PMCID string | Sentences string | ner list |
|---|---|---|
PMC8382973 | After establishing a dose–response curve, the IC50 dose was estimated using appropriate correction techniques using GraphPad Prism statistical software. | [
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PMC11764090 | Similarly, WRKY22 transcription factor is essential for cold stress adaptation in A. thaliana buds (Table 2). | [
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PMC7802142 | The cells were harvested and homogenated. | [
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PMC10890055 | First, we compared the sensitivity of hFOB 1.19 to Zn in the presence and absence of the selection reagent, G418. | [
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PMC9429973 | Here, we confirm the implication of miR-625-5p in the regulation of apoptosis in T-ALL cells in vitro. | [
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PMC6889484 | Blot probed with α-A3G (green) and α-tubulin (red). ( | [
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PMC11377827 | Template cDNA (20 ng) was amplified using the ABI 7900HT Real-Time PCR system (Applied Biotechnology or Quantstudio 7). | [
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PMC11317131 | Only phage capable of recombining AP and CP express gIII and produce phage fast enough to keep from being drained from the system. | [
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PMC11401350 | We used physical particle titers as determined by p24 content. | [
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PMC9436459 | The total synthetic investigations towards this family of compounds by various chemistry research groups are summarized for the first time. | [
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PMC11696659 | The inclusion criteria for the patients at high risk of lung cancer were: age above 40 years; who smoked more than 400 cigarettes (20 packs) per year; presented nodules after x-ray radiography and/or haemoptysis; were having a bronchoalveolar lavage (BAL) and blood extraction performed following standard clinical practice for diagnosis; and gave informed consent to participate. | [
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PMC9429973 | Adults (>16 years old) who received inpatient or outpatient RBC transfusions from 2013 to 2021 were included (n = 53,941). | [
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PMC11515150 | Kaplan–Meier survival curve (log-rank test). | [
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PMC5035325 | Most specimens had strong intensity to EGFR (17 of 30 animals, 57 %) and to NeuGcGM3 (14, 47 %). | [
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PMC11544771 | This study has demonstrated that CPX is synergistic with PRE in inhibiting cell proliferation and inducing apoptosis of NSCLC (A549 and A427) cells. | [
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PMC11001582 | iPSNs were differentiated in accordance with the diMNs protocol previously described and maintained at 37 °C with 5% CO2. | [
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PMC9429973 | Neurotoxicity was documented after 2 cycles. | [
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PMC5261804 | Here we describe MEDICI (Mining Essentiality Data to Identify Critical Interactions), a new computational approach that leverages high-throughput gene knockdown data and protein interaction network topology to rank PPIs based on their criticality for the survival and proliferation of cancer cells. | [
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PMC11116779 | Interestingly, flow cytometry dot plots for physical parameters (forward scatter vs. side scatter) showed an increase in the side scatter of all the cells, already at the concentration of 100 μg/mL, and further increased when 500 μg/mL of PS-NPs were administered to the cells (Supplementary Figure S7). | [
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PMC9046263 | Furthermore, in cancer cells with known epigenetic dysregulation, HERVs have been implicated as potential oncogenic drivers. | [
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PMC11621565 | Statistical analyses used fold-change calculation as fold increase to control followed by statistical significance testing (One-Way ANOVA followed by Dunnett’s Test), *p < 0.05, **p < 0.01, ***p < 0.001. | [
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PMC10571053 | When we performed cytotoxicity assays with imidazole ketone erastin and piperazine erastin, the knockout clones displayed increased sensitivity to both compounds by about 3- to 4-fold compared to parental cells; however, no difference in sensitivity to erastin was noted [Supplementary Table 2]. | [
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PMC11799620 | The control in this assay is Quercetin. | [
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PMC11680578 | Building on previous studies, our research reveals a significant decrease in the number of small blood vessels in the group treated with PTX + RGZ compared to those treated with just RGZ, PTX, or control. | [
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PMC8270637 | Next, we tested the cytotocicity of T cells for HCC cells after TGF-β1enhanced the expression of PD-1 and CTLA-4. | [
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PMC11700247 | These effects were abrogated in the presence of an anti–major histocompatibility complex I (MHC I) antibody (Figure 3D). | [
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PMC7823217 | Integration of organotypic constructs within simulated physiology of microfluidic platforms are challenging with the potential to incorporate all the required characteristics of human in vivo tumours. | [
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PMC11569208 | This mechanism was eventually found to be secondary to activation of the epidermal growth factor receptor (EGFR) subsequently leading to changes in STAT phosphorylation and NF-κB signaling to subvert IFN-1 responses towards more of an IFN-2 phenotype. | [
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PMC11705547 | However, FASN inhibitors can also induce drug resistance and immune evasion by suppressing the PI3K-AKT-mTOR pathway and inhibiting T cell activation and function. | [
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PMC11760643 | P2X7 expression on memory B cells (205.3 ± 6.0) was significantly greater compared with total B cells (154.3 ± 7.7) (p = 0.002; Figure 3G). | [
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PMC10024132 | Survival of the mice was monitored. | [
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PMC10772747 | The results obtained from the flow cytometry analysis in Figure 5 (C and D) showed a significant effect on cell cycle distribution after treatment with EBE (P<0.0001). | [
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PMC11536589 | Mouse ductal cells identified by the gene markers Krt19 and Krt7. ( | [
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PMC11536589 | All primer sequences used in our study are listed in Table S1. | [
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PMC11754432 | Streptolysin O binds to accessible cholesterol in the plasma membrane and forms pores, allowing the entry of propidium iodide, which normally cannot enter intact cells. | [
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PMC10729469 | Nucleotide sequences represent the guide RNAs targeting the alpha and beta regions of the TCR. | [
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PMC11661024 | This cancer arises from the cervix due to an irregular cell growth with the ability to metastasize to other human parts of the body . | [
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PMC11394112 | Food pellets and water were sterilized and provided as much as necessary or desired. | [
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PMC11786156 | Descriptive statistics were calculated using Microsoft Excel 2013 (Microsoft Corporation, Santa Rosa, California, USA). | [
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PMC11696576 | The organic solvent was evaporated under reduced pressure and the residue was purified by column chromatography [EtOAc-petroleum ether (bp 40–60 °C), 3:7]. | [
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PMC11732635 | The treatment of CAEBV is still evolving and includes antiviral drugs, immune system regulators, and hematopoietic stem cell transplantation (HSCT). | [
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PMC9960565 | Therefore, 0.25 g of G1.5COONa PAMAM (0.09 mmol) was dissolved in 10 mL of UPW and added dropwise to the aquated cisplatin mixture under stirring. | [
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PMC11790971 | The simultaneous recording of 2PF, 3PF, THG, SHG, and 3PF FLIM signals provides both structural and metabolic information about the samples (Fig. 1c). | [
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PMC10560648 | Moreover, a protein called p15 (also known as CDKN2B, INK4B, p15INK4B) captures the cell cycle in the G1 phase by inhibiting cyclin-dependent kinase 4/6 (CDK4 / 6). | [
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PMC11640476 | It was observed that FI values significantly increased after one resazurin treatment, with a slight increment after 2 and 3 resazurin treatments, confirming that residual resazurin/resorufin remains trapped in the gel and is slowly released over the days following incubation (Figure 6A). | [
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PMC9429973 | Summary/Conclusion: In this comparative analysis, tec showed statistically improved DOR when compared with belamaf and numerically favorable results for other outcomes. | [
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PMC4360730 | Each selected slim term is listed in the facet when there are biosamples that slim to that term. | [
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PMC11718274 | Fig. 3 Photomicrograph of TEM imaging showed the well distribution and cubic shape of Y 2 O 3 NPs with an average particle size of 14.15 nm. | [
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... |
PMC7348793 | Finally, for a 15,617 bp NUMT to be amplifiable, at least three conditions should be met: (a) the NUMT should have a near-genomic length (these are outnumbered by shorter NUMTs in all known genomes. | [
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... |
PMC10919056 | Univariate and multivariate stepwise Cox regression analysis of RS and clinical characteristics in ccRCC. | [
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PMC11802855 | The co-culture system of MM cells and mouse BMDMs was established using a Transwell co-culture system. | [
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PMC8633974 | These results cumulatively support the utility of TatDE CRISPR-Cas9 in eliminating latent proviral HIV-1. | [
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"O",
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PMC10652261 | 4-Cyano and 4-methoxy substitutions led to a significant decline in anti-APL activity. | [
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... |
PMC9429973 | Forty percent of these molecular diagnoses were detected by targeted NGS panel technology. | [
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PMC11155445 | Overall compound (92ab) was concluded as the most potent inhibitor of AChE enzyme (Fig. 31). | [
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PMC10938377 | In its place, the Orn side chain (having nearly the same length as the Met side chain) of bound Au–LANA and LANA–Au is sandwiched between two carboxylate groups, resulting in ion pairing with the ammonium group (Fig. 2c). | [
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... |
PMC11467800 | The embryos were first examined for proper yolk sac injection, and any embryos showing cells in the bloodstream were excluded 24 h after injection. | [
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PMC4485786 | Sample slides were transferred to a wet chamber and stained with Zytochem-Plus AP Polymer-Kit (Zytomed Systems, Germany). | [
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PMC9429973 | Furthermore, there were no significant differences in other biomarkers. | [
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PMC11352666 | In this study, we demonstrated MERTK expression in EWS cell lines and patient samples. | [
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... |
PMC7685376 | p < 0.05, **p < 0.01, ***p < 0.001. ( | [
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"O",
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... |
PMC11733919 | Schematic representation of MNP@T@CD26@17D nanoplatform designed to target and eliminate senescent cells. ( | [
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PMC11683240 | Furthermore, cells were incubated with 100 μM α1AT without PT. | [
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"O",
"O",
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PMC11337594 | This indicates that PARP1 is not cleaved by CASP3, but rather by other downstream proteins induced by p53 in A375 cells. | [
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... |
PMC9739791 | Interestingly, the antitumor efficiency of the oxaliplatin-PPA mixture and irradiation showed no statistically significant difference from the oxaliplatin and control groups. | [
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... |
PMC11622247 | The intercalation of the QB or TO dye, forcibly formed by hybridization with the target, closes quenching channels. | [
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PMC5854676 | The experimental scheme for cell labelling used 96 well plates for sub-culturing and experimentation, as follows. | [
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PMC7338939 | Therefore, a number of antitumor agents are developed against certain signaling pathways such as EGFR, AKT, and BRAF (10). | [
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... |
PMC11490153 | The medium bands at 2967, 2915, and 2856 cm presented stretching vibration of –CH due to sp hybridization, and the band at 1717 cm attributed to the carbonyl group. | [
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... |
PMC9429973 | The median number of cytogenetic abnormalities increased from 1 to 2 with no change in the median number of mutations from diagnosis to HMA-F, but both had significant increases by paired t-test (p<0.001). | [
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... |
PMC11301095 | The American Centers for Disease Control and Prevention (CDC) has approved miltefosine for clinical use when necessary. | [
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PMC11394730 | The intricate interplay between cellular metabolism and cancer progression has led researchers to explore the therapeutic potential of various natural compounds derived from plants, fruits, and other sources. | [
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... |
PMC7338939 | These results were also confirmed by histopathological evaluation (Table 2). | [
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PMC10891340 | Thereafter, fresh DMEM with CCCP (20 μM) or DMSO cultured at 37°C for 3 h, then carefully washed with PBS, sealed with 1% methylcellulose and DMEM containing 2% FBS cultured at 37°C for 72 h, and then directly calculated the number of virus plaques using the mean values from the repeated wells. | [
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... |
PMC9429973 | Results: A total of 34 chemotherapy cycles for hematological malignancies were analyzed. | [
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PMC11806182 | Testosterone and estradiol might have adverse roles in UCEC, while drugs like troglitazone, valproic acid, retinoic acid, and progesterone demonstrated various effects on gene expression and cellular processes. | [
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PMC10882807 | P < 0.05, **p < 0.01, ***p < 0.001). ( | [
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... |
PMC9454852 | Considering the similarity in EC50 values obtained for REN and MM98 cell lines, and since the epithelioid is the most frequent histotype, we decided to perform subsequent experiments on the epithelioid REN cells using Met5A cells as a reference control cell line. | [
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"... |
PMC11566417 | Briefly, cryopreserved samples were thawed at 37 °C and dissociated using 0.25% trypsin-ethylenediaminetetraacetic acid (EDTA) (Corning, Corning, NY), dispase (Sigma-Aldrich, St. Louis, MO) and DNAse-1 (Worthington, Lakewood, NJ) and triturated. | [
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"O",
"O",
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... |
PMC6102174 | Swertia macrosperma (Dazi Zhangyacai), the congeneric species of S. mileensis, is widely used for curing hepatitis in Yunnan Province, China. | [
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"tok... |
PMC11700523 | Previously, we reported that under hyperglycemic conditions in diabetic nephropathy, de-ubiquitination of MR protein is induced by phosphorylation by the protein kinase C pathway and O-linked N-acetylglucosamine (O-GlcNAc) modification by the hexosamine pathway, resulting in the elevation of MR protein levels and aldosterone-mediated MR transactivation . | [
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... |
PMC11568601 | After 6 h of transfection, the media was replaced with fresh DMEM complete media (HyClone, USA) and cultured for 48 h. Then the proteins were extracted and the transfection efficiency was calculated via a western blot experiment. | [
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... |
PMC10818573 | Although EBV DNA levels subside over time following new infections, EBV can be periodically released into the oral secretions of carriers . | [
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"... |
PMC7351993 | b SRS images of PS and PMMA particles (representative of n = 9786 and n = 4063, respectively) at the four wavenumbers and decomposed images of the particles. | [
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"tags": [
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... |
PMC11126803 | Together, results from Figure 4, A–J suggest that ERβ may function via modulating ZEB1 expression to promote the Matrigel-coated 2D and collagen I-based 3D VM formation and invasion in RCC cells. | [
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"tags": [
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... |
PMC11753949 | Since the presence of spine apparatus was only reported in mammals, we searched the entire brain electron microscopy dataset of D. melanogaster, FlyWire (https://flywire.ai). | [
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"O",
"O",
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... |
PMC8658661 | The case of liver cancer focuses on the following pathways: the transforming growth factor β (TGF-β) , proto-oncogene Wnt/β-catenin , phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) , c-Jun N-terminal kinase (JNK)/signal transducer and activator of transcription (STAT) , Hedgehog and tumor protein 53 transduction pathways . | [
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... |
PMC10723784 | Data represent the mean ± SE of the mean of n = 4, *p < .05, **p < .01, and ***p < .001 compared to control values. | [
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... |
PMC11666785 | The average intensity and number of molecules in that region are estimated. | [
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... |
PMC3203927 | The box-plot displays differences between populations without making any assumptions of the underlying statistical distribution. | [
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PMC11787651 | The flow rate was 300 nl/min. | [
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PMC6835428 | As member of the Inhibitor of apoptosis protein (IAP) family , SVV induces chemotherapy and radiotherapy resistance in OC through the inhibition of apoptosis. | [
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PMC8662250 | Results were expressed as optical density (OD; arbitrary units = mm) and normalized against the expression of the housekeeping protein GAPDH. | [
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... |
PMC11754784 | To validate our therory, we simulated the diffusion trajectories with or without a difusion boundary using MATLAB codes (Supplementary Note 2). | [
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... |
PMC11194678 | Statistical data for the population of cells containing HTT Q72 aggregates. ( | [
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PMC11657744 | Throughout the cell cycle, centrioles perform distinct functions by organizing spindle poles during mitosis and transitioning into basal bodies to initiate cilia assembly during interphase . | [
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PMC3888431 | Three new classes were introduced for the SAMS system: Region::Isogroup, Region::Group::Isotig and Region::Source::NGSContig, based on the nomenclature of the GS de novo Assembler (Roche Applied Sciences). | [
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PMC9693627 | Expression was induced by adding IPTG up to 0.25 mM, cells were incubated for 4 h at 30 °C. | [
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... |
PMC11711127 | It can lead to the exhaustion of immune cells, a decrease in their functionality and an increased production of proinflammatory cytokines. | [
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... |
PMC5673060 | Uniprot keyword protein localisation annotation terms linked to either statistically significant DasR or A204 parental up-regulated phosphoproteins generated using the DAVID functional annotation tool . ( | [
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