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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Results: Of 366 included patients, only 128 (35.0%) received HMA therapy, while 238 (65.0%) did not.
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PMC10654497
= ns; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.
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PMC9429973
CMV reactivation was detected in 68% of pts (96.9% for GCV and 19.8% for C, p<0.001).
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PMC11740573
The appropriate concentration of vitamin D is necessary for the proper functioning of the immune, muscular, nervous, and cardiovascular systems .
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PMC10955424
Samples were lysed in lysis buffer and 50–60 μg protein per monoculture sample, or 100–120 μg protein per co-culture sample were loaded on the gel.
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PMC11476837
Then, cells were washed twice with HBSS and incubated at 37 °C in the dark.
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PMC9878562
Further studies are required to describe the molecular mechanism that supports the release of LTB4 upon ACKR3/CXCR4 stimulation.
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PMC9429973
Further analysis of the ‘novel therapies’ group found that, in non-transplant patients, the prognosis of the IgD and non-IgD patients was similar, but in transplant patients, IgD MM patients showed worse outcomes compared to non-IgD MM patients (figure).
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PMC11672142
binding at the Trp moiety, at minimum, exhibits a reduction potential well within the biological window to be an effective Fe(II) reductant of the RNR R2 tyrosyl radical and thus inactivate the enzyme and also redox cycle.
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PMC11637276
To test this, we assessed the ability of NHE1 knockdown cells (S12D Fig) to internalise pH-rodo labelled collagen I and found that NHE1 down-regulation significantly impaired collagen I uptake (S12B Fig).
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PMC3931643
After 1 h, the beads were pelleted and washed twice with lysis buffer.
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PMC10114490
Our strategy allows the generation of an unlimited source of clonal, homogeneous, non-transformed induced hepatocyte-like cells, capable of performing typical hepatic functions and suitable for pharmaco-toxicological high-throughput testing.
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PMC11629143
A,B) mAb light chain (A) and heavy chain (B) mRNA expression levels in the same CHO‐K1 cell line measured at week 0 and week 10 of culture expressing either dCas9 alone, dCas9‐p300 or a combination of dCas9‐p300 and dCas9‐TET1.
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PMC11766309
Pan-cancer prognostic significance of YKT6 for DFI and DSS. (
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PMC4485786
Fully engrafted mice were inoculated with 1 × 10 A204 cells at week 12.
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PMC8873393
C Heat-map diagram showing the twelve clusters of differentially expressed annotated lncRNA transcripts in the chromatin fraction following UV exposure.
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PMC11798926
For N-terminal tags, a methionine codon was added to the 5′ end of the sequence encoding the epitope tag and the original methionine start codon was replaced with this sequence.
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PMC10994876
Employing host cell engineering techniques for CHO cells serves as a valuable approach to address the constraints encountered in biologics manufacturing.
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PMC10654497
Therefore, the SFRGs involved in ferroptosis may be positive indicators of survival outcomes in patients with lung cancer.
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PMC11310713
Representative H&E histology showing cross-sections of the uterus.
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PMC11095939
ChIP-qPCR showing H3K27ac occupancy at the Mecp2 promoter at the indicated time points after PHx.
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PMC9429973
The comparison of T CD4+ maturation pattern showed that HC had significantly higher central memory, naïve counts and exhaust CD279+ counts, while R had higher effector memory, senescent CD57+ and senescent CD27-.(Fig.1E) When analyzing the T CD8+ maturation subsets, we found that HC had significantly higher central memory, naïve and exhaust CD279+ while patients had higher effector memory, effector T, senescent CD57+ and CD27-.(Fig.1F) No differences were observed between AUTO and ALLO patients regarding B and T maturation patterns.
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PMC9429973
Methods: Cases of acute GI-GVHD after allogeneic HSCT occurring between 2016 and 2021 were assessed.
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PMC9436459
The only one ketalized type A-II MDAAs isomulberrofuran G (57) was discovered from M. alba, whose possible precursor was compound 55.
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PMC9429973
A. Beccaria, A. Grossi, F. Fioredda, M. Lanciotti, E. Palmisani, P. Terranova, M. Lupia, G. Dell’Orso, I. Ceccherini, C. Dufour, M. Miano DOPO Clinic and Hematology Unit, Division of Pediatric Hematology and Oncology; Laboratory of Genetics and Genomics of Rare Diseases; Hematology Unit, Division of Pediatric Hematology and Oncology, IRCCS Istituto Giannina Gaslini, Genova, Italy Background: An accurate differential diagnosis in children with Marrow Failure (MF) is crucial for the clinical management of the disease.
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PMC10823017
Combination treatment with BYL719 (10µM) and ICA-1 (10µM) decreased the number of cells undergoing early apoptosis (4.57%) (P<0.05), and it significantly increased late apoptosis (16.4%) (P<0.001).
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PMC10178190
Our data showed that there is no correlation between ERK1/2 phosphorylation and platinum sensitivity in OC cells exposed to CM.
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PMC9429973
Therefore research efforts have been directed to improving anticancer drug efficacy by co-administration of TKIs as Pgp modulators.
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PMC10812665
Whether it occurs in c-I-inhibited neurons depends on the extent that the succinate dehydrogenase reaction and the αKG-dehydrogenase reaction would still be working.
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PMC9684669
This work was partially supported by the intramural research programs of the National Center for Advancing Translational Sciences, National Institutes of Health, and the Natural Science foundation of Zhejiang Province (LY19H160046 to WH).
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PMC11047729
In another study, the influence of I3C on the chronic myeloid leukemia cells from the K562 cell line was examined.
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PMC9429973
Summary/Conclusion: Although type 1 GD remains a rare lysosomal storage disorder, patients with the diagnosis of MGUS could be considered for GD screening with DBS, especially when other symptoms (thrombocytopenia, splenomegaly, hyperferritinemia) are present.
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PMC9429973
Six patients were able to complete the study protocol.
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PMC9812014
These alkaloids had a maximum non-toxic concentration (MNTC) of < 3.2 µg/mL towards the MDBK culture cells.
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PMC8469018
The linearity ranged from 100 ng to 100 µg and the measure of error of analysis was 1%.
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PMC11591038
Depending on the experimental model systems, therefore, HIF-1α may enhance, suppress, or have no direct effects on the phosphorylation status of tau proteins.
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PMC9429973
The least absolute shrinkage and selection operator (LASSO) approach was utilized to choose the potential predictors from the primary dataset.
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PMC11267830
The fourth ring shows the average quantitative values of both groups.
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PMC9684669
DMSO was used as non-treated control.
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PMC11300639
According to RNA-seq of RNF26, RNF26 knockdown decreased the mRNA level of VEGFA, which is regulated by the mTOR signaling pathway (Fig. 4a).
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PMC9429973
There were no significant differences in any efficacy endpoint between pediatric (<18 y; n=65) and young adult (≥18 y; n=14) pts.
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PMC8916024
Then, clean tags were searched against the reference database (http://drive5.com/uchime/uchime_download.html) to perform reference-based chimaera checking using the UCHIME algorithm (Knight, 2011).
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PMC11640476
This standardization is crucial for advancing drug screening and ensuring robust research findings.
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PMC11799978
As a result, CAFs are reprogramed toward a quiescent phenotype with reduced tumor-promoting capability.
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PMC9429973
The evolution of 1L and R/R MCL treatment patterns and the associated patient characteristics and outcomes requires further exploration in larger datasets, given extensive heterogeneity in practice patterns.
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PMC9844987
To exclude rare promoters within the panel, tag clustering was performed on CTSSs with at least 1 CAGE read in at least 5 LCLs.
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PMC9429973
The vast majority of the patients were Black (91%), Hispanic (5%) and White (1%).
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PMC6337547
A study showed that, at 0–0.7 mmol·L, rosmarinic acid, caffeic acid, and danshensu were as effective as quercetin (positive control), which scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in a concentration-dependent manner.
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PMC6643347
Progressive diminution of subpopulations of immune cells, the hallmark of HIV infection, inevitably results in the deterioration of certain functions of the immune system, of which antigen presentation, stimulation of T cell proliferation, and regulation of antibody production by B cells are the most prominent.
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PMC11765243
After washing with PBS, they were fixed with 1% formaldehyde.
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PMC10823017
These results reveal that ICA-1 reduces invasion by 60% (P<0.001) in the 786-0 cell line ( Figure 9C ).
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PMC9817179
The complete iPython notebook containing the source code used to perform the simulation is provided a supplementary file ‘Kinetic Simulation.zip.’
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PMC11774112
First, PLA was protected from hydroxy groups with tert-butyldimethylsilyl (TBDMS) and then activated with dicyclohexylcarbodiimide (DCC) and 1-Hydroxybenzotriazole (HOBt), and dicyclohexylurea (DCU) was removed by filtration.
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PMC11531744
ROC curve of the risk score in predicting 1-, 2-, and 3-years OS in TCGA OC patients. (
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PMC11756514
Data were analyzed using FlowJO 10 (FlowJo, LLC).
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PMC11786704
Quantification result of (J). (
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PMC10729469
This leads to the maintenance of brain tissue homeostasis and repair and shown to be effective in a broad range of neurodegenerative diseases that include amyotrophic lateral sclerosis, stroke, PD, and AD [28, 35–40].
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PMC11337594
Data in A, E, F and G are shown as mean + SEM.
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PMC9429973
Summary/Conclusion: To our knowledge, this is the first study describing genomics (N=69) and genotype-phenotype correlation (N=56) in patients with HS in Central-Europe.
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PMC11462673
C Flow cytometry revealed that MBZ treatment induced more apoptotic cells in a dose-dependent manner.
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PMC9027909
Based on the phylogenetic and molecular analyses of a signature region through the small subunit ribosomal RNA (SSU rRNA) gene of Blastocystis sp., at least 22 distinct subtypes have been reported from humans and animals .
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PMC7757104
In this context, certain cytokines have been demonstrated to induce phenotypes consistent with the EMT in transformed epithelial as well as tumor cell lines (47,48).
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PMC11271278
Some of the identified enhancer hijacking genes exhibit high copies (log2(CN) > 2).
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PMC8526701
Moreover, our study also suggests BRD9 inhibition as a potential mechanism to suppress tumorigenic progression and reduce associated malignancy.
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PMC11633763
Therefore, an in‐depth analysis of the mechanism underlying increased aerobic glycolysis in osteosarcoma cells may provide new treatment opportunities for osteosarcoma.
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PMC9429973
Standard of care frontline therapy consists of various types of targeted therapy or chemoimmunotherapy (CIT), but it is reserved for patients with advanced-stage disease.
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PMC10873328
Figure 2a showed the AUC of the four predicted models.
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PMC9878278
We next examined whether BMP6 in turn can modulate IFN-β-associated antiviral response by treating SC with both BMP6 and IFN-β.
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PMC9429973
The results were considered statistically significant when p<0.05.
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PMC9429973
Aims: This study aimed to answer the question whether combined inhibition of the proteasome and the autophagosome is safe and tolerable.
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PMC4485648
There are several examples showing improved anticancer effects of SFN combined with other compounds (20,22,53,54).
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PMC11527437
The authors did not identify any concerning cross-reactivity of the TCRs against a select panel of peptides derived from the human proteome that were structurally related to the G12V peptide.
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PMC11767725
The composition of the skin microbiota undergoes significant changes with aging, influenced by shifts in host factors such as sebaceous gland activity, skin lipids, natural moisturizing factors (NMFs), and antimicrobial peptides (AMPs).
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PMC6642070
1 Lovastatin attenuates exercise capacity in mice and increases blood and muscle lactate levels. (
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PMC11483468
The telomere length of tumour cells cannot be maintained; thus, cells enter the crisis period and eventually die.
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PMC11792740
Second, T-cell depletion is closely associated with tumor prognosis.
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PMC9111184
Due to the side effects of synthetic drugs, attention is now being directed to alternative medicines of plant origin (Loke et al., 2010).
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PMC11033180
Representative traces of miniature postsynaptic currents (mPSCs) recorded in whole-cell configuration from enteric neurons exposed to Fc or Sema5A-Fc.
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PMC9019892
As expected, in the GIST‐48B cell line, which is KIT independent, neither compound showed an effect on the downstream mediators of the KIT signalling pathway.
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PMC7759933
Alternatively, hepatic carcinoma-derived cell lines, such as HepG2, C3A, HepaRG, HuH6, and many others, are frequently used in genotoxicity studies, due to their unlimited growth, availability, and high reproducibility of results.
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PMC6835428
So far, different antigens present on the surface of OC cells have been considered suitable for OC targeting (Table 1).
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PMC10719213
Previous studies with other nucleoside analogs have demonstrated multiple mechanisms of mitochondrial toxicity and cell-specific effects .
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PMC8164677
Lifestyle, social and environmental factors are also considered to be important risk factors evident from its high incidence in the industrialized world.
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PMC11755467
The precursor was divided into two fragments, one of which was composed of the 3′ terminus and approximately half of the 3p strand and the second fragment comprised the whole 5p strand, the terminal loop and the remaining half of the 3p strand.
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PMC11343332
Strong antioxidants, these bioflavonoids have been linked to several health advantages, including anti-cancer properties.
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PMC9429973
Biomarkers of complement activation may prove valuable as a prognostic tool to predict which patients that potentially could benefit from complement-inhibiting therapy in the future.
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PMC11464982
The use of a food enzyme shall be authorised only if it is demonstrated that: it does not pose a safety concern to the health of the consumer at the level of use proposed;there is a reasonable technological need;its use does not mislead the consumer.
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PMC11748618
This study provides a baseline for understanding the genetically regulated impact of CHD1L-mediated HIV inhibition, but further investigations into CHD1L expression in HIV-relevant cell types, induction of likely causal variants to confirm regulatory potential, and determining the mechanism of action of CHD1L will be necessary to assess the potential of CHD1L as a novel HIV therapeutic target.
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PMC11380329
The Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2019 provides the most up-to-date assessment of a mutually exclusive and collectively exhaustive list of diseases and injuries for 204 countries and territories from 1990 to 2019 .
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PMC8345486
The ionic structure of the cesium salt of [3-chroma-bis(1,2-dicarba-closo-undecaborane](-1)ate, 3 crystallized in the monoclinic space group P21/n and consisted of chroma bis(dicarbollide) anions and Cs cations.
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PMC9429973
Moreover, platelet reactivity remained also strong as demonstrated by high area under the curve (AUC) values in HIMEA low (figure 1).
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PMC11411004
However, this effect is not unique, as HDAC inhibitors such as moxistat (Weber et al. 2022) also increase qmAb by increasing histone acetylation and subsequent mRNA levels; the potential mechanism of action of I-4 on monoclonal mass remains to be elucidated.
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PMC8633974
As experimental and control groups were independent of each other and comparisons were pre-selected for stimulated or unstimulated, and amongst stimulated groups alone, Sidak's test was chosen over the Bonferroni method as control of entire family-wise error with the latter method was unnecessary.
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PMC11036064
.
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PMC11758416
The assay utilizes L cells expressing the FC receptor CD32 as the target cell (Figure 2A), followed by staining for Annexin V and 7-AAD for the assessment of death of the target cells (Figure 2B).
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PMC9096373
Hence, the differences of tumor volume and TGIR in the APA + RT group were most significant compared with the other groups (Table 2).
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PMC11064533
We tested this hypothesis using an adhesion assay in the presence of antibiotic stress.
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PMC11013014
M.p.
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PMC9014716
(Volcano map): Expressions of miRNAs regulated by PS-T via microarray (Affymetrix Gene Chip 4.0): 1257 were up-regulated miRNAs, 1259 were down-regulated miRNAs, and 62 were unchanged miRNAs. (
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PMC11277157
The sub-networks that are unique to cells of the KD of DJ-1 are highlighted.
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