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OTAR3088
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BioData-CellLine_annotated

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PMC11562028
The blood of each mouse was mixed in an anticoagulant tube, and the blood routine index analysis was performed with the routine test instrument.
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PMC11476666
The present study investigated the effects of RSV and its analogue DHS on A549 cells, with a specific focus on stemness features.
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PMC11682172
Among the proteins is coronin-1 A, a protein related to cell motility.
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PMC11367146
This suggests that ESR1-daucosterol had greater stability during the course of the simulation (Fig. 5B).
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PMC11024707
In the first study on mi-RNA and autism, which was carried out in 2014, mi-RNA-151a-3p was found to be significantly underexpressed when compared to healthy controls .
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PMC11612315
Representative traces of calcium influx elicited by 100 nM control CAP (b), GLP-1 (c), exendin-4 (d), or liraglutide (e).
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PMC8009078
Several parameters from MD simulation have suggested the stability between the protein and ligands.
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PMC11739696
Despite their promising applications, the safety profile of Co3O4NPs, including their genotoxicity and long-term effects, requires careful evaluation to ensure their safe use in clinical settings.
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PMC9024365
After fixation and permeabilization, cells were stained with anti-SD4 antibodies for total SD4.
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PMC9275501
Additionally, NDDS usually have good biocompatibility (Sun et al., 2021b), low side effects (Zhu et al., 2019), targeting (Lan et al., 2021b), controlled release characteristics (Chen et al., 2020a), which have brought promising prospect in cancer therapies due to their uniquely appealing properties (Maleki et al., 2021; Liu et al., 2021b).
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PMC8270637
At day 3, mice were injected with TGF-β1 (70 ng/mL or 280 ng/mL) or normal saline via the tail vein once daily at a dosage of 5 mL/kg.
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PMC11434983
The distribution coefficient (Do/w) values were calculated by dividing the counts in the 1-octanol phase by those in the PBS phase .
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PMC9429973
The project has been approved by the Ethical Committee of Germans Trias I Pujol Hospital (PI-20-103).
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PMC11271278
Somatic structural variants, including deletions, duplications, inversions, and translocations, dramatically alter genomic structures in cancer cells.
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PMC5311252
NSCLC cell lines U1810, A549 (ATCC, Rockville, MD, USA, CCL-185), NCI-H1703 (ATCC, CRL-5889) and SK-MES-1 cells (ATCC, HTB-58) were cultured in RPMI-1640 AQ media (Sigma-Aldrich, St Louis, MO, USA, R2405).
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PMC11127909
As Fig. 3A–C shows, 143B-EFHD1 cells mainly had larger, tubular, densely packed mitochondria than 143B-V cells in both the control and cisplatin groups.
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PMC9960565
The monodentate G0.5COO(Pt(NH3)2Cl)8 and G2.5COO(Pt(NH3)2Cl)32 metallodendrimers, together with the bidentate G2.5COO(Pt(NH3)2)16 metallodendrimer, were even more active towards the cisplatin-resistant cell line (A2780cisR cells) than the correspondent cisplatin-sensitive one (A2780 cells).
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PMC4270159
Harvest protein as in Step 5 after 2 hr of treatment.
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PMC11576293
Thiouridine (c-form) of compound 8.
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PMC11144200
In clinical practice, the standard of care for treating cancer has changed beyond the empirical application of cytotoxic therapy to customized therapy.
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PMC8839885
In contrast, the activity of 2HE2 in restoring platinum drug sensitivity to OC was not affected by the presence of cobimetinib, providing further support for the argument that 2HE2 function in restoring platinum drug sensitivity to OC cells is ERK1/2 independent.
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PMC4839679
In addition, we used glycerol gradient analysis to confirm that PBRM1 is fully reincorporated specifically into the PBAF complex and that overexpression doesn’t result in PBRM1 monomer or alterations in PBAF complex stoichiometry (S1 Fig).
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PMC11552389
As a result, the size of tumor nodules was tracked every 2 days.
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PMC11126803
Animal experiments were approved by the Animal Experiment Ethics Committee of Nankai University.
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PMC9429973
mPFS was overall 10.4 months (m) 95%CI [7.3; 14.7]; it was 23m 95%CI [14.7; -] in L2, 6.2m 95%CI [1.3; 12.2] in L3 and 7.1m 95%CI [4.6; 9.2] in L4+.
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PMC9545474
The crude product was dissolved in deuterated water and filtered through celite.
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PMC11345828
Calibration and quality control samples were prepared using blank plasma from untreated animals.
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PMC11732635
EBV, Epstein-Barr virus; gp350, glycoprotein 350; NK, natural killer.
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PMC9352806
However, the detailed mechanism of BMS in fat-lowering effect remains elusive.
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PMC11704834
The current data indicates that the transcriptional repression of E-cadherin contributes to TLE1-mediated attenuation of EGFR-TKI apoptosis.
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PMC11429241
However, there are still limitations to these in vitro models.
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PMC7887261
All 6 controls harbored MOB3A p.F69_I75del, whereas 4/5 LCs harbored STAU2 p.N364M fs*67del.
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PMC6627640
A highly significant upregulation of genes normally repressed by H3K27 methylation and the polycomb repressive complex 2 (PRC2) was noted in cisplatin resistant TGCT cells regardless of their parental origin which correlated with a substantial decrease in global H3K27me3, H2AK119 ubiquitination, and expression of BMI1.
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PMC6835428
To overcome the problems of short blood circulation time and potential aggregation of cationic lipids, the authors added PEG molecules to the lipid components (lipid–PEG).
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PMC10530622
Accordingly, Bhardwaj and co-workers (2017) demonstrated that, in animal models of hyperoxaluria, OPN levels, ER stress (increases in GRP78, ATF4 and XBP1), and apoptosis were correlated with the extent of CaOx crystal deposition in the renal tissue .
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PMC10940855
EC tube formation was inspected and photographed at 50x magnification using a Zeiss inverted light microscope (Carl Zeiss Microscopy), and branch point counting was performed for quantification analysis.
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PMC5916734
Dissolved carbon dioxide is a source of the carboxyl group being attached, while the reduced dihydroquinone form of vitamin K (KH2 ) acts as an electron donor and a co-factor of GGCX.
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PMC11740207
The molecular mechanisms by which SpLCs differentiate into mesodermal lineages involve several key processes guided by the Wnt and BMP pathways, which promote mesodermal development by inducing mesoderm-specific genes (Vacanti et al., 2001).
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PMC11752740
We then placed five grams of this powder into a cylindrical filter paper and inserted it into a specialized Soxhlet flask.
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PMC10761218
The MTT assay results indicated that the leaf, stem, and root methanolic extracts of W. somnifera showed significantly higher in vitro cytotoxicity in HepG2 cells, with IC50 values of 43.06 ± 0.615, 45.60 ± 0.3, and 314.4 ± 0.795 μg/mL than in L929 cell lines with 78.77 ± 0.795, 90.55 ± 0.800, and 361.70 ± 0.795 μg/mL, respectively.
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PMC9261184
For emphasis, this means that ∼8% of all LNG that is sent into the generator engines slips out and is emitted directly to the atmosphere.
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PMC10932641
For instance, lncRNA PVT1 can activate the PI3K/AKT and MAPK/ERK signaling pathways to promote RCC cell proliferation by directly targeting miR-328-3p (26).
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PMC11477621
C NMR (100 MHz, CDCl3) δ 188.9, 171.0, 131.4, 129.7, 121.4, 108.5, 48.8, 29.7, 27.2, 27.1.
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PMC6160470
A similar effect is also elicited by ATP-depleting agents, or when both nucleotide-binding sites are inactivated by mutations.
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PMC10988555
In our case, no in vivo embryo toxicity was observed when the chicken embryos were exposed to the IC50 of the different cobalt complexes for 48 h, which is an important indicator for in vivo absence of toxic side effects in nontumor cells.
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PMC10006224
The NIPBL KD plot shown corresponds to the experiment co-depleting NIPBL and CTCF.
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PMC11301242
Theoretically, genomic instability and/or defects in DNA repair mechanisms are essential to initiate ecDNA formation.
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PMC11638288
In advanced colorectal cancer, a decrease in NKp46 NK cells is correlated with lower survival rate .
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PMC9848491
UCEC patients were divided into low risk group and high risk group according to the median risk score.
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PMC10125312
Almada et al. showed that irradiation for 5 min at the higher laser power (2 W) decreased cellular viability even in the absence of AuNRs, whereas cells irradiated with AuNRs saw their viability impaired with lower laser powers such as 1 W. Furthermore, Zhang et al. showed how colocalization of AuNRs with laser irradiation increases temperature locally and impairs cellular viability, highlighting how different temperatures produce different cell death types.
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PMC11739696
However, the therapeutic efficacy of cobalt oxide nanoparticles (Co3O4NPs) in melanoma treatment remains unexplored.
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PMC10530622
Finally, another idea that arises from this section is the variability of the oxalate concentrations used in the different studies for a broad range of mechanisms.
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PMC11621565
In the cells that follow the dopaminergic differentiation protocol, a differentiation medium was added from the beginning to prevent the detachment of cells from the E-16 plates when changing the medium after 24 h of incubation (excluding day 0 presented in the differentiation protocol).
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PMC5916734
Panel A – amplification of whole ORF regions of the target genes in genomic DNA (gDNA) by PCR.
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PMC9429973
The study was approved by the local ethics committee and all donors and controls signed informed consent.
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PMC10033453
The remaining live adherent cells after infection with a low MOI (0.1) were also visualized by crystal violet staining (Figure 1C).
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PMC9429973
Subclonal somatic mutations, also found in other myeloid neoplasms (MN), have been described and are associated with disease progression and poor prognosis.
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PMC9429973
These and other data provided by RENEHOC will allow for health pharmaco-economic, epidemiologic and outcomes research in Colombia and Latin America.
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PMC9429973
Only 1 DLT (elevated troponin T/asymptomatic myocarditis) was reported in Cohort 2 and no DLTs were reported in Cohort 1.
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PMC9429973
S. Le Gouill, M. Długosz-Danecka, S. Rule, P. Luigi Zinzani, A. Goy, S. D. Smith, J. K. Doorduijn, C. Panizo, B. Shah, A. Davies, R. Eek, E. Jacobsen, A. P. Kater, T. Robak, P. Jain, R. Calvo, H. Yang, M. Wang Institut Curie, Paris, France; Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland; Plymouth University Medical School, Plymouth, United Kingdom; AstraZeneca, Mississauga, Ontario, Canada; IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia “Seràgnoli,” Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale Università di Bologna, Bologna, Italy; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ; University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America; Erasmus MC Cancer Institute, HOVON Lunenburg Lymphoma Phase I/II Consortium, Rotterdam, Netherlands; Clínica Universidad de Navarra, Pamplona, Spain; Moffitt Cancer Center, Tampa, FL, United States of America; Cancer Research UK Experimental Cancer Medicines Centre, University of Southampton Faculty of Medicine, Southampton, United Kingdom; Border Medical Oncology, Albury, NSW, Australia; Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America; Amsterdam University Medical Center, Amsterdam, on behalf of HOVON, Amsterdam, Netherlands; Copernicus Memorial Hospital, Medical University of Lodz, Lodz, Poland; MD Anderson Cancer Center, University of Texas, Houston, TX; AstraZeneca, Gaithersburg, MD; AstraZeneca, South San Francisco, CA, United States of America Background: Blastoid and pleomorphic variants of mantle cell lymphoma (MCL) are considered high risk and have poor prognoses.
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PMC11740207
This mechanism is frequently observed in mesenchymal tumors, such as bone sarcomas, and can also be found in gliomas and neuroendocrine cancers (Henson et al., 2002).
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PMC9429973
We cocultured CFDA-SE stained TCF3-PBX1-positive patient-derived leukemia cells and cell lines with cerebral organoids.
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PMC11047729
When the DNA mutation occurs (1.),
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PMC11347429
Principal component analysis (PCA) demonstrated good separation between infected patients and healthy controls ( Figure 1 ).
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PMC9429973
Of note, only 3/7 relapsed cases that presented a positive selection for TP53 mutations showed the presence of BTK mutations at the time of relapse.
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PMC10667689
T-cell immunoglobulin and mucin domain-3 (TIM-3) is a transmembrane molecule first identified as an immunoregulator.
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PMC6892818
Notably, we detected substantial amounts of soluble Trx-1 protein in RCC cell culture supernatants (data not shown), supporting Trx-1 over-expression.
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PMC7338939
Therefore, to seek the mechanism of resistance to Notch inhibitors, a set of experiments was done to clarify the gene roles.
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PMC9844987
Gene lists for FDA approved drug-targets (Wishart et al., 2018), essential genes (Hart et al., 2017) and GWAS hits (MacArthur et al., 2017) were downloaded from the MacArthur Lab Repository (https://github.com/macarthur-lab/gene_lists; MacArthur, 2019).
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PMC11547917
The TAC method gave values almost 10 times higher than DPPH and 25 times higher than ABTS.
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PMC11604768
These signaling events culminate into cellular responses with significant molecular efficacy and frequently result in activation or regulation of the roughly 1600 transcription factors (TFs) encoded by the human genome.
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PMC11699178
In the high-throughput transcriptome data, the expression levels of 18 intersecting genes were displayed, showing the most significant variation in HIF-1α expression, significantly decreased (Fig. 2E).
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PMC9429973
Diagnosis was established according to the WHO 2016 criteria.
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PMC9429973
Median PFS after 1 ASCT was 32 mo.
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PMC2777936
FZD5 and b) FZD7 expression profiles were determined using real-time RT-PCRs.
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PMC9429973
Median TNF-α serum were 2.1 pg/mL (0.8-6.9 pg/mL) & 1.8 pg/mL (0.4-3.3 pg/mL) in control & subject group respectively (p = 0.671 & p = 0.766).
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PMC9429973
Summary/Conclusion: With improvements to capacity on the Saphyr instrument, and automation of key processes, we believe that OGM has the potential to replace G-band chromosome analysis currently used as a global screen in routine diagnostics for haematological malignancy.
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PMC11011837
The identified differences within these T-ALL cell lines highlight the possibility to further investigate their sensitivity to new personalized therapeutic approaches.
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PMC9429973
Here we identified heterogeneity of CLL-1 expression within the CD34CD38 compartment of the KG1a AML cell line, which led us to explore whether this marker could more accurately identify LSCs.
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PMC11597167
Rosmarinic acid, EGCG, oleuropein, and quercetin (also used as the reference) were able to inhibit BACE1 with their respective IC50 values 4.06 ± 0.68, 1.62 ± 0.12, 9.87 ± 1.01, and 3.16 ± 0.30 mM. The inhibitory compounds were observed to occupy the non-catalytic site of the BACE1.
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PMC11739484
Researchers used its diverse collection of signaling pathways to deepen their understanding and explore therapeutic targets.
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PMC8623816
The cDNA probe 1 corresponding to the dsRNA-1 sequence is 373 bp in length and was obtained using specific primers (RdRpProbeF: 5′-GGATGAAGTCAAGCAG-3′ and RdRpProbeR: 5′-GGCGACAGTACGATGG-3′).
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PMC11481779
However, for the HiCDiffusion model, that task is much harder - as we are dealing with the sequence-only model, and epigenetic tracks that can indicate very strongly looping factors (e.g., CTCF) are not present in the input data.
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PMC11750696
ATF6 pathway.
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PMC9429973
Increased 2,3-diphosphoglycerate (2,3-DPG) concentrations, along with decreased oxygen affinity of hemoglobin, may be related to the variability of clinical outcomes in SCD.
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PMC11648299
The relative risk of being diagnosed with a keratinocyte carcinoma (i.e., BCC or cSCC) of DD patients was 1.6 (95% CI, 1.0-2.5, P = 0.036), while for BCC it was 1.8 (95% CI, 1.1–2.9, P = 0.012).
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PMC11765879
After performing the scratch and treating the cells with 40 and 60 µg/mL of ZSC extract for 24 h, the results revealed the inhibitory potential of the extract on cell migration.
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PMC11546117
These data disagree with data related to human non-lactating cells, as MRP3 and MRP4 were not detectable .
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PMC9429973
We then explored the safety and efficacy of addition of VEN to this regimen.
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PMC9429973
Results: A total of 6,215 patients with follicular lymphoma (FL) were included in this study.
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PMC7553912
From these findings, OSM seems to regulate inflammation through the production of inflammatory cytokines rather than by recruitment of M1 macrophages in the process of kidney stone formation.
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PMC11434983
The fac-[Tc(CO)3(imQz)(PPh3)] complex 2’ was synthesized with a high Radiochemical Yield (RCY) of 85%.
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PMC11763764
To date, we found only one study on SORL1 in ovarian cancer .
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PMC8041314
Furthermore, novel scaffolds (Screen 5) were chosen that have never been reported before regarding the ABC transporters ABCB1, ABCC1, and ABCG2 according to the initial data set of 1049 compounds (Supplementary Table 4).
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PMC11740207
Isolating ABs from patient blood samples may offer valuable diagnostic and therapeutic insights, especially for neurological conditions such as stroke and neurodegenerative diseases (Serrano-Heras et al., 2020).
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PMC11768927
Conversely, VSV can manipulate autophagy to enhance its replication, resulting in enhanced oncolysis by autophagic death.
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PMC9429973
Vaccination against SARS-CoV-2 is a leading strategy to change the course of the COVID-19 pandemic.
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PMC11701801
In cBAF-deficient cancer cells, inhibition of CBP/p300 leads to marked repression of KREMEN2, which reduces cell viability; this suggests that expression of the KREMEN2 gene is induced cooperatively by CBP and p300 and that it is required for the viability of cBAF-deficient cells.
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PMC11548041
These findings demonstrate enhanced uptake of aptamer-functionalized MNVs by EpCAM-positive tumor cells.
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PMC11746948
Data are presented as mean ± SD.
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