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PMC11787355
d–f were analyzed with two-way ANOVA multiple comparison corrected with Holm–Šidák method.
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PMC11363012
Protoplasts are then trapped in the wells of a Sievewell plate (step 2).
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PMC7802142
The results were normalized to cel-miR-39 or U6 snRNA levels.
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PMC8316344
TRIB2 deletion still increased labile iron level even when FTH1, FTL, FPN1, PCBP2, TF, SLC11A2, and NCOA4 was knocked down in Bel-7404 cells; however, the effects were diminished when TFRC was knocked down (Fig. 4C), suggesting that TRIB2 reduces labile iron via TFRC.Fig.
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PMC9250505
A total of four treatment groups were tested in 6 PDXs respectively.
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PMC11725127
These findings collectively suggest that GA could relatively specifically inhibit the deubiquitinating activity of USP2 in vitro.
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PMC9429973
Summary/Conclusion: Inotuzumab ozogamicin has shown high efficacy in adult patients with r/r B-ALL.
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PMC11612508
Drug delivery involves modifying chemical characteristics like hydrodynamic diameter size, zeta potential, and hydrophobicity to maximize therapeutic effects and minimize adverse effects.
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PMC9429973
Notably, using an LNP-SM formulation enhanced activity of siMA6, showing a substantial impact on cell proliferation, viability, and capacity to self-renew.
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PMC11281366
In this study, we provide evidence supporting the notion that the HIV-1-mediated enhancement of CD59 cell-surface expression and packaging helps protect virions and infected cells from ADCML.
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PMC9250505
For the staining intensity score, no staining was 0, weak staining was 1, moderate staining was 2 and, strong staining was 3.
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PMC11746948
Samples were suspended in lysis buffer (100 mM Tris-HCl pH 7.2, 5 mM EDTA, 150 mM NaCl, 2.5% SDS, inhibitor cocktail).
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PMC9429973
Image: Summary/Conclusion: The overall frequency of complications of SCD is highest in homozygous SCD and lowest in SCD-S/C. With the most frequent β-mutation being IVS-I-110 G>A among our patients, further data on the rare complications such as sepsis and stroke are required in order to guide the decision which patients will likely benefit from penicillin prophylaxis and screening by transcranial Doppler ultrasound.
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PMC11519583
e Protein expression of Ror2, αTubulin, phosphorylated p38 (p-p38), and p38 proteins in MPs, transfected with the indicated siRNAs, and stimulated with either Wnt5b (200 ng/ml) or vehicle for 1 h. Right graphs show the relative band intensity of Ror2 and p-p38 normalized using αTubulin and p38, respectively (n = 5).
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PMC9429973
However, in spite of that, LMWH prophylaxis did not have significant impact on the development of VTE rates in the PEG-a treated patients (22/120 (18.33%) vs. 7/23 (30.43%), p=0.1861).
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PMC10093184
Surprisingly, CD276 expression in D-17 cells originating from an OS metastasis was inferior to those observed in COS cells, which were isolated from parental osteosarcomas.
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PMC11047729
It also gradually reduces the expression of Bcl-2, but it has no impact on TERT expression .
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PMC10810426
In contrast, knockdown of all 5 nucleoporins dramatically reduced infection in BMDCs, to similar levels seen with AZT and raltegravir treatment (Fig 5B).
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PMC10443665
Gum tragacanth (GT) is a dried, natural, polysaccharide from stems and branches of various species of Astragalus like A. gossypinus which grows in some regions of Iran.
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PMC10212663
Therefore, we hypothesized that KRAS‐mt RANKL‐high LUAD promotes biologically malignant behavior by changing the expression of cell adhesion molecules.
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PMC11240448
The abrupt decrease in the DPDonc score (Figure 4F) is explained by a saddle-node bifurcation (a fold catastrophe) that occurs when a stable steady-state solution corresponding to the oncogenic state disappears .
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PMC9545714
Calculation of the individual relative change in TEWL for the group that exhibited the significant change ranged between 21 and 53% improvement from baseline.
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PMC9429973
Results: The CAM161519 robustly activated NK cell degranulation (CD107a) and inflammatory cytokine production (IFNg) against B cell lines.
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PMC9429973
At last follow-up, 29 patients (81%) were in CR.
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PMC10887351
In addition, the injection into the central system of the β3-AR agonist activated some areas within the hypothalamus that are recognized for their role in the regulation of appetite and body weight .
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PMC11547917
Cells were washed three times in PBS (pH 7.4), centrifuged at 1000 rpm for 10 min, and the supernatant discarded.
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PMC9429973
There are few reports on the relationship between DLBCL and AP2M1.
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PMC11228511
In both human and mouse studies, FTIs were reported to reduce disease in mouse models of progeria (4, 42–44).
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PMC9429973
STP938 exposure induced a concentration dependent inhibition of T cell cytokine release in whole blood samples, with higher STP938 concentrations producing near-complete suppression (Figure C).
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PMC9429973
A confirmatory phase 3 study is planned to further evaluate the efficacy and safety of Clifutinib at 40 mg daily in FLT3-mutated R/R AML.
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PMC9370419
The pGFP-HBx was a gift from Prof. Xin Wang (Addgene 24931) .
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PMC11319300
The concept of chromatin accessibility and enhancer characteristics that facilitate the birth of new genes has been proposed in prior research (Majic and Payne, 2020).
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PMC10968586
Treatment of human glioblastoma cell lines A-172 and U-251 with 200 μM and 400 μM OLE for 24 h reduced cell viability in a dose-dependent fashion, triggering apoptosis and suppressing cell migration and invasion abilities with a mechanism involving the increase in Bax, MMP2, MMP9, and phospho-Akt levels, the reduction in Bcl-2 protein levels, and caspase-9 and caspase-3 activation .
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PMC10728200
Flow cytometry analysis was performed using the FITC filter for oxidized C11-BODIPY (emission: 510 nm) and the PE-TexasRed filter for reduced C11-BODIPY (emission: 590 nm).
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PMC9429973
Those include e.g. a distinct pattern of enriched sdRNAs in NPM1-mutated patients.
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PMC11477621
Introduction of phenyl groups into the linker chain, as exemplified by 11 and 14, resulted in a slight diminution of inhibitory activities (Table 1).
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PMC6835762
Jbeily et al. converted the PGA into an atom transfer radical polymerization (ATRP) macroinitiator, and subsequently glycerol mono-methacrylate was polymerized by ATRP from the PGA backbone, yielding an amphiphilic graft copolymer able to self-assemble in water .
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PMC11803149
Libraries were quantified using a Qubit 1x dsDNA HS assay kit on a Qubit Flex Fluorometer.
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PMC10890055
For example, the same extract of Zn-1Mg in DMEM/Ham’s F-12 medium (Zn concentration = 73 µmol∙L) did not have any adverse effect on the hFOB 1.19 cell line; however, the metabolic activity of L929 was decreased to 2%.
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PMC10877303
Mohasana Akter Mita: Writing – original draft, Investigation, Formal analysis, Data curation, Conceptualization.
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PMC9429973
Besides gene mutations and deletions, the functionality of p53 protein can be disrupted by other mechanisms, such as aberrant phosphorylation.
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PMC9429973
Chromosome karyotype abnormalities were found in 12.5% (3/24) of patients.
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PMC11764090
Cold stress can quickly induce the expression of many transcription factors, thus activating a large number of downstream cold response gene expression transcription factors that play a key role in regulating gene expression (Figure 3).
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PMC11638255
This dose was selected based on prior optimization studies to ensure adequate tumor material was available to study the synergy between copper chelation and immunotherapy.
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PMC9681981
RNA extraction and cDNA synthesis In this study, RNA was extracted from bacterial cells using a commercial RNA extraction solution (RNX-Plus, CinnaGen, Iran) according to the manufacturer’s instructions.
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PMC11591030
It also significantly decreased the T-AOC, SOD, GPx, and CAT activities (p < 0.05).
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PMC6450504
-tubulin structures stained green. (
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PMC11173119
Fidan et al. (2015) reported a cell line derived from fibroblasts of an FMF patient carrying a homozygous p.Met694Val mutation in the MEFV gene .
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PMC11499381
A–C) are C-terminal fusion constructs, (D–F) are N-terminal fusion constructs. (
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PMC11742290
Cumulating evidence from many studies indicates that LGR5 is important for normal embryonic development [24, 26–31].
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PMC8336407
The calibration curve for arbutin over the known concentration range was linear (r = 0.99) (Fig. 1a) We performed HPLC using a Knauer Smartline Liquid Chromatography System (Knauer, Germany).
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PMC11711871
F Measurement of adrenal sEH activity (mUnits/mg protein) under NSD (n = 6 per group and genotype) and HSD (GR, n = 5; GR, n = 6) conditions.
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PMC11401350
C,D FACS analysis of the percentage GFP + CD8 + and GFP + CD4 + cells in the PGK-GFP group and hCD34 + CD8 + and hCD34 + CD4 + cells in the PGK-CAR group at sacrifice.
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PMC10976516
Lung tumors are among the most recalcitrant solid cancers and, although the last decade has seen a steady development of immunotherapeutic approaches against lung cancer such as immune checkpoint inhibitors (ICIs) becoming first-line standard therapies alone or in combination with long-established chemo- and radiotherapies, clinical course and prognosis of especially advanced lung cancer remains rather poor (Table 1).
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PMC11291697
Intermittent light stimulation triggered the discharges and ictal phenomena.
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PMC10748106
However, compared to the inactive Geniposide, all of them are different in size, and in HBD and HBA.
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PMC11529598
C. Invasion ability of miR-3154 sponge U251 cells and control U251 cells was measured using invasion assay. *
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PMC11495567
Activation of this apoptotic pathway supports the observation of decreased cell viability.
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PMC11739484
Databases like GEPIA2, HPA, MEXPRESS, and miRNet were employed for expression, survival, methylation, and miRNA-mRNA network analyses.
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PMC8557138
The authors demonstrated the establishment of vasculature with aberrant morphology, multiple tip cell formation, poorly perfusable immature vessels in response to cancer cell secretome (Kim et al. 2013).
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PMC8875242
Therefore, knowledge of the molecular mechanisms underpinning pharmacokinetic DDI is essential for selecting appropriate antivirals and optimal antiviral doses .
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PMC2777936
All authors read and approved the final manuscript.
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PMC9429973
Notably, anti-IgM stimulation induced high Ca influx and high VLA-4 affinity state in both TKO-high and TKO-low, irrespective of IB treatment.
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PMC11806182
In contrast, three miRNAs—miR-331, let-7f, and miR-424—were found to be down-regulated in PCOS samples.
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PMC11401350
B Transduction of murine splenic T cells after TCR-stimulation was performed with mCD8-LVs (10 ng p24 content) or VSV-G-LVs (2 ng p24 content) carrying the EF1a-GFP or the PGK-GFP expression cassettes Transduction was analyzed by FACS on day 3 post-transduction by gating on CD4 + T cell and CD8 + T cells and summarized in (C).
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PMC11742047
A solution consisting of two reference mass compounds was infused over the whole analysis by an Agilent 1260 Iso Pump at 1 mL/min.
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PMC9429973
The rates of thromboses or bleeding events were not different when either prednisone or dexamethasone were included in the induction treatment regimen.
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PMC11201245
The use of these patient materials is based on their consent and a vote of the Ethics Committee of the Medical Faculty of the Christian-Albrechts University in Kiel (B327/10).
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PMC9429973
However, we showed that CLL growth in cKO mice was drastically delayed compared to the control mice (A).
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PMC11604768
From these we created and validated a robust reporter for androgen receptor activity (Fig. 3c) and distinct heavy metal responsive reporters (Fig. 3d).
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PMC9429973
T cells in CLL appear selected by restricted antigens, with evidence suggesting that the selecting epitopes may lie within the clonotypic B-cell receptor immunoglobulins (BcR IG).
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PMC11682224
Additionally, the keratinocytes themselves exhibit some degree of hypoxia.
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PMC9429973
Pre-transfusion and Post transfusion recipient vitals showed a marked decrease in Blood Pressure from 110/70 mmHg to 70/50 mm Hg with Pulse increased from 88 bpm to 118 bpm.
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PMC11562028
Compared with the control group (Re-CDs, 0 μg mL), the wound healing rate of the A498 cells was ∼46.9% ± 7.9% at the Re-CDs administered concentration of 90 μg mL. The changes in the longitudinal migration ability of the A498 cells after administration was detected by the cell transwell migration assay (Fig. 3C).
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PMC8540692
However, with the addition of NaBu in a molar ratio of 1:1000, the permeability increased—Papp was 1.065 × 10 ± 4.321 × 10 cm s. The greatest, more than 4-fold elevation in permeability was observed when using the combination of CCM:NaBu in a ratio 1:750 (Papp 2.218 × 10 ± 1.049 × 10 cm s).
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PMC5839394
Accordingly, no DNA fragmentation was evident in SKBR3 cells after 24 h of Ag-NPs-EPS exposure (Figure 5B), suggesting that apoptosis was not prominent in AgNPs-EPS -induced cell death, at least in the first 24 h of treatment.
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PMC10667689
Apparently, the glycolytic pattern is associated with chemoresistance and high levels of mTORC1, and its activation following TIM-3/Gal-9 ligation has been reported previously (2, 3, 12, 40–42).
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PMC11394730
Oncogenes like c-Myc and HIF-1α are master inducers of cancer glycolysis via the direct or indirect transactivation of cancer glycolytic genes .
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PMC11674441
The cells were then incubated for 48 h. Subsequently, the plates were washed three times with PBS, and a detection antibody (7-B6-1-biotin) dissolved in PBS containing 0.5% foetal bovine serum (PBS–0.5% FBS) at a concentration of 1 mg/mL was added (100 µL/well).
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PMC9512971
The probabilities of meeting the assessment of effectiveness or ineffectiveness with 50 patients per group (100 in total) were calculated at various analysis time points by applying numerical simulations in SAS version 9.4.
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PMC11718809
Similarly, circ01592 binds miR-218, enhancing the expression of its target gene ELOVL5 and promoting TAG synthesis and fatty acid composition .
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PMC10553757
BMJ Open 12, e062478.
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PMC10033453
Area under tumor growth curves was compared by one-way ANOVA with Holm-Šídák correction for type I error. (
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PMC6267596
We isolated aneuploid/polyploid populations of DH/DE-DLBCL cells after treatment with the aurora kinase (AK) inhibitor alisertib.
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PMC11705862
The total protein content was measured using BCA kit (Thermo Scientific).
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PMC9429973
The RP2D is AZA 75 mg/m2 on D1-5 plus VEN 400 mg on D1-14, every 28D.
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PMC8389560
Intercellular contacts formed by connexins or pannexins can also be involved in the release of ATP and other active substances, both in neighboring cells and in the extracellular environment .
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PMC10823017
indicates P≤0.05, ** indicates P≤0.01, *** indicate P≤0.001, **** indicates P≤0.0001).
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PMC8903741
CHO cells were cultured in a 6-well plate up to the confluency reached 80–85%.
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PMC9895440
To develop an antigen-specific ex vivo model for human T cell exhaustion, we transduced human healthy donor peripheral CD8 T cells with a lentiviral construct encoding a TCR specific for the cancer-testis antigen NY-ESO-1.
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PMC11507371
It becomes apparent that NF-κB’s role is context-dependent, influenced by cell type and microenvironmental factors.
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PMC10578720
Chronic HBV persistent infected mice were established to evaluate the role of activating the tricarboxylic acid (TCA) cycle in macrophages for HBV clearance.
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PMC8414691
These results suggested that SRCAP activity plays a role in the recruitment of a number of cytokinesis regulators to the midbody.
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PMC7612475
P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; NS, nonsignificant.
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PMC11727062
10-Gingerol, a natural compound derived from zingiberis rhizoma, exhibits a range of biological activities, including anti-inflammatory, antioxidant, and antitumor effects.
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PMC9096373
250 mg/tablet; Hengrui Pharmaceutical Co., Ltd., Jiangsu, China) combined with RT group (APA + RT group; n=12).
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PMC5600151
Among those non-viral vectors, dendrimer-based vectors have drawn great interest for over two decades as potential nucleic acid delivery systems.
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PMC11704135
Furthermore, some pyrimidine derivatives exhibit pro-apoptotic activity by inducing programmed cell death in cancer cells.
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PMC11412721
D, E) Analysis of Burkitt lymphoma-specific dataset #phs00235.
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PMC6102174
11Structures of compounds 162–174 Structures of compounds 162–174 Phyllanthus urinaria (Yexiazhu) distributed in most part of China is always used for antiinflammatory, antiviral, antibacterial, and antihepatotoxic purposes.
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