OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11806818	Reprinted with permission from . (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reprinted", "with", "permission", "from", ".", "(" ] } ]
PMC11711127	Such targeted suppression is likely through tailored mechanisms: Tbet+ Tregs express T-cell immunoreceptor with Ig and ITIM domains (TIGIT) which in turn induces DCs via CD155 to express IL-10 and downregulate IL-12 (128).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Given the clinical and laboratory findings, the patient was diagnosed with Idiopathic thrombocytopenic purpura (ITP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "the", "clinical", "and", "lab...
PMC11087301	Moreover, Wang et al. found that µ-opioid receptor agonists (MORAs) make metastasis of bladder cancer easier regarding EMT-CTC axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", "...
PMC11769516	STG is also responsible for LPO and inhibition of mitosis and the cell cycle .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "STG", "is", "also", "responsible", "for", "LPO", "and", "inhibit...
PMC11772585	β-Tubulin was used for the normalization control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-Tubulin", "was", "used", "for", "the", "normalization", "control", "." ] } ]
PMC11185260	Figure 4scL-SMARCB1 nanocomplex inhibits BT-12 tumor growth in vivo.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "4scL-SMARCB1", "nanocomplex", "inhibits", "BT-12", "tumor", "growth", "in", "vivo", "." ...
PMC6627640	In all cases each cisplatin resistant cell line was compared to its corresponding parental line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "cases", "each", "cisplatin", "resistant", "cel...
PMC10847511	In HR-related genes other than BRCA1, 4 genes from 6 samples (1 RAD51C, 1 CDK12, 1 FANCF, and 3 RAD50) were considered to be silenced due to DNA methylation of the promoter region, but their HRD scores and signature 3 were not significantly elevated (Figure S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11483468	The histogram showing the RTLs of Hela and PLC-PRF-5 cells, which were measured by qPCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "histogram", "showing", "the", "RTLs...
PMC11367146	Plant-derived products have been reported to alleviate osteoarthritis symptoms .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plant-derived", "products", "have", "been", "reported", "to", "alleviate", "osteoarthritis", "symptoms", "....
PMC5363531	REN cells were incubated with both drugs, as single agent or in combination, concomitantly or sequentially, either at IC50 dose for each drug or at the reduced dose of 100 nM for both drugs.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Our center is a referral institute for management of blood disorders with huge representation of patients with hematological malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "center", "is", "a", ...
PMC11301095	CT and MRI imaging confirmed cerebral edema and encephalitis, characteristic of PAM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CT", "and", "MRI", "imaging", "confirmed", "cerebral", "edema", "and", ...
PMC11665555	The stable gemcitabine-resistant cell line (5637GR) was created through continuous gemcitabine exposure to achieve an IC50 > 100 μM. Expression analysis showed that 5637GR had significantly elevated OXCT1 expression when compared its isogenic parental line (P = 0.033; Supplemental Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794568	EDU cell proliferation assay was performed to assess the proliferation ability of cutaneous melanoma cells with both CRIP1 and TFAM knocked down (scale bar 50 μm). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11066331	PLS-DA classifier Root Mean Square Error (RMSE) (B) and accuracy (C) visualized as functions of the number of input components.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10587429	Frozen-thawed CD34 HSCs may also be used with the price of lower chimerism than fresh cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frozen-thawed", "CD34", "HSCs", "may", "also", "be", ...
PMC11541241	They further found that the TOR pathway was involved in various life processes in S. sclerotiorum, including abiotic stress response, CWI (through regulating the phosphorylation of a key MAP kinase SsSMK3), and the autophagy pathway (via SsATG1 and SsATG13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7452526	The zeta potential describes the degree of stability of colloidal dispersion nanoparticles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "zeta", "potential", "describes", "the", "degree", "of", "stability", "of"...
PMC8414691	The Lipofectamine RNAi-MAX reagent (Thermo Scientific) was used for transfections, according to the manufacturer’s protocol; 24 h after the second transfection, cells were harvested for cytological and immunoblotting analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10958426	It is well known that cancer cells are quite different from their normal counterparts, but the in vivo differences between cancer cells and their normal counterparts have not been systematically studied at single cell resolution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11661024	Probiotics are live microorganisms that usually benefit the host's health after administration in adequate amounts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Probiotics", "are", "live", "microorganisms", "that", ...
PMC11638288	Giuliana et al. analyzed the binding of NCR-Fc fusion proteins using flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Giuliana", "et", "al.", "analyzed", "the", "binding", "of", "NCR-Fc", ...
PMC11394227	A complete IgG1 molecule contains 16 disulfide bonds, and the correct folding of disulfide bonds enables IgG1 molecules to form the correct conformation, maintain the integrity of IgG1 molecules, and maintain their biological activity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092418	A P value of ≤ 0.05 was statistically significant, and an R value closer to 1 showed the reliability of the association between the IC50 value of each drug and expression level of each marker.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11085211	Primary antibodies against KIT (A4502; Dako, Glostrup, Denmark), phospo-KIT (3391; Cell Signaling, Danvers, MA, USA), PARP-1 (9542, Cell-Signaling), and actin (A1978; Sigma-Aldrich) were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11218145	Finally, the light signal was collected and calibrated into [Ca] values, as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "light", "signal...
PMC11763533	The main proton binding site responsible for pH- sensitivity has been identified, involving the electrostatic interactions between E311 and R337, and between H310 and E354, that keep a closed active site conformation favorable for green emission at alkaline pH values, and is broken at acidic pH values opening and polarizing the active site, resulting in red light emission .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591794	For this purpose, primer sets specific for target sequences were designed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", "purpose", ",", "primer", "sets", "specific", "for", "target", ...
PMC11544771	We have shown that treatment with CPX (2–5–10 μM) dose-dependently reduces cell viability in cancer cells (e.g., A549, A427, and Rh30) cells, but does not exhibit significant cytotoxicity in normal human primary fibroblasts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "...
PMC11763126	After six weeks, the mice were euthanized, and tumor weights were recorded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "six", "weeks", ",", "the", "mice", "were", "euthanized"...
PMC11802929	We observed consistent results with or without the dominant clones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "observed", "consistent", "results", "with", "or", "without", "the", "dominant", "clones", ...
PMC10669966	No. 11756500, Invitrogen™, Thermo Fisher Scientific, Waltham, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "11756500", ",", "Invitrogen", "™", ",", "...
PMC11023271	Student’s t-test was performed for data comparisons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Student", "’s", "t-test", "was", "performed", "for", "data", "comparisons", "." ] } ]
PMC11747467	P-value < 0.05; , P-value < 0.01; , P-value < 0.001; ***, P-value < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Z-stack affirmed that the CRISPR reached the nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Z-stack", "affirmed", "that", "the", "CRISPR", "reached", "the", "nucleus", "." ] } ]
PMC11791264	Error bars represent the mean ± SD (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "the", "mean", "±", "SD", "(", "n", "=", ...
PMC8193813	These include particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), and volatile organic compounds (VOCs), including carbonyls, energetics, chlorinated organics, metals from filter analyses, and perchlorate (Aurell et al., 2017; Zhou et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9275501	The aqueous phase and lipid bilayer of liposomes can contain a variety of drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "aqueous", "phase", "and", "lipid", "bilayer", "of", "lipo...
PMC11486946	However, the low throughput of single-molecule imaging for data acquisition, which arises from its expertize- and manual-dependent workflow, prevents this method from being employed for large-scale single-molecule analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10335954	Moreover, TRIP13 functions as an upstream regulator of more than 593 downstream genes involving 10 signaling pathways, including the JAK/STAT and p53 signaling pathways, which play critical roles in developing various malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11172027	After 24 h of incubation, none of the NASeLM concentrations used showed a significant reduction in mitochondrial activity compared to the 24 h control (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753435	Candidate peptides are generated using all of the peptides in the training set.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Candidate", "peptides", "are", "generated", "using", "all", "of", "the", ...
PMC11594641	Another subtype of extracellular vesicles—ectosomes/microvesicles (MVs)—is produced by the budding of the plasma membrane and has a diameter of around 50–1000 nm .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11672142	This provides insight into Fe(III) complexation by DefNEtTrp in reaction with the intracellular LIP, which consists of small molecular Fe(III) species.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11578343	From Equation (4), it can numerically calculate the frequency dependent storage ( G ′) and loss ( G ″) moduli.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7369657	CQDs with a sheet-shaped structure are simply prepared via a unique pulse process, which covers the nanocarbon particles with hydroxyl groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CQDs", "with...
PMC9812014	West Nile virus is an ssRNA virus and the causative agent of West Nile fever.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "West", "Nile", "virus", "is", "an", "ssRNA", "virus", ...
PMC9429973	Closing these gaps in knowledge informs the fundamental characteristics of NK dysfunction during leukemia and is of significant interest for targeting, therapeutic interventions and NK cell-mediated immunotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8164677	As to the question why a particular combination is additive in the resistant cell line but antagonistic in the parent cell line, it is suggested that the difference may be associated with differential expression of some key proteins, some of which we selected in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Ten patients (19.6%) had undergone hematopoietic stem cell transplantation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ten", "patients", "(", "19.6", "%", ")", "had", "undergone", "hematopoietic", ...
PMC11306331	Fraction of cells where condensate dissolution was observed is indicated for each MBP level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fraction", "of", "cells", "where", "condensate", "dissolution", "was",...
PMC11665555	Furthermore, the metabolic pathway enrichment analysis between the sensitive lines showed that oxidative processes were inhibited in GR-OXCT1KO compared with the parental cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10380508	This gene family, consisting of PAX1-PAX9, encodes a group of nine transcription factors (PAX1-PAX9), which are expressed in various human cancers and which have been implicated in the onset of malignancies, such as alveolar rhabdomyosarcoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766350	DsRed expression was equal across all samples, while GFP expression differed in line with previous observations (Figure S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DsRed", "expression", ...
PMC9429973	This is a complex process that requires the joint participation of a multidisciplinary team and the patient involvement in order to realize the risks still present many years after ASCT regardless the underlying disease’s remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213179	Pooled amplicons were sequenced using the Illumina HiSeq platform.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pooled", "amplicons", "were", "sequenced", "using", "the", "Illumina", "HiSeq", "platform", "." ] } ]
PMC9429973	CGP was often sent late in the clinical course.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CGP", "was", "often", "sent", "late", "in", "the", "clinical", "course", "." ] } ]
PMC11566417	For example, in immortalized human endothelial cells, expression of proteins associated with the endothelial phenotype remained constant as a result of immortalization, but expression of other proteins, such as cytokeratin (KRT) 7 and calumenin (CALU), varied despite immortalization .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8978939	We decided to explore the relationship of these variants with fibronectin regulation, since it has been explored since 1998 and is the most described HIF-independent function to date (19).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11139449	The HITI protocol enables site-specific gene knockout and EGFP knock-in without requiring homology arms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "HITI", "protocol", "enables", "site-specific", "gene", "knockou...
PMC11762280	These findings suggest that the indicators of PANoptosis simultaneously occur in the epidermis of human skin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "the", "indicat...
PMC11380329	Cell line was checked before the experiment to ensure it is mycoplasma-free.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "line", "was", "checked", "before", "the", "experiment", "to", "ensure", ...
PMC11568601	p < 0.05, **p < 0.01, vs. the control group To explore the role of IRE1 in TGT-induced ER stress, siIRE1s were designed and successfully transfected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792766	This study evaluates the compatibility of food simulants specified in the latter regulation with in vitro biological testing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "evaluates", "the", "c...
PMC11611077	The cells transfected with EF1α promoter tended to show higher expression level compared with those transfected with CMV promoter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "transfected", "wi...
PMC11394730	During the developmental stage, anthocyanins trigger caspase activation in cancer cells, facilitated by ROS and JNK/p38-MAPK (Figure 13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "th...
PMC10178190	Mono- or TA HS-5 cultures were then incubated for three days, collected, and centrifuged at 3000 rpm for 5 min at room temperature to remove cells.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10606998	The results of the combined use of gamma radiation and SPIONs suggest a cell line-specific effect of radiosensitization, at least in this range of photon energies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9918897	Based on our results, further research could provide a more accurate picture of the underlying mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "our", "results", ",", "furth...
PMC9429973	Eligible pts who received IC (n = 31) tended to have shorter median overall survival (13 months) vs pts who received VEN-based therapies (n = 27; 23 months; HR, 1.45, 95% CI, 0.66–3.17; not sig.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706491	Different cell cycle mutants were used to determine the measured and the calculated cell size (rep2Δ for G1/S; cdr1Δ, cdr2Δ, 5xwee1 and cdc25-22 for G2/M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791478	B, Dose–response study with a single dose of XB002.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "Dose", "–", "response", "study", "with", "a", "single", "dose", ...
PMC11502066	Further preclinical studies are highly needed to better understand the underlying molecular and pharmacological mechanisms, as well as to improve the activity and selectivity profiles of flavonoids in interacting with specific GPCRs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742864	At present, the mechanisms of lipid raft alteration by ω-3 LCPUFAs in lung cancer are not fully understood, and the underlying mechanisms are still to be investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8623816	In this study, we isolated a dsRNA virus named Rhizoctonia solani dsRNA virus 5 (RsRV5) from strain D122 of R. solani AG-1 IA with a unique genome organization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10588957	Following phosphorylation, AMPK can activate SIRT1 by altering the ratio of NAD/NADH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "phosphorylation", ",", "AMPK", "can", "activate", "SIRT1", "by...
PMC5415764	Although PTX application has improved the duration and quality of life for some ovarian cancer patients, unfortunately, the majority eventually suffer from the attenuated therapeutic outcome owing to drug resistance as in the case of other chemotherapeutic drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422150	A series of 20 von Frey filaments with increasing calibrated forces from 0.008 g to 300 g were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "series", "of", "20", "...
PMC11463018	C NMR (126 MHz, DMSO-d6) δ: 165.65, 164.20, 151.37, 144.09, 139.32, 138.68, 131.10, 129.59, 129.20, 128.80, 128.72, 127.12, 126.73, 111.28, 111.12, 45.69, 20.96.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640419	The CC50 values for these concentrations are presented in Tables S1 and S2 of the Supporting Information, which also includes the exact values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10253553	The interaction between mTORC1 and mTORC2 is dynamic , such that inhibition of mTORC2 can cause an increase in the activity of mTORC1, as shown by the statistically significant increase in the phosphorylation of S6 (S235/236), which is a readout of mTORC1 activity, in cells transfected with Ri # 2 relative to control cells transfected with NT-siRNA (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	In this cohort of melanoma patients, the percentage of SNX9+ cells among CD8 T cells before treatment correlated with poor response to ICB (Fig. 2f).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9370419	One α-helix domain named H-box motif (Ile88 to Leu100), could dock to the top surface of the DDB-1 BPC domain and regulate the CUL4-DDB-1 E3 complex productiveness .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11218145	The following primary and secondary antibodies, purchased from Proteintech Europe (Manchester, UK), were employed: BAX (50599-2-Ig BAX Rabbit Polyclonal antibody), β-tubulin (10068-1-AP Beta Tubulin Polyclonal antibody), Peroxidase-conjugated Affinipure Goat Anti-Mouse IgG(H + L) (SA00001-1) and Peroxidase-conjugated Affinipure Goat Anti-Rabbit IgG(H + L) (SA00001-2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8073654	Compound 17 reduced carrageenin-induced paw edema in rats by 83.9% at a dose of 300 mg/kg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "17", "reduced", "carrageenin-induced", ...
PMC8735881	Error bars indicate the means ± standard deviations (SD). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "indicate", "the", "means", "±", "standard", "deviations", "(", ...
PMC10890307	Additionally, the µ was 60% to 70% higher in acidic compared to neutral conditions when cells were grown under normoxia or hypoxia, respectively (Table 1 and Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	Ten percent of the eluate was resolved on SDS-PAGE and silver-stained using the silverquest kit (LC6070; Invitrogen, Thermo Fisher Scientific, Waltham, MA, USA), while the remaining material was processed for mass spectrometry at the Proteomics Center (University of Padova and Azienda Ospedaliera di Padova).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627060	Further research is necessary to fully understand the signaling pathways that lead to TQ-BSA NP-induced apoptotic death in lung cancer A549 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Further",...
PMC7136814	Cells were then stained for 2 hrs with mixture of fluorochrome-conjugated antibodies in Perm/Wash buffer: Bcl-2 (clone 100) from BioLegend, MYOD1 (polyclonal) and NOG (polyclonal) from Bioss Antibodies, MYOD1 (clone SPM427) and myogenin (clone MGN185 + F5D) from Novus Biologicals, and ID1 (clone B-8) from Santa Cruz Biotechnology, followed by staining with PE-streptavidin (Invitrogen) if biotinylated antibody was included in the staining mixture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502327	Autophagy is a cell death pathway different from apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Autophagy", "is", "a", "cell", "death", "pathway", "different", "from", "apoptosis", "." ] } ]
PMC11271800	Among them, high levels of chemokine CCL22 secreted by TAMs can inhibit T cell proliferation and activity, thus promoting tumor cell growth (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367939	Synaptophysin was detected by immunofluorescence (IF).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Synaptophysin", "was", "detected", "by", "immunofluorescence", "(", "IF", ")", "." ] } ]
PMC10079526	The graphs show cell viability in ratio to control per cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "graphs", "show", "cell", "viability", "in", "ratio", "to", "control", ...
PMC11188874	Difficulties in identifying tumor-specific peptides that are presented by MHC-I molecules and the ability of tumor cells to impair antigen presentation as they evolve under T-cell selection limit the success immunotherapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746942	For siRNA transfection, S1PR3 siRNA or negative control siRNA was then transfected into HaCaT cells by using Lipofectamine™ RNAiMAX (Invitrogen, 13778030) according to the manufacturer’s guidelines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10919056	After knocking down GJB1, the protein expression of E-cad, N-cad, VIM, Bax, and Bcl-2 was detected in the A-498 cell line. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC11015054	There have been shown to be a multispecies 18S rRNA m6A‐modified methyltransferase , , and regulate ribosome function and development. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "have", "...

PMC11806818

Reprinted with permission from . (

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PMC11711127

Such targeted suppression is likely through tailored mechanisms: Tbet+ Tregs express T-cell immunoreceptor with Ig and ITIM domains (TIGIT) which in turn induces DCs via CD155 to express IL-10 and downregulate IL-12 (128).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Given the clinical and laboratory findings, the patient was diagnosed with Idiopathic thrombocytopenic purpura (ITP).

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PMC11087301

Moreover, Wang et al. found that µ-opioid receptor agonists (MORAs) make metastasis of bladder cancer easier regarding EMT-CTC axis.

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PMC11769516

STG is also responsible for LPO and inhibition of mitosis and the cell cycle .

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PMC11772585

β-Tubulin was used for the normalization control.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-Tubulin", "was", "used", "for", "the", "normalization", "control", "." ] } ]

PMC11185260

Figure 4scL-SMARCB1 nanocomplex inhibits BT-12 tumor growth in vivo.

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PMC6627640

In all cases each cisplatin resistant cell line was compared to its corresponding parental line.

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PMC10847511

In HR-related genes other than BRCA1, 4 genes from 6 samples (1 RAD51C, 1 CDK12, 1 FANCF, and 3 RAD50) were considered to be silenced due to DNA methylation of the promoter region, but their HRD scores and signature 3 were not significantly elevated (Figure S2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11483468

The histogram showing the RTLs of Hela and PLC-PRF-5 cells, which were measured by qPCR.

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PMC11367146

Plant-derived products have been reported to alleviate osteoarthritis symptoms .

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PMC5363531

REN cells were incubated with both drugs, as single agent or in combination, concomitantly or sequentially, either at IC50 dose for each drug or at the reduced dose of 100 nM for both drugs.

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PMC9429973

Our center is a referral institute for management of blood disorders with huge representation of patients with hematological malignancies.

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PMC11301095

CT and MRI imaging confirmed cerebral edema and encephalitis, characteristic of PAM.

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PMC11665555

The stable gemcitabine-resistant cell line (5637GR) was created through continuous gemcitabine exposure to achieve an IC50 > 100 μM. Expression analysis showed that 5637GR had significantly elevated OXCT1 expression when compared its isogenic parental line (P = 0.033; Supplemental Figure 2B).

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PMC11794568

EDU cell proliferation assay was performed to assess the proliferation ability of cutaneous melanoma cells with both CRIP1 and TFAM knocked down (scale bar 50 μm). (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11066331

PLS-DA classifier Root Mean Square Error (RMSE) (B) and accuracy (C) visualized as functions of the number of input components.

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PMC10587429

Frozen-thawed CD34 HSCs may also be used with the price of lower chimerism than fresh cells.

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PMC11541241

They further found that the TOR pathway was involved in various life processes in S. sclerotiorum, including abiotic stress response, CWI (through regulating the phosphorylation of a key MAP kinase SsSMK3), and the autophagy pathway (via SsATG1 and SsATG13).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7452526

The zeta potential describes the degree of stability of colloidal dispersion nanoparticles.

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PMC8414691

The Lipofectamine RNAi-MAX reagent (Thermo Scientific) was used for transfections, according to the manufacturer’s protocol; 24 h after the second transfection, cells were harvested for cytological and immunoblotting analysis.

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PMC10958426

It is well known that cancer cells are quite different from their normal counterparts, but the in vivo differences between cancer cells and their normal counterparts have not been systematically studied at single cell resolution.

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PMC11661024

Probiotics are live microorganisms that usually benefit the host's health after administration in adequate amounts .

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PMC11638288

Giuliana et al. analyzed the binding of NCR-Fc fusion proteins using flow cytometry.

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PMC11394227

A complete IgG1 molecule contains 16 disulfide bonds, and the correct folding of disulfide bonds enables IgG1 molecules to form the correct conformation, maintain the integrity of IgG1 molecules, and maintain their biological activity .

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PMC11092418

A P value of ≤ 0.05 was statistically significant, and an R value closer to 1 showed the reliability of the association between the IC50 value of each drug and expression level of each marker.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11085211

Primary antibodies against KIT (A4502; Dako, Glostrup, Denmark), phospo-KIT (3391; Cell Signaling, Danvers, MA, USA), PARP-1 (9542, Cell-Signaling), and actin (A1978; Sigma-Aldrich) were used.

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PMC11218145

Finally, the light signal was collected and calibrated into [Ca] values, as previously described .

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PMC11763533

The main proton binding site responsible for pH- sensitivity has been identified, involving the electrostatic interactions between E311 and R337, and between H310 and E354, that keep a closed active site conformation favorable for green emission at alkaline pH values, and is broken at acidic pH values opening and polarizing the active site, resulting in red light emission .

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PMC11591794

For this purpose, primer sets specific for target sequences were designed.

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PMC11544771

We have shown that treatment with CPX (2–5–10 μM) dose-dependently reduces cell viability in cancer cells (e.g., A549, A427, and Rh30) cells, but does not exhibit significant cytotoxicity in normal human primary fibroblasts .

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PMC11763126

After six weeks, the mice were euthanized, and tumor weights were recorded.

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PMC11802929

We observed consistent results with or without the dominant clones.

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PMC10669966

No. 11756500, Invitrogen™, Thermo Fisher Scientific, Waltham, MA, USA).

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PMC11023271

Student’s t-test was performed for data comparisons.

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PMC11747467

P-value < 0.05; **, P-value < 0.01; ***, P-value < 0.001; ****, P-value < 0.0001.

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PMC8633974

Z-stack affirmed that the CRISPR reached the nucleus.

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PMC11791264

Error bars represent the mean ± SD (n = 3).

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PMC8193813

These include particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), and volatile organic compounds (VOCs), including carbonyls, energetics, chlorinated organics, metals from filter analyses, and perchlorate (Aurell et al., 2017; Zhou et al., 2017).

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PMC9275501

The aqueous phase and lipid bilayer of liposomes can contain a variety of drugs.

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PMC11486946

However, the low throughput of single-molecule imaging for data acquisition, which arises from its expertize- and manual-dependent workflow, prevents this method from being employed for large-scale single-molecule analysis.

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PMC10335954

Moreover, TRIP13 functions as an upstream regulator of more than 593 downstream genes involving 10 signaling pathways, including the JAK/STAT and p53 signaling pathways, which play critical roles in developing various malignancies.

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PMC11172027

After 24 h of incubation, none of the NASeLM concentrations used showed a significant reduction in mitochondrial activity compared to the 24 h control (Figure 2A).

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PMC11753435

Candidate peptides are generated using all of the peptides in the training set.

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PMC11594641

Another subtype of extracellular vesicles—ectosomes/microvesicles (MVs)—is produced by the budding of the plasma membrane and has a diameter of around 50–1000 nm .

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PMC11672142

This provides insight into Fe(III) complexation by DefNEtTrp in reaction with the intracellular LIP, which consists of small molecular Fe(III) species.

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PMC11578343

From Equation (4), it can numerically calculate the frequency dependent storage ( G ′) and loss ( G ″) moduli.

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PMC7369657

CQDs with a sheet-shaped structure are simply prepared via a unique pulse process, which covers the nanocarbon particles with hydroxyl groups.

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PMC9812014

West Nile virus is an ssRNA virus and the causative agent of West Nile fever.

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PMC9429973

Closing these gaps in knowledge informs the fundamental characteristics of NK dysfunction during leukemia and is of significant interest for targeting, therapeutic interventions and NK cell-mediated immunotherapy.

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PMC8164677

As to the question why a particular combination is additive in the resistant cell line but antagonistic in the parent cell line, it is suggested that the difference may be associated with differential expression of some key proteins, some of which we selected in this study.

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PMC9429973

Ten patients (19.6%) had undergone hematopoietic stem cell transplantation.

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PMC11306331

Fraction of cells where condensate dissolution was observed is indicated for each MBP level.

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PMC11665555

Furthermore, the metabolic pathway enrichment analysis between the sensitive lines showed that oxidative processes were inhibited in GR-OXCT1KO compared with the parental cell line.

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PMC10380508

This gene family, consisting of PAX1-PAX9, encodes a group of nine transcription factors (PAX1-PAX9), which are expressed in various human cancers and which have been implicated in the onset of malignancies, such as alveolar rhabdomyosarcoma .

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PMC11766350

DsRed expression was equal across all samples, while GFP expression differed in line with previous observations (Figure S2).

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PMC9429973

This is a complex process that requires the joint participation of a multidisciplinary team and the patient involvement in order to realize the risks still present many years after ASCT regardless the underlying disease’s remission.

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PMC10213179

Pooled amplicons were sequenced using the Illumina HiSeq platform.

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PMC9429973

CGP was often sent late in the clinical course.

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PMC11566417

For example, in immortalized human endothelial cells, expression of proteins associated with the endothelial phenotype remained constant as a result of immortalization, but expression of other proteins, such as cytokeratin (KRT) 7 and calumenin (CALU), varied despite immortalization .

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PMC8978939

We decided to explore the relationship of these variants with fibronectin regulation, since it has been explored since 1998 and is the most described HIF-independent function to date (19).

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PMC11139449

The HITI protocol enables site-specific gene knockout and EGFP knock-in without requiring homology arms.

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PMC11762280

These findings suggest that the indicators of PANoptosis simultaneously occur in the epidermis of human skin.

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PMC11380329

Cell line was checked before the experiment to ensure it is mycoplasma-free.

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PMC11568601

p < 0.05, **p < 0.01, vs. the control group To explore the role of IRE1 in TGT-induced ER stress, siIRE1s were designed and successfully transfected.

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PMC11792766

This study evaluates the compatibility of food simulants specified in the latter regulation with in vitro biological testing.

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PMC11611077

The cells transfected with EF1α promoter tended to show higher expression level compared with those transfected with CMV promoter.

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PMC11394730

During the developmental stage, anthocyanins trigger caspase activation in cancer cells, facilitated by ROS and JNK/p38-MAPK (Figure 13).

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PMC10178190

Mono- or TA HS-5 cultures were then incubated for three days, collected, and centrifuged at 3000 rpm for 5 min at room temperature to remove cells.

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PMC10606998

The results of the combined use of gamma radiation and SPIONs suggest a cell line-specific effect of radiosensitization, at least in this range of photon energies.

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PMC9918897

Based on our results, further research could provide a more accurate picture of the underlying mechanisms.

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PMC9429973

Eligible pts who received IC (n = 31) tended to have shorter median overall survival (13 months) vs pts who received VEN-based therapies (n = 27; 23 months; HR, 1.45, 95% CI, 0.66–3.17; not sig.).

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PMC11706491

Different cell cycle mutants were used to determine the measured and the calculated cell size (rep2Δ for G1/S; cdr1Δ, cdr2Δ, 5xwee1 and cdc25-22 for G2/M).

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PMC11791478

B, Dose–response study with a single dose of XB002.

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PMC11502066

Further preclinical studies are highly needed to better understand the underlying molecular and pharmacological mechanisms, as well as to improve the activity and selectivity profiles of flavonoids in interacting with specific GPCRs.

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PMC11742864

At present, the mechanisms of lipid raft alteration by ω-3 LCPUFAs in lung cancer are not fully understood, and the underlying mechanisms are still to be investigated.

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PMC8623816

In this study, we isolated a dsRNA virus named Rhizoctonia solani dsRNA virus 5 (RsRV5) from strain D122 of R. solani AG-1 IA with a unique genome organization.

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PMC10588957

Following phosphorylation, AMPK can activate SIRT1 by altering the ratio of NAD/NADH.

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PMC5415764

Although PTX application has improved the duration and quality of life for some ovarian cancer patients, unfortunately, the majority eventually suffer from the attenuated therapeutic outcome owing to drug resistance as in the case of other chemotherapeutic drugs.

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PMC11422150

A series of 20 von Frey filaments with increasing calibrated forces from 0.008 g to 300 g were used.

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PMC11463018

C NMR (126 MHz, DMSO-d6) δ: 165.65, 164.20, 151.37, 144.09, 139.32, 138.68, 131.10, 129.59, 129.20, 128.80, 128.72, 127.12, 126.73, 111.28, 111.12, 45.69, 20.96.

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PMC11640419

The CC50 values for these concentrations are presented in Tables S1 and S2 of the Supporting Information, which also includes the exact values.

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PMC10253553

The interaction between mTORC1 and mTORC2 is dynamic , such that inhibition of mTORC2 can cause an increase in the activity of mTORC1, as shown by the statistically significant increase in the phosphorylation of S6 (S235/236), which is a readout of mTORC1 activity, in cells transfected with Ri # 2 relative to control cells transfected with NT-siRNA (Figure 2B).

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PMC9895440

In this cohort of melanoma patients, the percentage of SNX9+ cells among CD8 T cells before treatment correlated with poor response to ICB (Fig. 2f).

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PMC9370419

One α-helix domain named H-box motif (Ile88 to Leu100), could dock to the top surface of the DDB-1 BPC domain and regulate the CUL4-DDB-1 E3 complex productiveness .

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PMC11218145

The following primary and secondary antibodies, purchased from Proteintech Europe (Manchester, UK), were employed: BAX (50599-2-Ig BAX Rabbit Polyclonal antibody), β-tubulin (10068-1-AP Beta Tubulin Polyclonal antibody), Peroxidase-conjugated Affinipure Goat Anti-Mouse IgG(H + L) (SA00001-1) and Peroxidase-conjugated Affinipure Goat Anti-Rabbit IgG(H + L) (SA00001-2).

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PMC8073654

Compound 17 reduced carrageenin-induced paw edema in rats by 83.9% at a dose of 300 mg/kg.

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PMC8735881

Error bars indicate the means ± standard deviations (SD). (

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PMC10890307

Additionally, the µ was 60% to 70% higher in acidic compared to neutral conditions when cells were grown under normoxia or hypoxia, respectively (Table 1 and Table 2).

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PMC11676169

Ten percent of the eluate was resolved on SDS-PAGE and silver-stained using the silverquest kit (LC6070; Invitrogen, Thermo Fisher Scientific, Waltham, MA, USA), while the remaining material was processed for mass spectrometry at the Proteomics Center (University of Padova and Azienda Ospedaliera di Padova).

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PMC11627060

Further research is necessary to fully understand the signaling pathways that lead to TQ-BSA NP-induced apoptotic death in lung cancer A549 cells.

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PMC7136814

Cells were then stained for 2 hrs with mixture of fluorochrome-conjugated antibodies in Perm/Wash buffer: Bcl-2 (clone 100) from BioLegend, MYOD1 (polyclonal) and NOG (polyclonal) from Bioss Antibodies, MYOD1 (clone SPM427) and myogenin (clone MGN185 + F5D) from Novus Biologicals, and ID1 (clone B-8) from Santa Cruz Biotechnology, followed by staining with PE-streptavidin (Invitrogen) if biotinylated antibody was included in the staining mixture.

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PMC11502327

Autophagy is a cell death pathway different from apoptosis.

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PMC11271800

Among them, high levels of chemokine CCL22 secreted by TAMs can inhibit T cell proliferation and activity, thus promoting tumor cell growth (Figure 2).

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PMC11367939

Synaptophysin was detected by immunofluorescence (IF).

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PMC10079526

The graphs show cell viability in ratio to control per cell line.

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PMC11188874

Difficulties in identifying tumor-specific peptides that are presented by MHC-I molecules and the ability of tumor cells to impair antigen presentation as they evolve under T-cell selection limit the success immunotherapies.

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PMC11746942

For siRNA transfection, S1PR3 siRNA or negative control siRNA was then transfected into HaCaT cells by using Lipofectamine™ RNAiMAX (Invitrogen, 13778030) according to the manufacturer’s guidelines.

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PMC10919056

After knocking down GJB1, the protein expression of E-cad, N-cad, VIM, Bax, and Bcl-2 was detected in the A-498 cell line. (

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PMC11015054

There have been shown to be a multispecies 18S rRNA m6A‐modified methyltransferase , , and regulate ribosome function and development. ,

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