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OTAR3088
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BioData-CellLine_annotated

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PMC11741906
Only 7 miRNAs had similar patterns of significant expression changes in the cisplatin-resistant A2780cis, and SK-OV-3 cell lines in comparison to sensitive cell line A2780 (Supplementary File 2).
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PMC11552389
TEM images of autophagosomes in A375 and A375R cells.
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PMC10898159
CS-1 and CS-2 are functioned as FTO inhibitors preventing KIT m6A mRNA demethylation.
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PMC11342785
Data for TPPP-PixDE (control) or different synMAP TPPP-IDR condensates are shown (mean ± SEM, TPPP-PixDE, n = 3; TPPP-DDX4-PixDE, n = 3; TPPP-FUS-PixD, n = 3; TPPP-LAF-1-PixDE, n = 3).
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PMC11802929
We performed further analysis by directly linking the key physicochemical properties to phenotypes independent of the PG-TCR groups.
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PMC10870498
Then, serine mutations were introduced at K437 and K537 sites of KIF23.
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PMC4839679
IGFBP1 is a member of the IGFBP family, which are HIF target genes that play important roles in regulating glucose availability by binding to insulin-like growth factors.
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PMC11754094
This is remarkably fast for a therapeutic based on CRISPR-Cas nucleases and begins a new era for gene editing therapy.
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PMC6650823
Particularly, allergen sensitization selectively increased pulmonary LT biosynthesis in female mice.
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PMC7504302
Based on their biological function, membrane proteins can be grouped as receptors, cell adhesion molecules, glycosylphosphatidylinositol (GPI)- and lipid-anchored proteins, transporters, and cell membrane-associated enzymes.
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PMC8389560
In order to understand which of the specific receptors is activated by ATP secretion in response to the application of SeNP in A-172 cells, a series of experiments was carried out using purinergic receptor antagonists.
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PMC11023271
The same dividing cells are necessary to heal wounds and when malignant form tumors.
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PMC8526701
C BRD9 mRNA level in GISTs and adjacent nontumor tissues was examined by real-time PCR.
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PMC11204465
The biosynthesis of AFs involves a series of enzymatic and biotransformation reactions, as shown in Figure 3.
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PMC11695623
G,H) Effect of silencing DCUN1D5 on cell apoptotic ability detected by flow cytometry. (
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PMC11240448
This topology is defined by causal connections and their strengths .
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PMC9275501
DOX@CUR loaded micelles showed synergistic effect, and the combined treatment of DOX and CUR nanoparticles enhanced the cytotoxicity of MDA-MB231 cells by promoting apoptosis.
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PMC9429973
36 patients were planned to be included into the trial.
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PMC11599565
Magnification 40 × .
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PMC8996378
For example, compound 10 exhibited superior MDR reversal effect in MCF-7/ADR cells due to the enhancement of ATPase.
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PMC11726183
The newly synthesized molecules were drawn using MarvinSketch 24.1.2 to obtain the 2D structure of ligands.
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PMC11612508
They exhibited considerable drug-release characteristics.
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PMC7823217
Fig 5 Bioprinted ovarian cancer model: A. The major subtype of ovarian neoplasm histologically divided in two subclassifications: Type I ovarian cancer contains low-grade, slow developing neoplastic cells that genuinely comes from boarder line tumors, which itself arises from ovarian surface epithelium, cysts, or endometriosis.
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PMC6803987
It demonstrates that esculetin had no obvious short-term toxicity for ducks.
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PMC11666785
While the technique is useful for standard data acquisition, the technique may not be suitable for high-density blinking.
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PMC11628309
However, the full potential of BE (2)-M17 cells line as a model of PD and other dopaminergic alterations remains to be exploited.
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PMC9164404
This research highlighted the development of Abplatin and the use of multi-omics for the mechanism elucidation of prodrug, which is the key to the clinical translation of prodrug.
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PMC7053076
The IκB activation leads to disintegration of the NF-κB complexes.
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PMC10932641
The effect of silencing and overexpressing GPRC5D-AS1 on Ki67 protein expression.
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PMC11791264
Overall, these results imply a tumor-promotive effect of SETD7 in OC.Figure 1SETD7 plays a tumor-promotive role in OC cells.
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PMC8708099
In the present study, an in vitro approach is used to evaluate the anti-inflammatory properties of osthole, and its potential use as a drug.
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PMC11680982
First, the effects of CDK4/6 inhibitors and endocrine therapy separately on the HER2 pathway in HR/HER2-low breast cancer were not examined.
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PMC11787355
Exogenous peptides do not necessarily induce immunogenicity against naturally processed and presented antigens.
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PMC6461034
For low‐level input samples from patients (Appendix Fig S9C and D), the combined INKA score shows the more robust EGFR response, compared to the individual INKA components.
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PMC6684588
Histograms of muscle fiber diameter in ACE-083-injected and uninjected (contralateral) TA muscles.
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PMC10890307
The tumor cell lines and fibroblasts were cultured in RPMI-1640 (Sigma-Aldrich, St. Louis, MO, USA) supplemented with 10% heat-inactivated fetal calf serum (FCS, Hyclone, Logan, UT, USA), 100 μg/mL of streptomycin, and 100 U/mL of penicillin at 37 °C with 21% oxygen and 5% CO2.
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PMC11011837
Initially, an extraction mixture was prepared consisting of 33 mL of MTBE, MeOH, and CHCl3 at a ratio of 1:1:1 (MMC).
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PMC11506670
The phosphate group of GDP is notably protruding outward of the binding pocket for all of the NRAS mutants, unlike in the wild-type version.
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PMC9429973
All patients started treatment after diagnosis.
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PMC10847511
The homologous recombination repair (HR) pathway is the most precise and essential DNA damage repair mechanism for DNA double-strand breaks.
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PMC11486946
e The probability distribution of EGFR spot brightness.
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PMC9429973
The primary reasons for discontinuation (not mutually exclusive) were intolerance (54/78 [69%]), resistance (18/78 [23%]), and signs of ineffectiveness (14/78 [18%]).
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PMC11129910
Mammospheres > 40 μm were counted manually under a light microscope, and experiments were done in triplicate.
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PMC9966931
A mycelial disc of actively growing fungi was placed in the center of a Petri dish with PDA medium and the target hybrid molecule (DMSO in controls) at different concentrations.
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PMC11741906
In this regard, one of the potential mechanisms that might regulate cell fate, and contribute to cisplatin resistance, is epigenetic changes [, , ].
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PMC11607321
MOSA provides a generative unsupervised deep learning model for cancer discovery that utilizes SHapley Additive exPlanations (SHAP) values for model explainability, facilitating the identification of underlying biological mechanisms and drug targets.
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PMC11519788
A total of 2×10 mCherry-labeled UBC cells and U937 cells (1: 1) were seeded in the 6-well ultra-low attachment plates (#3471; Corning).
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PMC9545474
We previously reported that the cytotoxic activity of the electron‐deficient complex 3 is inhibited by the ROS scavenger NAC, thus indicating ROS production to be part of the possible MoA for this complex.
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PMC9386809
The introduction of soft donors along with the presence of hard donors might be useful in tuning the stereoelectronic environment around the metal center.
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PMC9429973
Moreover, there was also no major toxicity (e.g. cytopenias, infections) seen at day 100.
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PMC11591038
These findings again imply the crucial role of HIF-1α, which may be mediated by its transcriptional activity to maintain metabolic integrity and restore compromised energy metabolism in affected AD brains, in both neurons and glia.
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PMC11789597
RPMI 8226 cells expressing shNC or shCAV1 were adjusted to be consistent according to their cell number and viability.
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PMC11577421
Cell culture was restricted to passages 1–7 after defrosting.
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PMC11774112
All tumors that had been excised from the mice are shown, corresponding to the groups designated above in Panel D. (F) Results of H&E staining of different organs and tumors in nude mice.
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PMC9503541
A549 cells were seeded into 96-well plates at a density of 3 × 10 cells/well and allowed to adhere for 24 h. Then, the cells were treated with 10 µg/mL GE fractions, 10 µM docetaxel (positive control), and 1% v/v DMSO (negative control) and incubated for 24 h at 37 °C, 5% CO2.
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PMC10850553
Importantly, neutrophil-including microenvironment can be observed almost specifically at the site of rupture in lesions induced in animals.
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PMC11406030
In normal unprovoked cells, LMTK3 is expressed in the nucleus.
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PMC11750161
The mean data was fitted to an equation to derive a single-phase exponential decay curve.
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PMC11482552
The OncoPredict HPV QC test addresses these issues by including an exogenous control for both nucleic acid extraction and PCR amplification, which enable the separate monitoring of both the extraction efficiency and the potential PCR inhibition for each sample.
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PMC10631132
In order to generate OCs, iPSCs must undergo mesodermal and hematopoietic differentiation, which is followed by terminal OC differentiation [10, 37–39].
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PMC11703992
In vitro experiments, including overexpression and knockdown, demonstrated that DDIT4 leading to a chronic, low-intensity inflammatory state in CD4+ Memory T cells, eventually promoting the development of GCA.
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PMC10723784
The level of caspase 3/7 was also determined using Apotox‐Glo Triple assay.
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PMC7519871
It showed higher binding affinity with E-value of −7.6 Kcal/Mol and −7.7 Kcal/Mol with Akt and NF-kB respectively, whereas, BA had the binding energies of −5.5 Kcal/Mol and −6.4 Kcal/Mol respectively (Table 3).
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PMC6889484
To exploit the innate antiviral function of restriction factor cytidine deaminase APOBEC3G (A3G), we developed self-activating lentiviral vectors that efficiently deliver HIV-1 Vif-resistant mutant A3G-D128K to target cells.
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PMC11790971
Additionally, they could facilitate the study of developmental biology, neurobiology, and beyond, offering unprecedented insights into the fundamental processes governing life at the cellular level.
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PMC9429973
All patients have inform consent signed and RT-PCR test positive for SARS-Cov2.
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PMC8073654
Phenylbutenoids have been isolated mainly from Z. cassumunar but have been found in other Zingiberaceae plants, including Z. purpureum , Z. montanum , which is known as “Bangle” or “cassumunar ginger,” Z. neesanum , and Alpinia flabellate .
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PMC11723947
Over Representation Analyses (ORA) and Gene Set Enrichment Analyses (GSEA) were performed using clusterProfiler R package v.4.6.2.
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PMC10729469
One-way ANOVA followed by Turkey’s post hoc test was used to determine significant differences between experimental groups. *
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PMC9118379
The data set was acquired using a Q-Exactive Orbitrap spectrometer (Thermo Fisher Scientific, San Jose, CA) with higher-energy collisional dissociation for peptide fragmentation.
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PMC9429973
Methods: Using flow cytometry we analyzed blood and BM samples from 20 patients (pts) with CCUS/MDS (10 CCUS and 10 low risk-MDS) and 6 elderly healthy controls (EHC).
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PMC10969097
It was also able to significantly re-sensitise MDR cancer cells (KB-vin, HepG2-vin and NCI-H460/MX20) to conventional chemotherapeutic agents (i.e., paclitaxel and mitoxantrone) .
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PMC9429973
Also, the regulation of CD20 in BCP-ALL is not well defined.
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PMC11085211
Afterwards, the activity of the four subfractions was tested in GIST-882, with cell viability evaluated after 24 h of treatment with two different concentrations (12.5 µg/mL and 50 µg/mL) compared to the control (Figure 4).
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PMC6892818
As positive controls for TRAF1 (a), TRAF2 (b) and TRAF3 (c) protein expression induction, in RCC cell immunoblotting experiments (top panels) lysates from HCT116 cells that were treated with control (‘C’) or treated with mCD40L (‘mL’) for 6 h were included, while for HRPT cell experiments (bottom panels) lysates from ACHN cells untreated or treated with mCD40L for 6 h were used.
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PMC11206502
No. 103275-100; Agilent Technologies), according to the manufacturers’ instructions.
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PMC11750712
The LibraT1 study is an ongoing, multicenter, international, single-arm phase 1/2 study of TRBC1-directed autologous chimeric antigen receptor (CAR) T cells (AUTO4) in relapsed/refractory TRBC1-positive PTCL.
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PMC11762280
We established acute UVB injury model on mice dorsal skin and found that the severity of erythema, edema, and erosion were positively correlated with UVB dose (Fig. 1A–C).
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PMC11679892
A total of 250 μL of isopropanol was added to the collected upper phase, pipetted, and left at room temperature for 10 min.
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PMC11549612
Significant up-regulation and hypomethylation of BOLA1, BOLA2, and BOLA3 were observed across 12 KIRC cell lines.
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PMC6835428
CH conjugation with PEI and PEG can bypass the problems of low solubility and delivery effectiveness.
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PMC9429973
Data cut-off was Nov 22, 2021.
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PMC9429973
Although many AML patients initially respond to current treatment, the majority of them relapse.
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PMC9516401
They speculated that APDS inactivated IDE in the short term, leading to increased insulin levels and decreased blood sugar (Jevas, 2011 ▶).
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PMC8540692
In this manuscript, the abbreviation CCM is used to describe all three compounds (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) present in the curcumin from Curcuma longa chemical substance under investigation.
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PMC4270159
HER3.
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PMC11138140
Therefore, the temporal dynamics of cardiomyocyte hypertrophic responses have remained highly understudied.
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PMC3888431
With this study, assembled genome data of CHO cells was made publicly available for the first time.
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PMC11679326
SRs bind to components of the cell walls of Gram-positive and Gram-negative bacteria, as well as fungi (e.g., lipoteichoic acid, lipopolysaccharide, β-glucan), and induce the development of an immune response.
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PMC11471157
If used in a living organism, there is a high risk of triggering a severe allergic reaction.
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PMC11657744
FACS analysis demonstrated that cells with siRNA-depleted Cep89 or Fbf1 were significantly more likely to reside in the G0/G1 phase than control cells (Fig. 3C).
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PMC11723210
The captured hologram is back-propagated to the two object planes with the angular spectrum method to generate initial phase guesses and of the two object fields.
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PMC7039683
This isolation protocol was previously described as a method for harvesting oral periderm (Zhang et al., 2017), but in our experiment it was clear that the epithelial layers were harvested together.
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PMC6617630
Additionally, we found that BET inhibition through JQ1 depleted the BRD4 binding at the MYC promoter.
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PMC11200978
Cryoablation (CA) is an established treatment modality for a variety of cancers and has been shown to be superior to radiation therapy in the treatment of NSCLC in a recent meta-analysis .
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PMC11543853
We speculate that the reduced efficiency of genome replication was caused by predominant genome release in endosomes, where the virus genomes may have been degraded by RNases.
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PMC11525028
Data are presented as the mean ± SD; ns, not significant; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001, by one-way ANOVA with Tukey’s multiple comparisons test (C and I) and two-way ANOVA with Tukey’s multiple comparisons test (B).
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PMC11739484
The AUC values observed for MMP7, MMP11, and MMP14 are comparable to these known markers, emphasizing their potential as reliable diagnostic tools.
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PMC9412887
More importantly, after pretreatment of SSB NMs twice, adoptive therapy of NK92 cells showed the strongest antitumor effect with tumor inhibition rate of 78.15%.
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PMC11342785
N here refers to droplet number.
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