OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC3675084	Ovarian cancer cell line A2780-1A9 and its paclitaxel resistant subline 1A9-PTX10 were obtained from Dr. Tito Fojo (National Cancer Institute, Bethesda, MD) .	[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O...
PMC10698968	B STR profiling data obtained by ATCC of the patient’s tumour sample (left) and MF-R 3 cells at passage 10 (hypothesized immortalization passage) (right) The research protocol was approved by the Local Ethics Committees (AVEC and CEROM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC2118063	The data from this study identify the transcription factor, IRF8, as another important regulator of the GC program of molecular differentiation by demonstrating two striking and previously unappreciated roles in B cell biology, the direct transcriptional activation of both BCL6 and AICDA, critical determinants of GC development, and function and effects on GC organization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672881	After three PBS washes, the cells were scraped and centrifuged at 15,000× g for 10 min at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "thr...
PMC9429973	Additionally, association of CNS relapse with survival and the correlation of CNS-IPI score, age, albumin, origin of cell, and DHL/DEL status with cumulative CNS relapse incidence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10698968	C Panel of six representative pictures of TEM analysed samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Panel", "of", "six", "representative", "pictures", "of", "TEM", "analysed", "samples", ...
PMC11269933	The co-immunoprecipitation coIP results demonstrated the specific interaction between CgERK1/2 and CgPK in the lysates of cells co-transfected with Flag-CgPk and Myc-CgErk1/2 (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11741906	Interestingly, Opławski et al. evaluated the clinical and molecular characteristics of 48 diagnosed ovarian cancer patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "Opławski", "et", "al.", ...
PMC11656657	L, Milano (MI), Italy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "L", ",", "Milano", "(", "MI", ")", ",", "Italy", "." ] } ]
PMC11696576	Fig. 4Binding mode of GK420 acid in cPLA2α binding pocket after MD simulation.a The docking poses with the five lowest docking scores in the substrate binding site of cPLA2a are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718817	Among many molecular pathways that influence the production of cytokines and the expression of costimulatory and coinhibitory molecules, the NLRP3 inflammasome and NLRP3-dependent cytokines IL-1β and IL-18 are pivotal for the fate of CTL effector function .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	For this, HEK293T cells were transfected with MOR-nLuc, mCit-arrestin3 and GRK2.	[ { "tags": [ "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", ",", "HEK293", "T", "cells", "were", ...
PMC9583612	Innovation in technologies to quantify methane emissions can now enable target-based approaches to emissions mitigation and differentiation across operators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Innovation", "in", "technologies", ...
PMC11536589	The CCK8 assay was conducted using different concentrations of MRTX1133 (ranging from 0 to 10 µM) and PKF-118-310 (ranging from 0 to 500 nM).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657744	Representative immunofluorescent images of MEFs.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "immunofluorescent", "images", "of", "MEFs", "." ] } ]
PMC8427838	B Schematic of wild type GST-TMIGD1 and GST-RRKK motif mutant TMIGD1 (4A-TMIGD1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Schematic", "of", "wild", "type", "GST-TMIGD1", "and", "GST...
PMC10454535	However, RES has been shown to have very low bioavailability , and several of its derivatives have been studied in the interest of identifying more effective novel treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11548041	Aptamers offer many advantages over the more widely used and studied antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aptamers", "offer", "many", "advantages", "over", "the", "more", "widely", "used...
PMC11240448	However, how these mutations affect biochemical network functions in the cancer cells, and specify disease manifestation is unknown .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "how", ...
PMC9429973	Aims: The aim of this study was to develop potential treatment procedure based on the use of iPS cells generated from epithelial cells of patients with congenital neutropenia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11004721	Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for the A549 cell line were erroneously copied across for the A2780 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11429241	This includes extensive general biocompatibility studies that show their excellent biocompatibility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "includes", "extensive", "general", "biocompatibility", "studies", "that", "show", "...
PMC10667689	Meanwhile, a significant decrease was also observed at 48 and 72 h post-treatment with Gal-9 compared to the PMA group ( Table 2 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11723947	In response, they mobilize different gene networks that establish lineage-specific developmental programs, and coordinate the acquisition of specific phenotype and functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC9429973	Anemi grade III was most commonly appear in Flu/Cph+R regime (n=4 – 8%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anemi", "grade", "III", "was", "most", "commonly", ...
PMC6901583	An example is the upregulation and role of chemokine (C–C motif) ligand 2 (CCL2) in many cancers, including GIST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7553912	The apparent molecular weights are indicated on the right. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "apparent", "molecular", "weights", "are", "indicated", "on", "the", "right", ".", "...
PMC10253973	The cellular penetration analysis of ruthenium complexes showed that erlotinib significantly increased compound 5 uptake in the A2780 and A2780cisR cells compared to uptake of 5 alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC5963610	Survival benefit of the combination therapy was completely abrogated in mice depleted of NK1.1 cells (Figure 5B) or CD4T and CD8T cells (Supplementary Figure 8B and 8D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Prior to lymphodepletion, ‘aplastic’ patients displayed increased systemic inflammation (median ferritin 1168 ng/ml), impaired hematopoietic function (median platelet count 101 G/l) and high tumor burden (median LDH 344 U/l). ‘	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	Vehicle control.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Vehicle", "control", "." ] } ]
PMC9429973	Summary/Conclusion: In a regimen with more (6 vs 4), but lower single fludarabine dosage (30mg/m vs 40mg/m) and a shorter infusion duration (30min vs 60min) resulting in higher AUC (40mgh/l vs 20 mgh/l) than previously published.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271278	Highlighted are the genes on the MYC-ERBB2 ecDNA that are significantly differentially expressed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Highlighted", "are", "the", "genes", "on", "the", "MYC-ERBB2", "ecDNA", ...
PMC11746948	Data are presented as mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "mean", "±", "SD", "." ] } ]
PMC10530622	Genome wide association studies have failed to identify susceptibility loci around any of the mendelian genes responsible for PH , although a small case-control study, enrolling 225 patients, did find an association between the SLC26A6 p.G539R allele and lithiasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621493	We recently demonstrated that PLA2G4D is capable of catalyzing the acylation of the glycerol head group of PG and LPG, resulting in the formation of hemi-bis(monoacylglycero)phosphate and bis(monoacylglycero)phosphate, respectively (12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11172027	This mechanism appears to be based on the increased activity of selenium-dependent enzymes such as glutathione peroxidase and thioredoxin reductase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "mechanism", "appears...
PMC8839885	2HE2 exhibited very weak estrogenic activity and was able to antagonize the estrogenic effect of estradiol .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2HE2", "exhibited", "very", "weak", "estrogenic", "act...
PMC9429973	KMT2A break outside the main cluster was found in intron 7 on 4 cases of KMT2A-MLL10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KMT2A", "break", "outside", "the", "main", "cluster", ...
PMC11681005	The hypoDMRs and hyperDMRs in MIBC were stratified into subgroups by utilizing profiles of histone modifications and transcription factor binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hypoDMRs", "and", ...
PMC5925824	100 μl of serially diluted anti-PD-L1 antibody or control IgG was then added and incubated at room temperature for 2 h. After washing, the plate was incubated with goat anti-human IgG F(ab’)2-HRP conjugate (Jackson ImmunoResearch, West Grove, PA) at room temperature for 1 h. The plates were washed and then incubated with 3, 3′, 5, 5′-tetramethylbenzidine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476222	A database containing the accurate monoisotopic mass with isotopic distribution for ganglioside structures, including varying ceramide moieties (chain length variation) and charge state information (doubly and singly deprotonated ions), was generated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767793	On the other hand, the TEM revealed the core sizes (DTEM) of the Au-PEI@NIST and Au-PEG-COOH@NIST as 11.5 ± 1.8 nm (Figure 1b) and 14.3 ± 0.9 nm (Figure 1e), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329237	MDA concentration was measured by washing the cells with ice-cold PBS and homogenizing them in 400 µl of 0.5% Triton X-100.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MDA", "conce...
PMC11361748	Primary antibodies (S1 Table) diluted in blocking buffer were added and the preparations were incubated at 37°C for 1 h. The Duolink PLA Fluorescence kit (Millipore Sigma) was used according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7840816	Representative Western blot image of SOX9 protein in PTC cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "Western", "blot", "image", "of", "SOX9", "protein", "in", "PTC", "c...
PMC9895440	All animal experiments were performed in accordance with Swiss federal regulations and licenses (numbers 2408_34213, 2370_34209) were approved by the cantonal veterinary office of Basel-Stadt (CH).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614415	Immunoblot analysis of whole cell lysates from 1A9 and PTX10 cell lines probed for Aurora-A, Aurora-B and PP2A as a loading control. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], ...
PMC11532793	Another area for possible improvement is the statistical treatment of small counts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "area", "for", "possible", "improvement", "is", "the", "statistical", ...
PMC11206251	After treatment with different concentrations of the PEIM, the contents of TNF-α (Figure 4A), IL-1β (Figure 4B) and IL-6 (Figure 4C) in the supernatant of HepG2 cells decreased gradually compared to the control group (p < 0.05 or p < 0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973725	The results suggested that patients with higher ZNF677 mRNA expression levels had a longer overall survival than those with low ZNF677 mRNA levels (Figure 3c).Table 1.Methylation status of ZNF677 between normal tissues and ccRCC tissuesZNF677 MethylationUnmethylationFrequency of methylationNormal2474.2%Tumor51985% Table 2.The correlation between ZNF677 methylation and clinicopathological feature in ccRCCZNF677 Methylation StatusItemMethylatedUnmethylatedXp valueAge (years) ≤552240.0050.941>55295 Sex Male2650.0640.800Female254 Smoking status NO2361.4250.232YES283 Pathological T stage pT11465.2940.021pT2-T4373 Lymph node metastasis Positive1975.1160.023Negative322 Distant metastasis M04591.1760.278M160 Fuhrman classification I–II2186.9740.008III–IV301 Final Stage I1465.0560.143II171 III122 IV80 Figure 3.Low expression of ZNF677 was due to hypermethylation. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929	X-axis: Cell capture status.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "X-axis", ":", "Cell", "capture", "status", "." ] } ]
PMC11803149	Adoptive transfer of OT-I TCR-T cells or OT-I T cells was performed by intravenously injecting cells into mice on day 8 after tumor transplantation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10761218	Similarly, leaf and stem methanolic extracts showed no significant effect on the L929 cell line (p ≥ 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",...
PMC11756514	The innate immune system plays a critical role in the rapid recognition and elimination of pathogens through pattern recognition receptors (PRRs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11629143	Treatment with A485 was observed to reduce cell proliferation, but normalization of ChIP data to amounts of chromatin compensates for differences in cell number.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10729469	Eight-month-old non-Tg mice (n = 6) were untreated, and age-matched APP/PS1 mice were untreated or treated with 1 × 10 TCRAβ-Tregs, polyclonal Tregs (Treg), or EV-Tregs (TCR-Tregs electroporated with empty plasmid vector).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Immunocytochemistry staining (C) of endoplasmic reticulum marker Calnexin (magenta) in combination with plasma membrane marker MemGlow 488 (yellow) and cholesterol staining by filipin (Cyan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9684669	Cell viability of MDR ovarian cancer cells treated with 2 µM doxorubicin (Dox), 5 µM tannic acid (TA), or both for 48 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615101	The bar graph shows macroscopic arthritis score based on macroscopic observation in rats, a decreased level of macroscopic arthritis score in the siTaxilin group compared to the CIA group was observed. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394730	Furthermore, some research indicates that QUE’s anti-tumor effects stem from its capacity to trigger autophagy and apoptosis in cancerous cells and xenographmodels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11489351	The binding of Notch1 to the CBF promoter drives mVenus fluorescent protein expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "binding", "of", "Notch1", "to", "the", "CBF", "promoter", "dri...
PMC11629461	Each dot on the bar column represents data from one cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "dot", "on", "the", "bar", "column", "represents", "data", "from", "one", ...
PMC8193046	In total, 29 extended positive hit substructures including the 8 clear positive hits as defined by C@PA resulted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "total", ",", "29", "e...
PMC9429973	The Phase 2 component will further evaluate safety, PK, PD and preliminary efficacy of the combination at the LANRA RP2D.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Phase...
PMC11126803	E, clinical sample test results show that the mRNA level of LncRNA-SERB in cancer tissues is higher than that in para-cancerous normal tissues from our collections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11568601	In addition, the curative treatments inevitably cause long-term complications, including neurocognitive dysfunction, cardiomyopathy, and liver and kidney toxicity, all of which may influence the prognosis of cancer patients .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224206	However, it has not been our intention to provide detailed experimental protocols; rather, to hope that if our paper stimulates interest in thermal homeostasis in the gametes and early embryo, it will prompt others to refine existing techniques and develop new ones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6901583	Thus, new insights have been gained in this work regarding the involvement of BRD4 in GIST pathogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "new", "insights", "have",...
PMC11337594	A375 cells in 6-well plates were transfected with 2 µg/well of the px458-p53/CASP3/GSDME-KO plasmid using polyethyleneimine (9002-98-6#, Acmec, Shanghai, China).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704834	In parallel, human GAPDH forward, 5'-CCCACTCCTCCACCTTTGAC-3' and reverse, 5'-TTGCTGTAGCCAAATTCGTTGT-3' were used as control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "parallel", ",", "human", "GAPDH"...
PMC10958426	Paired Wilcoxon signed rank test was used to examine whether the differences were significant. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Paired", "Wilcoxon", "signed", "rank", "test", "was", "used...
PMC9429973	However, there is no report about the anti-tumor effect of flumatinib in combination with Bcl-2 inhibitor in B-ALL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "is", ...
PMC11676169	The samples were collected on a FACSCalibur (BD Biosciences) using Cell Quest software 5.1 (BD Biosciences) or a BD LSR II flow cytometer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10874773	oligandrumZhu et al., 2009401,3-DihydroxyneoanisatinNeuroprotectionI. lanceolatumLiu et al., 2020412β-Hydroxy-6-deoxyneoanisatinI. lanceolatumNie et al., 202242MajucinI. jiadifengpiCheng & Micalizio, 201443(2S)-Hydroxy-3,4-dehydroneomajucinI. jiadifengpiCheng & Micalizio, 201444NeomajucinAnti-inflammationI. angustisepalumFukuyama & Huang, 200545(2S)-HydroxyneomajucinI. majusFukuyama & Huang, 2005466-Deoxy-neomajucinI. majusFukuyama & Huang, 200547AngustisepalinI. majusSy & Brown, 1998482-OxoneomajucinAntiviralI. jiadifengpiZhang et al., 2013492,3-DehydromajucinI. majusFukuyama & Huang, 2005501,2-DehydroneomajucinI. jiadifengpiFukuyama & Huang, 200551(2R)-Hydroxy-3,4-dehydroneomajucinI. majusFukuyama & Huang, 200552(1S)-2-Oxo-3,4-dehydroneomajucinI. majusFukuyama & Huang, 200553(1R)-2-Oxo-3,4-dehydroxyneomajucinI. majusFukuyama & Huang, 200554(1R,10S)-2-Oxo-3,4-dehydroneomajucinI. majusFukuyama & Huang, 200555Jiadifenoxolane ANeuroprotectionI. jiadifengpi(Kubo et al., 2009)56Jiadifenoxolane BI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Surface markers typically used to isolate hematopoietic stem and progenitor cells (HSPCs) massively change upon inflammation, which questions the reliability of using flow cytometry to study the system upon inflammation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	Then, the dried samples were reconstituted in 100 μl of 50% methanol in dichloromethane by sonication on ice for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ...
PMC11098378	Third, IEPs often drive virulence and thus their characterization can reveal pathogenesis mechanisms .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Third", ",", "IEPs", "often", "drive", "virulence", "and", "thus...
PMC11544122	No. A-420-10).	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "A-420", "-", "10", ")", "." ] } ]
PMC11756907	As a result, reduced graphene oxide (rGO) is obtained, being a material with an intermediate degree of oxygen enrichment, which is an intermediate form between graphene oxide and unoxidized graphene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	Using drugs or radiation, it is possible to cause the tumor to become inflamed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "drugs", "or", "radiation", ",", "it", "is", ...
PMC11033180	To investigate whether the effects induced by Sema5A on synaptic vesicle exocytosis and synapsin phosphorylation could translate into changes in the electrophysiological properties of enteric neurons, cell-attached and whole-cell patch-clamp recordings were performed as previously established.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	Metal nanomaterials, such as copper oxide (CuO) nanoparticles (NPs), have shown significant promise in cancer therapy due to their ability to induce apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	Number of migrated moDCs after 4 hours of LPS treatment (200 ng/ml) and IgG isotype control, pembrolizumab (αPD-1 antibody) or atezolizumab (αPD-L1 antibody) at 200 μg/ml.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11279397	This review classification summarizes the antiviral abilities of monomeric components of Perilla frutescens with OB greater than 20% against various viruses and their mechanism of action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This step is required for subsequent fusion of the membranes to release cytolytic cargo toward target cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "step", "is", "required", "for", "su...
PMC9352806	BMS enhanced the expression of DAF-16 and LGG-1 proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BMS", "enhanced", "the", "expression", "of", "DAF-16", "and", "LGG-1", "proteins", "." ] } ]
PMC9429973	Aims: The aim of the study was to clarify the validity of WW for POAML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The", "aim", "of", "the", "study", ...
PMC9429973	We provide unique insights into the genetic complexity of CK-AML, and evidence of the resulting functional outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "provide", "unique", "insights", ...
PMC5810978	The inoculum was not removed after inoculation for these HuNoV and HuSaV culture trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inoculum", "was", "not", "removed", "after", "inoculation", ...
PMC7961460	For confocal microscopy, 7.5 × 10 MCF-7 cells were plated onto coverslips in 12-well plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "confocal", "microscopy", ",", "7.5", "...
PMC9429973	Methods: Experiments were carried out on primary AML patient samples and flow cytometry was used to identify subpopulation specific responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "E...
PMC9429973	Of the included studies, 15 (53.6%) utilized a prospective, observational study design and, aside from seven multinational studies, data from 11 unique countries were reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727145	Histological samples underwent a dehydration process (i.e., ascending alcohol series) and xylene clarification before they could be mounted using Eukitt mounting agents (Biosystems, Bobingen, Germany) and a cover glass.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11392912	The graph represents the level of TNF-α mRNA fold change, measured after transfection with total miRNA from turmeric, fenugreek, kalonji, and flax seed. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11515150	Eleven days after transplantation, mice were divided into four treatment groups (n = 4) according to the average radiance of the bioluminescent imaging: group freezing solution (control), group Mock-NK, group IL-15 CAR-NK, and group 12 C CAR-NK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9622879	Let be a price that has a value in the range from the selling price to buying price proposed by the EP.34[12pt] $$ P_(t) P_(t) P_(t) $$α·PMG(t)≤Pmid(t)≤PMG(t)In this study, we use .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678368	Infrared and Raman spectroscopy, combined with DFT (ωB97X-D) calculations, provided valuable information about metal–ligand interactions, the cis or trans conformation of the aldehyde group in the ligands, and the presence of trans isomers in the metal complexes obtained in the solid state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: This is the first study demonstrating that the alpha catalytic subunit of PI3K is a targetable non-canonical driver of LCH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9910796	ASFV belongs to the family Asfarviridae, within the recently established Phylum Nucleocytoviricota , a monophyletic clade of large and giant DNA eukaryotic viruses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC3675084

Ovarian cancer cell line A2780-1A9 and its paclitaxel resistant subline 1A9-PTX10 were obtained from Dr. Tito Fojo (National Cancer Institute, Bethesda, MD) .

[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O...

PMC10698968

B STR profiling data obtained by ATCC of the patient’s tumour sample (left) and MF-R 3 cells at passage 10 (hypothesized immortalization passage) (right) The research protocol was approved by the Local Ethics Committees (AVEC and CEROM).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "...

PMC2118063

The data from this study identify the transcription factor, IRF8, as another important regulator of the GC program of molecular differentiation by demonstrating two striking and previously unappreciated roles in B cell biology, the direct transcriptional activation of both BCL6 and AICDA, critical determinants of GC development, and function and effects on GC organization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11672881

After three PBS washes, the cells were scraped and centrifuged at 15,000× g for 10 min at 4 °C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "thr...

PMC9429973

Additionally, association of CNS relapse with survival and the correlation of CNS-IPI score, age, albumin, origin of cell, and DHL/DEL status with cumulative CNS relapse incidence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10698968

C Panel of six representative pictures of TEM analysed samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Panel", "of", "six", "representative", "pictures", "of", "TEM", "analysed", "samples", ...

PMC11269933

The co-immunoprecipitation coIP results demonstrated the specific interaction between CgERK1/2 and CgPK in the lysates of cells co-transfected with Flag-CgPk and Myc-CgErk1/2 (Figure 4A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11741906

Interestingly, Opławski et al. evaluated the clinical and molecular characteristics of 48 diagnosed ovarian cancer patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "Opławski", "et", "al.", ...

PMC11656657

L, Milano (MI), Italy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "L", ",", "Milano", "(", "MI", ")", ",", "Italy", "." ] } ]

PMC11696576

Fig. 4Binding mode of GK420 acid in cPLA2α binding pocket after MD simulation.a The docking poses with the five lowest docking scores in the substrate binding site of cPLA2a are shown.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11718817

Among many molecular pathways that influence the production of cytokines and the expression of costimulatory and coinhibitory molecules, the NLRP3 inflammasome and NLRP3-dependent cytokines IL-1β and IL-18 are pivotal for the fate of CTL effector function .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11806106

For this, HEK293T cells were transfected with MOR-nLuc, mCit-arrestin3 and GRK2.

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PMC9583612

Innovation in technologies to quantify methane emissions can now enable target-based approaches to emissions mitigation and differentiation across operators.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Innovation", "in", "technologies", ...

PMC11536589

The CCK8 assay was conducted using different concentrations of MRTX1133 (ranging from 0 to 10 µM) and PKF-118-310 (ranging from 0 to 500 nM).

[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11657744

Representative immunofluorescent images of MEFs.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "immunofluorescent", "images", "of", "MEFs", "." ] } ]

PMC8427838

B Schematic of wild type GST-TMIGD1 and GST-RRKK motif mutant TMIGD1 (4A-TMIGD1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Schematic", "of", "wild", "type", "GST-TMIGD1", "and", "GST...

PMC10454535

However, RES has been shown to have very low bioavailability , and several of its derivatives have been studied in the interest of identifying more effective novel treatments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11548041

Aptamers offer many advantages over the more widely used and studied antibodies.

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PMC11240448

However, how these mutations affect biochemical network functions in the cancer cells, and specify disease manifestation is unknown .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "how", ...

PMC9429973

Aims: The aim of this study was to develop potential treatment procedure based on the use of iPS cells generated from epithelial cells of patients with congenital neutropenia.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11004721

Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for the A549 cell line were erroneously copied across for the A2780 cell line.

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PMC11429241

This includes extensive general biocompatibility studies that show their excellent biocompatibility.

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PMC10667689

Meanwhile, a significant decrease was also observed at 48 and 72 h post-treatment with Gal-9 compared to the PMA group ( Table 2 ).

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PMC11723947

In response, they mobilize different gene networks that establish lineage-specific developmental programs, and coordinate the acquisition of specific phenotype and functions.

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PMC9429973

Anemi grade III was most commonly appear in Flu/Cph+R regime (n=4 – 8%).

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PMC6901583

An example is the upregulation and role of chemokine (C–C motif) ligand 2 (CCL2) in many cancers, including GIST.

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PMC7553912

The apparent molecular weights are indicated on the right. (

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PMC10253973

The cellular penetration analysis of ruthenium complexes showed that erlotinib significantly increased compound 5 uptake in the A2780 and A2780cisR cells compared to uptake of 5 alone.

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PMC5963610

Survival benefit of the combination therapy was completely abrogated in mice depleted of NK1.1 cells (Figure 5B) or CD4T and CD8T cells (Supplementary Figure 8B and 8D).

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PMC9429973

Prior to lymphodepletion, ‘aplastic’ patients displayed increased systemic inflammation (median ferritin 1168 ng/ml), impaired hematopoietic function (median platelet count 101 G/l) and high tumor burden (median LDH 344 U/l). ‘

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PMC4270159

Vehicle control.

[ { "tags": [ "O", "O", "O" ], "tokens": [ "Vehicle", "control", "." ] } ]

PMC9429973

Summary/Conclusion: In a regimen with more (6 vs 4), but lower single fludarabine dosage (30mg/m vs 40mg/m) and a shorter infusion duration (30min vs 60min) resulting in higher AUC (40mg*h/l vs 20 mg*h/l) than previously published.

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PMC11271278

Highlighted are the genes on the MYC-ERBB2 ecDNA that are significantly differentially expressed.

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PMC11746948

Data are presented as mean ± SD.

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PMC10530622

Genome wide association studies have failed to identify susceptibility loci around any of the mendelian genes responsible for PH , although a small case-control study, enrolling 225 patients, did find an association between the SLC26A6 p.G539R allele and lithiasis .

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PMC11621493

We recently demonstrated that PLA2G4D is capable of catalyzing the acylation of the glycerol head group of PG and LPG, resulting in the formation of hemi-bis(monoacylglycero)phosphate and bis(monoacylglycero)phosphate, respectively (12).

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PMC11172027

This mechanism appears to be based on the increased activity of selenium-dependent enzymes such as glutathione peroxidase and thioredoxin reductase.

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PMC8839885

2HE2 exhibited very weak estrogenic activity and was able to antagonize the estrogenic effect of estradiol .

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PMC9429973

KMT2A break outside the main cluster was found in intron 7 on 4 cases of KMT2A-MLL10.

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PMC11681005

The hypoDMRs and hyperDMRs in MIBC were stratified into subgroups by utilizing profiles of histone modifications and transcription factor binding.

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PMC5925824

100 μl of serially diluted anti-PD-L1 antibody or control IgG was then added and incubated at room temperature for 2 h. After washing, the plate was incubated with goat anti-human IgG F(ab’)2-HRP conjugate (Jackson ImmunoResearch, West Grove, PA) at room temperature for 1 h. The plates were washed and then incubated with 3, 3′, 5, 5′-tetramethylbenzidine.

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PMC11476222

A database containing the accurate monoisotopic mass with isotopic distribution for ganglioside structures, including varying ceramide moieties (chain length variation) and charge state information (doubly and singly deprotonated ions), was generated.

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PMC11767793

On the other hand, the TEM revealed the core sizes (DTEM) of the Au-PEI@NIST and Au-PEG-COOH@NIST as 11.5 ± 1.8 nm (Figure 1b) and 14.3 ± 0.9 nm (Figure 1e), respectively.

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PMC10329237

MDA concentration was measured by washing the cells with ice-cold PBS and homogenizing them in 400 µl of 0.5% Triton X-100.

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PMC11361748

Primary antibodies (S1 Table) diluted in blocking buffer were added and the preparations were incubated at 37°C for 1 h. The Duolink PLA Fluorescence kit (Millipore Sigma) was used according to the manufacturer’s instructions.

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PMC7840816

Representative Western blot image of SOX9 protein in PTC cell lines.

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PMC9895440

All animal experiments were performed in accordance with Swiss federal regulations and licenses (numbers 2408_34213, 2370_34209) were approved by the cantonal veterinary office of Basel-Stadt (CH).

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PMC2614415

Immunoblot analysis of whole cell lysates from 1A9 and PTX10 cell lines probed for Aurora-A, Aurora-B and PP2A as a loading control. (

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PMC11532793

Another area for possible improvement is the statistical treatment of small counts.

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PMC11206251

After treatment with different concentrations of the PEIM, the contents of TNF-α (Figure 4A), IL-1β (Figure 4B) and IL-6 (Figure 4C) in the supernatant of HepG2 cells decreased gradually compared to the control group (p < 0.05 or p < 0.01).

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PMC8973725

The results suggested that patients with higher ZNF677 mRNA expression levels had a longer overall survival than those with low ZNF677 mRNA levels (Figure 3c).Table 1.Methylation status of ZNF677 between normal tissues and ccRCC tissuesZNF677 MethylationUnmethylationFrequency of methylationNormal2474.2%Tumor51985% Table 2.The correlation between ZNF677 methylation and clinicopathological feature in ccRCCZNF677 Methylation StatusItemMethylatedUnmethylatedXp valueAge (years) ≤552240.0050.941>55295 Sex Male2650.0640.800Female254 Smoking status NO2361.4250.232YES283 Pathological T stage pT11465.2940.021pT2-T4373 Lymph node metastasis Positive1975.1160.023Negative322 Distant metastasis M04591.1760.278M160 Fuhrman classification I–II2186.9740.008III–IV301 Final Stage I1465.0560.143II171 III122 IV80 Figure 3.Low expression of ZNF677 was due to hypermethylation. (

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PMC11802929

X-axis: Cell capture status.

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PMC11803149

Adoptive transfer of OT-I TCR-T cells or OT-I T cells was performed by intravenously injecting cells into mice on day 8 after tumor transplantation.

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PMC10761218

Similarly, leaf and stem methanolic extracts showed no significant effect on the L929 cell line (p ≥ 0.05).

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PMC11756514

The innate immune system plays a critical role in the rapid recognition and elimination of pathogens through pattern recognition receptors (PRRs).

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PMC11629143

Treatment with A485 was observed to reduce cell proliferation, but normalization of ChIP data to amounts of chromatin compensates for differences in cell number.

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PMC10729469

Eight-month-old non-Tg mice (n = 6) were untreated, and age-matched APP/PS1 mice were untreated or treated with 1 × 10 TCRAβ-Tregs, polyclonal Tregs (Treg), or EV-Tregs (TCR-Tregs electroporated with empty plasmid vector).

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PMC11754432

Immunocytochemistry staining (C) of endoplasmic reticulum marker Calnexin (magenta) in combination with plasma membrane marker MemGlow 488 (yellow) and cholesterol staining by filipin (Cyan).

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PMC9684669

Cell viability of MDR ovarian cancer cells treated with 2 µM doxorubicin (Dox), 5 µM tannic acid (TA), or both for 48 hours.

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PMC11615101

The bar graph shows macroscopic arthritis score based on macroscopic observation in rats, a decreased level of macroscopic arthritis score in the siTaxilin group compared to the CIA group was observed. (

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PMC11394730

Furthermore, some research indicates that QUE’s anti-tumor effects stem from its capacity to trigger autophagy and apoptosis in cancerous cells and xenographmodels.

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PMC11489351

The binding of Notch1 to the CBF promoter drives mVenus fluorescent protein expression.

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PMC11629461

Each dot on the bar column represents data from one cell.

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PMC8193046

In total, 29 extended positive hit substructures including the 8 clear positive hits as defined by C@PA resulted.

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PMC9429973

The Phase 2 component will further evaluate safety, PK, PD and preliminary efficacy of the combination at the LANRA RP2D.

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PMC11126803

E, clinical sample test results show that the mRNA level of LncRNA-SERB in cancer tissues is higher than that in para-cancerous normal tissues from our collections.

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PMC11568601

In addition, the curative treatments inevitably cause long-term complications, including neurocognitive dysfunction, cardiomyopathy, and liver and kidney toxicity, all of which may influence the prognosis of cancer patients .

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PMC11224206

However, it has not been our intention to provide detailed experimental protocols; rather, to hope that if our paper stimulates interest in thermal homeostasis in the gametes and early embryo, it will prompt others to refine existing techniques and develop new ones.

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PMC6901583

Thus, new insights have been gained in this work regarding the involvement of BRD4 in GIST pathogenesis.

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PMC11337594

A375 cells in 6-well plates were transfected with 2 µg/well of the px458-p53/CASP3/GSDME-KO plasmid using polyethyleneimine (9002-98-6#, Acmec, Shanghai, China).

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PMC11704834

In parallel, human GAPDH forward, 5'-CCCACTCCTCCACCTTTGAC-3' and reverse, 5'-TTGCTGTAGCCAAATTCGTTGT-3' were used as control.

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PMC10958426

Paired Wilcoxon signed rank test was used to examine whether the differences were significant. (

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PMC9429973

However, there is no report about the anti-tumor effect of flumatinib in combination with Bcl-2 inhibitor in B-ALL.

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PMC11676169

The samples were collected on a FACSCalibur (BD Biosciences) using Cell Quest software 5.1 (BD Biosciences) or a BD LSR II flow cytometer.

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PMC10874773

oligandrumZhu et al., 2009401,3-DihydroxyneoanisatinNeuroprotectionI. lanceolatumLiu et al., 2020412β-Hydroxy-6-deoxyneoanisatinI. lanceolatumNie et al., 202242MajucinI. jiadifengpiCheng & Micalizio, 201443(2S)-Hydroxy-3,4-dehydroneomajucinI. jiadifengpiCheng & Micalizio, 201444NeomajucinAnti-inflammationI. angustisepalumFukuyama & Huang, 200545(2S*)-HydroxyneomajucinI. majusFukuyama & Huang, 2005466-Deoxy-neomajucinI. majusFukuyama & Huang, 200547AngustisepalinI. majusSy & Brown, 1998482-OxoneomajucinAntiviralI. jiadifengpiZhang et al., 2013492,3-DehydromajucinI. majusFukuyama & Huang, 2005501,2-DehydroneomajucinI. jiadifengpiFukuyama & Huang, 200551(2R*)-Hydroxy-3,4-dehydroneomajucinI. majusFukuyama & Huang, 200552(1S*)-2-Oxo-3,4-dehydroneomajucinI. majusFukuyama & Huang, 200553(1R*)-2-Oxo-3,4-dehydroxyneomajucinI. majusFukuyama & Huang, 200554(1R*,10S*)-2-Oxo-3,4-dehydroneomajucinI. majusFukuyama & Huang, 200555Jiadifenoxolane ANeuroprotectionI. jiadifengpi(Kubo et al., 2009)56Jiadifenoxolane BI.

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PMC9429973

Surface markers typically used to isolate hematopoietic stem and progenitor cells (HSPCs) massively change upon inflammation, which questions the reliability of using flow cytometry to study the system upon inflammation.

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PMC11746948

Then, the dried samples were reconstituted in 100 μl of 50% methanol in dichloromethane by sonication on ice for 10 min.

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PMC11098378

Third, IEPs often drive virulence and thus their characterization can reveal pathogenesis mechanisms .

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PMC11544122

No. A-420-10).

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PMC11756907

As a result, reduced graphene oxide (rGO) is obtained, being a material with an intermediate degree of oxygen enrichment, which is an intermediate form between graphene oxide and unoxidized graphene.

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PMC10976516

Using drugs or radiation, it is possible to cause the tumor to become inflamed.

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PMC11033180

To investigate whether the effects induced by Sema5A on synaptic vesicle exocytosis and synapsin phosphorylation could translate into changes in the electrophysiological properties of enteric neurons, cell-attached and whole-cell patch-clamp recordings were performed as previously established.

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PMC11680562

Metal nanomaterials, such as copper oxide (CuO) nanoparticles (NPs), have shown significant promise in cancer therapy due to their ability to induce apoptosis.

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PMC11777207

Number of migrated moDCs after 4 hours of LPS treatment (200 ng/ml) and IgG isotype control, pembrolizumab (αPD-1 antibody) or atezolizumab (αPD-L1 antibody) at 200 μg/ml.

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PMC11279397

This review classification summarizes the antiviral abilities of monomeric components of Perilla frutescens with OB greater than 20% against various viruses and their mechanism of action.

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PMC9429973

This step is required for subsequent fusion of the membranes to release cytolytic cargo toward target cells.

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PMC9352806

BMS enhanced the expression of DAF-16 and LGG-1 proteins.

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PMC9429973

Aims: The aim of the study was to clarify the validity of WW for POAML.

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PMC9429973

We provide unique insights into the genetic complexity of CK-AML, and evidence of the resulting functional outcomes.

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PMC5810978

The inoculum was not removed after inoculation for these HuNoV and HuSaV culture trials.

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PMC7961460

For confocal microscopy, 7.5 × 10 MCF-7 cells were plated onto coverslips in 12-well plate.

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PMC9429973

Methods: Experiments were carried out on primary AML patient samples and flow cytometry was used to identify subpopulation specific responses.

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PMC9429973

Of the included studies, 15 (53.6%) utilized a prospective, observational study design and, aside from seven multinational studies, data from 11 unique countries were reported.

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PMC11727145

Histological samples underwent a dehydration process (i.e., ascending alcohol series) and xylene clarification before they could be mounted using Eukitt mounting agents (Biosystems, Bobingen, Germany) and a cover glass.

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PMC11392912

The graph represents the level of TNF-α mRNA fold change, measured after transfection with total miRNA from turmeric, fenugreek, kalonji, and flax seed. (

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PMC11515150

Eleven days after transplantation, mice were divided into four treatment groups (n = 4) according to the average radiance of the bioluminescent imaging: group freezing solution (control), group Mock-NK, group IL-15 CAR-NK, and group 12 C CAR-NK.

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PMC9622879

Let be a price that has a value in the range from the selling price to buying price proposed by the EP.34[12pt] $$ P_(t) P_(t) P_(t) $$α·PMG(t)≤Pmid(t)≤PMG(t)In this study, we use .

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PMC11678368

Infrared and Raman spectroscopy, combined with DFT (ωB97X-D) calculations, provided valuable information about metal–ligand interactions, the cis or trans conformation of the aldehyde group in the ligands, and the presence of trans isomers in the metal complexes obtained in the solid state.

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PMC9429973

Image: Summary/Conclusion: This is the first study demonstrating that the alpha catalytic subunit of PI3K is a targetable non-canonical driver of LCH.

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PMC9910796

ASFV belongs to the family Asfarviridae, within the recently established Phylum Nucleocytoviricota , a monophyletic clade of large and giant DNA eukaryotic viruses .

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