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PMC11240052
Based on these results, inhibition of hsa_circ_0008285 expression could cause upregulation of miR-211-5p and down regulation of SIRT-1 and inhibited the proliferation and invasion of ovarian cancer cells.
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PMC11700247
Graphs show the mean ± standard error of the mean (SEM).
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PMC11295144
To investigate how the co-expression of GABAARs and NL2 in HEK293 cells may regulate the formation of synaptic contacts, HEK293 cells stably expressing α2β2γ2-GABAARs or the control HEK293 cells were transfected with GFP and cherry-tagged NL2 cDNAs, and co-cultured with the medium spiny neurons (Figure 1C).
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PMC7823217
However, recapitulating cellular communications is vital for paracrine and autocrine molecular signalling that affects key hallmarks of cancer.
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PMC9429973
Image: Summary/Conclusion: LP-108 showed favorable safety profile up to 600 mg with daily dose ramp-up schedule, and antitumor activity in patients with r/r B-cell NHL.
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PMC11621493
Higher levels of 18:1-18:1 DAG generated by mPLA2G4D suggest a preference for the MMAT reaction, however, the sum of 18:1-16:0 and 18:1-20:4 DAG account for 56% of 18:1-18:1 DAG highlighting that both reactions occur at comparable rates (Fig. 3K).
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PMC10376064
The supernatant (guanidine fraction containing aggregated Aβ) was collected and stored at −20 °C until further use.
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PMC3888431
Despite the recent rise in publicly available sequence information, proper assembly and annotation of these data sets is still a work in progress.
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PMC6771295
Statistical analysis was performed using GraphPad software.
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PMC7215722
Here, we evaluated the effect of DSS in inducing ER stress and an IBD-like phenotype in Caco-2 cells.
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PMC9429973
Results: Our results demonstrate that, in addition to inflammatory activation, heme strongly alters macrophage functional response to apoptotic cell damage by exacerbating their immune cell recruitment ability and impairing their efferocytic capacity.
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PMC10154881
A–N) ovalbumin (OVA) specific‐CD8 T‐cell analysis.
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PMC10813895
High-risk women who are carriers of inherited germline mutations in genes such as BRCA1, BRCA2, and PALB2 face a potentially seven-fold higher risk than those who are at average risk .
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PMC11766309
YKT6 may mediate autophagy flux changes in CESCs through targeting the TGFB1/TGFBR1 signaling pathways.
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PMC6461034
Pre‐wet the HLB sorbent with 6 ml acetonitrile and apply vacuum to achieve a flow rate of 1 drop per second (1–1.5 ml/min).
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PMC11530949
Additionally, Figure 6D demonstrates that the occurrence of both early and late apoptosis as well as necrosis in cells treated with both the extract and the Ag-doped CuO NPs was significantly higher than the control cells.
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PMC11762280
The statistic of epidermal thickness and average optical density of TUNEL positive staining were analyzed (n = 4).
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PMC7868205
A general expectancy in screening an anticancer drug is to sensitize and destroy the cancer cells rather than the normal cells.75 The mechanism of cytotoxicity of nanoparticles is dependent on mechanisms that involve (i) an increase in calcium levels, (ii) genotoxic effects that lead to cell cycle arrest at G2/M phase, and (iii) ROS, JNK signaling and mitochondria-dependent apoptosis.76 To conclude, the therapeutic index is low for the metastatic HeLa cells, in comparison to the normal cells (HEK-293), as analysed through the present report.
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PMC9872547
Curcumin and dendrosomal carriers were then mixed with this optimal ratio in acetone.
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PMC11629192
The subcutaneous administration of OFA, delivered into the hypodermis, may lead to more efficient and selective targeting of B cells residing in the lymphatic circulatory system than intravenous administration directly entering the systemic circulation .
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PMC9895440
Heatmaps were generated using ComplexHeatmap_2.4.3.
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PMC9822769
Therefore, the percentage of intracellular Pt bound to DNA (PDNA%) is defined as the ratio between platination and cellular accumulation, corrected by the factor related to the cellular content of DNA:(1)PDNA%=PDNA×6.551000×cellular accumulation×100.
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PMC8345486
UV measurements were performed on a GBC Cintra10 UV-VIS spectrometer (Dandenong, Australia).
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PMC11721064
However, the limited availability of healthy limbal tissue and the need for prolonged systemic immunosuppression restrict the efficacy of these approaches .
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PMC11696576
Standard curves fit using 4-parameter logistic regression in myassays.com were used to calculate eicosanoid concentrations.
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PMC11502443
Interestingly, both receptors have been shown to interact with receptor activity-modifying proteins (RAMPs) (Serafin et al., 2020; Lorenzen et al., 2019; Bower et al., 2018).
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PMC9688728
After 20 days, the cell population did not change its doubling time and retained morphological features (Supplementary Figure S1a).
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PMC7582629
The region 1500–1760 cm is characterized by the contribution from C=O stretching vibrations (amide I band) with contributions of water, proteins (C=C), nucleic acids, and lipids (C=C stretch).
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PMC11544122
Equimolar amounts of GST-tag and GST-CXCR4 C-tail (1 µM) were then incubated with HEK293 cell lysates transfected with FLAG-SNX9 or with recombinant purified HIS-SNX9 (0.2 µM) for 2 h at 4 °C.
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PMC11661040
Previous studies have shown that the Wnt signaling pathway is a key pathway controlling OS development(Ji et al. 2020).
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PMC10926885
A, C) The knockdown efficiency of NDE1 in T24 cell line was verified by western blot; (B) and (D) NDE1 knockdown efficiency in 5637 cell line was detected by western blot; (E, F) The effect of NDE1 on the migration and invasion of T24 cells was investigated by scratch assay; (G, H) The effect of NDE1 on the migration and invasion of 5637 cells was investigated by scratch assay. (
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PMC9429973
The inclusion criteria were a diagnosis satisfying the PVSG criteria and, from 2016 on, the WHO criteria.
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PMC11786767
Scale bars represent (A) whole cells: 10 μm; enlarged segment: 1 μm; (B) 2 μm.
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PMC8973725
Therefore, we inferred that ZNF677 expression might serve as a favorable prognostic biomarker for ccRCC.
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PMC11767817
We found that in hypoxia, 2a had the opposite effect compared to normoxia on SOD2, SIRT2, p27, and DKK-4, as the expression of these proteins was decreased.
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PMC10761571
Therefore, recent studies aim to provide modified NPs to improve their biocompatibility, therapeutic efficacy, and reduce their unwanted features.
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PMC11566417
b Relative mean fluorescence intensity (MFI) relative to the control comparing the generation of ROS in neutrophils cultured in primary and immortalized p10 and p20 MDEC CM, respectively. (
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PMC9429973
Trogocytotic ICTs generated from both types of T cell activation have a similar TCR distribution.
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PMC11792090
During in vitro expansion, we observed that the survival and proliferation ability of UCAR-T cells were significantly restricted compared to mock CAR-T cells ( Figure 4A ), as was their tumor-killing capability at a lower E:T ratio ( Figure 4B ).
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PMC7887261
Samples and data were collected by the familial LC recruitment sites of the GELCC, that included the University of Cincinnati, University of Colorado Health Science Center, Karmanos Cancer Institute at Wayne State University, Louisiana State University Health Sciences Center-New Orleans, Mayo Clinic, University of Toledo, Johns Hopkins University, and Saccomanno Research Institute.
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PMC11770746
The organic phase was then completely removed using a rotary evaporator at 60 °C and 50 mbar to form a thin layer of lipid on the bottom of the flask.
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PMC10142392
Initially, the initiator was used for the ROP reaction of caprolactone that yielded a polymer with secondary bromide end groups.
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PMC11783017
These results suggest that the Cis/Mn/NH@PGP hydrogel can increase ROS generation, promote apoptosis, inhibit MYC expression, and thereby suppressing tumor growth and bone destruction.
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PMC5963610
Overall, this data suggest that the cellular immune response induced indistinctly by the NGcGM3 vaccine and the 7A7 mAb mediate the synergistic effect of their combination.
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PMC8956657
In the absence of binding partners, the FITC-tagged peptide migrated towards the cathode (Fig. 1B, lane 1), whereas the IMPα proteins migrated towards the anode (Fig. 1B, lanes 2–6).
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PMC11345828
Despite the improvement achieved in IV clearance from compounds 19 and 20, all reported analogs showed low oral bioavailability in mice Finally, modification of the 4-position ether was also evaluated.
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PMC11437637
Samples were analyzed on the flow cytometer.
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PMC11604768
Fig. 2TRE-MPRA benchmarking with fetal bovine serum and forskolin.a Promoter responses of HEK293 cells treated with 10% FBS (left) or 20 µM forskolin (right) (n = 3 each) compared to untreated cells (n = 4).
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PMC9429973
On initial examination, splenomegaly was found in all cases.
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PMC10452486
Inference: Face-2 of non-classical HLAs is also found on activated T and B cells, NK cells, monocytes, and placental extravillous cytotrophoblasts.
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PMC9927933
However, the association study did not reveal the cause or consequence of UBE2C/UBE2S overexpression in lung cancer development.
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PMC4395774
All assays were done in triplicate.
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PMC9429973
Use of duvelisib (DUV), an oral dual inhibitor of phosphatidylinositol 3-kinase (PI3K)-δ and PI3K-γ isoforms, in PTCL is as an investigational agent only.
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PMC6461034
Here, we combined label‐free kinase‐centric and substrate‐centric information in an Integrative Inferred Kinase Activity (INKA) analysis.
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PMC9429973
Summary/Conclusion: This study analysis demonstrated that an online education consisting of a 30-minute expert commentary with synchronized slides summarizing the presentations from a Medscape Live Virtual Townhall, effectively improved the knowledge and confidence of hem/oncs regarding the latest clinical trial data investigating novel epigenetic agents for B- and T-cell lymphomas.
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PMC10033453
VMG was intranasally administered at doses of 1e7, 1e8, 1e9, or 1e10 TCID50 in 10 μL to female Balb/c mice, with 6 mice per experimental group.
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PMC11240448
The SVM cell state separation implies a geometrical interpretation where the maximal margin hyperplane separates clouds of data points corresponding to different cell states and phenotypes .
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PMC11469524
The search included variable modifications of methionine oxidation, N-terminal acetylation, deamidation (N and Q) and phosphorylation (STY) and fixed modification of carbamidomethylated cysteine.
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PMC10142392
When the length of the hydrophilic PEO block chain is greater than that of the secondary hydrophobic block, micelles are formed.
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PMC9777812
The expression levels of bta-miR-106b and genes were normalized by U6 and GAPDH, respectively.
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PMC7171147
Fig. 2COL11A1 upregulates FAO through DDR2-α1β1 integrin-Src-Akt signaling.a Real-time PCR of CPT1A, ACAA2, and HADHA genes in ES2 cells expressing scrambled, shITGA1, shITGB1, or shDDR2.
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PMC8358006
The color and size of each point represented the −log10 (P value) values and enrichment scores.
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PMC7215832
The major difference between RFC and PCFT is the optimal external pH at which they exert their function, PCFT being most efficient at an acidic pH of 5.5 (a pH at which RFC is not functional), while RFC has an optimal pH of 7.4 (where PCFT is active, but less effective) .
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PMC8524093
Some of these mechanisms have already been described for anti-CHIKV antibodies.
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PMC9429973
Results: The median follow-up time was 23 (2-96.5) months with a total of 33 patients dead and 34 patients relapsed among the 139 patients and the 3 years OS, LFS, CIR and NRM rates after transplantation were 71.7 ± 4.6%, 61.3 ± 4.5%, 27.2 ± 4.1%,11.2 ± 2.9%, respectively.
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PMC11033180
In this study, we identified Sema5A as a molecular signal controlling these processes by promoting axonal complexity and limiting synaptic activity.
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PMC11055510
The OD value in the ov-IL1RAP+mimics group was significantly lower than that in the ov-IL1RAP+mimics nc group (Fig. 7B).
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PMC9927933
Thus, we believe that APC/C is a newly identified E3 ligase, in addition to β-TrCP (41–43) and SAG (49), that promotes ubiquitylation and degradation of DEPTOR in a cell cycle–dependent manner.
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PMC11411131
A hypothetical model of the non-NMD pathway was then examined (Fig. 1C).
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PMC6684588
Weight of injected gastrocnemius muscle after ACE-083 treatment compared to uninjected, contralateral gastrocnemius.
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PMC10291556
This multifactorial mechanism of action, affecting a number of different biological/biochemical pathways and processes, may represent a great advantage as it is very difficult for tumor cells to develop resistance against so many different mechanisms acting simultaneously.
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PMC11337594
In recent years, immune checkpoint blockade (ICB) therapy has achieved great success in clinical studies of advanced melanoma, with objective remission rates of 19%, 45%, and 58% for anti-CTLA4, anti-PD1, and anti-CTLA4 and anti-PD1 combination therapy, respectively .
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PMC11763111
NSG mice were intravenously inoculated with 5 × 10 CCRF-CEM-Luc-GFP-B2M cells and 5 × 10 HLA-A2 mismatched alloreactive PBMCs, primed as described above.
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PMC9429973
EFS in axi-cel patients was not associated with preTx TB (HR, 1.01 [95% CI, 0.88-1.16]; P=.89) or LDH (HR, 0.98 [95% CI, 0.74-1.29]; P=.86), but was worse in SOC patients with higher preTx TB (HR, 1.17 [95% CI, 1.03-1.32]; P=.01) or higher LDH (HR, 1.29 [95% CI, 1.02-1.63], P=.03).
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PMC8557138
The hypoxic microenvironment of the tumor induces the expression of Hypoxia-inducible factor (HIF)-1α, which leads to transcriptional upregulation of VEGF-A in the cancer cells (Carmeliet and Jain 2000).
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PMC11610461
In KC, tumor cells preferentially derive energy through the aerobic glycolysis-mediated hypoxic response pathway rather than by oxidative phosphorylation (Akhtar, Al-Bozom & Al Hussain, 2018).
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PMC9681981
However, the production of this toxin was not affected by the VirS/VirR regulatory system in this strain.
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PMC8382973
The optical density was read using an Infinite F50 absorbance microplate reader (Tecan).
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PMC11473750
c Immunoblot analysis of RNF121 expression in human MYCN amplified neuroblastoma cell line, SK-N-BE(2)-C, across the 4 days following transfection with either RNF121 or mutant RNF121.
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PMC11337594
A representative density plot of Annexin V-FITC/PI staining is shown in Fig. 1D. (
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PMC11634027
The protocadherins Fat and Dachsous regulate organ growth, shape, patterning, and planar cell polarity.
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PMC9429973
In total, 110 (65.1%; 95% confidence interval [CI] 57.4–72.3) patients achieved complete response as the best response and 50 (29.6%; 95% CI 22.8–37.1) patients achieved partial response.
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PMC5716223
Nuclear protein extract from Jurkat cells stimulated by TPA and calcium ionophore was used as positive control (2 days: − NGF vs + NGF, 2.2 vs 3.0, p < 0.05).
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PMC9878278
Data is presented as mean ± SEM from at least 3–5 independent experiments. *
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PMC7642379
When analyzing more local copy number variations between progeny cell lines and the parental strain, some interesting loss or gain of full or partial elements compared to the parental HEK293 were identified.
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PMC11697703
E and F) Top 10 over-represented biological processes by GO analysis of predicted targets of miR-193b (E) and miR-365 (F).
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PMC11731614
N = 4 across two biological replicates.
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PMC11461833
However, the other functions of HERVH need to be explored.
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PMC8357004
For apoptosis determination, the Caco-2 cells were cultured at a density of 4 × 10 cells/well and incubated overnight without treatment.
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PMC10421378
A 30% NaOH solution was used for pH regulation.
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PMC10723784
In separate experiments, cells were seeded in 96‐well plates and after 24 h elapsed they were exposed to different concentrations of drugs or vehicle.
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PMC10093184
Our experiments confirmed the ability for anchorage-independent cell growth of COS4288 and D-17 cells.
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PMC11806818
However, the defects of relatively low substrate selectivity and catalytic efficiency of the nanozymes have not been resolved, hindering further improvement of the sensitivity of this aptasensor.
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PMC11767725
Symptom severity, assessed using the Seborrheic Dermatitis Area Severity Index (SDASI), significantly improved, with mean SDASI scores decreasing from baseline (T0) to T8 (p < 0.0001).
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PMC9429973
Stratified models for each of the risk scores (HLH-2004 and HLH-2009) were compared using Akaike’s information criterion (AIC) and the Harrell’s concordance index (C-index).
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PMC9424261
E Reciprocal IP experiments of GSS, MDM2 and SYVN1 in wild-type Bel-7402 and Bel-7404 cells.
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PMC11222184
Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) biological process analyzes were performed using the Enrich web tool.
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PMC11737091
The slides and the intensity of immunohistochemical staining were analyzed under light microscopy.
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PMC10808409
The H-NMR spectrum of FA showed the characteristic signals for 4-Hydroxy-3-methoxycinnamic acid (Ferulic acid) (Bunzel et al., 2005).
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PMC11704135
9Mass fragmentations of compound 14.
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