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OTAR3088
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BioData-CellLine_annotated

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PMC11678448
Pasteurella can cause both pneumonia-type pasteurellosis and systemic pasteurellosis in goats .
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PMC11335267
For quantification, the standardized uptake value (SUV) was calculated as the ratio between radioactivity concentration (kBq/ml) and the injected dose (kBq) divided by body weight.
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PMC9268183
Indeed, because of their recurrent use throughout history, some of them are already considered classical.
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PMC7334607
These two dose-response plots demonstrate how the heatmap (left) values were calculated, where the control EC50 values are averaged, and the heatmap values represent the log2 fold change between a given replicate and this mean EC50 value.
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PMC11754784
Source data are provided as a Source Data file.
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PMC4659567
The position of the representative C2–H signal of 3Claza observed in the 10% MeOD-d 4/D2O solution correlated with that of free 3Claza dissolved in the same mixture of solvents, indicating that 3Claza released from the structure of 2.
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PMC9429973
Patients’ characteristics and outcomes are summarized in Table 1.
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PMC11770130
Further studies are required to elucidate whether it is a common mechanism or an adipocyte-specific phenomenon.
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PMC11172027
The IC50% of NASeLM on the mitochondrial activity of Jurkat cells was achieved at a concentration around 375 µg/mL. The inhibition of mitochondrial activity was more pronounced after 72 h compared to 48 h or 24 h. A significance of p < 0.01 could already be achieved with 125 µg/mL NASeLM compared to the 72 h control (67.9 ± 4.2% vs. 100.0 ± 8.1%; n = 3).
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PMC11740207
They exhibit a distinct immunophenotype, often expressing key surface markers such as CD34 (commonly used to identify SCs, particularly HSCs and MsPCs), CD73 (indicating immunomodulatory capacity and support for regenerative processes), CD90 (associated with tissue repair and regenerative potential), and CD44 (involved in cell adhesion to the extracellular matrix and SC mobility, playing a role in tissue repair) but not Lin (lineage negative, indicating the absence of markers typical of mature, committed cells) and CD45 (characteristic of mature immune and blood cells).
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PMC6468656
The results of this study indicated a novel signaling mechanism in ccRCC metastasis.
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PMC11541409
Of note, imatinib (1 µM for 48 h) increased the expression levels of OXPHOS proteins (CII-SDHB, CIII-UQCRC2, CV-ATP5A) in imatinib-sensitive GIST T1 and 882 cells (Fig. 4C).
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PMC9964635
The docking findings demonstrate that molecules have the ability to affect a variety of targets.
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PMC10958426
Stromal cells and endothelial cells in tumor tissue highly expressed genes associated with extracellular matrix organization, response to wounding and angiogenesis.
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PMC9919300
The most causative factor of NAFLD is obesity, which is strongly linked with insulin resistance (IR), as 70–80% of NAFLD patients are obese or diabetic.
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PMC10965680
The global goat diversity is astounding, with more than 557 different registered breeds and a population of 1.006 billion as of 2022 estimates (Kim et al., 2019; Wang et al., 2016).
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PMC11747949
Protein screening of patient samples showed significant CCL2 upregulation in tumor specimens compared to normal bone tissues (Dou et al. 2021).
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PMC11429241
TPP is a perfect fit for this task, as it is an advanced 3D-printing technique combining a μm-level resolution with complete freedom in the design of the final structure.
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PMC9250505
For the immunohistochemistry procedure, dewaxing was executed in xylene at room temperature for 15 min twice, then rehydration was carried out using ethanol with a concentration gradient of 100, 90, 80, 70, 50, and 0%.
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PMC11653533
F. benghalensis is a huge evergreen tree local to dry districts of equatorial nations, such as South Asia (India, Sri Lanka, Pakistan, Bangladesh) and the Southern and Eastern portion of Nigeria, it usually develops from low altitudes to 2000 ft or 610 m (B.D Arimah OPO.
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PMC6889484
We generated NL4-3[SEMQ] virus and infected the parental CEM and CEMSS as well as CEM/D128K and CEMSS/D128K cells (Figure 6).
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PMC11537649
Total RNA was extracted using the Trizol method and reverse transcribed into cDNA.
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PMC11805741
Chromatographic analysis revealed zeaxanthin as the major carotenoid (48.3%).
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PMC9429973
Aims: Our aim was to assist in overcoming this limitation and offer best practices that empower patients living with hematological malignancies by increasing their involvement in the development of novel PROMs.
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PMC11438317
E Interaction of Vav YF, as indicated, with 3xHA-LP-DACS.
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PMC11095939
not significant; ****p<0.0001 by two-way ANOVA. (
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PMC11012313
However, one requirement for all of these processes is the need to modify metabolism so that uncontrolled proliferation and survival can occur .
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PMC11026382
To examine the model more closely, we considered the relationship between TYMS catalytic activity and DHFR mutational sensitivity.
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PMC11742864
Crucially, both ω-3 LCPUFAs and their derivatives seem to exhibit cytotoxic effects mainly against carcinoma cells, but not normal cells, while it is possible to enhance tumor cell sensitivity to drugs when combined with other pharmaceutical agents, such as ICIs, targeted inhibitors, and other chemotherapeutic agents.
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PMC11569208
48 h later, cells were infected with VSV∆51-GFP (MOI 0.01). (
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PMC11785489
Given the correlation structure of TCR sequence features, we iteratively masked out correlated blocks of features using the Partition Explainer of the python package “shap”.
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PMC10530622
Escherichia coli produce citrate lyase, leading to hypocitraturia and consequently CaOx supersaturation with stone formation.
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PMC9429973
Similarly, mucositis and GI toxicities were not affected by the Mel mg/kg dose.
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PMC9429973
In R/R patients, 3-year DFS and OS were 13% and 20% respectively.
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PMC9428827
To define if the observed accumulation was related to an increment in proliferation, the incorporation of BrdU by the cells in treated mice was measured.
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PMC11180402
Interestingly, knockdown of MMP-2 or MMP-9 in 5637 cells resulted in significantly reduced invasion, similar to that observed following ISO treatment (Fig. 2F-2I), whereas shPTEN reversed the ISO-mediated inhibition of BMIBC anchorage-independent growth in 5637 cells (Fig. 2J-K).
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PMC9429973
Results: Twenty-six patients were enrolled in the study.
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PMC11469524
After establishing these quantitative network models, we found that the BL-2-derived network structure forms a solid base to describe signaling networks in cell lines from Diffuse large B cell lymphoma (DLBCL) with aberrant BCR signaling.
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PMC10728200
The cells were seeded in a 96-well plate with 2 × 10 cells and 100 µl medium per well.
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PMC10092581
In contrast, among the Ag(I) selenourea complexes, only [AgCl] was as effective as the reference gold‐based drug (Figure 3, panel B).
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PMC11687167
Recent research confirmed that PCSK9 is associated with inflammation and that it promotes inflammatory responses by interacting with scavenger receptors (SRs) of inflammatory mediators such as lectin-like oxidized LDL receptor-1 (LOX-1) .
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PMC11477621
The reaction mixture was stirred at room temperature overnight.
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PMC4270159
i. Based on the expected MWs of the targets, lab will determine the optimal percentage gel to use.
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PMC11532793
It implements bias-adjusted deviances that allow unbiased estimation of quasi-dispersions even for genes or transcripts at very low expression levels.
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PMC11515150
The absence of overt toxicity supports the potential development of our approach.
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PMC8010066
Antibiotic resistance and pathogenicity are influenced during the infection.
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PMC11590870
Moreover, the MOPHs increased Caco-2 antioxidative activity to a greater extent by 73.45% and 83.62% at 250 and 500 µg/mL, respectively.
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PMC8270637
CTLA-4 antibody for Western blot and NFATc1 antibody for chromatin immunoprecipitation (ChIP) assay were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA).
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PMC5672695
Objective: This study aimed to investigate the association between cord blood cotinine levels and birth outcome, and to determine whether fetal metabolic gene polymorphisms of glutathione-S-transferase (GST) modulates the effect of environmental tobacco smoke (ETS) exposure during pregnancy.
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PMC9429973
The cHL cell lines were treated with VPX (or control DX) viral proteins to eliminate SAMHD1 as previously described (Herold et al, Nat Med 2017;23(2):256), and with a CDK inhibitor (Palbociclib) to restore SAMHD1 activity through dephosphorylation.
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PMC9429973
Given the emerging evidence that endothelial cells (ECs) that reside within the TME can possess immunomodulatory activity, we next evaluated CD20-TCB-mediated T cell responses in the presence of this stromal cell compartment.
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PMC10728535
The concentrated distribution of chips around zero indicates that undesired variation has almost been eliminated.
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PMC10587429
Isolate mononuclear cells from cord blood by ficoll-paque density gradient centrifugation.
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PMC11064533
Prior to the addition of bacterial strains, monolayers of 5637 were washed with PBS and then 500 µL of infection medium was pipetted in each well.
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PMC8140214
However, further pharmacological studies are required to establish its beneficial effects in patients with disrupted oxidative balance such as diabetes mellitus.
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PMC11352877
There is substantial evidence of their importance both in resistance to treatment and worse disease outcomes.
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PMC11468365
Table 1The summarization of the related worksMain features of drugsMain features of cell lineDeep learning modelOutputDeepDSC Used drug SMILES to extract drug featuresGene expression data is used to create a feature vector for the cell lineProcesses the concatenated vector of drug and cell line features through three fully connected layersLoewe synergy scoreAuDNNsynergy Used drug SMILES to extract drug featuresGene expression, copy number, and genetic mutation data are used to create a comprehensive feature vectorProcesses the drug and cell line features by passing them through fully connected layersLoewe synergy scoreSynPred Used drug SMILES to extract drug featuresUtilized gene expression, copy number variation, methylation, global chromatin profiling, metabolomics, microRNA, and proteomics featuresUtilized a fully connected subnetwork to integrate cell line features with the features of the two drugsLoewe synergy, Bliss synergy, highest single agent model, and Zero interaction potency modelMatchMaker Used drug SMILES to extract drug featuresGene expression data is used to create a feature vector for the cell lineConcatenate each drug feature with the cell line feature and pass the combined data through two parallel fully connected subnetworks.
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PMC11472569
Using the MEK inhibitor U0126 to block ERK activation sensitizes gemcitabine-resistant pancreatic cells to gemcitabine, both in vitro and in vivo.
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PMC9429973
Of the 127 patients included in analysis, 16% were aged ≥ 75 years, 58% were male, 88% were White, and 39% were high risk.
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PMC11509309
To select the extracts containing molecules with anti-prion activity, we used a yeast-based screening method , whose effectiveness has already been widely proven .
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PMC11777207
Alternatively, if PD-L1 monotherapy is to be used within the context of cancer, rational design of new PD-L1 antibodies should consider binding properties that exclusively block PD-1–binding domain while sparing the CD80-binding domain.
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PMC11779605
In our study, the attached tumor cells exhibited increased percentages of endothelial cells and decreased hypoxia reflective of tumor angiogenesis providing a blood supply of oxygen in attached tumors, and not in aggregates or spheroids of cancer cells in ascitic fluid.
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PMC7136814
TPA/GSK126 treatment not only induced expression of MYOG suggesting cell differentiation but also exhibited a therapeutic effect by reducing on average 2-fold absolute numbers of live cells in RMS cell cultures (p < 0.001) (Figure 3).
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PMC11087055
Blue, clockwise; red, counter-clockwise rotation.
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PMC11470999
Comprising 905 amino acids, CIP2A features an N‐terminal armadillo repeat domain (amino acids 1−560) and a C‐terminal coiled‐coil region.
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PMC11772585
Notably, all of these metabolic indicators were upregulated in METTL1-deficient HSC-1 and A431 cells following ATF4 overexpression, further supporting the role of METTL1 in promoting tumorigenesis through ATF4-mediated glycolysis.
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PMC9065483
Cells were lysed at 24 hpi and analyzed for mRNA expression of NF-κB related and proinflammatory genes by quantitative polymerase chain reaction (n = 3, mean ± SD; ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 by one-way ANOVA). (
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PMC11574271
F The invasion ability was evaluated by trans-well assay.
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PMC11539788
The lentiviruses used for RNF19A overexpression (LV-RNF19A) or knockdown (shRNF19A) and the corresponding control lentivirus (LV-Ctrl, shNeg) in the present study were all purchased from Sangon Biotech (Shanghai, China).
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PMC7759933
In drug development and hepatotoxicity research, there is a high demand for establishing new, reliable, and uniformed models with higher predictability for the consequences of human exposure.
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PMC9341513
Figure 1, A–C, shows cartoons of the IGH and CCND1 loci in healthy cells, as well as two different rearrangements which are studied here.
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PMC9587298
Caffeic acid ([M – H] ion at m/z 179, Fig. 4b)) showed the typical product ions formed due to CO2 elimination yielding product ion at m/z 135 and consecutive loss of CO yielding a product ion at m/z 107.
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PMC6799808
It has been described that G. lucidum extracts can increase intracellular calcium levels and induce ROS production in MCF-7 breast cancer cells.
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PMC11650848
The FASSTT Offspring Trial was conducted to investigate the effects of maternal folic acid (FA) administration on the cognitive development of children, and these were followed up at 3 years, 7 years and 11 years of age .
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PMC9429973
We calculated the median Mel mg/kg dose and compared the outcomes of patients receiving median and above versus below median dose.
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PMC11301242
Gene expression values were calculated as TPM (transcripts per million).
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PMC11461833
Progerin was found to lead to the upregulation of the corresponding genes in skin-derived precursor stem cells (SKPs) from patients with HGPS .
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PMC9429973
We did not observe significant differences in the hematological toxicity, that may be explained by the features of local supportive care.
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PMC10523483
Samples were collected with the written informed consent of patients.
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PMC11742670
Cancer has many challenges in discovering a safe and affordable cost of new treatment and excessive cost of investment in cancer care.
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PMC10847511
Mutations with unknown locus-specific copy numbers in either the CCLE or CLP dataset were determined for LOH status using the other dataset.
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PMC9429973
Focus of infection was lungs in 68.5%, sinusitis in 6.8%, skin & soft tissues in 5.6%, neutropenic enterocolitis in 2.2%, pyelonephritis in 1.1%, splenic abscess in 1.1% & bacteraemia with no obvious focus in 14.7% patients.
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PMC10291556
The experiment was performed in triplicate.
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PMC11476106
Longer culture time slightly increased PDX73 cell numbers, and VN secretion to culture media remained elevated under all the 3D conditions studied.
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PMC11377827
Tissue specific responses have been observed (e.g. glioma stem cells and pancreatic cancer cells) (Nelson et al, 2022; Zhang et al, 2022), potentially explaining why we did not detect DUBs that have been previously implicated.
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PMC11706297
Compound I (Figure 1) and compound II (Figure 1) revealed antibreast cancer effects related to EGFR (IC50= 0.06 μM) and HER2 inhibition (IC50= 0.18 μM), respectively.
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PMC10745221
In orthotopic xenograft mouse models, the 143B-R cells grew smaller tumors than the 143B-P cells and did not metastasize unlike the 143B-P cells.
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PMC7090062
Fig. 5MiR-30a sensitizes GIST cells to imatinib via autophagy.a GIST-T1 and GIST-882 cells treated with single 3-MA, 3-MA, and miR-30a inhibitor or the negative control were exposed to imatinib, then the cell viability was measured by the CCK-8 assay.
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PMC11587541
Another possibility is that telomere shortening leads to cellular senescence, which can impair the ability of motor neurons to regenerate and repair themselves.
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PMC9429973
The gene expression analysis of niche factors was performed by real-time PCR.
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PMC9429973
Aims: Analyze in-hospital overall survival and causes of death in COVID-19 patients during specific therapy for hematologic malignancies.
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PMC11506670
For GDP docking simulations, the AutoDock Vina 1.5.7 package was used .
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PMC10907726
The 143B cells (1 × 10) were seeded into a 6-well plate (Corning, USA).
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PMC11545737
GBP1 was found to be active against both wild-type meningococcus and the lpxA-defective mutant, which has no LOS .
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PMC11798926
Rat cultures were transfected with the indicated plasmids using the subsequently detailed protocol between 5 and 9 days in vitro (DIV).
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PMC6803987
Its structure is shown in Figure 1.
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PMC11640419
Following this incubation period, seven proteins of different signaling pathways responsible for the induction of different apoptosis pathways in the cell were identified in the lysate of experimental and control samples using a kit (MILLIPLEX MAP 7-plex DNA Damage/Genotoxicity Magnetic Bead Kit and MILLIPLEX MAP Early Apoptosis 7-plex Magnetic Bead Kit panels) (Figure 4, Table S3).
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PMC10850553
Scale bar: 50 μm.
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PMC11451829
In contrast, grade 4 showed a decrease in the level of inflammation (level 3) but with a particular organization of the cell infiltrate: subepithelial multifocal organization (Fig. 3G), lymphoid mass (Fig. 3H) and granuloma (Fig. 3I).
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PMC2614416
These activated forms of oxygen contribute to oxidative stress that modifies lipids, proteins, DNA and carbohydrates.
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