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PMC8609870
In this study, we firstly performed transcriptome sequencing analysis on the tissues of 3 patients with RSA and 3 patients with normal abortion, and found key molecules by constructing lncRNA-related ceRNA network, which is helpful to explore the pathogenic mechanism of RSA.
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PMC9118379
Therefore, we adopted a similar concept to examine the existence of consecutive variant site-specific b- or y-ions in variant spectra.
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PMC11665584
Identification of reliable transcriptomic markers to discern neutrophil heterogeneity is still forthcoming and will help distinguish if these neutrophils are pro- or antiinflammatory (72).
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PMC9429973
Identification of phospholipid entities with differential impact on healthy versus leukemic cells might help refine LSC targeted therapies.
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PMC11545737
Recently, galectin-3 has been found to be implicated in internalization of LPS and subsequent activation of non-canonical pyroptosis .
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PMC11705862
Using PLA, we detected an interaction between VAMP2 and both IRIS-1 (Fig. 3A, quantification in B) as well as IRIS-2 (Fig. 3C, quantification in D), implicating their association with the secretory vesicles.
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PMC11106977
Further elucidation of the structural features of OGA should uncover its substrate recognition mechanism.
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PMC7192625
We found categorical ChAs values of chromatin state to be larger than those obtained with distance-preserving randomization (Supplementary Figure S7), to a varying extent depending on the cell types.
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PMC10142392
In this case, previous research has shown that sustained-release systems are more effective in delivering drugs to targeted areas in the body, reducing the frequency of administration, decreasing toxicity, and improving patient compliance with treatment.
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PMC11365983
Quantification in serum-starved Gli2-mGFP-expressing NIH3T3 cells reveals substantially higher Gli1 protein levels with Foxc1 OE: 14-, 20- and 26-fold increases vs non-treated wild-type control at 0, 3 and 6 h (n = 1).
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PMC10713411
Click-iT EdU cell proliferation assay (Thermo Fisher Scientific, USA) was used for cell proliferation test and a laser confocal microscope was used for the observation of cells.
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PMC11551844
On the A172 cell line, ansellone A showed an IC50 value of 9.90 ± 2.50 μM, whereas the IC50 value of AuNPs-ansellone was 9.60 ± 5.44 μM. Contignasterol and AuNPs-contignasterol displayed IC50 values of 8.39 ± 1.74 μM and 18.22 ± 3.22 μM, respectively.
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PMC11742231
Of the possible drug–cell interactions, approximately 18.6% were missing.
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PMC11594806
Through A2ARs, ADO also inhibits dendritic cell function.
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PMC11622247
Light-harvesting probe C7-2AF568-QB-OMe afforded a 40 pM limit of detection (LOD) compared to 2 nM with the traditional FIT probe C7-QB-OMe.
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PMC10490530
In the case of combination treatment, A2780NP and A2780NPp cells did not show any significant increase in PIK3CA activity (p = 0.047).
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PMC10547921
These compounds have been advanced into the evaluation as ADC drug payloads.
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PMC11640115
Because acquired immunity influences cancer progression and recurrence, our group proposed the immune-modified GPS (imGPS), which adds the peripheral blood lymphocyte count as a component of the mGPS .
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PMC11509278
The IC50 values of serial samples of Serbian propolis for the human colon cancer cell line HCT-16 were 26.33~143.09 µg/mL .
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PMC11536589
KO: knockout; ROS: Reactive oxygen species; MDA: malondialdehyde; GSH: Glutathione The transcription factor of NFE2L2 is recognized as upstream regulatory of MGST1 in PDAC (Kuang et al. 2021), but AsPC1-MR cells showed decreased NFE2L2 expression compared with AsPC1 cells (Fig. S3A).
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PMC11665555
Paradoxically, OVOL1 expression was associated with poor overall survival and gemcitabine resistance in multiple cell lines.
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PMC10047551
A greater variation in PD-L1 mRNA expression was present in the tumor relative to the normal tissues (Figure S6F).
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PMC11040965
Data from real-time PCR and the 2 method, normalized to RNU44 (miR29b) and GAPDH (DNMT3B) and expressed as fold change relative to the average value for plasma cells from 10 controls (patients with benign hematological diseases).
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PMC11365427
On the other hand, regulating the metabolic pathways of cancer cells through alterations in nutrient supply or specific metabolic inhibitors is a viable strategy for therapy.
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PMC11763126
Following the incubation period, cells were fixed, stained, and imaged.
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PMC11680562
On the other hand, the blank gel did not demonstrate any harmful impact on HeLa cells.
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PMC9429973
The inclusion of pts was possible at any step if they met the key inclusion criteria:CML in chronic phase,age ≥18 years (y),TKI therapy duration 3 y,MMR and DMR duration2 y and 1 y.The inclusion into TFR was done after the dose reduction phase in pts with a DMR duration≥2 y and ≥MR4.5 at the time of TKI stop.
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PMC11547972
RCC resistance development towards TKIs and ICIs involves Akt activation, as recently reported by Aweys et al. .
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PMC11700165
The oncogenic capacity was significantly stronger upon TEL-SYK expression compared to ITK-SYK or BTK-SYK expression.
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PMC11306331
Total RNA was isolated from our FUS-CHOP NIH3T3 cell line using the RNeasy mini kit (Qiagen).
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PMC11763111
After 48 h of co-culturing with tumor cells, we constructed transcriptome analysis of 4KO-LLT1 and 4KO CAR-T cells to investigate the mechanism by which LLT1 overexpression affects CAR-T cell functionality.
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PMC11470381
Our approach expands upon current methodologies by not only tracking migrating cells but also imaging fluorescently labeled cellular components.
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PMC11773391
The levels of MGMT in MM tissues from nude mice were analysed using Western blotting (*p < 0.05 and **p < 0.01 compared with the control group). (
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PMC11026382
Null mutations disappeared from our sequencing counts within the first three time points (8 h) of the selection experiment, preventing accurate inference of growth rate.
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PMC7987994
Error bars stand for the standard error deviation of six measurements.
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PMC9429973
Disease characteristics were derived from the EHR, including the presence of high-grade lymphoma (positive rearrangement in C-MYC and BCL-2 or BCL-6 biomarkers) and primary refractory disease (2L started within 6 months not due to patient preference, drug shortage, insurance reasons, toxicity, or pandemic reasons).
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PMC11697703
These results indicate that MAPK8 signal in somata is reduced by either miR, whereas MAPK8 signal in the neuropil might be preferentially regulated by miR-193b.
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PMC11697189
Calibration curves were drawn to determine the accuracy of nomogram for OS at 1-, 3-, and 5-years. (
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PMC11381192
Conversely, patients with low CSI had enhanced immune checkpoint expression and lower TIDE scores, suggesting that these patients may be more responsive to ICB immunotherapy. ,
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PMC8658661
At the same time, based on the descriptions in the databases, the hepatic cell lines are described as “epithelial morphology”.
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PMC11612508
Following this, Fe3O4 magnetic NPs and GO were uniformly dispersed in the chitosan acetic acid solution using ultrasonic dispersion for half an hour.
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PMC11116779
The high diffusion of PS is due to its attractive features, such as low cost, low density, clarity, dimensional stability, and adaptability to radiation sterilization.
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PMC11509309
Extracts able to cure the [PSI+] prion were then assayed against a second yeast prion [URE3] (secondary screening).
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PMC11470999
Further studies demonstrated that PF dose dependently induces CIP2A downregulation (Figure 5B).
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PMC7136814
However, when ERMSs are advanced, recurrent, and/or metastatic, they are classified as high risk and exhibit poor response to treatment (chemoresistance), having a progression-free survival less than 1.5 years with a 5-year survival rate as low as 20% [3–5].
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PMC9622879
Five types of communal DERs were considered, consisting of PV systems, wind turbines, and diesel generator for electricity, and boiler and combined heat and power (CHP) for heating.
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PMC9429973
We purified these differentiations stages from CEBPA/CEBPE WT and KO mice and conducted global mRNA-seq and CEBPA/CEBPE ChIP-seq analyses, as well as complementary mechanistic validation experiments.
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PMC9776316
The current study demonstrated the cisplatin treatment activated the JNK-cJUN complex to drive the transcription of XRCC4 yet did not further explore how the JNK-cJUN complex was activated as such.
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PMC11782508
The cell lysate obtained from sonicated P. aeruginosa cells was subjected to ammonium sulfate precipitation.
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PMC8358006
Motif and statistical analysis were performed in HOMER software.
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PMC11740207
These results increase our chances of understanding the molecular mechanisms underlying malignant proliferation, as well as differences in cell cycle checkpoints (Skladanowski et al., 2009) and the types of cell stage division according to the Hayflick effect (HE) (Hayflick, 1965) between healthy VSELSCs and transformed VSCSCs as well as VSLSCs, along with their stage in vitro analogs.
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PMC11541409
C. Therapeutic antibodies targeting KIT.
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PMC9024365
C–E) Graphs depict the stratification of GluA1 (C), GluA2 (D), or GluK2 (E) puncta either co-localized or not co-localized with SD4 compared with the average cluster size of receptor alone.
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PMC11365427
Image created with BioRender.com with permission).
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PMC9429973
Patients were invited to generate questions about their condition which they felt should be addressed by research or a change in how their care is delivered.
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PMC11343332
Pycnogenol may provide therapeutic benefits for treating leukemia, according to the study .
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PMC9436459
In 2012, the Porco group developed a concise route towards the total synthesis of ( ±)-sorocenol B (149).
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PMC11740207
The cell’s chromatin undergoes significant condensation during apoptosis (Lecoeur et al., 1997; Coleman et al., 2001; Zhang et al., 2018; Aoki et al., 2020; Dou et al., 2020; Serrano-Heras et al., 2020).
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PMC11392912
Total miRNAs were isolated from plasma samples using miRNeasy Serum/Plasma (Qiagen, U.S.A.) isolation kit .
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PMC11401358
CD spectra of SF among different temperature treatments, showing an increase in the β-sheet structure content with increasing temperature. (
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PMC11711063
Enhanced mitogenic signaling was confirmed by a rapid transitory dip in inhibitory phosphorylation of Src at Tyr527, strong activation of the Erk1/2 kinase (Y204), and a lesser increase in Akt (T308) phosphorylation (Figure 2C) .
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PMC11366496
Viral vectors are used to directly interfere with the expression of RNF122, reducing its level in tumor cells and thus inhibiting tumor growth.
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PMC11594074
The docking simulation results are presented in Table 3, which includes docking scores and the interacting amino acids for the best docking pose of each compound.
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PMC9503541
Then, the cells in the monolayer were scratched with sterile p200 pipette tips and rinsed with PBS twice to remove the detached cells.
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PMC11684269
Moreover, the investigation of related mechanisms remains in its early stages, with few in-depth mechanistic analyses available.
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PMC11789597
MoAbs mediate MM cell death mainly through antibody‐dependent cell‐mediated cytotoxicity, antibody‐dependent cell phagocytosis, and complement‐dependent cytotoxicity.
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PMC11365983
The majority of genes dysregulated in the Pdgf mutant are similarly up- or down-regulated in Foxc1 mutant embryos; a correlation that extends to 1193 of 1324 genes; correlation coefficient ρ = 0.77, P = 2.2 × 10. (
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PMC11777207
KikGR mice were anesthetized and shaved in two spots on the upper dorsum.
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PMC11697703
Spine density and dynamics are key to determining the synaptic inputs each neuron receives.
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PMC11658074
In conclusion, AT can protect skin against photodamage.
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PMC11476222
Zhang et al. developed a method to investigate ganglioside–protein interactome using bifunctional probes, but only a few gangliosides could be targeted .
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PMC10538569
Cells were then washed 3 times with PBS to remove free viruses and seeded in triplicate in a 96 wells flat-bottom plate (2×10 per well) along with or without pRRL-GPI-scFv X5 or AB65-2A-GFP-transduced human primary CD4 T cells (1×10 per well).
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PMC10578720
Data presented as the mean ± SD, n=3, ns=p>0.05, **p<0.01, ****p<0.0001 (1-way ANOVA with Tukey post hoc test). (
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PMC11700247
B220 and CD19 alive cells after treatments. (
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PMC10933092
These findings provide new insights into the mA epitranscriptomic regulation of mRNA and lncRNAs in BLCA for the development of novel therapies.
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PMC6379402
This decomposition is done by solving the following multiple symmetric NMTF (MSNMTF):1[12pt] $$(})\,}_\, _i \|_}^2} ,$$(MSNMTF)min(S,G≥0) ∑iAi-G⋅Si⋅GTF2,where F denotes the Frobenius norm.
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PMC11806182
All analyses were performed using the R package TwoSampleMR .
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PMC11541241
Magnaporthe oryzae is the causal agent of the devastating blast of cultivated rice (Oryza sativa) and causes severe yield and substantial economic losses worldwide.
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PMC11297139
Droplet size was quantified by measuring the circumference of droplets using a Zen image viewer.
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PMC11746948
m Cell viability analysis in A375-GPX4-KO cells infected with WT or mutant Flag-GPX4 constructs, pre-treated with 2-BP, and then treated with RSL3.
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PMC11271278
HiChIP assays showed that CRISPRi resulted in an overall decrease in interactions between the MYC promoter and its enhancers, as expected (Fig. 6D–F).
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PMC9581083
The pathogenesis of warm-damp epidemic poisoning is mostly caused by sitting and lying on the ground when the climate is humid.
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PMC11628904
Immediately following burn injury, larvae were bathed in mNeon‐expressing C. albicans for 1 h with wound colonisation quantified 24 hpb.
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PMC11683130
IL-17 not only activates neutrophils but also promotes the proliferation of keratinocytes and the production of inflammatory chemokines(CXCL1, CXCL8, CCL20, TNF) by binding to IL-17 receptors.
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PMC11546117
Among the eighty-four analyzed genes, only three were not detectable (SLC22A9, SCLO1B1, and SLCO1B3).
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PMC11291697
Like glycine and serine metabolism, chemokine-mediated signalling pathway also plays a crucial role in CNS homeostasis by exerting neuroprotective and reparative functions and modulating synaptic transmission, blood brain barrier (BBB) activity and neuroinflammation .
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PMC9080589
13.0; SPSS, Chicago, IL, USA).
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PMC11588085
Grade 3 tumors displayed the highest stemness index, consistent with the histopathology grading for poorly differentiated cancer cells (SI Appendix, Fig. S1F).
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PMC9275501
In addition, APS combined with 5-FU could improve the anti-tumor effect accompanied by the immunosuppressive alleviation of 5-FU on immune system, which may be suitable as an immune adjuvant for chemotherapy (Li et al., 2020c).
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PMC11657695
Fourty-eight hours after transfection of the cells with a pool of siRNAs against KCNA2, KCNA2 expression was depleted at both mRNA and protein levels (Figure S7), and the number of cells was significantly reduced in both ES cell lines, compared with siRNA CT-transfected cells (Fig. 5G).
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PMC9429973
Eight patients have surprisingly achieved a notable PRafter failure of novel agents (i.e. Carfilzomib, Daratumumab and Pomalidomide).
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PMC5363531
These data indicate that the sequential administration mD led to higher efficacy, also when lower concentrations of the two drugs were tested.
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PMC11194678
These STAU1 droplets autonomously fused into larger ones over time (Fig. 2 C).
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PMC11779605
FGF7 protein levels in patient serum were categorized as above or below the median, and patient PFS or OS were compared between the two groups using the log-rank test.
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PMC11489351
This demonstrates that the transient increases in pHi (24 h) observed during differentiation may drive or reinforce the increased Notch activity required for temporal regulation of differentiation (4, 80, 81).
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PMC11591052
Importantly, 20E displays multiple beneficial pharmacological activities in humans, including anabolic, antioxidant, hypoglycemic, cardioprotective, hepatoprotective, neuroprotective, and other properties .
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PMC11519077
Similarly, our data showed a significant increase in the mRNA level of IL-12 in the IL-1β-induced Caco-2 group as the IBD model in comparison to the control group.
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PMC11737091
Wound healing assays for 786-O and A498 cells after DBF4 was knocked down. *,
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PMC11730320
In our patient, co-analysis of CD127 and CCR7 showed prematurely reduced expression on naive cells, but more critically, accelerated loss of CD127 within the memory compartment, with 80% of central memory no longer demonstrating expression (Fig. 4G, H).
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PMC10719213
For (b), the Student’s t-test was used.
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