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PMC9429973
Image: Summary/Conclusion: In summary, the previously developed VS screening protocol based on pharmacophore filtering and docking was validated on novel SFK inhibitors that were predicted as Pgp ligands in agreement with the experimental results.
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PMC9429973
Lower infection risk recipients also seem to have increased innate immune response.
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PMC8658661
This is not critical for some work, such as studying the amount of protein in a cell.
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PMC11467964
All cell lines were cultured in Dulbecco's modified Eagle's medium (Gibco, 11965118), with 10% fetal bovine serum (Gibco, A5670701) and 1% penicillin‐streptomycin solution (New Cell & Molecular Biotech, C100C5).
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PMC2777936
Real-time PCR assays were used to determine a) FZD7 gene expression and b) POU5F1 gene expression.
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PMC11637276
Both inhibitors significantly reduced p38 phosphorylation in MDA-MB-231 cells, indicating inhibition of p38 (Fig 3F).
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PMC11757230
In Ema cells, separation from cADSCs led to a loss of apoptosis induction, an increase in cells in the S- and G2/M phases, and a reversal of the cADSC proliferation-inhibitory effect to a promoting effect.
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PMC11285179
Commonly used markers for identifying pericytes include platelet-derived growth factor receptor β (PDGFRβ), chondroitin sulfate proteoglycan 4 (CSPG4, also known as NG2), and alpha-smooth muscle actin (α-SMA).
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PMC11773391
The IC50 value was calculated with SPSS software (**p < 0.01 compared with the indicated treatment).
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PMC11464609
As expected, conventional metagenome sequencing was associated with a high host background (average non-viral reads: 99%).
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PMC11721587
K490R abolished whereas K279R only reduced Fu maturation and Ci activation, suggesting that IPS2 is more critical than IPS1 for Fu function.
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PMC9429973
DNA methylation, an epigenetic regulatory mechanism studied in multiple myeloma (MM) and many tumors, involves the addition of a methyl group to the carbon 5 position of cytosine.
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PMC9429973
In addition, it became apparent that, although the volume of blood supplied was reduced and the interval between transfusions increased, the patients’ hemoglobin levels remained adequately high in luspatercept treated patients.
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PMC9581083
purslane, Isatis tinctoria subsp.
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PMC10932641
Small non-coding RNA (sncRNA) is a series of RNA molecules approximately 19 to 25 nucleotides in length.
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PMC4277423
CCR5/CR2 and CCR5/GF1 cells were then infected with either X4-tropic HIV-1 Bru-3 or R5-tropic HIV-1 Bru-Yu2.
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PMC7338939
Additionally, the percentage of positive cells and intensity of the c-Myc and Ki-67 in all groups were the same, and only the mean fluorescent intensity for Ki-67 decreased (Figures 3C–H, P > 0.01).
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PMC10551595
It is hypothesized that the reactivation of mutant TP53 through the interaction with GinA would lead to an upregulation of downstream target genes such as P21, PUMA, and Bax at the mRNA expression level and P21 and MDM2 at the protein expression level.
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PMC10747160
For positive controls, a sample of 400 μL PBS was prepared in one of the 1.5 mL low-protein-binding microcentrifuge tubes instead.
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PMC7215722
Furthermore, we demonstrated that alterations in the membrane lipid composition result in impairment of protein trafficking.
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PMC11680049
Currently, many thousands of plants are known, in various organs of which valuable metabolites of a secondary nature with high biological activity accumulate .
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PMC11371747
Cell pellets were then assessed for radioactivity.
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PMC9592219
The abnormal expression of TOP2 protein was significantly associated with tumor resistance to adriamycin .
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PMC10882807
In addition, EIF4A3 was found to bind to circZFAND6 pre-mRNA transcript upstream region, leading to the high expression of circZFAND6 in breast cancer .
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PMC11321678
Subsequently, 1 × 10 shHTR2C, shGABRG2, and shCtrl Group 3/4 cells in 2 µl PBS were carefully injected into the cerebellum of 6–8week‐old female nude mice (BABL/c, Gempharmatech Co., Ltd, China) at the coordinates 2 mm lateral to midline and 1 mm posterior to lambda.
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PMC9429973
Further statistical analysis has not established significant differences in outcome (difference in EFS statistically insignificant, p=0.86), as we had expected in the short follow-up period.
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PMC11345828
NH4Cl, sat.
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PMC11727000
Clinically annotated gene expression datasets were analyzed initially through the R2: Genomics analysis and visualization platform (http://r2.amc.nl) (accessed 1 November 2024).
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PMC11665555
Here, gemcitabine-induced OXCT1 expression mediated ATP generation through fatty acid oxidation (FAO) energy required for dihydroorotate and UMP synthesis via orotidine monophosphate (Figure 4F).
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PMC10957991
3D cultures were performed with both MCF10A and 184A1 mammary epithelial cells.
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PMC2777936
In colony formation and proliferation assays, FZD5 repression conferred using lentiviral vectors FZD5-2 and FZD5-4 did not produce consistent growth inhibitory effects in NT2/D1-R1, Tera-1 or 833K cells (data not shown).
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PMC11392912
The nucleotides were synthesized with modification at 2′-O-methylation to mimic the plant miRNA .
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PMC11509224
The marine sponge genus Haliclona contains over 600 species, but only a small number of them have been classified and chemically investigated .
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PMC11591030
Compared to the CON and AOP groups, the LPS stress group significantly reduced the gene expression of Nrf2 and its downstream target genes (SOD, GPx, and CAT) in the PBLs but promoted the overexpression of the Keap1 gene.
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PMC7917457
CD8 T cells derived from cancer patients with known NY-ESO-1/MAGE-A3 tumor antigen expression were purified with a MACS cell separation column (Miltenyi Biotec, Lund, Sweden) and presensitized with peptide-pulsed (10 μg/mL), irradiated, autologous peripheral blood mononuclear cells (PBMCs) depleted of CD4 and CD8 T cells.
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PMC10547921
According to the combination mode, they designed an ADC with good stability in plasma and significant effectiveness on NCI-N87 mouse tumor model, which has potential in the research of targeted cancer therapy.
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PMC11592008
A significant UVB dose-dependent decrease in full-length NLRP1 protein expression was also detected in the lysates of irradiated PKs (Figure 2A).
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PMC11673902
Deformability is essential for the passage of cells through tiny channels such as capillaries.
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PMC11314247
The reaction mixture was stirred for 8 h at the same temperature.
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PMC9429973
Using the voting system, patients prioritised 14 key outcomes (shown in Figure 1).
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PMC9985266
After pretreatment with PD98059 (1 μmol/L, TOCRIS, Bristol, UK), SB203580 (100 nmol/L, TOCRIS, Bristol, UK), or 3-methyladenine (20 mmol/L, 3-MA, Absin, Shanghai, China) for 2 h, MRC-5 cells were exposed to IL-27 (100 ng/mL, eBioscience, California, USA) and/or TGF-β1 (40 ng/mL, eBioscience, CA, USA) for 48 h. In 6-well plates, cells were inoculated to 90% confluence (approximately 1 × 10 cells/well) before transfection.
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PMC6627640
The mean quality value across each base position in the read was >30 representing a 99.9% base call accuracy.
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PMC9368503
The ICR-SS-1 cell line was authenticated by short tandem repeat (STR) analysis at 16 loci (Table 6).
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PMC11803149
It may also serve as a potential therapeutic target to improve such therapy in elderly patients.
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PMC9429973
In contrast, Ddx41 and Ddx41 mice-derived cells showed a slightly reduced PB chimerism compared to Ddx41 mice-derived cells.
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PMC11468365
The bar in the figure shows the prediction of each cell whereas the bar color shows the cell line tissue.
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PMC9429973
Results: In total, 7 446 patients with CLL were identified, of whom 802 (11%) had T2D at CLL diagnosis.
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PMC11622247
Quantum yields were low (ϕss = 0.02, ϕds = 0.04), and quenching efficiency (Fig. 4) estimated from fluorescence of single labelled probes was high in both single and double stranded states.
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PMC11489275
The short-term mortality of patients had no significant relationship with the skin vascular and joint lesions of patients .
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PMC10577955
The mRNA expression levels of KRAS, VEGF, and Cyclin D1 were significantly lowered in all treated cells in comparison to untreated cells at P < 0.0001, BA treatment showed a prominent effect in decreasing their expression levels compared to other treated groups at P < 0.001 (Table 6 and Fig. 4).
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PMC11507371
Thus, Keap1 seems to interact with IKKβ in HaCaT cells, whereas the elevation in Nrf2 abundance in CAP-treated A431 cells (Figure 6A) suggests the involvement of Keap1 in reinforced sequestering of Nrf2.
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PMC11098378
Sequence-verified constructs were transformed into E. coli BL21 cells, induced, and recombinant protein was purified using glutathione sepharose beads (GE Healthcare Life Sciences).
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PMC11569208
Therefore, to investigate this potential new role for ACP2, we performed in silico analysis via RNA sequencing.
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PMC11748335
Conversely, in common HMD regions, the long LOCK regions displayed significantly lower levels of DNA methylation and gene expression than the background.
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PMC11547917
The toxicity of Aristolochia extracts on Caco-2 cells was investigated.
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PMC6450504
Among the alternatives to PEG for developing long-circulating liposomes are oxazolines ( Gaspar et al., 2014, 2015), poly[N-(2-hydroxypropyl) methacrylamide)] (Whiteman et al., 2001), poly-N-vinylpyrrolidones (Torchilin et al., 2001) and polyvinyl alcohol (Takeuchi et al., 2001).
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PMC9429973
Image: Summary/Conclusion: The increase in incidence and the improvement in survival during the period 2004-2018 can be partly explained by the diagnostic and therapeutic innovations over the 2 last decades.
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PMC11464609
d Illustration of case #4 with progressive multifocal leukoencephalopathy (PML) due to JC virus (JCPyV) infection.
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PMC9429973
Furthermore, whereas four (19%) patients had no imaging findings suggestive of cerebrovascular disease, they presented with TAMMV ≥200cm/s, so they were proposed to regular transfusion regimen for primary prevention of stroke.
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PMC11537649
CCK8 = cell counting kit 8, CDK6 = cyclin-dependent protein kinase 6, Lnc NEAT1 = long noncoding nuclear enriched autosomal transcript 1, qRT-PCR = quantitative real-time PCR.
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PMC10582049
Signature matrix for 3 CAF subpopulations were generated using our scRNAseq dataset.
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PMC10873328
In this report, an integrated evaluation of the expression profiles of hypoxia-related genes (HRGs) was conducted to assess the function of HRGs on OC progression, prognosis and chemoresistance.
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PMC10454535
Survival rates have been increasing with the introduction of novel treatments , but significant progress still needs to be made.
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PMC11611077
Outer hair cells (OHCs) in the mammalian organ of Corti elongate and contract in response to changes in their membrane potential.
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PMC11721587
In addition, Sufu was also recruited to the HA-Fu puncta together with Ci (fig. S5B). (
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PMC9429973
Due to the slow accumulation of deaths, the final analysis was performed with a clinical cut-off (CCO) date June 30, 2021, following the Data Monitoring Committee recommendation.
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PMC10170482
After 30 min of incubation at room temperature, fluorescence was captured.
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PMC11467964
Considering chemotherapy plays a vital role in abundant tumors, we assessed semi‐inhibitory concentration (IC50) of chemotherapeutical medications selected from commonly used drugs for tumors via “pRRophetic” package.
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PMC9895440
Then the NY-ESO-1 TCR virus was added, and cells were incubated for 2 days.
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PMC11023271
When they became confluent, the cells were starved overnight in serum-free DMEM.
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PMC11707577
The cellular localization of the delivered M13EGFR(TNP) was investigated (Figure 4 ) by confocal microscopy.
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PMC11531735
In vivo effect of Herceptin, ER121 and Enhertu in immunocompromised mice tumors using JIMT-1 cells, a Herceptin resistant breast cancer cell line.
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PMC5034105
Briefly, 30 μg of purified recombinant ZIKV-NS1 protein was mixed with an equal volume of complete Freund's adjuvant (Sigma-Aldrich) and injected subcutaneously into BALB/c mice.
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PMC11139449
The plates were cultured with normal growth media without drugs for 24 hours and kept in an incubator at 37 °C.
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PMC9388315
The cells were treated with certain concentrations of aqueous extract of Cinnamon for 24 h, then the supernatant was collected and used to evaluate lactate and glucose according to the kit manufacturer's instructions (Pars Azmun, Iran).
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PMC9143157
Cytotoxic chemotherapy is always the fundamental treatment for gynecological malignancies.
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PMC7504302
Often combined with a wide array of high throughput technologies, such as genome-wide RNAi and CRISPR screens as well as drug screening, functional cancer genomics studies entail the functional annotation of cancer-causing aberrations.
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PMC11546117
The barrier function of human cell lines (MCF-10A, PMC42-LA and MCF-7) was evaluated via the measurement of transepithelial electrical resistance (TEER) and transport of sodium fluorescein across the cells grown on transwell inserts.
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PMC11155445
Three novel fluorinated acyl thioureas (105a–c) were synthesized and investigated for their antibacterial activity against Gram-negative (P. aeruginosa and E. coli) and Gram-positive (B. cereus and S. aureus) bacteria (Fig. 40).
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PMC11490153
The flow cytometry analysis was also used to understand cell death mechanisms following treatment.
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PMC11657695
C Normalized expression of KCNA2 transcripts (FPKM) in A-673 cell line (N = 3).
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PMC11499955
TRZ, CTX, and DUR target extracellular tumour receptors, whereas BVZ targets the growth factor VEGF-A secreted by the cells and bound at their surface.
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PMC5916734
The p1.1-F9-T2/S clone was used for further amplification.
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PMC11085211
Electrospray ionization in positive and negative modes was applied in the 50–1200 Da mass scan range.
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PMC9841531
Especially compound 30 with its 5-methyl-substituted 2-pyridyl residue showed similar inhibitory power against MCT1 as compound 24 and superior activity compared to the reference MCT1 inhibitor 8.
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PMC2614415
Mitotic cells were stained with anti-phospho-Histone H3 Serine 10 (Upstate, Charlottesville, VA) with 5% NFDM at a 1:200 dilution for 2 hours at 4°C.
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PMC11453018
Conversely, senolytics targeting the BCL-2 pathway, like Navitoclax , were completely ineffective in eliminating the senescent cells, further solidifying the involvement of the PI3K pathway.
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PMC10093184
To detect acidic polysaccharides such as glycosaminoglycans of cartilage-like matrix, Alcian blue staining and Safranin O staining were performed as described in Mulisch .
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PMC9596868
C, D) Isobologram analysis and CI versus FA plot for the nine drug combinations of quercetin and MST-312 in A2780 cells. (
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PMC9429973
Spleen volume was not correlated with hemoglobin level, platelet count, or JAK2V617F burden at diagnosis.
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PMC11701801
In addition, the concentrations of CP-C27 in the xenograft tumors were maintained at >1 μmol/L, whereas those in plasma decreased to <1 μmol/L (Supplementary Fig. S6G).
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PMC5311252
In conclusion, we propose the AAGUGC seed motif as an oncomotif and that oncomotif-miRNAs promote cancer cell proliferation.
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PMC11720808
The chemical structure of scutellarein. (
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PMC11519583
As conventional Ror2-ablated mice die neonatally , we generated MP-specific Ror2 cKO (Ror2, Pdgfrα) mice.
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PMC11066331
7 Comparison of the prediction accuracy of the machine learning classifiers in binary cell mixtures (A).
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PMC4360730
Therefore, we will need to expand the ontologies that are used to appropriately capture these details in the metadata.
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PMC11186948
Histone deacetylases (HDACs) are enzymes pivotal for histone modification (i.e. acetylation marks removal), chromatin accessibility and gene expression regulation.
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PMC9856122
They disrupted the entry of lysosomal function and exerted anti-viral action .
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PMC11591052
Moreover, the use of the PI3K inhibitor LY294002 clearly revealed the importance of the PI3K/AKT/mTOR pathway in the 20E-mediated induction of glycolysis and respiration.
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PMC11555465
Toxoplasma infections in pregnant women can have particularly severe consequences for the fetus.
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