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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Unfortunately, ABT-737 is characterized by poor bioavailability, so a new approach to target Bcl-xL must be investigated.
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PMC11394730
The gallic acid group significantly increased the anticancer properties of catechins.
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PMC11392912
We investigated miRNA from four medicinally valued regularly consumed spices, and validated one of the most potential miRNA ‘Clo-miR-14’ for its thermal stability, and absorption in the plasma samples of RA patient’s by RT-PCR.
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PMC9688728
All operations and reagents used were maximally unified for each time-dependent cell line sample to minimize possible technical errors.
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PMC9917080
In our experiments, acute application of sorafenib in the concentration range of 1–10 μg/mL to A-172 cancer cells or cerebral cortex astrocytes did not cause an increase in [Ca]i, in contrast to the SeSo nanocomplex.
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PMC11755519
It has been observed that exosomal ELNAT1 regulates UBC9 transcription by forming a triplex structure with the promoter sequence, inducing hnRNPA1-related modification of H3K4me3.
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PMC11487720
The disaster may accidentally occur in the polar regions or outer space.
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PMC11301095
Its derivative, Artesunate, demonstrated notable effectiveness in treating protozoan-induced central nervous system diseases .
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PMC11357960
The mRNA expression of 15 SUMO machinery components were analyzed by real-time PCR using the SYBR Green PCR Master Mix (YEASEN Biotech Co., Ltd, China).
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PMC8728081
The particle size of Kajjali and Rasasindura was analyzed by dynamic light scattering (DLS) and transmission electron microscopy (TEM).
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PMC8345486
In this context, purinergic signaling is a first-line molecular target in personalized cancer treatment and is currently recognized as including novel checkpoint inhibitor targets .
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PMC11760643
Relative changes in intracellular Ca were calculated using the ratio of Fura‐2 AM fluorescence (F340 nm/380 nm).
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PMC9429973
Univariate Cox, multivariate Cox, Best Subset Regression (BSR) and LASSO regression analyses were used to determine the significant factors that influenced overall survival (OS).
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PMC11761919
The histopathological changes in liver, heart, spleen and kidney tissues from the four immunized groups with Fiber2-expressing E. faecalis were alleviated to various degrees.
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PMC10998613
A group of ss-Oligos (SI Appendix, Table S3) was used to edit CXCR4 and ADRB2 genes in Wild-Type MDA-MB-231 cells.
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PMC11519788
After 8 h-incubation period, U937 cells in the upper chamber were collected, counted and calculated the cells penetrating to the bottom chamber.
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PMC11352877
Although ANG1 and ANG2 are similar in structure, their biological activities differ significantly.
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PMC11770746
The Hebrew University of Jerusalem–Protocol Number: MD-23-17349-4.
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PMC11657744
To test this hypothesis, we stained for PCNA, a marker of the S phase, during ciliary disassembly.
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PMC11748363
The corresponding amine (2 mmol) was placed in a 50 mL round‐bottom flask, and 10 mL of anhydrous DCM and anhydrous pyridine (3 mmol, 237 mg) were added.
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PMC11283030
a. Representative immunostaining photomicrographs of ACLY and p-ACLY expression in ccRCC tissues (IHC).
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PMC11365427
Furthermore, pathway enrichment analysis revealed that the phenylalanine-associated pathway is a significant perturbation in all groups (Fig. 2B).
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PMC11769516
DON is mainly found in maize, wheat and rice .
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PMC10890055
On the contrary, some authors consider 37 °C to be a permissive temperature .
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PMC7519871
WDL, on the other hand, was found out to be synergistic at any of the applied sequence of drug administration (0/0, 0/4 or 4/0).
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PMC11519077
By luring monocytes and macrophages, MCP-1 plays a significant role in inflammation .
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PMC11753949
We have further shown, using a heterologous system (COS-7 cells) that artificially anchoring synaptopodin to the ER by fusing it to Sec61β, which contains a C-terminal anchor, results in structures (SALs) that resemble the spine apparatus in key morphological features and at least some molecular properties.
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PMC11155445
Transfer of electrons from thiocarbonyl group CS and a hydrogen atom from NH efficiently stabilized two radicals of DPPH.
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PMC11334037
P < 0.05; P < 0.01; P < 0.001.
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PMC11470381
dist1 < dist2.
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PMC11700247
CTR, XXX.
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PMC10158546
We also failed to detect expression of synaptic marker SYN1, or oligodendrocyte marker OLIG2 by ReN cells via western blotting at any time-point post differentiation (supplementary figure S1).
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PMC11088135
However, this effect was reversed after co-transfection with YAP1-plasmid (Fig. 6C, D).
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PMC11659921
Column line plot based on multifactorial Cox results. (
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PMC11506670
The full-length mutant amplicon was TA-cloned into the pTargeT™ mammalian expression vector (Promega Corporation, Madison, WI, USA).
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PMC9429973
Results: The database contained 136 MF pts who had received treatment with RUX.
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PMC6379402
Table 1 shows the top-20 prioritized genes in each of the four cancers.
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PMC5386478
Lysates were centrifuged at 13 000 × g for 10 minutes at 4 °C and the supernatants were collected and assayed for protein concentration with the Bradford assay method (Bio-Rad).
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PMC10958426
CNV region was defined as a duplication region or a deletion region when the mean CNV level of this region across all cells is larger than 0.01 or less than −0.01 in a patient.
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PMC10728535
Table 1 gives the details of the aforementioned six data sets.
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PMC10957991
Additionally, immunofluorescence stainings of the mammary epithelial cell lines revealed that some cells within the mammary epithelial cell populations display higher TRPV4 expression and that TRPV4 is concentrated at the mature cell–cell junctions (S1C,D).
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PMC10810426
The PCR product was diluted 10-fold, and 2.4 μl was used as input for the second qPCR, which was performed using MLV long terminal repeat (LTR) primers (Table 1) .
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PMC11591794
The apoptotic and cytotoxic effects of both DOX, which is frequently used in malignancies, and GA, whose anticancer effects have been detected in many types of cancer in recent years, on HaCaT and HeLa cell lines in vitro and the potential therapeutic consequences of targeting the P53/Bax axis in the treatment of cervical cancer were discussed .
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PMC9429973
To assess the complex mechanisms of action of ISB 1442 in a single system, a multiple mode of action of killing (MMoAK) assay was established to allow for simultaneous killing by natural killer cells (ADCC), autologous macrophages (ADCP), and complement from human serum (CDC).
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PMC9429973
Aims: We evaluated the efficacy and safety of ponatinib and blinatumomab in pts with newly diagnosed (ND), relapsed/refractory (R/R) Ph+ ALL or CML in lymphoid blast phase (CML-LBP).
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PMC6642070
Lactate concentrations in gastrocnemius (GAS) and tibialis anterior (TA) muscles of C57BL/6 J mice co-administered with lovastatin and DCA for 30 days (n = 10 each group).
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PMC11599565
To explore this hypothesis, we isolated “twin” cells using a micromanipulator and analyzed their stemness and neuronal gene expression at the single-cell level (Fig. 6, Panel A).
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PMC10565698
E. Construction of MUT and WT circUSP10 and miR-211-5p binding sites.
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PMC11661040
Results from three experiments are summarized in a histogram format.
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PMC11155445
All compounds showed good inhibitory activity against hCA-II in between 0.18 and 4.45 μM. Compounds (144f and 144i) showed prominent inhibition activity with IC50 values of 0.26 ± 0.03, and 0.38 ± 0.09 μM, respectively.
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PMC11770130
The complicated effects of NTSR2 inhibition on various cell types may disturb the feeding behavior of mice.
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PMC11413393
These results from preclinical models suggest that PRMT1 inhibition holds promise as a potential therapeutic strategy in the treatment of ccRCC.
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PMC11715644
For +ErBb2 cells, the jammed-elongated (dark magenta) phenotype was minimal, and most cells showed unjamming (blue), particularly in wide channels.
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PMC11655498
During latency, EBV establishes one of the four distinct latency patterns (Latency 0, Latency I, Latency II, and Latency III) in B cells, which is represented by the expression of distinct gene sets (Münz, 2019).
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PMC10047551
Tumor biopsies and cell lines were analyzed for PD-L1 DNA methylation, mRNA expression, and protein expression.
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PMC11033180
The arrows point to ChAT neurons expressing PlexinA2.(I, I′, and I″) Double immunolabeling for Plexin A2 (green) and nNOS (red) in the myenteric plexus of rat distal colon.
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PMC4839679
After the cells were washed twice with PBS, they were resuspended and stained with 50 μg/ml propidium iodide (PI), 100 μg/ml RNase A, and 0.2% Triton X-100.
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PMC9429973
Given the pervasiveness of anaemia in MDS, managing this, and subsequent fatigue is of vital importance.
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PMC9429973
This suggests that in vivo, highly mutated stem and progenitor cells retain the capacity to differentiate to mature myeloid and in some patients mature lymphoid cells and contribute significantly to circulating blood cells in MDS and CMML, prior to and following AZA treatment.
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PMC9429973
However, this technic remains technically challenging despite best practice guidelines, does not provide any insight into subclonal architecture and intraclonal diversity, and has a general failure rate ranging from 10 to 20%.
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PMC11576293
Yield 77%; m. p. 265–267°C; H NMR (300 MHz, CDCl3) δ (ppm) = 8.14 (d., 2H, Ar-H, J = 9 Hz), 7.72 (m, 3H, Ar-H and pyrimidine–C5-H), 7.44 (m., 3H, Ar-H), 7.04 (m, 3H, Ar-H), 6.86 (d., 2H, Ar-H, J = 8.7 Hz), 4.57 (s., 2H, SCH2C6H5), 3.91(overlap singlets, 6H, 2 OCH3), 3.81 (s, 3H, SCH2C6H4OCH3); C NMR (75 MHz, CDCl3) δ (ppm) = 171.9, 164.3, 164.2, 162.1, 160.1, 158.7, 138.6, 129.8, 128.9, 119.6, 116.7, 114.3, 113.9, 112.5, 107.5, 55.5, 34.9; HRMS (ESI+) calcd.
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PMC11786704
Dulbecco antimurine antibodies p38, p-p38, JNK, P-JNK, INOS, COX2 and β-Actin Monoclonal antibodies were purchased from Proteintech (Wuhan, China).
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PMC11766309
Furthermore, we found that only in KICH was the correlation between YKT6 mRNA expression and copy number alterations not significant (Figure 6C).
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PMC9429973
We next demonstrated that the MCL1 locus was transcriptionally targeted by NF-ΚB accounting for the MCL1 increase.
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PMC10006224
Fig. 1NIPBL KD affects cohesin-STAG1 and cohesin-STAG2 in opposite ways.a Asynchronously growing HeLa cells mock transfected (control) or transfected with siRNA against NIPBL (NIPBL KD) were analyzed by flow cytometry 72 h later.
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PMC10968586
In the next paragraphs, we discuss the role of OLE and HT absorption, bioavailability and toxicity to non-cancer cells, OLE and HT interaction with chemotherapy drugs, OLE- and HT-mediated repercussions on drug metabolism, and OLE and HT antioxidant activity in the context of chemotherapy-induced oxidative stress as determinants of the net OLE and HT activity on cancer insurgence and growth in humans.
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PMC10745221
Additionally, a difference in ADMA in this molecular weight region was not observed in replicate anti-ADMA immunoblots of cell lysates (S2 Fig).
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PMC10243817
Gene expression was compared between cells with different treatments using the edgeR package (version 3.12.1), and genes with a corrected P < 0.05 and |log2 (fold change)| ≥ 1 between 2 groups were considered to have significantly differential expression (5).
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PMC11365983
Note the shortening of the cilium (red), most apparent in the homozygous mutant (Foxc1) compared to controls. (
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PMC11247842
BaseRecalibrator was applied to the raw alignment bam files using GATK 3.8 .
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PMC10165258
Etoposide library contains a control solution of the fluorescent dye CF488A (Biotium) diluted at 6 μM maximum final concentration in 3% DMSO.
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PMC10452486
Similarly, B2m increases the stability of the peptide on the groove of the HC .
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PMC10024132
Fresh retroviral supernatants were collected from transiently transfected Plat-A packaging cells and used to infect PBMCs (2×10 cells/mL) starting at day 8 of the 14-day γ9δ2 T cell expansion procedure, i.e., after stimulation with IL-2 (25 ng/mL) and Zoledronate (1 μM) for 8 days in RPMI-1640 medium.
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PMC11742670
Drug_NameIC50Magnesium oxide 0.006296 Iofetamine0.006341Silver nitrate0.006341Liothyronine sodium0.006341Cisplatin0.006341Aluminum hydroxide0.006341Pentetate calcium trisodium yb 1690.006341Liothyronine0.006341Calcium carbonate0.006341Carboplatin0.006341Sodium stibogluconate0.006341Hydrotalcite0.006341Iobenguane0.006341Oxaliplatin0.006341Cisplatin0.006341Sodium iodide0.006341Halothane0.017352Magaldrate0.128526Magnesium carbonate0.369054 The predicted IC50 of the most potent drugs for the A-549 cell line.
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PMC11612508
Following this, the medium was substituted with a new one containing microspheres, with or without the TMZ drug, and further incubated for 24 and 48 h, both in the absence and presence of a magnetic field.
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PMC11344246
Nodes (proteins) are coloured by betweenness centrality in the MOC co-expression network and sized by fPocket drug score.
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PMC10957991
Early after attachment and spreading, we noticed a delay in the spreading of the single epithelial cells (Fig. S4B).
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PMC11572213
The TET2 gene is frequently mutated in various cancers, including acute myeloid leukemia (AML).
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PMC11047729
In pediatric APL, the standard treatment has ATRA in every stage and the studies demonstrate that ATO may soon be included in the therapy as well .
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PMC11640555
Human GBM cell lines U-87MG (U-87 MG ATCC HTB-14TM Homo sapiens brain glioblastoma grade IV), U-138MG (U-138 MG ATCC HTB-16™ Homo sapiens brain glioblastoma grade IV), and A-172 (A-172 ATCC CRL-1620™ Homo sapiens brain glioblastoma) purchased from ATCC (American Type Culture Collection, Rockville, MD, USA), brain microvascular endothelial cell line (hCMEC/D3) and human blood–brain barrier endothelial cells (BMECs) were cultured as previously described .
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PMC9429973
For EHR data, median OS was 34.0 (28.2-42.8), with median OS of 46.9 (42.8-NE) for patients with 1 PL (n=587), 28.2 (23.8-41.7) for patients with 2 PL (n=584), and 20.8 (14.9-29.8) for patients with 3 PL (n=245).
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PMC9429973
Aims: In a phase I clinical trial, we explored the efficacy and safety of KO7CAR T-cells for relapsed or refractory (R/R) T-cell malignancies (NCT04916860 & NCT04938115).
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PMC11770199
The purified double-stranded cDNA fragments were end repaired, A base added, and ligated to Illumina sequencing adapters.
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PMC11766174
On average, 95,293 ± 27,388 cells were scanned per serial dilution (Figure 2B).
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PMC11252033
Low energy ligand-protein complexes were subjected to AMMP energy minimization using VegaZZ (Pedretti et al., 2004), then Cluster analysis was performed on docked results using a root-mean-square (rms) tolerance of 1.5 Å. The analysis of the binding mode of the docked conformations was carried out using the Autodock plugin within PyMol software v0.99 (Alexander et al., 2011).
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PMC4277423
Finally, we showed that transducing human CD4 T cells with a single lentiviral vector expressing both sgRNA CR2 and Cas9 efficiently disrupt CCR5 gene.
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PMC11786767
C: Ratio of the biotin-DHPE signal in the intrachromosomal area to that at the periphery.
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PMC9429973
Patient-reported outcomes to evaluate anxiety and depression were assessed among subgroups using the Generalized Anxiety Disorder-7 (GAD-7) scale (0–21) and the Patient Health Questionnaire (PHQ-8) scale (0–24), respectively.
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PMC9429973
This population specifically expressed common myeloid markers, such as VIM, CD81, and SPI1 as well as approximately 200 other genes (p-value < 0.05, log-fold change > 0.69) and made up around 10% of the entire GFI1B wildtype cell population.
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PMC8540692
Moreover, it was reported to exert antitumor effects in many tumors including not only colorectal cancer , but also breast cancer , and GBM .
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PMC10197932
Briefly, the 2 x 106 cells were incubated for 10 min 37 °C with 50 μM of MBB, then washed with PBS and analyzed for GSH content using FACS Melody a 405 laser and using a BV421 filter.
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PMC9822769
Unfortunately, the difficulty in inducing profound ATP depletion in the adherent human colon adenocarcinoma SW480 cells employed did not allow to clearly differentiate between the two possible mechanisms: active and then energy-dependent or facilitated and then energy-independent transport.
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PMC10329237
In addition to its anti-fibrotic activity, its low toxicity and adverse effects have made LOS an interesting agent for combination therapy in IPF.
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PMC10568263
The fabricated HSP70-immunosensor had a good linear dynamic range of 0.001 ng mL to 1000 ng mL with a LOD of 0.17 pg mL and did not require a secondary antibody for labeling.
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PMC10048572
The lysates were centrifuged and 2 µL of the supernatant (1/10 of the total amount) was used for each PCR reaction .
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PMC9221284
However, Trans2 (revealed in this work) is obtained by an alternative splicing acceptor site within exon 2 (Figure 2B and Figure S4).
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PMC11697189
Previous studies showed that HSPA8 affected the function of tumor-associated genes, it could inhibit the degradation of mutant forms of p53 and p73, and binds to the non-phosphorylated tumor-suppressor retinoblastoma (Rb) protein to reduce its degradation.
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PMC11092382
Asteraceae]), Zi Hua Di Ding (Violae Herba—Viola yedoensis Makino [Violaceae]), Lu Hui (Aloe Vera—Aloe barbadensis Miller and Aloe ferox Miller [Asphodelaceae]), Zhu Dan Fen (Suis Fellis Pulvis—Sus scrofa domestica Brisson. [
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PMC9429973
It is likely that health is improved also for adults, but the expected residual chronic morbidity and reduced life expectancy is not clear, and accurate prognosis is important for planning health care services and in evaluating the impact of new therapies.
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PMC8996378
The results showed that compound 51 was an effective potential drug to reverse ABCB1-mediated MDR by inhibiting ABCB1 transport function and increasing the intracellular concentration of TAX (Liu et al., 2015).
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