovic, B. B. Bogumiła Osękowska, A. Kopińska, M. Gentile, B. P. MARTÍNEZ, P. Robak, E. crusoe, R. LUIS GERARDO, M. Gajewska, V. Gergely, M. Delforge, Y. Cohen, G. Alessandro, C. peña, C. Shustik, G. Mikala, K. Žalac, A. H. Denis, B. Peter, K. Weisel, J. martinez lopez, A. Waszczuk-Gajda, M. Krzystanski, A. Jurczyszyn Head of Hematology Division, Tel Aviv Medical Center, Tel AVIV, Israel; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, United States of America; Complejo Asistencial de Avila, Complejo Asistencial de Avila, Avila, Spain; Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw, Poland; Division of Hematology, Clinical Hospital Merkur, Zagreb, Croatia; Pomeranian Medical University in Szczecin, Pomeranian Medical University in Szczecin, Szczecin; Department of Haematology, Oncology and Internal Diseases, University Clinical Centre, Medical University of Warsaw, Warsaw, Poland; Hematology Unit, AO Cosenza, Cosenza, Italy; (University Hospital of Salamanca, Cancer Research Center-IBMCC, Salamanca, Spain; Medical University of Lódź, Medical University of Lódź, Lódź, Poland; : Federal University Of Bahia, University Hospital and Rede D’or Oncologia, Bahina, Brazil; Clinic Barcelona Hospital Universitari, Clinic Barcelona Hospital Universitari, Barcelona, Spain; Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland, Warsaw, Poland; Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary; Department of Hematology, UZ Leuven, Leuven, Belgium; Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Hematology, Department of Medical Science, Surgery and Neuroscience, University of Siena, Siena, Italy; Sección Hematología, Hospital del Salvador, Santiago, Chile; Hematology Department, MUHC - McGill University Health Centre, montreal, Canada; Department of Hematology and Stem Cell Transplantation, South-Pest Central Hospital, Budapest, Hungary; Department of hematology of Clinics for Internal Medicine, University Hospital Center ‘‘Sestre Milosrdnice’’, Zagreb, Croatia; N Ireland Centre for Stratified Medicine, Ulster University, Londonderry, Ireland; Department of Medicine, Warren Alpert Medical School, Brown University, Rhode Island, United States of America; : University Medical-Center Hamburg-Eppendorf, Hamburg, Germany; Nieves Lopez-Muñoz Hospital, Madrid, Spain; Department of Hematology, Oncology and Internal Diseases, Warsaw Medical University, Warsaw; Department of Hematology; Department of Hematology, Jagiellonian University Medical College, crakow, Poland Background: The continuing improvement in response rates and overall survival (OS) of multiple myeloma (MM) patients exposed to the cumulative effect of multiple anti-MM agents including IMiDs, PIs, mAbs and cytotoxic chemotherapy, has resulted in an increased risk for second primary malignancies (SMPs).
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PMC11548041
Consequently, aptamers can be used as molecular probes for targeted imaging or therapeutic applications .
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PMC11750712
Cells were washed and resuspended in BD Stain buffer (BD Biosciences).
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PMC9919300
To evaluate the impact of the chosen treatments on the ROS levels in our steatosis model, we performed a fluorescence microscopy analysis by employing the redox-sensitive fluorochrome H2DCFDA (green fluorescence) and DHE (red fluorescence).
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PMC11106977
Yang et al. reported that OGT-mediated O-GlcNAcylation modifications suppress macrophage pro-inflammatory polarization by regulating S6 kinase beta 1 (S6K1) O-GlcNAcylation/ phosphorylation and S6K1 activation .
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PMC9429973
Peak rituximab levels were also elevated in responders vs non-responders.
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PMC10898159
Perspective of KIT in GIST.
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PMC11401358
Therefore, SF can serve as a good antioxidant biomaterial for therapeutics, and its β-sheet structure-based antioxidation mechanism provides a novel theoretical basis, which could be a new cue for more antioxidant biomaterial discovery and identification.
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PMC8068766
Robust multiarray average (RMA) background correction and quantile normalization of the data were performed.
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PMC5810978
Capsid sequence-based HuSaV genotyping was performed based on phylogenetic analysis using reference sequences and the method described previously .
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PMC11474209
Several neurotoxin cases were reported in France, where animals died after drinking water contaminated with anatoxins.
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PMC9622879
Figure 9 depicts the selling energy of the community with three CEMSs.
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PMC11705901
The impact of four common OXTR SNPs (rs1042778, rs4686302, rs2254298 and rs237887) on OXTR gene expression were tested in human neuroblastoma cell line, SH-SY5Y, a commonly used cell line for neurological disease.
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PMC9429973
FLT3 mutated patients showed even lower expression of DNAM-1 (P=0.02) and NKG2D (P=0.13) in CD56 NK.
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PMC11462673
The mixtures were then subjected to rotational incubation at room temperature for 1 h. The samples were next fragmented and DNA were extracted.
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PMC11172027
Similar to the mitochondrial activity at 24 h of incubation, both showed a clear significance to their equivalent NALM samples (250 µg/mL: 12.1 ± 2.8%; n = 3; p < 0.01.
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PMC9429973
Aims: This study aims to assess the risk of developing SSN in patients with CML.
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PMC11089031
We analyzed the expression pattern of ZNF692 in ccRCC patients who received TKI therapy and patients who received ICB therapy.
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PMC11612508
Furthermore, the release pattern of temozolomide-loaded GO/CS/IO microspheres was examined under both non-magnetic and magnetic field conditions.
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PMC11727907
Additionally, treatment with IGF-1 also increases, with the same temporal trend of MDA, the activity of glutathione reductase (GR) and glutathione peroxidase (GPx) (Figure 7C and Figure 7D, respectively), two enzymes involved in antioxidant defenses, and of glucose-6-phosphate dehydrogenase (G6PD), the first enzyme of the cytosolic pentose phosphate pathway (PPP) involved both in redox balance and building block formation.
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PMC11739504
Confocal microscopy analysis revealed that the fluorescence intensity of IFT25 (red) at primary cilia decreased in the renal tubule from 16 weeks Kat2b knockout mice compared to the wild-type.
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PMC11502962
However, PD-1 expression has been found in M2-state tumor-associated macrophages (29).
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PMC11611077
The membrane was then treated with 5% skimmed milk (Wako, Tokyo, Japan) in PBS containing 0.05% Tween 20 (PBS-T) and incubated with anti-6×His-tag mouse monoclonal antibody (Proteintech, Rosemont, IL) diluted at 1:10,000 at 4°C overnight.
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PMC11224020
Bottom, box plot showing the minimum to maximum range of NF-κB (P65) intensity (N = 2, n = 55 cells in 4 µm (cPLA2), n = 63 cells in 3 µm (cPLA2), n = 34 cells in 4 µm (cPLA2)).
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PMC11732523
Flow cytometry monitoring of immune cell populations provided valuable insights into immune recovery, guilding therapeutic adjustments.
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PMC11635087
Chloroplasts were visualized according to chlorophyll autofluorescence (magenta).
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PMC11541409
Journal of Clinical Oncology, 2024.
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PMC11604015
However, CD4 CAR-T cells can retain fratricide skills for peripheral CD4-positive T cells, which may cause CD4-positive T cell aplasia and increase the risk of opportunistic infections.
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PMC5311252
Representative pictures from one of the replicates of each analysis is shown.
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PMC11665555
Together, OXCT1 was identified to orchestrate metabolic and transcriptomic changes downstream of OVOL1 that contributed to the development of gemcitabine resistance.
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PMC11095939
Protein degradation via ubiquitination is the most prevalent recycling machinery used by cells.
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PMC9503669
Additional modalities are likely required to trigger an effective adaptive immune response targeting reactivated HIV-1 reservoir cells.
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PMC10218459
In A673 cells, CPP treatment was used alone, as the cytostatic application alone led to a significant increase in the relative caspase 3/7 compared to the control treatment (Figure 6A).
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PMC11413393
The junction count exon count (JCEC) methodology was used and events were filtered based on absolute Includsion Level Difference (ΔPSI) > 0.1 between indicated conditions with FDR < 0.05.
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PMC11317131
HDFa cells (4.7 × 10) were seeded in 6-well plates and the next day cells were transfected with 3.6 μg of PE5max, 360 ng of each epegRNA plasmid, 1.44 μg of integrase expression plasmid, and 1.44 μg of donor plasmid DNA using Lipofectamine 3000.
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PMC9512971
However, several factors related to the design of the study and the mechanism of action of camostat mesilate should be considered:Viral entry pathway—Although TMPRSS2 is one of the primary routes of viral entry, the viral particles might exploit other pathways, such as endocytosis, to compensate for reduced entry via TMPRSS2.
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PMC6468656
The high level of MMP10 in renal cancer patients was found to be associated with poor survival (p = 0.000284, Figure 6A).
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PMC11473750
b Kelly cells transiently transfected with Myc-tagged wild-type RNF121 (RNF121) or mutant RNF121 for 48 h. Shown here are representative images of immunofluorescent staining using an anti-Myc-tag antibody for the RNF121 protein and a GM130 antibody for the cis-Golgi.
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PMC9398137
Statistical significance: *, 5% simultaneous significance level; NS, not statistically significant, for details see Supplementary Materials and Methods.
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PMC10957991
Objective used was Zeiss Plan Apo 63x/1.40, WD 0.19 mm (Oil).
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PMC11543853
Movies of 40 frames were recorded for each 10 s of exposure.
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PMC10033453
VMG exhibited in vitro efficacy by inducing oncolysis in a broad range of sarcoma subtypes across multiple species.
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PMC8303372
Starting from the twenty-fourth hour, the recordings report the effect of GA 500 and 200 µM (administered in both free and vehiculated form) on cell viability, determined by varying the electrical impedance offered by the cell layers.
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PMC11732628
The Bcl-2 family proteins, Bcl-2 and Bax, play a crucial role in regulating apoptosis (26).
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PMC11731161
As shown in Fig. 7B–D, while single SEL treatment had a moderate effect on tumor growth, the combination of USP7 silencing with SEL led to significant tumor growth inhibition.
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PMC2011258
The anti-mitotic drug vindesine was coupled chemically to a monoclonal antibody raised originally against the human osteogenic sarcoma cell line, 791T.
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PMC11300639
In contrast, we demonstrated that knockdown of CDK4 significantly increased the protein level of TSC1 (Fig. 1c) but slightly changed the mRNA level of TSC1 in 786-O and A498 cells (Fig. 1d).
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PMC8623816
The results showed the presence of two major structural proteins with a molecular mass of about 60 kDa (Figure 4c).
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PMC11655536
P < 0.05, **P < 0.001, ****P < 0.0001.
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PMC7685376
All data and error bars are presented as the mean ± SD from at least three independent experiments.
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PMC11792740
If the tumor recurs or metastasizes, these memory T cells can be swiftly activated to resume their antitumor function, thereby enhancing the therapeutic impact and minimizing the likelihood of recurrence .
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PMC11515150
Tumor burden was monitored by bioluminescence images. (
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PMC10899471
miR-939-3p suppresses BATF2 expression via binding to its 3’UTR region. (
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PMC11768927
However, further studies have confirmed the role of HIF-1α in promoting resistance.
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PMC8303372
During storage of the array, small molecules in the atmosphere can absorb to the electrodes’ gold surfaces, resulting in increased electrode impedance.
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PMC11394227
No direct evidence of ER expansion or lipid regulation by QSOX has been reported.
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PMC6450504
The assay was performed in triplicate, and sink conditions were maintained during the experiment.
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PMC9429973
We observed 1L CT/CIT use decreased starting 2014 (pre-2014: 58.1%; 2014–2016: 46.0%; 2017–2019: 24.6%; 2020–2021: 0%), while 1L targeted agent use increased over time (pre-2014: 30.5%; 2014–2016: 43.1%; 2017–2019: 67.0%; 2020–2021: 94.7%).
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PMC11680049
The study of the accumulation and localization of secondary metabolites allowed us to evaluate the biological activity and cytotoxicity of in vitro Sequoia cultures.
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PMC11721295
Similarly, we analyzed how the KRAS inhibitor MRTX affected fibroblast signaling by staining for p-STAT3 of lung sections obtained from mice with orthotopic KPL-86 lung tumors treated with vehicle or MRTX.
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PMC11674441
For RNA sequencing (RNA-seq), reads were mapped to the GRCh37/hg19 genome using STAR (v2.4.0a) .
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