Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC6364197
no. 5174s), primary antibodies, goat anti-mouse (cat.
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PMC3915447
CCRF CEM Cells grown in PBS, b) cells with 50 µM FA only, c) cells with SPIO only, and d) cells with SPIO-FA Expression of caspase-3, bax, bcl-2 and survivin protein in CCRF CEM cells by western blot after separate and combined treatment with SPIO, FA and SPIO-FA for 72 hours.
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PMC9429973
Summary/Conclusion: The prevalence of MMS in our center (1,8%) is lower than described in other studies.
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PMC9429973
However, WGS enabled further characterization of these patients, by identifying several types of activation mechanisms and co-occurring alterations for each oncogene.
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PMC11476837
Besides cardiotoxicity, the administration of doxorubicin in clinical settings is correlated with neurotoxicity .
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PMC11607638
Early oogenesis is initiated after a blood meal, to stimulate a single layer of the follicular epithelial cells surrounding the oocyte to secret eggshell proteins, in preparation for eventual oviposition. ,
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PMC9429973
2.
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PMC9250505
Pictures were obtained with a digital CCD camera system (JVC, Tokyo, Japan).
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PMC11650848
Briefly, women with singleton pregnancies who had taken FA at 400 µg per day during the first trimester (as recommended in the UK and worldwide for prevention of neural tube defects, NTD) were recruited to this double-blinded RCT at the 14th gestational week from antenatal clinics at the Causeway Hospital, Coleraine, Northern Ireland.
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PMC6267596
U2932 (obtained in 2012), VAL (obtained in 2013), OCI-Ly18 (obtained in 2016), and U2904 (obtained in 2016) were cultured in RPMI-1640 medium (Mediatech, VA) supplemented with 10% fetal bovine serum at 37°C in a humidified atmosphere containing 5% CO2.
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PMC6835762
More recently, PGA was used to evaluate the validity of commonly used solubility parameters .
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PMC11615101
The coverslip was then washed and incubated (1.5h) with diluted (1:300) primary antibodies; anti-TLR-2 and anti-TLR-4 (Santa Cruz Biotechnology, USA).
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PMC8806312
For instance, a microenvironment with low CD4+ and CD8+ tumor infiltrating lymphocytes (TILs) may contribute to a weakened antitumor immune response .
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PMC10547921
Figure 24 Key structures and mechanisms of action of PDCs. (
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PMC11569208
786-0 cells were seeded in 96well plates and transfected with respective siRNA at a concentration of 0.2µM using Invitrogen’s Lipofectamine RNAiMAX reagent, then infected with oncolytic vesicular stomatitis virus (VSV∆51) tagged with firefly luciferase (FLuc).
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PMC4816271
IL-2 and IFN-γ levels in harvested co-culture supernatants were measured using Human Duoset Elisa kits (R and D systems) according to the manufacturer’s instruction.
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PMC11718809
Circ 11103 enhanced the synthesis of triglyceride and fatty acid by adsorbing miR-128 in bovine gland cells .
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PMC9429973
Multivariate analysis revealed the most significant factor of clinical success was the granulocyte recovery within 14 days.
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PMC11545737
Yersinia-induced caspase-8 activation leads to pyroptosis in macrophages with both GSDMD and GSDME activation.
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PMC11632064
Cytoscape visualization of significantly enriched gene sets in MeWo cells treated with BI-D1870 for 72 h compared to DMSO. (
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PMC11033180
enteric neurons culture section) and plated in Transwell inserts (6.5 mm Transwell ®, 0.4 μm Pore Polyester membrane inserts, cat: 3450, Costar) at a concentration of 64,000 cells/100 μL. Rat ENS cultures were prepared from E15 rat embryo intestines as previously described.
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PMC9817179
Among the numerous biomolecular transactions investigated using fixed-cell imaging is liquid–liquid phase separation (LLPS), a long-observed behavior of polymers in solution (Gibbs, 1879; Graham, 1861; Hyman et al., 2014) that has recently generated much excitement in biological research communities due to its proposed roles in cellular organization and functions (Banani et al., 2017; Boeynaems et al., 2018; Mitrea and Kriwacki, 2016; Shin and Brangwynne, 2017).
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PMC11644761
In addition, numerous studies have already demonstrated that alterations in genome-wide DNA methylation are involved in regulating neuroblastoma cell differentiation, leading to functional consequences .
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PMC9429973
Primary endpoint is OS rate at 6 months.
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PMC11634794
The relationship between LAMP1 and autophagy, LC3C and VHL. (
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PMC9672323
MTT assay was used to evaluate cell proliferation.
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PMC8164677
Created with BioRender.com.
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PMC9429973
M. Ababou, A. Hammani, A. Siham, W. Elfaria, E. M. Mahtat, S. Jennane, H. EL Maaroufi, K. Doghmi Clinical Hematology, Military hospital Mohammed v, Rabat, Morocco, Rabat, Morocco Background: Primary refractory Hodgkin’s lymphoma (PRHL)is defined as disease progression during initial first-line therapy or early relapse of less than 3 months , this entity is a therapeutic challenge for hematologists, as the response rate to second-line therapy remains lower (51% vs. 83%, P < 0.0001) Aims: Compare different parameters between patients with PRHL and patients with non-PRHL to reveal factors that could predict the primary refractory character of our patients.
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PMC9429973
An unfavorable prognosis was associated with RUNX1, SRSF2, and U2AF1 gene mutations.
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PMC11641532
For apoptosis analysis, transfected cells were stained with the Annexin V-FITC/PI Apoptosis Detection Kit (Beyotime, Shanghai, China) and analyzed by flow cytometry to determine the percentage of apoptotic cells.
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PMC11791203
Additionally, other soluble proteins released from mitochondria during apoptosis enhance the caspase cascade by neutralizing inhibitor of apoptosis proteins (IAPs).
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PMC10411253
The 3D molecular structure was built using Swiss-PdbViewer, which showed the substitution of Arg312 with Cys312 weakened the sidechain interaction with Leu280 (Figure 1g).
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PMC11423992
A Tukey two-way ANOVA test for curves in treated groups compared to the control group demonstrated statistical significance (*p<0.05, adjusted for multiple hypotheses). (
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PMC11354239
The binding of RTX to CD20 induces cell death through various mechanisms involving the patient’s immune system , including antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and antibody-dependent phagocytosis (ADP) (Figure 1).
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PMC11694625
The stock solution of 3a–3d in DMSO was added into Tris-HCl-NaCl buffer (5.0 mL, 0.05 M Tris-HCl/0.1 M NaCl, pH 7.4) to prepare a working solution with a final concentration of 0.1 μM. The amount of DMSO in the working solution is no more than 1%.
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PMC8839885
These results confirmed that altered sensitivity to platinum is not related to the expression levels of copper or the ABC transporters examined in this study.
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PMC10958426
We found genes in high CNV variation regions have significant higher correlation coefficient between gene expression level and CNV level than low CNV variation regions (Fig. 2F).
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PMC11474209
Growing data suggest that MC-LR can cause hepatocytes to induce apoptosis and necrosis, influence how these cells regulate their immune systems, and even encourage hepatocellular cancer.
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PMC9429973
In univariate analysis stage ≥III, age ≥65 years, B symptoms, hemoglobin <105 g/L, low LMR, high NLR were associated with a shorter PFS (p<0.05), while stage ≥III, advanced age, low LMR and high NLR were associated with worse OS (p<0.05).
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PMC11752740
Following this incubation, the medium was replaced with fresh medium containing different concentrations of pistachio hull extract (ranging from 0.156 to 10 mg/mL) and CFZ (ranging from 0.0032 to 0.05 mg/mL).
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PMC4360730
CL details individual cell types and so is used for homogeneous mixtures of cells that have been separated from their original structure but do not contain genetic changes that would alter their biology from the ontology description (e.g. hepatic stellate cell—CL:0000632, mesenchymal stem cell of the bone marrow—CL:0002540).
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PMC11650848
Alternative exon and all transcripts marked, raw images found in Additional file 4: Fig. S5.
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PMC11323699
This metastatic allograft model serves as a highly relevant syngeneic representation of intraperitoneal high-grade serous TP53- and BRCA2-mutated ovarian carcinoma, suitable for evaluating PARPi (olaparib) efficacy .
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PMC11756514
no. 15140-122, Thermo Fisher Scientific).
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PMC9429973
The remaining 6.6% (45/680) had unexplained thrombocytosis.
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PMC10873328
In summary, the hub HRGs were identified and used to establish effective prognosis and diagnosis models for OC diagnosis and prediction.
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PMC9429973
Linearity was established in the MRD 10-10 range (r=0.94 [95%CI 0.91-0.96]).
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PMC11470381
Preparation of cell chambers for live-cell imaging Prepare 4 µg/mL of ICAM-1 solution in sterile and filtered 1× PBS from stock solution (see Recipes).
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PMC11609529
This integration is crucial for guiding future clinical research and developing targeted therapies for patients with YM-positive cancers.
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PMC11750165
In the F2 generation, three genotypes were obtained: wild-type (PEX1), heterozygotes (PEX1), and homozygotes with 2-bp deletion mutation (PEX1).
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PMC10976516
injected K7M2-Luc lung metastatic osteosarcoma cell line in syngeneic BALB/cJ mice, followed by systemic application of MYXV-LIGHT-loaded PBMCs.
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PMC10391797
Kaplan–Meier survival curves were compared using the log-rank test.
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PMC11420784
After gentamicin treatment, the mice were sacrificed and bladders were collected.
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PMC9429973
Due to the strict association of COVID-19 with thrombosis, the Hemostasis Service of Bergamo hospital had a central role in guiding anticoagulant treatments in patients during the acute and post-discharge phases.
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PMC10932641
The effect of silencing and overexpressing GPRC5D-AS1 on β-catenin protein expression.
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PMC10933092
A, B) Distribution of messenger RNA (mRNA) and long noncoding RNA (lncRNA) with a significant change in both mA and expression levels after stable knockdown of tRNA methyltransferase 61A (TRMT61A) in 5637 cells.
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PMC9954564
It presents marked geographic differences in prevalence, which is mostly about 0.5% to 2% but can be up to 4.7% in Nigeria and more than 8% in India.
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PMC11767793
ANOVA was performed with Sigmaplot 12.0 (SPSS, Chicago, IL, USA) for the MTS cytotoxicity assays to determine statistical differences using p < 0.05.
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PMC11206502
The non-muscle-invasive bladder carcinoma cell line 5637 has been used as an in vitro model for high-risk superficial bladder tumors with specific molecular characteristics (Bcl-2 and Bcl-X positive expression and P53 tumor suppressor mutation) .
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PMC11607321
Features ranked in the top five from each omic dataset also validated the capacity of our approach to recover well-established molecular processes associated with cancer (Fig. 4a), for example, CDKN2A copy number alterations, as well as sensitivity to the SRC family inhibitor, dasatinib.
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PMC9429973
The second block searched all MeSH terms for MM.
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PMC11746948
As 2-BP is widely used as a general protein palmitoylation inhibitor, we hypothesized that 2-BP enhances cellular vulnerability to ferroptosis by altering the palmitoylation of ferroptosis-relevant proteins.
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PMC11627398
Additionally, NK cells have been implicated in the pathogenesis of septic shock .
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PMC11506670
Scratch wound assays were conducted to assess the impact of the novel NRAS mutants on the migratory capacity of both HCT116 and NIH3T3 cells.
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PMC11700165
Although, we envisaged that a shorter isoform is also produced in cells expressing BTK-SYK, it might be subject to rapid degradation making its detection difficult.
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PMC9341513
The input data are shown below the map; the green block and dashed lines show the position of the insert. (
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PMC9599726
We conclude that VP acts on both iron and GSH metabolism, whereas CA3 mainly acts on antioxidant features of the cell through GSH metabolism.
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PMC9429973
The research results were published in Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia in 2017 in the New England Journal of Medicine.
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PMC11172027
The cell values are shown in percentages.
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PMC11786704
Serum liver and kidney function indicators: (A) Aspartate aminotransferase (AST), (B) Alanine aminotransferase (ALT), (C) Blood urea nitrogen (BUN) and (D) Creatinine (CRE). (
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PMC11740508
All effects were more pronounced in M231 cells than in M231 mutants.
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PMC11721064
The purified P3 LNCs were double-stained for Vim (red fluorescence) and CK12 (green fluorescence), ΔNP63α (green fluorescence) (scale bar = 50 μm).
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PMC9429973
MFC detected circulating lymphoma cells in 17 out of 52 patients studied (33%).
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PMC10362265
However, these inferences were not supported by our simulations.
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PMC11703992
Moreover, we investigated the diagnostic ability of significant genes and the typical markers of GCA via Receiver Operating Characteristic (ROC) curves .
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PMC9918897
Xanthohumol dissolved in beer or in the water–alcohol matrix did not have a protective effect on tumor growth, nor did it have a positive effect on plasma antioxidant capacity either.
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PMC7185206
Variability of PD-L1 protein-to-mRNA ratios is shown by cancer subtype in a violin plot. (
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PMC11682224
CHD1L promotes the migration and invasion of cutaneous squamous cell carcinoma cells in a hypoxic environment. (
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PMC11515150
NT-T: nontransduced T Contrary to T cells, NK cells derived from PB possess nearly no expression of CD5 (Fig. 3a).
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PMC9429973
Image: Summary/Conclusion: We hereby validated that BH3 profiling predicted remarkable on-target cytotoxicity of venetoclax in adult ETP-ALL and T-ALL.
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PMC9429973
We used fluorochrome-labeled monoclonal antibodies against CD3, CD8, CD45 molecules, viability reagent and tetramers which were formed from MHC class I monomers loaded with immunodominant epitopes of cytomegalovirus pp65 protein (HLA-A*0201/NLV, HLA-B*0702/TPR, HLA-B*0702/RPH) and Streptavidin, R-Phycoerythrin conjugate (SAPE).
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PMC9599726
For Bordet TMA, ten replicate samples were available, while for KU Leuven TMA, two replicate samples were available.
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PMC11496728
The intracellular proteins of CHO-WT, CHO-KO-1, CHO-KO-2, and CHO-KO-3 were extracted, and the cells were lysed using an ultrasonic cell disruptor.
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PMC11762280
G UVB skin damage of DSF or vehicle treated mice was evaluated by scores (n = 8).
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PMC11012313
In the current study, we ask whether LMP2A alters B cell lymphoma metabolism by increasing ATP generation and the mechanism by which LMP2A achieves these alterations.
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PMC9503685
It is known that the surface of cancer cells has negative charges that can associate with the positively charged structure of ceragenins and AMPs.
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PMC9429973
E. Katodritou, D. Dalampira, T. Triantafyllou, M. Gavriatopoulou, S. Delimpasi, A. Pouli, T. Papadopoulou, E. Verrou, A. Sevastoudi, K. Tsirou, L. Katsika, G. Douganiotis, N. Karampatzakis, T.-E. Metallinou, V. Palaska, M. Kotsopoulou, C. Lalayianni, M.-C. Kyrtsonis, E. Spanoudakis, D. Maltezas, A. Chatzivasili, M.-A. Dimopoulos, E. Terpos, E. Kastritis Hematology, Theagenio Cancer Hospital, Thessaloniki; Clinical Therapeutics, National and Kapodistrian University of Athens; Hematology and Bone Marrow Unit, Evangelismos General Hospital; Hematology, Agios Savvas Cancer Hospital; Hematology, Metaxa Cancer Hospital, Athens; Hematology and Bone Marrow Unit, George Papanicolaou General Hospital, Thessaloniki; First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Athens; Hematology, University Hospital of Alexandroupolis, Alexandroupolis; Hematology, Venizelion General Hospital, Heraclion, Greece Background: Revised International Staging System (R-ISS) has improved the prognostic value of ISS in multiple myeloma (MM).
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PMC11240571
The levels of PD-L1 in tumor cells and the release of exosomal PD-L1 were augmented after irradiation with RT.In the microenvironment of cancer, innate immunity is inhibited in a process known as immune tolerance.
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PMC11760643
In contrast, anti‐P2X7 mAb‐mediated CDC was not observed in the majority of lymphocyte populations, which expressed relatively low amounts of cell surface P2X7.
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PMC11055323
Here we show acquisition of oncogenic potential by nuclear condensate remodeling.
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PMC9917080
A-172 Human glioblastoma cells are highly resistant to the action of sorafenib, since its pro-apoptotic effect is recorded only after 48 h of exposure and at high doses.
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PMC9856122
Thus, BBIalkaloids should be further structurally explored for the treatment of newly emerged viral strains.
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PMC11746948
j Immunofluorescence staining for GPX4 and ZDHHC20 was performed in A375 cells infected with lentiviruses encoding a control plasmid or an HA-ZDHHC20 plasmid.
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PMC11798926
Number in parentheses indicates position of the leftmost amino acid.
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PMC11437637
The participants’ complete medical records, including general information, laboratory reports, pathological reports, and PBL detection reports, were collected.
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PMC8526701
B GIST-T1 cells were treated with GSK602 at indicated concentrations for 24 h. Left, PUMA expression was analyzed by western blotting.
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PMC11522251
As expected, HOXB8 and p-STAT3 expression rose in cetuximab-resistant colon cancer cells, whereas both were decreased in cetuximab-sensitive colorectal cancer cells.
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PMC11531744
These results also showed that the 25-genes prognostic model had an unusual capability for the prediction of survival and could be a durable and productive model of prognosis.
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PMC9429973
Ligand binding results in receptor dimerization and subsequent activation via autophosphorylation, causing downstream activation of various signaling pathways such as PI3K/AKT, MAPK/ERK, JAK/STAT and Notch.
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PMC11746948
b Representative images of large intestine tumorigenesis in Vil1-Cre; APT2, Vil1-Cre; APT2, and Vil1-Cre; APT2 mice.
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