OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11012313	EBV is associated with the development of Burkitt’s lymphoma, classic Hodgkin’s lymphoma, and diffuse large B cell lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EBV", "is", ...
PMC11541409	FGFR, NTRK, and ALK translocations can act as oncogenic drivers in these subtypes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FGFR", ",", "NTRK", ",", "and", "ALK", "translocations", ...
PMC8540692	The ability of curcumin to demethylate tumor suppressor genes was previously demonstrated .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ability", "of", "curcumin", "to", "demethylate", "tumor", "suppressor", "...
PMC11295144	The beads were pulled down by centrifugation after extensive washing and denatured with Laemmli SB (62.5 mM Tris, pH 8.0, 2% SDS, 10% glycerol, 0.0025% Bromophenol Blue, 100 mM DTT) for SDS/PAGE and immunoblotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	We performed two opposing mutagenesis screens, aimed at identifying DUBs that either activate or suppress the HIF response (Fig. 1A; Dataset EV1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Aims: To describe the results in overall survival (OS), progression-free survival (PFS), mortality and treatment-related mortality (TRM), and the factors involved in them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Hepatic toxicity (CTCAE 5.0, 2017) was observed at 9 (18%) patients Cph+R group (Grade I - 10%; Grade II - 8%) in Flu/Cph+R 9 (20%) patients (Grade I - 15 %, Grade II – 5%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11088135	Total RNA was extracted from cell samples using TRIzol reagent (Invitrogen) and reverse transcribed into cDNA using the PrimeScript RT kit (Takara) according to manufacturer's instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	The cells of each cell line showed different rates of spheroid formation: A2780 and its resistant sublines—7 days, SKOV—3–2 weeks, and OVCAR-3—3 weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	Cell proliferation assays were performed using Sulforhodamine B (SRB) colorimetric assay, as previously described (Lin et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11723947	The immune system is highly efficient at protecting the host against a wide diversity of endogenous and exogenous dangers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "immune", "system", "is", ...
PMC11638764	Our study provides a detailed proteomic analysis of the effects of a potent p97 inhibitor, CB-5083, on different cellular compartments, revealing distinct patterns of protein regulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7334607	Owing to the novelty of LSD1 inhibitors (including SP-2509), there is very little known regarding genomic biomarkers of sensitivity or resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7171147	Interestingly, COL11A1-induced upregulation of fatty acid synthesis and FAO is modulated by the same signaling molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "COL11A1-induced", "upregulation",...
PMC11700340	Still, these studies showed that there was a lack of investigation into the cytotoxicity of linagliptin against cervical cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Still", ",", "the...
PMC11128598	All cells were incubated at 37°C in a 5% CO2 atmosphere.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cells", "were", "incubated", "at", "37", "°", "C", ...
PMC11773391	Although there has been a lot of drug research on melanin therapy this year, the utility of these strategies has been limited to some extent due to adverse effects, financial costs, and inherent or acquired tumour resistance mechanisms that lead to the recurrence and death of patients, and the prognosis of malignant melanoma remains poor, with only about 30% of malignant melanoma cells showing a transient clinical response to chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11665555	Orthotopic grafts of 5637P, 5637GR, and GR-OXCT1KO lines were monitored for tumor growth by ultrasound and μCT imaging (Figure 7, A and B).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11565047	Analysis was carried out on aligned and quantified data to determine the transcriptomic changes following each hormonal treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analysis", "was", "carried", "out", "o...
PMC5308810	Currently, there are several clinical trials of AMD 3100, CTCE-9908, and neutralizing antibody that target SDF-1/CXCR4 signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "there", ...
PMC11499381	Cells were returned to ice for 2 min, after which 360 µL of SOC broth (Takara BioSciences) was added to the cells, and the cells incubated for 1 h at 37°C with occasional mixing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10772747	EBE compounds are known to inhibit the Cell cycle pathway in breast cancer can affect the activation of CDK 4/6 and the release of E2F from the Rb-E2F complex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674441	Somatic variants were identified using Fisher’s exact test-based methods with the following parameters, as previously described : (i) base quality ≥ 15, (ii) sequencing depth ≥ 10, (iii) variant depth ≥ 4, (iv) variant frequency in the tumour ≥ 10%, (v) variant frequency in normal samples < 2%, and (vi) Fisher p-value < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267830	g Immunohistochemistry was used to determine the Ki67-positive regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Immunohistochemistry", "was", "used", "to", "determine", "the", "Ki67-positive", "regions", "." ] ...
PMC11252553	Data are presented as mean values with standard errors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "mean", "values", "with", "standard", "errors", "." ] } ]
PMC11791478	After cooling for 10 minutes, the sections were rinsed 10 times with distilled water and 10 times with Splash-T buffer (Mosaic Laboratories).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9872547	This phenomenon disrupts cell cycle regulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "phenomenon", "disrupts", "cell", "cycle", "regulation", "." ] } ]
PMC11650848	CpGNMeanSDNMeanSDChange in methylation (%)ZFP57 DMR methylation (Cord blood)65261.2218.514166.3616.785.140.169ZFP57 DMR methylation (11-year blood)61354.539.481056.578.642.040.601ZFP57 DMR methylation (EPIC 850 k array)154564.3814.634170.6112.226.230.012Statistical comparisons by independent t-test (cord blood and 11-year blood) and using Limma to generate comb-p value for EPIC array.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Of the eight patients who developed thrombosis at diagnosis, six received eculizumab and to-date they have not had a new thrombotic episode [median time of f/u 22 months (range 12 - 179)].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615828	These results indicate RIVET can modulate animal behavior by perturbation of synaptic transmission in a reversible manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "indicate", "RIVET", "can", ...
PMC10253973	Some of these complexes may be subject to multiple anti-tumor mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "of", "these", "complexes", "may", "be", "subject", "to", "multiple", "anti-tu...
PMC11474209	445 taxa of cyanobacteria from 129 genera and 46 groups have been found on islands in the Atlantic Ocean.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "445", "taxa", "of", "cyanobacteri...
PMC9429973	Variables with a p<0.2 on univariate analysis were included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Variables", "with", "a", "p<0.2", "on", "univariate", "analysis", "were", "included", "." ] } ]
PMC8316344	4TRIB2 reduced labile iron level in a TFRC-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4TRIB2", "reduced", "labile", "iron", "level", "in", "a", "TFRC-dependent", "manner", "." ] } ]
PMC11453018	iP300w-treated samples exhibited a marked decrease in cell confluence, along with a noticeable increase in cell size and a more flattened, spread-out morphology. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11098378	E3 ubiquitin ligase activity can be revealed by demonstrating: 1) autoubiquitination function; 2) polymerization of free ubiquitin chains; and/or 3) direct ubiquitination of a substrate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301242	We observed a significant increase in active histone H3K27 acetylation (H3K27ac) and H3K4 methylation (H3K4me3) marks in regions identified as circular amplicons by WGS, compared to samples without ecDNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: This is a TiP and there are no results at this time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "This", "is", "a", "TiP", "and", "there", "...
PMC11748335	Interestingly, we observed that the majority of poised promoters in differentiated cells retain the bivalent state found in ESCs, especially those within short LOCKs (Fig. 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6114978	The Taqman based approach utilized the following primers and probes: MST1(STK4)-F 5′-TTGACACTCCTTTGGCACTC-3′; MST1(STK4)-R 5′-CCTCCCACATTCCGAAAACC-3′; MST1(STK4) Probe 5′-CAGCTCCTGCAGCACCCAT TTG-3′; MST2(STK3)-F 5′-GATTTAAGAATGGTTGCAAT TTCATCT-3′ MST2(STK3)-R 5′-GACCTCTGGATTGTTA TGGAG T-3′; MST2(STK3) Probe 5′-TGGCGCTGGCTC TGTCTCA-3′;LATS1 -F 5′-GTGAAGAGATGTTTGC CAGTTG-3′; LATS1-R 5′-AGTTGTGTGATTGGTGGA GTG-3′; LATS1 Probe 5′-TGTTTGTGCCAAGAAAGGAGGTTGTC-3′; LATS2-F 5′-ACACCGACAGTTAGACA CATC-3′; LATS2-R 5′-AACTCACAGATTTCGGCCTC-3′; LATS2 Probe 5′-ACAGGACAGCATGGAGCCCAG-3′; ACTB-F 5′-ACCTTCTACAATGAGCTGCG-3′; ACTB-R 5′-CCTGGATAGCAACGTACATGG-3′; ACTB Probe 5′-ATCTGGGTCATCTTCTCGCGGTTG-3′; POLR2A-F 5′-TCAGCATGTTGGACTCGATG-3′; POLR2A-R 5′-CGTATTCGCATCATGAACAGC-3′; POLR2A- Probe 5′-ACCACCTCTTCCTCCTCTTGCATCT-3′; The following qPCR cycling conditions were used: 95°C(95°C, 60°C)40.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Telomeric length was measured by qPCR technique and proinflammatory cytokines concentrations as well as immunophenotype were assessed by flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":...
PMC8041314	In a next step, the compounds of Supplementary Table 2 were categorized into “active” [1 (“one”); IC50 value <10 μM] and “inactive” [0 (“zero”); IC50 values ≥10 μM].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11761919	Survival rate of chickens in each group. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Survival", "rate", "of", "chickens", "in", "each", "group", ".", "(" ] } ]
PMC11365983	NIH3T3 cells with shRNA-mediated knockdown of Foxc1 accumulate lower levels of Gli1 on stimulation of Hh signaling with Smoothened agonist (SAG; Fig. 3A–C).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222726	Leaves and branches of some Bursera also contain flavonoids and luteolin 3′-O-rhamnoside is very common .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Leaves", "and", "branches", "of", "some", "Bursera", "also"...
PMC9429973	Bleeding and thrombosis were registered in patients with active MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bleeding", "and", "thrombosis", "were", "registered", "in", "patients", "with", "active", "MM", ...
PMC10936243	Providing bedding is more to management and not really related to post-operative” [D062]. “	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Providing", "bedding", "is", "more", "to", ...
PMC11743316	Contrary to Complexes I and II, Complex III may release ROS on either side of the mitochondrial inner membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Contrary", "to", "Complexes"...
PMC11748618	Variants potentially driving the genetic association with HIV spVL were filtered for at least one functional annotation from the HaploReg analysis and used as input to the BIMBAM Bayesian modeling framework.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Baseline mean platelet count was similar between subgroups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Baseline", "mean", "platelet", "count", "was", "similar", "between", "subgroups", "." ] } ]
PMC10823017	The antibodies to anti-Phospho PKC-ζ (T410) (2060), anti-PARP (9532), anti-Cleaved PARP (5625), anti-BCL-2 (2872), Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (9101), c-Myc (D84C12) (5605), Phospho-Akt (Ser473) (9271), Phospho-PDK1 (Ser241) (3061), PDK1 (3062) Phospho-MEK1/2 (Ser217/221) (9121), MEK1/2 (9122), Akt (pan) (40D4) (2920), Vimentin (R28)(3932), Phospho-vimentin (Ser39)(13614), N-cadherin (D4R1H) (13116) and anti-α-Tubulin (2125) were procured from Cell Signaling Technology (Danvers, MA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574271	Subsequently, the cells underwent immunoprecipitation using an anti-HIF-2α antibody, and the ubiquitination level of HIF-2α was assessed through immunoblotting with an anti-ubiquitin antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9424261	2RNA-seq and TMT screened out the gene HERPUD1.A Three genes that were co-upregulated were identified by RNA-seq and TMT in Bel-7402 and Bel-7404 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], ...
PMC6364197	3D scaffold provides greater physiological relevance in comparison with conventional 2D culture (6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3D", "scaffold", "provides", "greater", "physiological", "relevan...
PMC7351993	To demonstrate this potential, we prepared two culture conditions for hiPSCs, which were grown in two different culture media as described above, and acquired their SRS images.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973085	Pale yellow solid (84%); mp: 243–245 °C. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pale", "yellow", "solid", "(", "84", "%", ")", ";", "mp", ...
PMC11055510	RT-qPCR analyzed the expression of circABCB10, circMAN1A2, circEPSTI1, circITCH, circHIPK3, and circLARP4 in SKOV3, A2780, and ISOE-80 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O"...
PMC9386809	In the next step, media was removed, and FBS-free media (serum-free media) was added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "next", "step", ",", ...
PMC10932641	The creation of the negative control group was as follows: for preparation of the siNC diluent, 5 µL of siRNA was diluted with 120 µL Opti-MEM and mixed gently; for preparation of the oeNC diluent, 5 µL of pcDNA3.1 was diluted with 120 µL Opti-MEM and mixed gently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11633763	Free β‐catenin translocate into the nucleus and exerts its transcriptional activity, regulating gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Free", "β‐catenin", "translocate", "into", "the", "nucleus", ...
PMC10976516	Herbst et al.; Alexander et al.; Duma et al.RadiotherapyRadiation therapy (RT) is used to treat cancer to raise the likelihood of curing the disease, improve local tumor control, and provide palliative care (e.g., improve symptoms and quality of life).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786600	Assessment of collagen content of diabetic wounds using MT staining (n = 3) (* indicates p < 0.05 compared with the control group; # indicates p < 0.05 compared with PED0 group; Δ indicates p < 0.05 compared with PED2 group; ◇ indicates p < 0.05 compared with PED4 group).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7570809	To allow for this flexibility, integrins are comprised of 18 α and 8 β subunits that pair to form at least 24 different functional heterodimeric receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: We have examined 107 patients diagnosed with CLL in SI «RRC RM&HE» from 2017 to 2020.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "...
PMC11805741	In contrast, the DMSO-treated group showed a moderate reduction in migration (44.98% at 24 h and 86.61% at 48 h), indicating some inhibitory effect of the solvent itself.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9454852	The contact point between mitochondria and the ER, called MAM (mitochondria-associated ER membrane), contributes to the movement of Ca from the ER to the mitochondria , and this flux is mediated by the IP3R on the ER membrane, VDAC (voltage-dependent anion channel) on the outer mitochondrial membrane, and the MCU (mitochondrial calcium uniporter) on the inner mitochondrial membrane .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732628	It is also reported that miR-490-3p expression is reduced in hepatocellular carcinoma and miR-490-3p overexpression can inhibit cell proliferation, invasion and metastasis (23).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	After 4 mos, pts who only have PR or SD will be randomized (1:1) to receive an infusion of ZILO or matching placebo (Pbo) and continue to receive Ibr.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461025	The cells were incubated with the XTT reagent for 4 hours and the absorbance was measured at 490nm using a microplate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC7039683	We then mapped the small (<100 bp) ATAC-seq fragments, which are indicative of nucleosome free regions (NFRs), within the zebrafish genome (Buenrostro et al., 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10812665	All analyses were conducted using a Waters ACQUITY ultra-performance liquid chromatography (UPLC) and a Q-Exactive high resolution/accurate mass spectrometer interfaced with a heated electrospray ionization (HESI-II) source and Orbitrap mass analyzer operated at 35,000 mass resolution (Thermo Fisher Scientific, Waltham, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5811757	Desired genetic modifications could be achieved by introducing a double-strand break (DSB) at a specific target sequence followed by stimulation of cellular DNA repair pathways, including error-prone non-homologous end joining (NHEJ) and the homologous recombination (HR) (14).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	Inhibition of TNFSF11 in A2780 and HEY cell lines resulted in a significant decrease in cell viability (Figure 11C,F), a significant decrease in proliferation (Figure 11G,H), and a decrease in the ability of inducing endothelial cells’ tube formation in vitro (Figure 11I,J).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11672881	Briefly, 2 × 10⁵ A375 cells were plated in 60 mm plates for 24 h and then treated with 10 µM TQ, 25 µM CU, or their combination for 24 h. The ROS levels were measured using CM-H2DCFDA (Invitrogen, Carlsbad, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11789597	J and K) Purified NK (pNK) cells were co‐culture with RPMI 8226 cells expressing shNC and shCAV1 at the ratio of 2:1 for six hours and the apoptosis of MM cells was determined using flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11434983	First, the rhenium precursor, [NEt4]2[Re(CO)3 Br3], reacts with the pyridine-2-carboxaldehyde, which coordinates with nitrogen and oxygen atoms, and then the 6-amino-4-[(3-bromophenyl)amino] quinazoline as added forming the complex 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502443	However, the relative activation of different signalling pathways by tirzepatide will remain unaffected by the presence of BSA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "relative",...
PMC9874064	Data are expressed in mean ± SD from n independent experiments (n = 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "expressed", "in", "mean", "±", "...
PMC11204465	A new compound, oxisterigmatocystin I (20), was isolated from Aspergillus versicolor A-21-2-7 of South China Sea sediments .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8010066	All the tests were done in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "tests", "were", "done", "in", "triplicate", "." ] } ]
PMC11697703	This decrease was not found in layer II-III neurons electroporated with scrambled control constructs (Figure 2N).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "decrease", "was", "not", "foun...
PMC11612315	At room temperature, Ca imaging was conducted in mouse DRG, HEK293T, and hTRPV1-expressing CHO K1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "At",...
PMC11320834	The combination showed an improved outcome in BRCA-wild-type patients with platinum-sensitive recurrent ovarian cancer compared to olaparib alone .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "showed", "an", "...
PMC7602170	Interestingly, the PI3K/AKT/mTOR signaling activity is related with an upregulation of eIF3B .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "the", "PI3K/AKT/mTOR", "signaling", "activity", "is", ...
PMC11277157	Among the coding genes, approximately 200 upregulated differentially expressed genes (DEGs) signified a coordinated antiviral innate immune response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "c...
PMC11786767	Our line scan analysis indicated that the peak of PS signals was closer to the edge of mitotic chromosomes compared with the peak of biotin-DHPE signals (Fig. 4C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	When compound 26 was dosed IV as a single agent at 60 mg/kg q7d in a subcutaneous xenograft model, tumor regression was observed with outgrowth occurring around day 7 after treatment start.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Future research should also continue to move towards a balance between efficacy and toxic side effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future", "research", "should", "also", "continue", "to...
PMC11742431	Flow cytometry analysis showed that the pro‐apoptotic effects of KVN and K14N were 48.5% and 42.3% for 5637 (Figure 4B), 17.1% and 17.3% for UMUC‐3 (Figure 4D), respectively, while A375 had no pro‐apoptotic effect (Figure 4F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754291	Viability assessments occurred on days 3, 5, and 7, targeting wells in the first, second, and third rows respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	They also interact with chromatin, altering its structure and affecting transcription of several genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "also", "interact", "with", "chromatin", ",", "alter...
PMC10411253	Anatomical dissection might induce risks of damaging the deferential testicular blood supply or destroying male excretory ducts that are close to or even enclosed in the Müllerian derivatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8481254	Data are shown as the mean ± SD. **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "the", "mean", "±", "SD", ".", "", "" ] } ]
PMC11777207	As expected, we found increased anti-IgG–associated signal in the presence of PD-L1–blocking antibodies compared to untreated BMDCs (fig. S6C), suggesting that the ligand remained on the surface of the BMDCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Two pts in the PBO arm received transfusions due to both an AE and clinically significant or poorly tolerated anemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "pts", "in", "th...
PMC11155445	N-Benzoylthioureapyrrolidine carboxylic acid derivatives (93aa–ae, 93ba–bb) synthesized by Poyraz et al. were investigated against AChE and BChE enzymes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6835428	This last observation suggests that LPP silencing reduced tumor angiogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "last", "observation", "suggests", "that", "LPP", "silencing", "reduced", "tumor", "angio...
PMC9429973	I. H. Nielsen, K. Piil, L. Kjeldsen, K. Grønbæk, M. Jarden Department of Hematology; Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen; Department of Public Health, Aarhus University, Aarhus; Department of Clinical Medicin, University of Copenhagen, Copenhagen, Denmark Background: Informal family caregivers play a pivotal role in supporting patients with hematologic malignancies during their treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11762280	P < 0.01. ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.01", ".", "", "", "*" ] } ]
PMC9351137	CFDP1 depletion did not result in an increase of multipolar spindle, but led to 32% of metaphases with monopolar spindles (Additional file 4: Fig. S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11012313

EBV is associated with the development of Burkitt’s lymphoma, classic Hodgkin’s lymphoma, and diffuse large B cell lymphoma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EBV", "is", ...

PMC11541409

FGFR, NTRK, and ALK translocations can act as oncogenic drivers in these subtypes .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FGFR", ",", "NTRK", ",", "and", "ALK", "translocations", ...

PMC8540692

The ability of curcumin to demethylate tumor suppressor genes was previously demonstrated .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ability", "of", "curcumin", "to", "demethylate", "tumor", "suppressor", "...

PMC11295144

The beads were pulled down by centrifugation after extensive washing and denatured with Laemmli SB (62.5 mM Tris, pH 8.0, 2% SDS, 10% glycerol, 0.0025% Bromophenol Blue, 100 mM DTT) for SDS/PAGE and immunoblotting.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11377827

We performed two opposing mutagenesis screens, aimed at identifying DUBs that either activate or suppress the HIF response (Fig. 1A; Dataset EV1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

Aims: To describe the results in overall survival (OS), progression-free survival (PFS), mortality and treatment-related mortality (TRM), and the factors involved in them.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Hepatic toxicity (CTCAE 5.0, 2017) was observed at 9 (18%) patients Cph+R group (Grade I - 10%; Grade II - 8%) in Flu/Cph+R 9 (20%) patients (Grade I - 15 %, Grade II – 5%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11088135

Total RNA was extracted from cell samples using TRIzol reagent (Invitrogen) and reverse transcribed into cDNA using the PrimeScript RT kit (Takara) according to manufacturer's instructions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8345486

The cells of each cell line showed different rates of spheroid formation: A2780 and its resistant sublines—7 days, SKOV—3–2 weeks, and OVCAR-3—3 weeks.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11790599

Cell proliferation assays were performed using Sulforhodamine B (SRB) colorimetric assay, as previously described (Lin et al., 2016).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11723947

The immune system is highly efficient at protecting the host against a wide diversity of endogenous and exogenous dangers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "immune", "system", "is", ...

PMC11638764

Our study provides a detailed proteomic analysis of the effects of a potent p97 inhibitor, CB-5083, on different cellular compartments, revealing distinct patterns of protein regulation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7334607

Owing to the novelty of LSD1 inhibitors (including SP-2509), there is very little known regarding genomic biomarkers of sensitivity or resistance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC7171147

Interestingly, COL11A1-induced upregulation of fatty acid synthesis and FAO is modulated by the same signaling molecules.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "COL11A1-induced", "upregulation",...

PMC11700340

Still, these studies showed that there was a lack of investigation into the cytotoxicity of linagliptin against cervical cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Still", ",", "the...

PMC11128598

All cells were incubated at 37°C in a 5% CO2 atmosphere.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cells", "were", "incubated", "at", "37", "°", "C", ...

PMC11773391

Although there has been a lot of drug research on melanin therapy this year, the utility of these strategies has been limited to some extent due to adverse effects, financial costs, and inherent or acquired tumour resistance mechanisms that lead to the recurrence and death of patients, and the prognosis of malignant melanoma remains poor, with only about 30% of malignant melanoma cells showing a transient clinical response to chemotherapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11665555

Orthotopic grafts of 5637P, 5637GR, and GR-OXCT1KO lines were monitored for tumor growth by ultrasound and μCT imaging (Figure 7, A and B).

[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC11565047

Analysis was carried out on aligned and quantified data to determine the transcriptomic changes following each hormonal treatment.

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PMC5308810

Currently, there are several clinical trials of AMD 3100, CTCE-9908, and neutralizing antibody that target SDF-1/CXCR4 signaling.

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PMC11499381

Cells were returned to ice for 2 min, after which 360 µL of SOC broth (Takara BioSciences) was added to the cells, and the cells incubated for 1 h at 37°C with occasional mixing.

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PMC10772747

EBE compounds are known to inhibit the Cell cycle pathway in breast cancer can affect the activation of CDK 4/6 and the release of E2F from the Rb-E2F complex.

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PMC11674441

Somatic variants were identified using Fisher’s exact test-based methods with the following parameters, as previously described : (i) base quality ≥ 15, (ii) sequencing depth ≥ 10, (iii) variant depth ≥ 4, (iv) variant frequency in the tumour ≥ 10%, (v) variant frequency in normal samples < 2%, and (vi) Fisher p-value < 0.05.

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PMC11267830

g Immunohistochemistry was used to determine the Ki67-positive regions.

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PMC11252553

Data are presented as mean values with standard errors.

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PMC11791478

After cooling for 10 minutes, the sections were rinsed 10 times with distilled water and 10 times with Splash-T buffer (Mosaic Laboratories).

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PMC9872547

This phenomenon disrupts cell cycle regulation.

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PMC11650848

CpGNMeanSDNMeanSDChange in methylation (%)ZFP57 DMR methylation (Cord blood)65261.2218.514166.3616.785.140.169ZFP57 DMR methylation (11-year blood)61354.539.481056.578.642.040.601ZFP57 DMR methylation (EPIC 850 k array)154564.3814.634170.6112.226.230.012Statistical comparisons by independent t-test (cord blood and 11-year blood) and using Limma to generate comb-p value for EPIC array.

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PMC9429973

Of the eight patients who developed thrombosis at diagnosis, six received eculizumab and to-date they have not had a new thrombotic episode [median time of f/u 22 months (range 12 - 179)].

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PMC11615828

These results indicate RIVET can modulate animal behavior by perturbation of synaptic transmission in a reversible manner.

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PMC10253973

Some of these complexes may be subject to multiple anti-tumor mechanisms.

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PMC11474209

445 taxa of cyanobacteria from 129 genera and 46 groups have been found on islands in the Atlantic Ocean.

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PMC9429973

Variables with a p<0.2 on univariate analysis were included.

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PMC8316344

4TRIB2 reduced labile iron level in a TFRC-dependent manner.

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PMC11453018

iP300w-treated samples exhibited a marked decrease in cell confluence, along with a noticeable increase in cell size and a more flattened, spread-out morphology. (

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PMC11098378

E3 ubiquitin ligase activity can be revealed by demonstrating: 1) autoubiquitination function; 2) polymerization of free ubiquitin chains; and/or 3) direct ubiquitination of a substrate .

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PMC11301242

We observed a significant increase in active histone H3K27 acetylation (H3K27ac) and H3K4 methylation (H3K4me3) marks in regions identified as circular amplicons by WGS, compared to samples without ecDNA.

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PMC9429973

Results: This is a TiP and there are no results at this time.

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PMC11748335

Interestingly, we observed that the majority of poised promoters in differentiated cells retain the bivalent state found in ESCs, especially those within short LOCKs (Fig. 5C).

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PMC6114978

The Taqman based approach utilized the following primers and probes: MST1(STK4)-F 5′-TTGACACTCCTTTGGCACTC-3′; MST1(STK4)-R 5′-CCTCCCACATTCCGAAAACC-3′; MST1(STK4) Probe 5′-CAGCTCCTGCAGCACCCAT TTG-3′; MST2(STK3)-F 5′-GATTTAAGAATGGTTGCAAT TTCATCT-3′ MST2(STK3)-R 5′-GACCTCTGGATTGTTA TGGAG T-3′; MST2(STK3) Probe 5′-TGGCGCTGGCTC TGTCTCA-3′;LATS1 -F 5′-GTGAAGAGATGTTTGC CAGTTG-3′; LATS1-R 5′-AGTTGTGTGATTGGTGGA GTG-3′; LATS1 Probe 5′-TGTTTGTGCCAAGAAAGGAGGTTGTC-3′; LATS2-F 5′-ACACCGACAGTTAGACA CATC-3′; LATS2-R 5′-AACTCACAGATTTCGGCCTC-3′; LATS2 Probe 5′-ACAGGACAGCATGGAGCCCAG-3′; ACTB-F 5′-ACCTTCTACAATGAGCTGCG-3′; ACTB-R 5′-CCTGGATAGCAACGTACATGG-3′; ACTB Probe 5′-ATCTGGGTCATCTTCTCGCGGTTG-3′; POLR2A-F 5′-TCAGCATGTTGGACTCGATG-3′; POLR2A-R 5′-CGTATTCGCATCATGAACAGC-3′; POLR2A- Probe 5′-ACCACCTCTTCCTCCTCTTGCATCT-3′; The following qPCR cycling conditions were used: 95°C(95°C, 60°C)40.

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PMC9429973

Methods: Telomeric length was measured by qPCR technique and proinflammatory cytokines concentrations as well as immunophenotype were assessed by flow cytometry.

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PMC8041314

In a next step, the compounds of Supplementary Table 2 were categorized into “active” [1 (“one”); IC50 value <10 μM] and “inactive” [0 (“zero”); IC50 values ≥10 μM].

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PMC11761919

Survival rate of chickens in each group. (

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PMC11365983

NIH3T3 cells with shRNA-mediated knockdown of Foxc1 accumulate lower levels of Gli1 on stimulation of Hh signaling with Smoothened agonist (SAG; Fig. 3A–C).

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PMC6222726

Leaves and branches of some Bursera also contain flavonoids and luteolin 3′-O-rhamnoside is very common .

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PMC9429973

Bleeding and thrombosis were registered in patients with active MM.

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PMC10936243

Providing bedding is more to management and not really related to post-operative” [D062]. “

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PMC11743316

Contrary to Complexes I and II, Complex III may release ROS on either side of the mitochondrial inner membrane.

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PMC11748618

Variants potentially driving the genetic association with HIV spVL were filtered for at least one functional annotation from the HaploReg analysis and used as input to the BIMBAM Bayesian modeling framework.

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PMC9429973

Baseline mean platelet count was similar between subgroups.

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PMC10823017

The antibodies to anti-Phospho PKC-ζ (T410) (2060), anti-PARP (9532), anti-Cleaved PARP (5625), anti-BCL-2 (2872), Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (9101), c-Myc (D84C12) (5605), Phospho-Akt (Ser473) (9271), Phospho-PDK1 (Ser241) (3061), PDK1 (3062) Phospho-MEK1/2 (Ser217/221) (9121), MEK1/2 (9122), Akt (pan) (40D4) (2920), Vimentin (R28)(3932), Phospho-vimentin (Ser39)(13614), N-cadherin (D4R1H) (13116) and anti-α-Tubulin (2125) were procured from Cell Signaling Technology (Danvers, MA).

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PMC11574271

Subsequently, the cells underwent immunoprecipitation using an anti-HIF-2α antibody, and the ubiquitination level of HIF-2α was assessed through immunoblotting with an anti-ubiquitin antibody.

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PMC9424261

2RNA-seq and TMT screened out the gene HERPUD1.A Three genes that were co-upregulated were identified by RNA-seq and TMT in Bel-7402 and Bel-7404 cells.

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PMC6364197

3D scaffold provides greater physiological relevance in comparison with conventional 2D culture (6).

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PMC7351993

To demonstrate this potential, we prepared two culture conditions for hiPSCs, which were grown in two different culture media as described above, and acquired their SRS images.

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PMC8973085

Pale yellow solid (84%); mp: 243–245 °C. (

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PMC11055510

RT-qPCR analyzed the expression of circABCB10, circMAN1A2, circEPSTI1, circITCH, circHIPK3, and circLARP4 in SKOV3, A2780, and ISOE-80 cells. (

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PMC9386809

In the next step, media was removed, and FBS-free media (serum-free media) was added.

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PMC10932641

The creation of the negative control group was as follows: for preparation of the siNC diluent, 5 µL of siRNA was diluted with 120 µL Opti-MEM and mixed gently; for preparation of the oeNC diluent, 5 µL of pcDNA3.1 was diluted with 120 µL Opti-MEM and mixed gently.

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PMC11633763

Free β‐catenin translocate into the nucleus and exerts its transcriptional activity, regulating gene expression.

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PMC10976516

Herbst et al.; Alexander et al.; Duma et al.RadiotherapyRadiation therapy (RT) is used to treat cancer to raise the likelihood of curing the disease, improve local tumor control, and provide palliative care (e.g., improve symptoms and quality of life).

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PMC11786600

Assessment of collagen content of diabetic wounds using MT staining (n = 3) (* indicates p < 0.05 compared with the control group; # indicates p < 0.05 compared with PED0 group; Δ indicates p < 0.05 compared with PED2 group; ◇ indicates p < 0.05 compared with PED4 group).

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PMC7570809

To allow for this flexibility, integrins are comprised of 18 α and 8 β subunits that pair to form at least 24 different functional heterodimeric receptors.

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PMC9429973

Methods: We have examined 107 patients diagnosed with CLL in SI «RRC RM&HE» from 2017 to 2020.

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PMC11805741

In contrast, the DMSO-treated group showed a moderate reduction in migration (44.98% at 24 h and 86.61% at 48 h), indicating some inhibitory effect of the solvent itself.

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PMC9454852

The contact point between mitochondria and the ER, called MAM (mitochondria-associated ER membrane), contributes to the movement of Ca from the ER to the mitochondria , and this flux is mediated by the IP3R on the ER membrane, VDAC (voltage-dependent anion channel) on the outer mitochondrial membrane, and the MCU (mitochondrial calcium uniporter) on the inner mitochondrial membrane .

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PMC11732628

It is also reported that miR-490-3p expression is reduced in hepatocellular carcinoma and miR-490-3p overexpression can inhibit cell proliferation, invasion and metastasis (23).

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PMC9429973

After 4 mos, pts who only have PR or SD will be randomized (1:1) to receive an infusion of ZILO or matching placebo (Pbo) and continue to receive Ibr.

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PMC11461025

The cells were incubated with the XTT reagent for 4 hours and the absorbance was measured at 490nm using a microplate reader.

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PMC7039683

We then mapped the small (<100 bp) ATAC-seq fragments, which are indicative of nucleosome free regions (NFRs), within the zebrafish genome (Buenrostro et al., 2015).

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PMC10812665

All analyses were conducted using a Waters ACQUITY ultra-performance liquid chromatography (UPLC) and a Q-Exactive high resolution/accurate mass spectrometer interfaced with a heated electrospray ionization (HESI-II) source and Orbitrap mass analyzer operated at 35,000 mass resolution (Thermo Fisher Scientific, Waltham, MA, USA).

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PMC5811757

Desired genetic modifications could be achieved by introducing a double-strand break (DSB) at a specific target sequence followed by stimulation of cellular DNA repair pathways, including error-prone non-homologous end joining (NHEJ) and the homologous recombination (HR) (14).

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PMC11659921

Inhibition of TNFSF11 in A2780 and HEY cell lines resulted in a significant decrease in cell viability (Figure 11C,F), a significant decrease in proliferation (Figure 11G,H), and a decrease in the ability of inducing endothelial cells’ tube formation in vitro (Figure 11I,J).

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PMC11672881

Briefly, 2 × 10⁵ A375 cells were plated in 60 mm plates for 24 h and then treated with 10 µM TQ, 25 µM CU, or their combination for 24 h. The ROS levels were measured using CM-H2DCFDA (Invitrogen, Carlsbad, CA, USA).

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PMC11789597

J and K) Purified NK (pNK) cells were co‐culture with RPMI 8226 cells expressing shNC and shCAV1 at the ratio of 2:1 for six hours and the apoptosis of MM cells was determined using flow cytometry.

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PMC11434983

First, the rhenium precursor, [NEt4]2[Re(CO)3 Br3], reacts with the pyridine-2-carboxaldehyde, which coordinates with nitrogen and oxygen atoms, and then the 6-amino-4-[(3-bromophenyl)amino] quinazoline as added forming the complex 1.

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PMC11502443

However, the relative activation of different signalling pathways by tirzepatide will remain unaffected by the presence of BSA.

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PMC9874064

Data are expressed in mean ± SD from n independent experiments (n = 5).

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PMC11204465

A new compound, oxisterigmatocystin I (20), was isolated from Aspergillus versicolor A-21-2-7 of South China Sea sediments .

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PMC8010066

All the tests were done in triplicate.

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PMC11697703

This decrease was not found in layer II-III neurons electroporated with scrambled control constructs (Figure 2N).

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PMC11612315

At room temperature, Ca imaging was conducted in mouse DRG, HEK293T, and hTRPV1-expressing CHO K1 cells.

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PMC11320834

The combination showed an improved outcome in BRCA-wild-type patients with platinum-sensitive recurrent ovarian cancer compared to olaparib alone .

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PMC7602170

Interestingly, the PI3K/AKT/mTOR signaling activity is related with an upregulation of eIF3B .

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PMC11277157

Among the coding genes, approximately 200 upregulated differentially expressed genes (DEGs) signified a coordinated antiviral innate immune response.

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PMC11786767

Our line scan analysis indicated that the peak of PS signals was closer to the edge of mitotic chromosomes compared with the peak of biotin-DHPE signals (Fig. 4C).

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PMC11345828

When compound 26 was dosed IV as a single agent at 60 mg/kg q7d in a subcutaneous xenograft model, tumor regression was observed with outgrowth occurring around day 7 after treatment start.

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PMC10547921

Future research should also continue to move towards a balance between efficacy and toxic side effects.

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PMC11742431

Flow cytometry analysis showed that the pro‐apoptotic effects of KVN and K14N were 48.5% and 42.3% for 5637 (Figure 4B), 17.1% and 17.3% for UMUC‐3 (Figure 4D), respectively, while A375 had no pro‐apoptotic effect (Figure 4F).

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PMC11754291

Viability assessments occurred on days 3, 5, and 7, targeting wells in the first, second, and third rows respectively.

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PMC9429973

They also interact with chromatin, altering its structure and affecting transcription of several genes.

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PMC10411253

Anatomical dissection might induce risks of damaging the deferential testicular blood supply or destroying male excretory ducts that are close to or even enclosed in the Müllerian derivatives.

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PMC8481254

Data are shown as the mean ± SD. **

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PMC11777207

As expected, we found increased anti-IgG–associated signal in the presence of PD-L1–blocking antibodies compared to untreated BMDCs (fig. S6C), suggesting that the ligand remained on the surface of the BMDCs.

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PMC9429973

Two pts in the PBO arm received transfusions due to both an AE and clinically significant or poorly tolerated anemia.

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PMC11155445

N-Benzoylthioureapyrrolidine carboxylic acid derivatives (93aa–ae, 93ba–bb) synthesized by Poyraz et al. were investigated against AChE and BChE enzymes.

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PMC6835428

This last observation suggests that LPP silencing reduced tumor angiogenesis.

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PMC9429973

I. H. Nielsen, K. Piil, L. Kjeldsen, K. Grønbæk, M. Jarden Department of Hematology; Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen; Department of Public Health, Aarhus University, Aarhus; Department of Clinical Medicin, University of Copenhagen, Copenhagen, Denmark Background: Informal family caregivers play a pivotal role in supporting patients with hematologic malignancies during their treatment.

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PMC11762280

P < 0.01. ***

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PMC9351137

CFDP1 depletion did not result in an increase of multipolar spindle, but led to 32% of metaphases with monopolar spindles (Additional file 4: Fig. S4).

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