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PMC11720107
Our experiments showed that after 6 h of exposure of BJ cells to 0.250 mg/mL of the tested extracts, the Ornak and Morado cultivars significantly decreased CAT mRNA expression by 70.8% and 28.4%, respectively, compared with the control (Figure 6A).
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PMC11724582
Therefore, the clinical aspects of the validation results can be completed and added to subsequent extension work.
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PMC11607638
EC50 = 1.18 nM. The abscissa in panels (A–H) is time in min. (
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PMC11719944
Moreover, it is well known that hormones such as prolactin (PRL) influence cellular responses.
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PMC11703992
D Detection of IL-1β, IL-2, IL-6, IL-17 and TNF-α expression levels in different groups of Jurkat cells (n = 3).
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PMC10114490
A Sequence of retrotranscribed SERPINA1 mRNA isolated from diHLC-T corresponding to the region of exon 6 containing the Glu366Lys mutation (PiZZ genotype).
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PMC11224206
It should be noted that while excess ROS are potentially harmful to many cell functions inducing DNA damage and compromising gene expression, they also perform essential signalling roles required in the embryo for components of pronuclear formation, first cleavage, cell proliferation and apoptosis .
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PMC11409031
Detection of the efficiency of PFN1 expression inhibited by small interfering RNA in the A2780 cell line. (
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PMC7171147
However, the molecular mechanisms by which ovarian cancer cells switch their metabolic phenotype to promote fatty acid metabolism and chemotherapy resistance are largely unknown.
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PMC11087301
They also found that infiltrating M2 macrophages promote EMT in TNBC cells indicated by enhanced N-cadherin and vimentin expression as well as increased cell migration.
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PMC9792775
HT-1080 was cultured in MEM-EBSS with 1% Non-Essential Amino Acids.
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PMC11643361
However, its activity against SW620 was lower than that of cisplatin, and it showed no significant effect against HepG2.
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PMC9429973
In the multivariable analyses we found no difference in PFS or OS with a hazard ratio of 0.94 (95% CI 0.81 - 1.10) and 0.99 (95% CI 0.83 - 1.17).
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PMC11696659
A, percentiles of telomere length.
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PMC5261804
We then examined the set of PPIs with nominal log rank p-value < 0.05 that were also essential in lung adenocarcinoma cell lines based on our analysis of Achilles data.
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PMC9318744
Here, we report the development of a robust A549-based cell line that highly expresses ACE2 and TMPRSS2 and remains relatively stable to SARS-CoV-2 infection susceptibility after multiple passages, providing a valuable cell line for performing high-throughput in vitro testing to evaluate the efficacy of SARS-CoV-2 antivirals and facilitate research on drugs for COVID-19 treatment.
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PMC9429973
For patients with PTCL-NOS, AITL, ENKTL, ALCL ALK- and ALCL ALK+, a comparison in terms of PFS was performed for those enrolled in the TCP2 and in the previous TCP1.
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PMC11674146
For instance, the deregulation of MYC, one of the most deregulated oncogenes in human malignancies, has been already characterized (Sewastianik et al., 2014).
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PMC3681794
Western blotting for HIF-1α and CA IX shows suppression of HIF-1α expression and transcriptional activity.
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PMC11470381
All media and buffers used for cell preparation and imaging should be filtered using 0.22 µm filters.
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PMC9429973
PLT count (>600×10/L) increased TE risk (HR=1.37 [95% CI, 0.763–2.468]) compared with PLT count ≤600×10/L, but this was not statistically significant (P>0.05).
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PMC11591038
The unmet demand for oxygen in human cancers can modify cellular metabolisms; these include the shift from oxidative phosphorylation to glycolysis, the enhanced synthesis of glycogen, and changes in the major substrate from glucose to glutamine for fatty acid synthesis.
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PMC11635087
As the host cultured mammalian cells, we used the Chinese hamster ovary (CHO)-K1 cell line, which has been used for the bioproduction of valuable substances and antibodies.
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PMC10380508
Cell line information, including its source and culture medium, is listed in Supplementary Table S1.
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PMC9429973
Overall, 5 patients had a TLS with 3 of them being clinical TLS.
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PMC11593031
Fluorescence in situ hybridization (FISH) was conducted as previously described using whole-chromosome paints (“SkyPaintTM DNA Kit M-10 for Mouse Chromosomes”, Applied Spectral Imaging, Edingen-Neckarhausen, Germany) for multicolor-FISH (mFISH), murine chromosome-specific multicolor banding (mcb) probe mixes for FISH-banding, and the microdissection-derived probe described under Section 2.2 .
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PMC10482220
In both plant and animal cells, SGs correspond to large, dynamic cytoplasmic structures at which untranslated mRNAs accumulate (Nover et al., 1989; Kedersha et al., 1999, 2002).
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PMC11537649
Lnc NEAT1 was knocked down in A375 cells.
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PMC11473843
The targeting of CDK5 with Seliciclib is being tested in clinical trials, and it is well tolerated in combination with other drugs such as Gemcitabine or Cisplatin in NSCLC patients (Le Tourneau et al, 2010).
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PMC7612475
Because our data indicate that the SF3B1 mutation gives rise to an HR defect, we hypothesized that this could be exploited therapeutically to treat tumors that have acquired this mutation.
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PMC3274243
Electrochemical open circuit potentials (OCP) generated at the cell:sensor interface are measured and processed by the analytical monitor, then displayed in real-time via proprietary software on a personal computer.
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PMC11629461
Note that the human thyroid follicular epithelial tumor cell SW579 was very sensitive to UVA irradiation; a 10 sec LED 380 pulse at 0.1 mWatt/cm was sufficient to trigger detectable calcium oscillations, a rather low dose similar to that used in primary rodent mast cells or mast cell line.
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PMC10560648
Sea-derived compounds, due to their chemical complexity and biological diversity, can be considered as major candidates for the discovery of new therapeutic agents.
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PMC9516447
A427 (A), H460 (B), HCT116 (C), LS180 (D), PANC-1 (E), and CFPAC-1 (F) cells were treated with either DMSO, HA15 (10μM) or YUM70 (10μM) for 24 hr.
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PMC9895440
As expected from our CRISPR-Cas9 screen and the initial validation, SNX9 KO increased degranulation and IFNγ secretion in Tex, whereas reduced IFNγ secretion was observed for SNX9 KO Teff (Fig. 3b, Supplementary Fig. 5d, e).
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PMC5941560
Interestingly, 6 of the 10 variants, involving 5 separate genes, are thought to cause cancer.
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PMC10114490
A-80-229A; 1/500), alpha-1-antitrypsin (Cell Marque 223A-15; 1/500) and Ki67 (ThermoFisher R-9106; 1/500).
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PMC9429973
Analysis of cells at the site of injection (right femur) revealed induction of differentiation from a granulocyte-monocyte progenitor (GMP) to a megakaryocyte-erythrocyte progenitor (MEP) or common myeloid progenitor (CMP) state in response to oral-AZA.
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PMC10936243
so that is why we just leave the cage empty without anything, so the urine will just flow to the bottom of the cage….It is not to say that expensive, but we prefer to just let the cat urine flow to the bottom of the cage….It is much easier that way, as compared to if they defaecate or urinate on the towel….
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PMC10114490
D α1-antytrypsin secretion was estimated from 24-h cell media using an ELISA kit.
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PMC11806106
These receptor sensors have a truncated C terminus removing the phosphorylation sites in the C terminus which are required for arrestin interaction.
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PMC6268318
Sond.,
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PMC11796104
Then, the hub genes in the PPI network were identified with four algorithms, including maximum neighborhood component (MNC), degree, and Edge Percolated component (EPC), in CytoHubba, a plugin in Cytoscape software.
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PMC9429973
Median time from the end of cBTKi therapy to discontinuation of the immediate post-cBTKi therapy or death was 3.9 months (95% confidence interval [CI]: 3.3-4.6) in the US and 2.4 months (n=196, 95% CI: 1.7-3.0) in Japan.
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PMC9429973
At cutoff, treatment was ongoing in 84 (53.5%) and 15 (19.7%) pts, respectively; the most common reason for discontinuation was lack of efficacy in 38 (24.2%) and 27 (35.5%) pts, respectively.
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PMC11764090
ET is involved in regulating a series of biological processes.
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PMC11759543
One hundred μl of dimethyl sulfoxide was added, and the absorbance was measured.
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PMC10125312
MTT measures the metabolic activity of cells, directly dependent on mitochondrial respiration, which is interpreted as a measure of cellular viability.
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PMC9429973
The Cumulative Incidence of Relapse (CIR) was estimated with competing-risks regression analyses according to the method of Fine & Gray.
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PMC9065483
Hundreds of different OV products using different viral platforms and genetic payloads are currently in clinical trial.
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PMC11697703
For each condition, images are shown with (bottom) and without (top) reconstruction. (
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PMC9429973
scRNA-seq and single-cell T cell receptor (TCR) sequencing were performed by the Chromium system (10x Genomics) from 16 PB and 9 LN of TFH lymphoma patients and 7 HLN.
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PMC9587866
Our study provided a 3D constructed EYA3 model and two promising medicinal compounds showing affinity for this protein.
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PMC6642070
It is supported by the fact that exercise exacerbates muscle syndromes induced by statins , as exercise will cause additional lactate accumulation.
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PMC11594588
Mitochondrial activation pathways also contribute to the altered structure of platelet apoptosis.
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PMC11055323
Chromosomal translocation is a frequent mechanism that leads to dis-regulated kinases, transcription factors.
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PMC10317042
Unlike the transcriptional activation mechanisms of HDACis, the transcriptional suppression mechanisms of HDACis are not well understood.
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PMC4005030
The neurotrophic effects of protocatechuic acid on neurite outgrowth and survival in cultured newborn rat cerebral cortical neurons was determined and it was found out that PCA increased the number of survival neurons with neurites and the average length of neuritis.
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PMC8633974
Four independent co-transfection screens were performed to ensure experimental accuracy.
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PMC11546117
The Papp values were calculated as follows:(3)Permeabilityapparentcms=dQdt(signals)∗1Areamembrane(cm2)∗Concentrationdonor(signalmL) The signal of the area-under-the-curve of the compound peak was obtained after the liquid chromatography with tandem mass spectrometry (LC-MSMS) bioanalysis and dilutions made during sample preparation and the injection volume were corrected.
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PMC10079526
DNA methyltransferases are in charge of DNA methylation site maintenance during cell division, in which they methylate CpG sites and consequently silence genes .
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PMC11678368
The results provide valuable insights into the impact of chloro-derivatives of 7-azaindole-3-carbaldehyde on the cytotoxic properties of metal complexes, which can be important for the future design of new metal-based anticancer drugs.
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PMC7171147
We demonstrated that phosphorylation of AMPK (indicative of AMPK activation) was increased by COL11A1 as early as 2.5 h and was retained until 96 h in ovarian cancer cells. (
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PMC10734950
ROS accumulation was identified with carboxy-H2DCFDA reagent and analyzed by flow cytometry.
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PMC11675244
On the other hand, Axin, another protein in this complex, is regularly degraded by tankyrase, a poly-ADP-ribose polymerase that attaches ADP-ribose polymers to Axin, targeting it for ubiquitination and degradation.
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PMC11730305
Compared to normal human cells, Co3O4@Glu-Ellagic acid nanoparticles showed significantly higher toxicity for liver cancer and the 50% inhibitory concentration was 94 and 187 µg/mL for the cancer and normal cells, respectively.
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PMC11087055
Therefore, the trajectories and streamlines show similar pattern when the cell flow is in stable-state; however, they are not completely consistent with each other when the cell flow is unstable and time-dependently changing (Batchelor, 2000; Aris, 2012; Greenshields and Christopher, 2022).
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PMC6617630
Images of U2932 (a-c) indicate a normal 2-fusion (f) signal pattern for MYC, amplification of BCL-2, and 4F for BCL6.
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PMC8992508
P-gp transports neutral and positively charged molecules: amphipathic compounds both in their unmodified form and as conjugates, lipid soluble compounds (molecular weights in the range of 300 to 1000) and compounds with aromatic rings and a positive charge at physiological pH. On theses bases, it is clear that P-gp can transport many endogenous compounds such as steroid hormones, lipids, peptides and small cytokines, but also a broad range of therapeutic drugs including anticancer drugs (e.g., vinca alkaloids, anthracyclines and taxanes), analgesics, antihistamines, antibiotics, antivirals, cardiac glycosides, calcium-channel blockers, calmodulin inhibitors and immunosuppressive agents.
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PMC11621565
Curli CsgA and PSMα-1 showed minimal or no changes.
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PMC4277423
At this time, we do not know what causes such a dramatic difference in CCR5, CD4 and CXCR4 gene disruption between T cell lines and primary T cells.
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PMC11281366
Lastly, HIV-1-mediated downregulation of miRNA-26a expression is shown to be dependent on integrated HIV-1 expression but does not involve viral accessory proteins.
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PMC10734950
Interestingly, F8-treatment did not affect STAT 1 (0.86) and phosphorylation.
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PMC11420784
The strains and plasmids used in this study are listed in Supplementary Tables 1 and 2.
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PMC10667689
Zhang et al. revealed that TIM-3 can prevent glycolysis in the RAW 264.7 macrophage cell line through downregulation of HK-2 expression (61).
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PMC11683240
Cells were left untreated as further control.
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PMC11472639
Patients with SMM (n = 16) were screened for eligibility (as discussed below) to perform strenuous exercise and all provided written informed consent, and n = 9 SMM patients subsequently completed all experimental procedures with no adverse events or serious adverse events occurring in this study.
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PMC9429973
However global protein synthesis was not affected and surprisingly, in all tested cell lines, the monoclonal component secretion in extracellular medium was preserved after 96 hours of arginine starvation.
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PMC9429973
Image: Summary/Conclusion: RUNX1-mut based patient-specific ddPCR assays could be developed for all RUNX1 mut AML pts.
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PMC11437637
Moreover, although lymphocytes were closely associated with the development of diabetes , hypertension , and hyperlipidemia , there is a lack of research on the relationship between lymphocytes and EC.
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PMC9424261
I Total ubiquitination of GSS, as co-IP by anti-GSS antibody for the indicated treatment in Bel-7402 cells with or without drug treatment, and measured by anti-total ubiquitin antibody.
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PMC11732523
Ying Huang: Software.
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PMC11790971
In addition to conventional evaluation metrics (e.g., balanced accuracy, precision, recall), the impurity score was created which can be used to measure the classification performance of cells with uncertain labels.
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PMC9100622
One of these loci encodes EGR2/KROX20, which was further shown to be a cis-mediated target of EWSR1-FLI1 and to be essential for EwS growth in vivo in xenograft models.
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PMC10849234
The use of genetically tractable systems to assess human neutrophil biology will therefore potentiate a better understanding of this crucial player in health and disease, potentiating the design of more effective interventions for both infectious and autoimmune diseases.
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PMC11680391
This finding was in contrast with our expectations that the agreement would be at least moderate to have a working relationship between the dairy farmer and herd veterinarian.
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PMC11472639
Future research should consider the optimal timings of exercise during daratumumab treatment in myeloma to avert exacerbation of daratumumab-mediated NK-cell lysis.
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PMC11638255
Taken together, these results indicate that copper chelation can shift neuroblastoma tumors towards a less aggressive phenotype by destabilizing the tumor microenvironment.
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PMC11754432
Lipids are essential in cutaneous biology, which is underscored by their importance in the formation of the permeability barrier as well as their involvement in modulating inflammation , cell growth and differentiation .
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PMC10092581
H157 cells were seeded into 8‐well tissue‐culture slides (BD Falcon, Bedford, MA, USA) at 5×10 cells/well (0.8 cm).
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PMC8469018
In the HepG2 liver cancer cell line, teriflunomide has an impact on DHODH transcription rate .
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PMC11700523
MR activation is caused by aldosterone or cortisol as a ligand; however, MR activation is possibly not mediated by aldosterone but by abnormalities in the transcription factor regulatory system.
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PMC11540664
To date, there are no effective biomarkers to screen patients with cancer to identify those who are more suitable for TKI+PD1 rather than single-agent TKI use.
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PMC10887351
The group showed that HDAC2 was the exact target of the cAMP response element binding protein (CREB), which was activated by β-ARs signaling, for angiogenesis, in a xenograft model of prostate cancer in mice.
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PMC11422150
Despite advances in medical research, there are still no effective treatments for SCI.
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PMC9429973
Aims: Our aim was to characterise EMCN as a novel complementary marker for purification of HSCs and to investigate its biological function in an EMCN knock-out (KO) mouse model.
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PMC11412752
Cells were lysed, and total RNA was extracted using TRIzol reagent.
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PMC7081114
We appreciate Professor Li-ping Wen and Professor Feng-lei Liu for their selfless help.
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PMC9429973
Here we present an update on the preliminary efficacy data of emavusertib + ibrutinib in R/R hematologic malignancies.
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PMC11544122
No. 11668019) was from Invitrogen (Waltham, WA).
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